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Protein

Rab3 GTPase-activating protein non-catalytic subunit

Gene

Rab3gap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein non-catalytic subunit
Alternative name(s):
Rab3 GTPase-activating protein 150 kDa subunit
Rab3-GAP p150
Short name:
Rab3-GAP150
Rab3-GAP regulatory subunit
Gene namesi
Name:Rab3gap2
Synonyms:Kiaa0839
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916043 Rab3gap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916631 – 1366Rab3 GTPase-activating protein non-catalytic subunitAdd BLAST1366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei899PhosphothreonineBy similarity1
Modified residuei914PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BMG7
PaxDbiQ8BMG7
PeptideAtlasiQ8BMG7
PRIDEiQ8BMG7

PTM databases

iPTMnetiQ8BMG7
PhosphoSitePlusiQ8BMG7

Expressioni

Gene expression databases

CleanExiMM_RAB3GAP2

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221114, 2 interactors
IntActiQ8BMG7, 1 interactor
STRINGi10090.ENSMUSP00000066325

Structurei

3D structure databases

ProteinModelPortaliQ8BMG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab3-GAP regulatory subunit family.Curated

Phylogenomic databases

eggNOGiKOG2727 Eukaryota
ENOG410XTJ2 LUCA
HOGENOMiHOG000290717
HOVERGENiHBG067039
InParanoidiQ8BMG7
KOiK19937
PhylomeDBiQ8BMG7

Family and domain databases

InterProiView protein in InterPro
IPR026059 Rab3-gap_reg
IPR029257 RAB3GAP2_C
IPR032839 RAB3GAP_N
PANTHERiPTHR12472 PTHR12472, 1 hit
PfamiView protein in Pfam
PF14656 RAB3GAP2_C, 1 hit
PF14655 RAB3GAP2_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BMG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA
60 70 80 90 100
WEETEPREPE EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV
110 120 130 140 150
RKWKHGDKGK EEMQFAVGWS GSVSAEEGEY VTSALCIPLA SQKRSSTGRP
160 170 180 190 200
DWTCIVVGFT SGYVRFYTEG VLLLAQLLNE DKVLQLKCRT YEIPRHPGVT
210 220 230 240 250
EQNEELSILY PAAIVTIDGF SLFQSLRACR NQVAKAAASG NENIQPPPLA
260 270 280 290 300
YKKWGLQDID TIIDHASVGI MTLSPFDQMK TASNIGGFNA AIKNSPPAMS
310 320 330 340 350
QYITVGSSPF TGFFYALEGS TQPLLSHVAL AVASKLTSAL FSAASGWLGW
360 370 380 390 400
KSKHEEDTVQ KQKPKMEPAT PLAVRFGLPD SRRHGESICL SPCNTLAAVT
410 420 430 440 450
DDFGRVILLD VARGIAIRMW KGYRDAQVGW IQIVEDLHER VPEKGGFSPF
460 470 480 490 500
GNTQGPSRVA QFLVIYAPRR GILEVWNTQQ GPRVGAFNVG KHCRLLYPGY
510 520 530 540 550
KIMGLNNVTS QSWQPQTYQI CLVDPVSASV KAVNVPFHLA LSDKKSERAK
560 570 580 590 600
DLHLVKKLSA LLRAKSPRPD SFETEIKELI LDIKYPATKK QALESILASD
610 620 630 640 650
RLSFSCLRNV TQTLMDTLKN QELESVDEGL LQFCASKLKL LHLYESVSQL
660 670 680 690 700
NTLDFHSDTP FSDNDLAVLL RLDDKELLKL RALLEKYKQE NTKATVRFSE
710 720 730 740 750
DADRVLPVKT FLEYLEYEKD ALSIRKIGEE ECVALGSFFF WKCLHGKSST
760 770 780 790 800
EEMCHSLESA GLSPQQLLSL LLSVWLSKEK DILDKPQSVC CLHTMLSLLS
810 820 830 840 850
KMKVAIDETW DSQSVSPWWQ QMRMACIQSE NSGAALLSAH VGHSVAAQMS
860 870 880 890 900
SGATDKKFSQ MELDADAEAL TDSWEALSLD TEYWKLLLRQ LEDCLILQTL
910 920 930 940 950
LHSKLSPPAA KAPSLQSEPL PRLSVKKLLE GGKGGIADSV AKWIFKQDLS
960 970 980 990 1000
PELLKCANKE RDVENPDEPR EDLLHLAYEQ FPCSLELDVL HAHCCWEYVV
1010 1020 1030 1040 1050
QWNKDPEEAR FLVRSIEHLK QILNPHVQNG IALMMWNTFL VKRFSAATYL
1060 1070 1080 1090 1100
MDKVGKSPKD RLCRRDVGMS DTALTSFLGS CLELLQTSLE ADISRDEVQV
1110 1120 1130 1140 1150
PVLDTEDAWL SVEGPISIVE LALEQKPIHY PLVEHHSVLC SILYASMRFS
1160 1170 1180 1190 1200
LKSVKPLALF DSKGKNAFFK DLTSIQLLPS GEMDPNFISV RQQFLLKVVS
1210 1220 1230 1240 1250
AAVQAQHSKD KDPSAEAANT HWKDLNWPGL AVDLAHHLQV SDDVIRRHYV
1260 1270 1280 1290 1300
GELYSHGADL LGEEAIFQVQ DKEVLASQLL VLTGQRLAHA LFHTQTKEGM
1310 1320 1330 1340 1350
ELLARLPPTL CTWLKAMNPQ DLQNTGVPIA ATAKLVHKVM ELLPEKHGQY
1360
SLALHLIDAV EAMATL
Length:1,366
Mass (Da):152,535
Last modified:April 12, 2005 - v2
Checksum:iA84C2C1416F673BA
GO
Isoform 2 (identifier: Q8BMG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1068: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):32,950
Checksum:i1BC695910AC3D832
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QKE4E9QKE4_MOUSE
Rab3 GTPase-activating protein non-...
Rab3gap2
1,387Annotation score:
A0A0A6YWM5A0A0A6YWM5_MOUSE
Rab3 GTPase-activating protein non-...
Rab3gap2
1,367Annotation score:

Sequence cautioni

The sequence AAH57872 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27296 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65667 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti727I → V in BAC27296 (PubMed:16141072).Curated1
Sequence conflicti747K → E in BAC27296 (PubMed:16141072).Curated1
Sequence conflicti747K → E (PubMed:19468303).Curated1
Sequence conflicti862E → V in BAC27296 (PubMed:16141072).Curated1
Sequence conflicti862E → V (PubMed:19468303).Curated1
Sequence conflicti906S → T in AAH57872 (PubMed:15489334).Curated1
Sequence conflicti1021Q → H in AAH57872 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0133131 – 1068Missing in isoform 2. 1 PublicationAdd BLAST1068

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031191 mRNA Translation: BAC27296.1 Different initiation.
AK048759 mRNA Translation: BAC33447.1
AC129195 Genomic DNA No translation available.
AC131084 Genomic DNA No translation available.
AC158963 Genomic DNA No translation available.
BC057872 mRNA Translation: AAH57872.1 Different initiation.
AK122385 Transcribed RNA Translation: BAC65667.2 Sequence problems.
RefSeqiNP_001157226.1, NM_001163754.1
UniGeneiMm.275841

Genome annotation databases

GeneIDi98732
KEGGimmu:98732

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031191 mRNA Translation: BAC27296.1 Different initiation.
AK048759 mRNA Translation: BAC33447.1
AC129195 Genomic DNA No translation available.
AC131084 Genomic DNA No translation available.
AC158963 Genomic DNA No translation available.
BC057872 mRNA Translation: AAH57872.1 Different initiation.
AK122385 Transcribed RNA Translation: BAC65667.2 Sequence problems.
RefSeqiNP_001157226.1, NM_001163754.1
UniGeneiMm.275841

3D structure databases

ProteinModelPortaliQ8BMG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221114, 2 interactors
IntActiQ8BMG7, 1 interactor
STRINGi10090.ENSMUSP00000066325

PTM databases

iPTMnetiQ8BMG7
PhosphoSitePlusiQ8BMG7

Proteomic databases

EPDiQ8BMG7
PaxDbiQ8BMG7
PeptideAtlasiQ8BMG7
PRIDEiQ8BMG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi98732
KEGGimmu:98732

Organism-specific databases

CTDi25782
MGIiMGI:1916043 Rab3gap2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2727 Eukaryota
ENOG410XTJ2 LUCA
HOGENOMiHOG000290717
HOVERGENiHBG067039
InParanoidiQ8BMG7
KOiK19937
PhylomeDBiQ8BMG7

Miscellaneous databases

ChiTaRSiRab3gap2 mouse
PROiPR:Q8BMG7
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB3GAP2

Family and domain databases

InterProiView protein in InterPro
IPR026059 Rab3-gap_reg
IPR029257 RAB3GAP2_C
IPR032839 RAB3GAP_N
PANTHERiPTHR12472 PTHR12472, 1 hit
PfamiView protein in Pfam
PF14656 RAB3GAP2_C, 1 hit
PF14655 RAB3GAP2_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBGPR_MOUSE
AccessioniPrimary (citable) accession number: Q8BMG7
Secondary accession number(s): Q6PEU0, Q80TQ6, Q8BX72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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