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Protein

Spondin-2

Gene

Spon2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Divalent metal cationSequence analysis1
Metal bindingi140Divalent metal cationBy similarity1
Sitei140Important for metal ion-dependent interaction with integrinBy similarity1
Metal bindingi159CalciumBy similarity1
Metal bindingi187CalciumBy similarity1
Metal bindingi191Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • antigen binding Source: MGI
  • lipopolysaccharide binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • signaling receptor binding Source: MGI

GO - Biological processi

  • cell adhesion Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • defense response to bacterium Source: MGI
  • defense response to fungus Source: MGI
  • defense response to virus Source: MGI
  • induction of bacterial agglutination Source: MGI
  • innate immune response Source: MGI
  • mast cell mediated immunity Source: MGI
  • opsonization Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of macrophage cytokine production Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI
  • response to lipopolysaccharide Source: MGI

Keywordsi

Biological processCell adhesion, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-2
Alternative name(s):
Mindin
Gene namesi
Name:Spon2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1923724 Spon2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003587126 – 330Spondin-2Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 170PROSITE-ProRule annotation
Glycosylationi282C-linked (Man) tryptophanBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BMS2
PaxDbiQ8BMS2
PRIDEiQ8BMS2

PTM databases

iPTMnetiQ8BMS2
PhosphoSitePlusiQ8BMS2

Expressioni

Tissue specificityi

Detected in heart, lung, thymus, spleen and lymph node.1 Publication

Gene expression databases

BgeeiENSMUSG00000037379
CleanExiMM_SPON2
ExpressionAtlasiQ8BMS2 baseline and differential
GenevisibleiQ8BMS2 MM

Interactioni

Subunit structurei

Monomer. Interacts with integrin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042701

Structurei

3D structure databases

ProteinModelPortaliQ8BMS2
SMRiQ8BMS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 220SpondinPROSITE-ProRule annotationAdd BLAST191
Domaini276 – 330TSP type-1PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR0P Eukaryota
ENOG410XX1S LUCA
GeneTreeiENSGT00890000139423
HOGENOMiHOG000114626
HOVERGENiHBG052919
InParanoidiQ8BMS2
OMAiHSRHSLV
OrthoDBiEOG091G0BT5
PhylomeDBiQ8BMS2
TreeFamiTF326913

Family and domain databases

Gene3Di2.20.100.10, 1 hit
2.60.40.2130, 1 hit
InterProiView protein in InterPro
IPR009465 Spondin_N
IPR038678 Spondin_N_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF06468 Spond_N, 1 hit
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS51020 SPONDIN, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BMS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVSLALGR ALWVFLLAMI GSTTSQPLGG ESVCTARPLA RYSITFIGKW
60 70 80 90 100
SQTAFPKQYP LFRPPAQWSS LLGAAHSSDY SMWRKNEYVS NGLRDFAERG
110 120 130 140 150
EAWALMKEIE AAGEKLQSVH AVFSAPAIPS GTGQTSTELE VHPRHSLVSF
160 170 180 190 200
VVRIVPSPDW FVGIDSLDLC EGGRWKEQVV LDLYPHDAGT DSGFTFSSPN
210 220 230 240 250
FATIPQDTVT EITASSPSHP ANSFYYPRLK SLPPIAKVTF VRLQQSPRAF
260 270 280 290 300
APPSLDLASR GNEIVDSLSV PETPLDCEVS LWSSWGLCGG PCGKLGAKSR
310 320 330
TRYVRVQPAN NGTPCPELEE EAECAPDNCV
Length:330
Mass (Da):35,965
Last modified:September 27, 2004 - v2
Checksum:i581F16E6A55F9A07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242R → Q in BAC26226 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028987 mRNA Translation: BAC26226.1
AY457639 mRNA Translation: AAR20834.1
CCDSiCCDS19200.1
RefSeqiNP_598664.3, NM_133903.3
XP_006503685.1, XM_006503622.2
UniGeneiMm.34694

Genome annotation databases

EnsembliENSMUST00000046186; ENSMUSP00000042701; ENSMUSG00000037379
GeneIDi100689
KEGGimmu:100689
UCSCiuc008xai.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSPON2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS2
Secondary accession number(s): Q6SJD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: July 18, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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