UniProtKB - Q8BMU0 (ZNF76_MOUSE)

BLAST

>sp|Q8BMU0|ZNF76_MOUSE Zinc finger protein 76 OS=Mus musculus OX=10090 GN=Znf76 PE=2 SV=1
MESLGLQTVRLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTIQKESFSFEDGQ
PVQLEDGSMAYIHHTPKEGCDPSALEAVQLEDGSTAYIHHPVPVPSDSAILAVQTEAGLE
DLAAEDEEGFGTDTVVALEQYASKVLHDSPASHNGKGQQVGDRAFRCGYKGCGRLYTTAH
HLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSG
DLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSAT
NYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSSCGKTYRQTSTL
AMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKPTHIAYLSEVKEESSAIPTQ
VAMVTEEDGPPQVALITQDGTQQVSLSPEDLQALGSAISVVTQHGSTTLTIPGHHEELAT
SGTHTVTMVSADGTQTQPVTIITSGALVTEDSSVASLHHQQVALLATANGTHIAVQLEDQ
QTLEEAISVATAAMQQGAVTLETTESGC

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History
Entry version 144 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Zinc finger protein 76

Gene

Znf76

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	165 – 189	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	195 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	225 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	255 – 279	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	285 – 309	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	315 – 339	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	345 – 368	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 76 Alternative name(s): Zinc finger protein 523
Gene namesⁱ	Name:Znf76 Synonyms:Zfp523
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:2687278 Zfp523

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000353096	1 – 568	Zinc finger protein 76Add BLAST		568

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	24	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q8BMU0
PeptideAtlas More...PeptideAtlasⁱ	Q8BMU0
PRIDEⁱ	Q8BMU0

PTM databases

iPTMnetⁱ	Q8BMU0
PhosphoSitePlusⁱ	Q8BMU0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024220 Expressed in 240 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	Q8BMU0 baseline and differential
Genevisibleⁱ	Q8BMU0 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	230298, 1 interactor
STRINGⁱ	10090.ENSMUSP00000002318

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BMU0
SMRⁱ	Q8BMU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	34 – 45	1Add BLAST	12
Repeatⁱ	62 – 73	2Add BLAST	12
Repeatⁱ	88 – 99	3Add BLAST	12

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	34 – 99	3 X 12 AA approximate repeatsAdd BLAST		66

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	165 – 189	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	195 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	225 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	255 – 279	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	285 – 309	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	315 – 339	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	345 – 368	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	Q8BMU0
KEGG Orthology (KO) More...KOⁱ	K20828
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	Q8BMU0
TreeFamⁱ	TF333498

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8BMU0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ 
        60         70         80         90        100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH 
       110        120        130        140        150
PVPVPSDSAI LAVQTEAGLE DLAAEDEEGF GTDTVVALEQ YASKVLHDSP 
       160        170        180        190        200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP 
       210        220        230        240        250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT 
       260        270        280        290        300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 
       310        320        330        340        350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC 
       360        370        380        390        400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK 
       410        420        430        440        450
PTHIAYLSEV KEESSAIPTQ VAMVTEEDGP PQVALITQDG TQQVSLSPED 
       460        470        480        490        500
LQALGSAISV VTQHGSTTLT IPGHHEELAT SGTHTVTMVS ADGTQTQPVT 
       510        520        530        540        550
IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ QTLEEAISVA 
       560 
TAAMQQGAVT LETTESGC

Length:568

Mass (Da):61,454

Last modified:March 1, 2003 - v1

Checksum:ⁱ1A3A1684C766CA7F

Isoform 2 (identifier: Q8BMU0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
312-316: EKPYV → GPAGV
317-568: Missing.

