Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-binding mitochondrial carrier protein SCaMC-1

Gene

Slc25a24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi32 – 431PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi68 – 792PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi99 – 1103PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi135 – 1464PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-1
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 1
Solute carrier family 25 member 24
Gene namesi
Name:Slc25a24
Synonyms:Scamc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917160 Slc25a24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 197Mitochondrial intermembraneSequence analysisAdd BLAST197
Transmembranei198 – 215Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini216 – 250Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei251 – 270Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini271 – 293Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei294 – 307Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini308 – 343Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei344 – 363Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini364 – 386Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei387 – 404Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini405 – 443Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei444 – 463Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini464 – 475Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175951 – 475Calcium-binding mitochondrial carrier protein SCaMC-1Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-acetyllysine; alternateCombined sources1
Modified residuei318N6-succinyllysine; alternateCombined sources1
Modified residuei334N6-acetyllysineBy similarity1
Modified residuei435N6-acetyllysine; alternateCombined sources1
Modified residuei435N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BMD8
MaxQBiQ8BMD8
PaxDbiQ8BMD8
PeptideAtlasiQ8BMD8
PRIDEiQ8BMD8

PTM databases

iPTMnetiQ8BMD8
PhosphoSitePlusiQ8BMD8

Expressioni

Gene expression databases

BgeeiENSMUSG00000040322 Expressed in 221 organ(s), highest expression level in ileum
ExpressionAtlasiQ8BMD8 baseline and differential
GenevisibleiQ8BMD8 MM

Interactioni

Protein-protein interaction databases

BioGridi230896, 1 interactor
STRINGi10090.ENSMUSP00000029477

Structurei

3D structure databases

ProteinModelPortaliQ8BMD8
SMRiQ8BMD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 54EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini55 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini86 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 157EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati192 – 276Solcar 1Add BLAST85
Repeati284 – 369Solcar 2Add BLAST86
Repeati381 – 469Solcar 3Add BLAST89

Domaini

The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00880000137904
HOGENOMiHOG000165728
HOVERGENiHBG108464
InParanoidiQ8BMD8
KOiK14684
OMAiKVGTFER
OrthoDBiEOG091G0C8S
PhylomeDBiQ8BMD8
TreeFamiTF313492

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BMD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRWLRAFVL PTAACHDAEP PTRYETLFRA LDRNGDGVVD IGELQQGLQS
60 70 80 90 100
LGIPLGQDAE EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK
110 120 130 140 150
NNDGKIEPSE IVQSLQMLGL HISEKQAELI LQSIDSDGTM TVDWNEWRDY
160 170 180 190 200
FLFNPVTDIE EIIRFWKHST GIDIGDSLTI PDEFTEDEKK SGQWWRQLLA
210 220 230 240 250
GGVAGAVSRT STAPLDRLKV MMQVHGSKSM NIFGGFRQMV KEGGIRSLWR
260 270 280 290 300
GNGTNVIKIA PETAVKFWAY EQYKKLLTEE GQKLGTFERF ISGSMAGATA
310 320 330 340 350
QTFIYPMEVL KTRLAVAKTG QYSGIYGCAK KILKHEGFGA FYKGYIPNLL
360 370 380 390 400
GIIPYAGIDL AVYELLKSYW LDNFAKDSVN PGVMVLLSCG ALSSTCGQLA
410 420 430 440 450
SYPLALVRTR MQAQATVEGA PQLSMVGLFQ RIVSKEGVSG LYRGITPNFM
460 470
KVLPAVGISY VVYENMKQTL GVAQK
Length:475
Mass (Da):52,902
Last modified:March 1, 2003 - v1
Checksum:iDB9BEE1C3D16AF41
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFB9A0A0G2JFB9_MOUSE
Calcium-binding mitochondrial carri...
Slc25a24
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27L → F in BAE40063 (PubMed:16141072).Curated1
Sequence conflicti27L → F in BAE39810 (PubMed:16141072).Curated1
Sequence conflicti133S → G in AAH55369 (PubMed:15489334).Curated1
Sequence conflicti475K → E in BAE41903 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032806 mRNA Translation: BAC28031.1
AK146034 mRNA Translation: BAE26847.1
AK167778 mRNA Translation: BAE39810.1
AK168090 mRNA Translation: BAE40063.1
AK170598 mRNA Translation: BAE41903.1
AL671921, AL845310 Genomic DNA Translation: CAM19805.1
AL845310, AL671921 Genomic DNA Translation: CAM26535.1
CT010461 Genomic DNA Translation: CAM28161.1
BC055369 mRNA Translation: AAH55369.1
CCDSiCCDS17772.1
RefSeqiNP_766273.1, NM_172685.3
UniGeneiMm.33574

Genome annotation databases

EnsembliENSMUST00000029477; ENSMUSP00000029477; ENSMUSG00000040322
GeneIDi229731
KEGGimmu:229731
UCSCiuc008rae.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032806 mRNA Translation: BAC28031.1
AK146034 mRNA Translation: BAE26847.1
AK167778 mRNA Translation: BAE39810.1
AK168090 mRNA Translation: BAE40063.1
AK170598 mRNA Translation: BAE41903.1
AL671921, AL845310 Genomic DNA Translation: CAM19805.1
AL845310, AL671921 Genomic DNA Translation: CAM26535.1
CT010461 Genomic DNA Translation: CAM28161.1
BC055369 mRNA Translation: AAH55369.1
CCDSiCCDS17772.1
RefSeqiNP_766273.1, NM_172685.3
UniGeneiMm.33574

3D structure databases

ProteinModelPortaliQ8BMD8
SMRiQ8BMD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230896, 1 interactor
STRINGi10090.ENSMUSP00000029477

PTM databases

iPTMnetiQ8BMD8
PhosphoSitePlusiQ8BMD8

Proteomic databases

EPDiQ8BMD8
MaxQBiQ8BMD8
PaxDbiQ8BMD8
PeptideAtlasiQ8BMD8
PRIDEiQ8BMD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029477; ENSMUSP00000029477; ENSMUSG00000040322
GeneIDi229731
KEGGimmu:229731
UCSCiuc008rae.1 mouse

Organism-specific databases

CTDi29957
MGIiMGI:1917160 Slc25a24

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00880000137904
HOGENOMiHOG000165728
HOVERGENiHBG108464
InParanoidiQ8BMD8
KOiK14684
OMAiKVGTFER
OrthoDBiEOG091G0C8S
PhylomeDBiQ8BMD8
TreeFamiTF313492

Miscellaneous databases

PROiPR:Q8BMD8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040322 Expressed in 221 organ(s), highest expression level in ileum
ExpressionAtlasiQ8BMD8 baseline and differential
GenevisibleiQ8BMD8 MM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSCMC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMD8
Secondary accession number(s): Q3TCQ2, Q3THY3, Q7TPC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again