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Protein

Zinc finger protein DZIP1

Gene

Dzip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in spermatogenesis via its interaction with DAZL. Has a role in primary cilium formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 206C2H2-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5632684 Hedgehog 'on' state

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein DZIP1
Alternative name(s):
DAZ-interacting protein 1 homolog
Gene namesi
Name:Dzip1
Synonyms:Kiaa0996
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914311 Dzip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471071 – 852Zinc finger protein DZIP1Add BLAST852

Proteomic databases

PaxDbiQ8BMD2
PRIDEiQ8BMD2

PTM databases

iPTMnetiQ8BMD2
PhosphoSitePlusiQ8BMD2

Expressioni

Tissue specificityi

Expressed in testis and undifferentiated ES cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000042156 Expressed in 261 organ(s), highest expression level in central nervous system
CleanExiMM_DZIP1
GenevisibleiQ8BMD2 MM

Interactioni

Subunit structurei

Probably interacts with DAZL. May participate in an RNA-binding complex that functions in both ES cells and germ cells (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-61407N
IntActiQ8BMD2, 8 interactors
MINTiQ8BMD2
STRINGi10090.ENSMUSP00000004055

Structurei

3D structure databases

SMRiQ8BMD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili214 – 307Sequence analysisAdd BLAST94
Coiled coili385 – 429Sequence analysisAdd BLAST45
Coiled coili488 – 508Sequence analysisAdd BLAST21

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 206C2H2-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJJY Eukaryota
ENOG4111HTD LUCA
GeneTreeiENSGT00530000063572
HOGENOMiHOG000112305
HOVERGENiHBG059529
InParanoidiQ8BMD2
KOiK16470
OMAiAKASYYQ
OrthoDBiEOG091G0R9K
TreeFamiTF330044

Family and domain databases

InterProiView protein in InterPro
IPR032714 DZIP1_N
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13815 Dzip-like_N, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BMD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFQKHVYYP LANSPEGPDA SAIGAAPMAF VPPSAASGPL PFFQFRPRLE
60 70 80 90 100
SVDWRRLSAI DVDKVAGAVD VLTLQENIMN ITFCKLEDEK CPHCQSGVDP
110 120 130 140 150
VLLKLIRLAQ LTIEYLMHSQ EFLTSQLNLV EERLRLSLLD YEQSKQLLTK
160 170 180 190 200
QAGEIKLLKE ECKRRKKMLS TQQLMIEAKA SYYQCHFCDK AFMNQAFLQS
210 220 230 240 250
HIQRRHTEDS HLEYNTKAQT DRLQKEIDML KEQLQLTRSQ LESAQHSHAV
260 270 280 290 300
RFSKDYEMQK SKEEDFLKLF DRWKEEEKEK LLEEMEKVKG MFMREFKELT
310 320 330 340 350
SKNSALEYQL LEIQKSNIQI KSNIGTLRDV TELREDHLPC PQDFQNMLQL
360 370 380 390 400
LDSQASKWTD RFQVLNEEHS KEKGQLLSHI EKLRSSMMKD LSADNVFYKR
410 420 430 440 450
RVEELGQKLQ EQNELIISQK QQIREFASKP YSSISELKGT PLTRQTLEPK
460 470 480 490 500
SAAPTTPMTA SATQNLDGAS SLTMVHEQVF SSHILEPIEE LSSEEEKGRE
510 520 530 540 550
NEQKLNKKTS LRKPSSTSPS PQELRTNLER ELGNKLRSFG IGANIQGIPC
560 570 580 590 600
EILNRSLKAM QVARHDLAKQ MPDIQQIRES LEHQLICKME EKVSLSSDRH
610 620 630 640 650
HVPSMTTFPP EEVPKATQLP HKSRPLVRQR TVFTDKVSVP KLKKNTKESH
660 670 680 690 700
FLRRFPSTKT PPFSSEEEPD EEDLLHAYLS PDSLATAATQ PPKSSMSHFG
710 720 730 740 750
KSAVKSDTDW TEGSEMDDSD FSPKLTGTSI TIQTDTVETM ALPQGSGNKA
760 770 780 790 800
VPGMNPADTV IKKESLQELK CTDADDEDWD ISSLEEEKSL GSKIEQREPP
810 820 830 840 850
PAKRDPSCTQ VQRAWGPVNP REFKEEGLHE NEPSTLKSNL VTVTDWSDVL

DV
Length:852
Mass (Da):97,263
Last modified:July 27, 2011 - v3
Checksum:iBF786BAE227DBD47
GO
Isoform 2 (identifier: Q8BMD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-309: Missing.
     771-798: CTDADDEDWDISSLEEEKSLGSKIEQRE → FGSVGRQLWSLSVLSDSRCGLNNVRSEI
     799-852: Missing.

