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Protein

Transcription factor Sp8

Gene

Sp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri356 – 380C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 410C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 438C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp8
Gene namesi
Name:Sp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2443471 Sp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471531 – 486Transcription factor Sp8Add BLAST486

Proteomic databases

MaxQBiQ8BMJ8
PaxDbiQ8BMJ8
PRIDEiQ8BMJ8

PTM databases

iPTMnetiQ8BMJ8
PhosphoSitePlusiQ8BMJ8

Expressioni

Developmental stagei

Expression is detected in the forebrain, midbrain/hindbrain boundary and neural tube. At the stage of limb bud outgrowth, expressed in a scattered manner in the ventral ectoderm, and is later confined to the apical ectodermal ridge (AER).1 Publication

Gene expression databases

BgeeiENSMUSG00000048562 Expressed in 79 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SP8
ExpressionAtlasiQ8BMJ8 baseline and differential
GenevisibleiQ8BMJ8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065746

Structurei

3D structure databases

ProteinModelPortaliQ8BMJ8
SMRiQ8BMJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 104Ser-richAdd BLAST94
Compositional biasi68 – 116Ala-richAdd BLAST49
Compositional biasi132 – 149Gly-richAdd BLAST18

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri356 – 380C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 410C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 438C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ8BMJ8
KOiK09198
OMAiHNGTAPN
OrthoDBiEOG091G0HX6
PhylomeDBiQ8BMJ8
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BMJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAATCNKIG SPSPSPSSLS DSSSSFGKGF HPWKRSSSSS SGSCNVVGSS
60 70 80 90 100
LSSFGVSGAS RNGGSSSAAA AAAAAAAAAA ALVSDSFSCG GSPGSSAFSL
110 120 130 140 150
TSSSAAAAAA AAAAAASSSP FANDYSVFQA PGVSGGSGGG GGGGGGGSGA
160 170 180 190 200
HSQDSSHQPV FISKVHTSVD GLQGIYPRVG MAHPYESWFK PSHPGLGAAA
210 220 230 240 250
DVGSAGASSW WDVGAGWIDV QNPNGAAALP GSLHPAAGGL QTSLHSPLGG
260 270 280 290 300
YNSDYSGLSH SAFSSGASSH LLSPAGQHLM DGFKPVLPGS YPDSAPSPLA
310 320 330 340 350
GAGSSMLSAG PAAQLGGSPR SSARRYSGRA TCDCPNCQEA ERLGPAGASL
360 370 380 390 400
RRKGLHSCHI PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKRFTRS
410 420 430 440 450
DELQRHLRTH TGEKRFACPV CNKRFMRSDH LSKHVKTHSG GGGSAGSGGG
460 470 480
KKGSDTDSEH SAAGSPPCHS PELLQPPEPG HRNGLE
Length:486
Mass (Da):48,417
Last modified:March 1, 2003 - v1
Checksum:i336C36B548646883
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJL2A0A1Y7VJL2_MOUSE
Transcription factor Sp8
Sp8
181Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030745 mRNA Translation: BAC27113.1
AK053093 mRNA Translation: BAC35264.1
CCDSiCCDS26213.1
RefSeqiNP_796056.2, NM_177082.4
XP_006516046.1, XM_006515983.3
XP_006516047.1, XM_006515984.3
XP_006516048.1, XM_006515985.3
XP_006516049.1, XM_006515986.3
XP_006516050.1, XM_006515987.3
XP_006516051.1, XM_006515988.3
XP_011242426.1, XM_011244124.2
UniGeneiMm.51682

Genome annotation databases

EnsembliENSMUST00000063918; ENSMUSP00000065746; ENSMUSG00000048562
GeneIDi320145
KEGGimmu:320145
UCSCiuc007pig.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030745 mRNA Translation: BAC27113.1
AK053093 mRNA Translation: BAC35264.1
CCDSiCCDS26213.1
RefSeqiNP_796056.2, NM_177082.4
XP_006516046.1, XM_006515983.3
XP_006516047.1, XM_006515984.3
XP_006516048.1, XM_006515985.3
XP_006516049.1, XM_006515986.3
XP_006516050.1, XM_006515987.3
XP_006516051.1, XM_006515988.3
XP_011242426.1, XM_011244124.2
UniGeneiMm.51682

3D structure databases

ProteinModelPortaliQ8BMJ8
SMRiQ8BMJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065746

PTM databases

iPTMnetiQ8BMJ8
PhosphoSitePlusiQ8BMJ8

Proteomic databases

MaxQBiQ8BMJ8
PaxDbiQ8BMJ8
PRIDEiQ8BMJ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063918; ENSMUSP00000065746; ENSMUSG00000048562
GeneIDi320145
KEGGimmu:320145
UCSCiuc007pig.2 mouse

Organism-specific databases

CTDi221833
MGIiMGI:2443471 Sp8

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ8BMJ8
KOiK09198
OMAiHNGTAPN
OrthoDBiEOG091G0HX6
PhylomeDBiQ8BMJ8
TreeFamiTF350150

Miscellaneous databases

PROiPR:Q8BMJ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048562 Expressed in 79 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SP8
ExpressionAtlasiQ8BMJ8 baseline and differential
GenevisibleiQ8BMJ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP8_MOUSE
AccessioniPrimary (citable) accession number: Q8BMJ8
Secondary accession number(s): Q8BWA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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