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Entry version 130 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Nucleolar protein 9

Gene

Nop9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 9
Alternative name(s):
Pumilio domain-containing protein NOP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nop9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915092, Nop9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759281 – 636Nucleolar protein 9Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BMC4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BMC4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BMC4

PRoteomics IDEntifications database

More...
PRIDEi
Q8BMC4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
295503

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BMC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BMC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019297, Expressed in testis and 280 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BMC4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212472, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8BMC4, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8BMC4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019441

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BMC4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BMC4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati92 – 123Pumilio 1Add BLAST32
Repeati189 – 223Pumilio 2Add BLAST35
Repeati313 – 348Pumilio 3Add BLAST36
Repeati351 – 386Pumilio 4Add BLAST36
Repeati509 – 544Pumilio 5Add BLAST36
Repeati547 – 581Pumilio 6Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni222 – 242DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 238Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOP9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2188, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004964

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029199_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BMC4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPNGSHI

Database of Orthologous Groups

More...
OrthoDBi
238378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BMC4

TreeFam database of animal gene trees

More...
TreeFami
TF327254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR040000, NOP9
IPR001313, Pumilio_RNA-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR13102, PTHR13102, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00025, Pumilio, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BMC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLGPRSAHK ARRQFSGAGR RGRAARGSGR PPPGRDGYPR LPAAARAEQA
60 70 80 90 100
PEALPHLSPE ALGYFRRALS ALKVAPDAAE ERELMARNIL KEVEAQALAL
110 120 130 140 150
ATNRTGSEML QELLGFSPLK PLCRVWAALR PNLRFVACHR CGVHVLQSAL
160 170 180 190 200
LQLPRLLRRP AEAEEEEEEE EEGGPSQTLE ELVLGLAAEV CDDFLFFCGD
210 220 230 240 250
THGSFVVRTL LQVLGGTLLE SERGKPRGSQ SSETQRTSAR ECKPTDFEVP
260 270 280 290 300
KTFLNRLQDL SACFLKDIAV FITDKISSFC LQVALQVLHQ KLPQHCAHLC
310 320 330 340 350
DAVIDYLSSR NSSADGSPLL LFLRDQTSSR LLEQVLLVLE AERLQRLYKD
360 370 380 390 400
HFQGQLCSLA EHPIANFPLQ RLLDAITSPE LLSLVFEELS PALEMVLAQG
410 420 430 440 450
HPGVVVALVE ACRRVGTHQA QVLQLLFEAF HCAEPPSRQA ACVPLFAALL
460 470 480 490 500
AYEVYYELME EEGAVPAEHQ VEMATARALR EVTVLGSLLL QHLLYFSNPG
510 520 530 540 550
LVLRSLSALT GPQLLTLAQS PAGSHVFDAI LSSPSVTHKQ RRRVLKTLKG
560 570 580 590 600
QYVALACSRH GSRVLDAIWS GAALGARKEI AAELGEKNQE LIQDPFGHHV
610 620 630
ARNVALTTFL KRREAWEQQQ STVAKRRRAL SSILED
Length:636
Mass (Da):70,046
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC4575FF7FA2756C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB29900 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC34455 differs from that shown. Reason: Frameshift.Curated
The sequence BAC39042 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61A → P in BAB29900 (PubMed:16141072).Curated1
Sequence conflicti61A → P in BAC39042 (PubMed:16141072).Curated1
Sequence conflicti110L → V in BAC34455 (PubMed:16141072).Curated1
Sequence conflicti402P → Q in BAB27705 (PubMed:16141072).Curated1
Sequence conflicti503L → V in AAH18523 (PubMed:15489334).Curated1
Sequence conflicti525H → N in BAB27705 (PubMed:16141072).Curated1
Sequence conflicti566D → Y in BAC29882 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK011570 mRNA Translation: BAB27705.1
AK015585 mRNA Translation: BAB29900.1 Different initiation.
AK032873 mRNA Translation: BAC28064.1
AK037831 mRNA Translation: BAC29882.1
AK050912 mRNA Translation: BAC34455.1 Frameshift.
AK083861 mRNA Translation: BAC39042.1 Different initiation.
AK146020 mRNA Translation: BAE26838.1
AK159798 mRNA Translation: BAE35379.1
BC018523 mRNA Translation: AAH18523.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27126.1

NCBI Reference Sequences

More...
RefSeqi
NP_080679.3, NM_026403.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000019441; ENSMUSP00000019441; ENSMUSG00000019297

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67842

UCSC genome browser

More...
UCSCi
uc007uao.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011570 mRNA Translation: BAB27705.1
AK015585 mRNA Translation: BAB29900.1 Different initiation.
AK032873 mRNA Translation: BAC28064.1
AK037831 mRNA Translation: BAC29882.1
AK050912 mRNA Translation: BAC34455.1 Frameshift.
AK083861 mRNA Translation: BAC39042.1 Different initiation.
AK146020 mRNA Translation: BAE26838.1
AK159798 mRNA Translation: BAE35379.1
BC018523 mRNA Translation: AAH18523.1
CCDSiCCDS27126.1
RefSeqiNP_080679.3, NM_026403.3

3D structure databases

SMRiQ8BMC4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212472, 2 interactors
IntActiQ8BMC4, 2 interactors
MINTiQ8BMC4
STRINGi10090.ENSMUSP00000019441

PTM databases

iPTMnetiQ8BMC4
PhosphoSitePlusiQ8BMC4

Proteomic databases

EPDiQ8BMC4
MaxQBiQ8BMC4
PaxDbiQ8BMC4
PRIDEiQ8BMC4
ProteomicsDBi295503

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74, 33 antibodies

Genome annotation databases

EnsembliENSMUST00000019441; ENSMUSP00000019441; ENSMUSG00000019297
GeneIDi67842
KEGGimmu:67842
UCSCiuc007uao.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161424
MGIiMGI:1915092, Nop9

Phylogenomic databases

eggNOGiKOG2188, Eukaryota
GeneTreeiENSGT00390000004964
HOGENOMiCLU_029199_1_0_1
InParanoidiQ8BMC4
OMAiTPNGSHI
OrthoDBi238378at2759
PhylomeDBiQ8BMC4
TreeFamiTF327254

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67842, 19 hits in 51 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nop9, mouse

Protein Ontology

More...
PROi
PR:Q8BMC4
RNActiQ8BMC4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019297, Expressed in testis and 280 other tissues
GenevisibleiQ8BMC4, MM

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR040000, NOP9
IPR001313, Pumilio_RNA-bd_rpt
PANTHERiPTHR13102, PTHR13102, 1 hit
SMARTiView protein in SMART
SM00025, Pumilio, 5 hits
SUPFAMiSSF48371, SSF48371, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOP9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BMC4
Secondary accession number(s): Q3TW87
, Q8BKR9, Q8BYV4, Q8VEF9, Q9D0C6, Q9D5A8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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