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Protein

Lysophosphatidic acid receptor 6

Gene

Lpar6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity).By similarity

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Chemistry databases

SwissLipidsiSLP:000001580

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
Gene namesi
Name:Lpar6
Synonyms:P2ry5, P2y5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914418 Lpar6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 56CytoplasmicSequence analysis10
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 90ExtracellularSequence analysisAdd BLAST13
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 134CytoplasmicSequence analysisAdd BLAST23
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 183ExtracellularSequence analysisAdd BLAST28
Transmembranei184 – 204Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini205 – 230CytoplasmicSequence analysisAdd BLAST26
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 272ExtracellularSequence analysisAdd BLAST21
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 344CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi163

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700261 – 344Lysophosphatidic acid receptor 6Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi284S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ8BMC0
PaxDbiQ8BMC0
PRIDEiQ8BMC0

PTM databases

iPTMnetiQ8BMC0
PhosphoSitePlusiQ8BMC0

Expressioni

Tissue specificityi

Ubiquitously expressed. Detected in the hair follicles and skin (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000033446 Expressed in 218 organ(s), highest expression level in liver
CleanExiMM_P2RY5
GenevisibleiQ8BMC0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042327

Structurei

3D structure databases

ProteinModelPortaliQ8BMC0
SMRiQ8BMC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ8BMC0
KOiK04273
OMAiFRIFYFA
OrthoDBiEOG091G0D67
PhylomeDBiQ8BMC0
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSNGSQCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP
160 170 180 190 200
AVFFQSTHSQ GNNTSEACFE NFPAATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF CFVPYNINLI
260 270 280 290 300
LYSLMRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI
Length:344
Mass (Da):39,439
Last modified:March 1, 2003 - v1
Checksum:i50270D1D14AEDAB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032901 mRNA Translation: BAC28077.1
AK169602 mRNA Translation: BAE41252.1
BC145940 mRNA Translation: AAI45941.1
BC145942 mRNA Translation: AAI45943.1
BC069991 mRNA Translation: AAH69991.1
BC047931 mRNA Translation: AAH47931.1
CCDSiCCDS27268.1
RefSeqiNP_780325.1, NM_175116.4
UniGeneiMm.390681

Genome annotation databases

EnsembliENSMUST00000044405; ENSMUSP00000042327; ENSMUSG00000033446
GeneIDi67168
KEGGimmu:67168
UCSCiuc007upq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032901 mRNA Translation: BAC28077.1
AK169602 mRNA Translation: BAE41252.1
BC145940 mRNA Translation: AAI45941.1
BC145942 mRNA Translation: AAI45943.1
BC069991 mRNA Translation: AAH69991.1
BC047931 mRNA Translation: AAH47931.1
CCDSiCCDS27268.1
RefSeqiNP_780325.1, NM_175116.4
UniGeneiMm.390681

3D structure databases

ProteinModelPortaliQ8BMC0
SMRiQ8BMC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042327

Chemistry databases

GuidetoPHARMACOLOGYi163
SwissLipidsiSLP:000001580

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8BMC0
PhosphoSitePlusiQ8BMC0

Proteomic databases

MaxQBiQ8BMC0
PaxDbiQ8BMC0
PRIDEiQ8BMC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044405; ENSMUSP00000042327; ENSMUSG00000033446
GeneIDi67168
KEGGimmu:67168
UCSCiuc007upq.2 mouse

Organism-specific databases

CTDi10161
MGIiMGI:1914418 Lpar6

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ8BMC0
KOiK04273
OMAiFRIFYFA
OrthoDBiEOG091G0D67
PhylomeDBiQ8BMC0
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Miscellaneous databases

PROiPR:Q8BMC0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033446 Expressed in 218 organ(s), highest expression level in liver
CleanExiMM_P2RY5
GenevisibleiQ8BMC0 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR6_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC0
Secondary accession number(s): A6H6N5, Q3TEJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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