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UniProtKB - Q8BMU0 (ZNF76_MOUSE)
Protein
Zinc finger protein 76
Gene
Znf76
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 165 – 189 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 195 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 225 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 255 – 279 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 285 – 309 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 315 – 339 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 368 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- central nervous system development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 76Alternative name(s): Zinc finger protein 523 |
Gene namesi | Name:Znf76 Synonyms:Zfp523 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2687278, Zfp523 |
VEuPathDBi | HostDB:ENSMUSG00000024220 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000353096 | 1 – 568 | Zinc finger protein 76Add BLAST | 568 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 24 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q8BMU0 |
PaxDbi | Q8BMU0 |
PeptideAtlasi | Q8BMU0 |
PRIDEi | Q8BMU0 |
ProteomicsDBi | 275098 [Q8BMU0-1] 275099 [Q8BMU0-2] |
PTM databases
iPTMneti | Q8BMU0 |
PhosphoSitePlusi | Q8BMU0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024220, Expressed in adult mammalian kidney and 266 other tissues |
ExpressionAtlasi | Q8BMU0, baseline and differential |
Genevisiblei | Q8BMU0, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 230298, 1 interactor |
STRINGi | 10090.ENSMUSP00000002318 |
Miscellaneous databases
RNActi | Q8BMU0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 34 – 45 | 1Add BLAST | 12 | |
Repeati | 62 – 73 | 2Add BLAST | 12 | |
Repeati | 88 – 99 | 3Add BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 99 | 3 X 12 AA approximate repeatsAdd BLAST | 66 | |
Regioni | 365 – 402 | DisorderedSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 165 – 189 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 195 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 225 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 255 – 279 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 285 – 309 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 315 – 339 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 368 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160911 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | Q8BMU0 |
OMAi | HITFLSE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BMU0 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BMU0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ
60 70 80 90 100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH
110 120 130 140 150
PVPVPSDSAI LAVQTEAGLE DLAAEDEEGF GTDTVVALEQ YASKVLHDSP
160 170 180 190 200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
PTHIAYLSEV KEESSAIPTQ VAMVTEEDGP PQVALITQDG TQQVSLSPED
460 470 480 490 500
LQALGSAISV VTQHGSTTLT IPGHHEELAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ QTLEEAISVA
560
TAAMQQGAVT LETTESGC
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB2KF19 | B2KF19_MOUSE | Zinc finger protein 523 | Zfp523 | 292 | Annotation score: | ||
F7B631 | F7B631_MOUSE | Zinc finger protein 523 | Zfp523 | 189 | Annotation score: | ||
A0A3B2W3I6 | A0A3B2W3I6_MOUSE | Zinc finger protein 523 | Zfp523 | 513 | Annotation score: | ||
A0A3B2W4C6 | A0A3B2W4C6_MOUSE | Zinc finger protein 523 | Zfp523 | 342 | Annotation score: | ||
A0A3B2W7W5 | A0A3B2W7W5_MOUSE | Zinc finger protein 523 | Zfp523 | 258 | Annotation score: | ||
B2KF18 | B2KF18_MOUSE | Zinc finger protein 523 | Zfp523 | 189 | Annotation score: | ||
A0A3B2WCZ0 | A0A3B2WCZ0_MOUSE | Zinc finger protein 523 | Zfp523 | 84 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035628 | 312 – 316 | EKPYV → GPAGV in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_035629 | 317 – 568 | Missing in isoform 2. 1 PublicationAdd BLAST | 252 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028222 mRNA Translation: BAC25822.1 CT009658 Genomic DNA No translation available. BC058346 mRNA Translation: AAH58346.1 BC060611 mRNA Translation: AAH60611.1 |
CCDSi | CCDS28573.1 [Q8BMU0-1] |
RefSeqi | NP_766205.1, NM_172617.3 [Q8BMU0-1] XP_006524155.1, XM_006524092.3 XP_017172898.1, XM_017317409.1 [Q8BMU0-1] |
Genome annotation databases
Ensembli | ENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000233613; ENSMUSP00000156638; ENSMUSG00000024220 [Q8BMU0-1] |
GeneIDi | 224656 |
KEGGi | mmu:224656 |
UCSCi | uc008bqg.2, mouse [Q8BMU0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028222 mRNA Translation: BAC25822.1 CT009658 Genomic DNA No translation available. BC058346 mRNA Translation: AAH58346.1 BC060611 mRNA Translation: AAH60611.1 |
CCDSi | CCDS28573.1 [Q8BMU0-1] |
RefSeqi | NP_766205.1, NM_172617.3 [Q8BMU0-1] XP_006524155.1, XM_006524092.3 XP_017172898.1, XM_017317409.1 [Q8BMU0-1] |
3D structure databases
SMRi | Q8BMU0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230298, 1 interactor |
STRINGi | 10090.ENSMUSP00000002318 |
PTM databases
iPTMneti | Q8BMU0 |
PhosphoSitePlusi | Q8BMU0 |
Proteomic databases
MaxQBi | Q8BMU0 |
PaxDbi | Q8BMU0 |
PeptideAtlasi | Q8BMU0 |
PRIDEi | Q8BMU0 |
ProteomicsDBi | 275098 [Q8BMU0-1] 275099 [Q8BMU0-2] |
Protocols and materials databases
Antibodypediai | 15181, 133 antibodies from 25 providers |
DNASUi | 224656 |
Genome annotation databases
Ensembli | ENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000233613; ENSMUSP00000156638; ENSMUSG00000024220 [Q8BMU0-1] |
GeneIDi | 224656 |
KEGGi | mmu:224656 |
UCSCi | uc008bqg.2, mouse [Q8BMU0-1] |
Organism-specific databases
CTDi | 224656 |
MGIi | MGI:2687278, Zfp523 |
VEuPathDBi | HostDB:ENSMUSG00000024220 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160911 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | Q8BMU0 |
OMAi | HITFLSE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BMU0 |
TreeFami | TF333498 |
Miscellaneous databases
BioGRID-ORCSi | 224656, 2 hits in 64 CRISPR screens |
ChiTaRSi | Zfp523, mouse |
PROi | PR:Q8BMU0 |
RNActi | Q8BMU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024220, Expressed in adult mammalian kidney and 266 other tissues |
ExpressionAtlasi | Q8BMU0, baseline and differential |
Genevisiblei | Q8BMU0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF76_MOUSE | |
Accessioni | Q8BMU0Primary (citable) accession number: Q8BMU0 Secondary accession number(s): Q6P9T2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 4, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families