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Protein

Leishmanolysin-like peptidase

Gene

Lmln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi261Zinc; catalyticPROSITE-ProRule annotation1
Active sitei262PROSITE-ProRule annotation1
Metal bindingi265Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi367Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: InterPro
  • peptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM08.003

Names & Taxonomyi

Protein namesi
Recommended name:
Leishmanolysin-like peptidaseCurated (EC:3.4.24.-By similarity)
Gene namesi
Name:Lmln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2444736 Lmln

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030771 – 681Leishmanolysin-like peptidaseAdd BLAST681

Proteomic databases

PaxDbiQ8BMN4
PRIDEiQ8BMN4

PTM databases

iPTMnetiQ8BMN4
PhosphoSitePlusiQ8BMN4

Expressioni

Gene expression databases

BgeeiENSMUSG00000022802 Expressed in 209 organ(s), highest expression level in retina
CleanExiMM_LMLN
GenevisibleiQ8BMN4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023497

Structurei

3D structure databases

ProteinModelPortaliQ8BMN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M8 family.Curated

Phylogenomic databases

eggNOGiKOG2556 Eukaryota
ENOG410XSAG LUCA
GeneTreeiENSGT00390000008796
HOGENOMiHOG000007103
HOVERGENiHBG087499
InParanoidiQ8BMN4
KOiK13539
OMAiGWLHKGA
OrthoDBiEOG091G03XZ
PhylomeDBiQ8BMN4
TreeFamiTF315265

Family and domain databases

InterProiView protein in InterPro
IPR001577 Peptidase_M8
PANTHERiPTHR10942 PTHR10942, 1 hit
PfamiView protein in Pfam
PF01457 Peptidase_M8, 2 hits

Sequencei

Sequence statusi: Complete.

Q8BMN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGSGGAG GPGPGPRGRW GGCLWVRGVL LVLGGLPAGA GAAPVSLGTS
60 70 80 90 100
PPCRHHVLSD TEVINKVHLK TNHVTKRDAD GHLRIKTIYD QSIEELLPEK
110 120 130 140 150
RYLVKNKLFP QAISYLEKTF QVRRPAGRIL LSRQCATNQY LRKENDPHRY
160 170 180 190 200
CTGECAVHTK CGPVIVPEEH LQQCRVCREG KWPCGAVGVL DPEGVRDADF
210 220 230 240 250
VLYVGALATE RCSHENIISY AAYCQQEAKM DRPIAGYANL CPNMISTQPQ
260 270 280 290 300
EFIGMLSTVK HEIIHALGFS AGLFAFYHDQ DGNPLTSRSA DGLPPFNYSL
310 320 330 340 350
GLYQWSDKVV RKVERLWNVR DNKIVRHTVY LLVTPRVVEE ARKHFNCPVL
360 370 380 390 400
EGMELENQGG MGTELNHWEK RLLENEAMTG SHTQNRVLSR ITLALMEDTG
410 420 430 440 450
WYKANYSMAE KLDWGRGLGC EFVRKSCKFW IDQHRQRRQV PSPYCDTLRS
460 470 480 490 500
NPLQLTCRQD QRAVAVCNLQ RFPNPLPPEY QYFDELTGIP AEDLPYYGGS
510 520 530 540 550
VEIADYCPFS QEFSWHLSGE YQRSSDCRIL ENQPELFKNY GAEQYGPHSV
560 570 580 590 600
CLLQKSAFIM EQCERKLSYP DWGSGCYQVS CSPQGLKVWV QDTSYLCSRA
610 620 630 640 650
GQVLPVRIQM NGWIHNGNLL CPSCWDFCEQ CPPETDPPAA NLTRALPLDL
660 670 680
CSCSSSLVVT LWLLLGNLFP LLAGFLLCVW H
Length:681
Mass (Da):76,575
Last modified:March 1, 2003 - v1
Checksum:i5E7A286E2F62D46B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030463 mRNA Translation: BAC26972.1
BC111899 mRNA Translation: AAI11900.1
BC112428 mRNA Translation: AAI12429.1
CCDSiCCDS28127.1
RefSeqiNP_766411.1, NM_172823.2
UniGeneiMm.131951

Genome annotation databases

EnsembliENSMUST00000023497; ENSMUSP00000023497; ENSMUSG00000022802
GeneIDi239833
KEGGimmu:239833
UCSCiuc007yzx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030463 mRNA Translation: BAC26972.1
BC111899 mRNA Translation: AAI11900.1
BC112428 mRNA Translation: AAI12429.1
CCDSiCCDS28127.1
RefSeqiNP_766411.1, NM_172823.2
UniGeneiMm.131951

3D structure databases

ProteinModelPortaliQ8BMN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023497

Protein family/group databases

MEROPSiM08.003

PTM databases

iPTMnetiQ8BMN4
PhosphoSitePlusiQ8BMN4

Proteomic databases

PaxDbiQ8BMN4
PRIDEiQ8BMN4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023497; ENSMUSP00000023497; ENSMUSG00000022802
GeneIDi239833
KEGGimmu:239833
UCSCiuc007yzx.1 mouse

Organism-specific databases

CTDi89782
MGIiMGI:2444736 Lmln

Phylogenomic databases

eggNOGiKOG2556 Eukaryota
ENOG410XSAG LUCA
GeneTreeiENSGT00390000008796
HOGENOMiHOG000007103
HOVERGENiHBG087499
InParanoidiQ8BMN4
KOiK13539
OMAiGWLHKGA
OrthoDBiEOG091G03XZ
PhylomeDBiQ8BMN4
TreeFamiTF315265

Miscellaneous databases

PROiPR:Q8BMN4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022802 Expressed in 209 organ(s), highest expression level in retina
CleanExiMM_LMLN
GenevisibleiQ8BMN4 MM

Family and domain databases

InterProiView protein in InterPro
IPR001577 Peptidase_M8
PANTHERiPTHR10942 PTHR10942, 1 hit
PfamiView protein in Pfam
PF01457 Peptidase_M8, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLMLN_MOUSE
AccessioniPrimary (citable) accession number: Q8BMN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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