« Hide

        10         20         30         40         50
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ 
        60         70         80         90        100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH 
       110        120        130        140        150
PVPVPSDSAI LAVQTEAGLE DLAAEDEEGF GTDTVVALEQ YASKVLHDSP 
       160        170        180        190        200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP 
       210        220        230        240        250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT 
       260        270        280        290        300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 
       310 
NYKNHVRIHT GGPAGV

Show »

Length:316

Mass (Da):34,563

Checksum:ⁱEC8D8BFAC2E183C9

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B2KF19	B2KF19_MOUSE	Zinc finger protein 523 Zinc finger protein 523	Zfp523	292	Annotation score:
B2KF18	B2KF18_MOUSE	Zinc finger protein 523 Zinc finger protein 523	Zfp523	189	Annotation score:
F7B631	F7B631_MOUSE	Zinc finger protein 523 Zinc finger protein 523	Zfp523	101	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035628	312 – 316	EKPYV → GPAGV in isoform 2. 1 Publication		5
Alternative sequenceⁱVSP_035629	317 – 568	Missing in isoform 2. 1 PublicationAdd BLAST		252

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028222 mRNA Translation: BAC25822.1 CT009658 Genomic DNA No translation available. BC058346 mRNA Translation: AAH58346.1 BC060611 mRNA Translation: AAH60611.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28573.1 [Q8BMU0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_766205.1, NM_172617.3 [Q8BMU0-1] XP_006524155.1, XM_006524092.3 XP_017172898.1, XM_017317409.1 [Q8BMU0-1]
UniGeneⁱ	Mm.267359

Genome annotation databases

Ensemblⁱ	ENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220 [Q8BMU0-1]
GeneIDⁱ	224656
KEGGⁱ	mmu:224656
UCSC genome browser More...UCSCⁱ	uc008bqg.2 mouse [Q8BMU0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BMU0	Zinc finger protein 76		RAT		568	UniRef90_Q8BMU0
Zinc finger protein 76		CRIGR		699
Zinc finger protein 76		TUPCH		571
Zinc finger protein 76		CALJA		570
Zinc finger protein 76		MACMU		570
+73

Protein	Similar proteins		Species	Score	Length	Source
Q8BMU0	Zinc finger protein 76		RAT		568	UniRef50_Q8BMU0
Zinc finger protein 76		CRIGR		699
Zinc finger protein 76		TUPCH		571
ZNF76 isoform 7		PONAB		570
Uncharacterized protein		AOTNA		570
+136
Q8BMU0-2	Zinc finger protein 76 (Fragment)		MERNU		78	UniRef50_Q8BMU0-2
Zinc finger protein 76 (Fragment)		ESCRO		373
Zinc finger protein 143b		PETMA		382
Uncharacterized protein		SARHA		130
Uncharacterized protein (Fragment)		ORNMO		360
+6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028222 mRNA Translation: BAC25822.1 CT009658 Genomic DNA No translation available. BC058346 mRNA Translation: AAH58346.1 BC060611 mRNA Translation: AAH60611.1
CCDSⁱ	CCDS28573.1 [Q8BMU0-1]
RefSeqⁱ	NP_766205.1, NM_172617.3 [Q8BMU0-1] XP_006524155.1, XM_006524092.3 XP_017172898.1, XM_017317409.1 [Q8BMU0-1]
UniGeneⁱ	Mm.267359

3D structure databases

ProteinModelPortalⁱ	Q8BMU0
SMRⁱ	Q8BMU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230298, 1 interactor
STRINGⁱ	10090.ENSMUSP00000002318

PTM databases

iPTMnetⁱ	Q8BMU0
PhosphoSitePlusⁱ	Q8BMU0

Proteomic databases

PaxDbⁱ	Q8BMU0
PeptideAtlasⁱ	Q8BMU0
PRIDEⁱ	Q8BMU0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220 [Q8BMU0-1] ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220 [Q8BMU0-1]
GeneIDⁱ	224656
KEGGⁱ	mmu:224656
UCSCⁱ	uc008bqg.2 mouse [Q8BMU0-1]

Organism-specific databases

CTDⁱ	224656
MGIⁱ	MGI:2687278 Zfp523

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	Q8BMU0
KOⁱ	K20828
OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	Q8BMU0
TreeFamⁱ	TF333498

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BMU0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024220 Expressed in 240 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	Q8BMU0 baseline and differential
Genevisibleⁱ	Q8BMU0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNF76_MOUSE
Accessionⁱ	Q8BMU0Primary (citable) accession number: Q8BMU0 Secondary accession number(s): Q6P9T2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 4, 2008
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BMU0 (ZNF76_MOUSE)

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Zinc finger protein 76

Znf76

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