Note: No experimental confirmation available.
Show »
Length:797
Mass (Da):90,933
Checksum:iAD5D1E8AA6C5C13B
GO
Isoform 3 (identifier: Q8BMD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):71,066
Checksum:iE46088504B7FEB01
GO

Sequence cautioni

The sequence BAC98066 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118H → Y in BAC28050 (PubMed:16141072).Curated1
Sequence conflicti474M → I in BAC28050 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109661 – 228Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_010967309Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_010968771 – 798CTDAD…IEQRE → FGSVGRQLWSLSVLSDSRCG LNNVRSEI in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_010969799 – 852Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129256 mRNA Translation: BAC98066.1 Different initiation.
BC098211 mRNA Translation: AAH98211.1
AK021163 mRNA Translation: BAB32310.1
AK032834 mRNA Translation: BAC28050.1
CCDSiCCDS37011.1 [Q8BMD2-1]
RefSeqiNP_080219.2, NM_025943.3 [Q8BMD2-1]
XP_006519446.1, XM_006519383.2 [Q8BMD2-1]
XP_006519447.1, XM_006519384.2 [Q8BMD2-1]
XP_006519454.1, XM_006519391.3 [Q8BMD2-3]
XP_011243448.1, XM_011245146.2 [Q8BMD2-1]
XP_017171615.1, XM_017316126.1 [Q8BMD2-3]
UniGeneiMm.87456

Genome annotation databases

EnsembliENSMUST00000004055; ENSMUSP00000004055; ENSMUSG00000042156 [Q8BMD2-1]
ENSMUST00000047208; ENSMUSP00000039689; ENSMUSG00000042156 [Q8BMD2-1]
GeneIDi66573
KEGGimmu:66573
UCSCiuc007uyy.1 mouse [Q8BMD2-3]
uc007uza.2 mouse [Q8BMD2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129256 mRNA Translation: BAC98066.1 Different initiation.
BC098211 mRNA Translation: AAH98211.1
AK021163 mRNA Translation: BAB32310.1
AK032834 mRNA Translation: BAC28050.1
CCDSiCCDS37011.1 [Q8BMD2-1]
RefSeqiNP_080219.2, NM_025943.3 [Q8BMD2-1]
XP_006519446.1, XM_006519383.2 [Q8BMD2-1]
XP_006519447.1, XM_006519384.2 [Q8BMD2-1]
XP_006519454.1, XM_006519391.3 [Q8BMD2-3]
XP_011243448.1, XM_011245146.2 [Q8BMD2-1]
XP_017171615.1, XM_017316126.1 [Q8BMD2-3]
UniGeneiMm.87456

3D structure databases

SMRiQ8BMD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61407N
IntActiQ8BMD2, 8 interactors
MINTiQ8BMD2
STRINGi10090.ENSMUSP00000004055

PTM databases

iPTMnetiQ8BMD2
PhosphoSitePlusiQ8BMD2

Proteomic databases

PaxDbiQ8BMD2
PRIDEiQ8BMD2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004055; ENSMUSP00000004055; ENSMUSG00000042156 [Q8BMD2-1]
ENSMUST00000047208; ENSMUSP00000039689; ENSMUSG00000042156 [Q8BMD2-1]
GeneIDi66573
KEGGimmu:66573
UCSCiuc007uyy.1 mouse [Q8BMD2-3]
uc007uza.2 mouse [Q8BMD2-1]

Organism-specific databases

CTDi22873
MGIiMGI:1914311 Dzip1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJJY Eukaryota
ENOG4111HTD LUCA
GeneTreeiENSGT00530000063572
HOGENOMiHOG000112305
HOVERGENiHBG059529
InParanoidiQ8BMD2
KOiK16470
OMAiAKASYYQ
OrthoDBiEOG091G0R9K
TreeFamiTF330044

Enzyme and pathway databases

ReactomeiR-MMU-5632684 Hedgehog 'on' state

Miscellaneous databases

PROiPR:Q8BMD2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042156 Expressed in 261 organ(s), highest expression level in central nervous system
CleanExiMM_DZIP1
GenevisibleiQ8BMD2 MM

Family and domain databases

InterProiView protein in InterPro
IPR032714 DZIP1_N
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13815 Dzip-like_N, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDZIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMD2
Secondary accession number(s): Q4QQM0, Q6ZQ10, Q9CRK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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