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Entry version 137 (07 Oct 2020)
Sequence version 2 (24 May 2004)
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Protein

BRCA2-interacting transcriptional repressor EMSY

Gene

Emsy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BRCA2-interacting transcriptional repressor EMSYBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EmsyBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924203, Emsy

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869691 – 1264BRCA2-interacting transcriptional repressor EMSYAdd BLAST1264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171PhosphothreonineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192O-linked (GlcNAc) serine1 Publication1
Glycosylationi200O-linked (GlcNAc) serineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Glycosylationi235O-linked (GlcNAc) threonineBy similarity1
Glycosylationi465O-linked (GlcNAc) threonineBy similarity1
Glycosylationi470O-linked (GlcNAc) threonineBy similarity1
Glycosylationi521O-linked (GlcNAc) serineBy similarity1
Modified residuei782PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1
Glycosylationi1069O-linked (GlcNAc) threonineBy similarity1
Modified residuei1085PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BMB0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BMB0

PeptideAtlas

More...
PeptideAtlasi
Q8BMB0

PRoteomics IDEntifications database

More...
PRIDEi
Q8BMB0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BMB0, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BMB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BMB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035401, Expressed in forelimb bud and 286 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BMB0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with the transactivation domain of BRCA2 (PubMed:14651845).

Interacts with CBX1 (via chromoshadow domain) (By similarity).

Interacts with ZMYND11 (By similarity). Does not interact with CBX3 or CBX5 (By similarity).

Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (By similarity). Within the complex interacts with CCAR2 and ZNF335 (By similarity). Components of this complex may associate with components of a histone methylation complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex, interacts with ASH2L and RBBP5 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231423, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8BMB0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038216

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BMB0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BMB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 114ENTPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 442Interaction with BRCA2By similarityAdd BLAST442
Regioni118 – 122Interaction with ZMYND11By similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi173 – 177Poly-Ser5
Compositional biasi290 – 355Ser-richAdd BLAST66
Compositional biasi359 – 428Gln-richAdd BLAST70
Compositional biasi460 – 600Thr-richAdd BLAST141
Compositional biasi683 – 687Poly-Ser5
Compositional biasi895 – 1048Gln-richAdd BLAST154

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4675, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007404_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BMB0

Identification of Orthologs from Complete Genome Data

More...
OMAi
XVSCSDE

Database of Orthologous Groups

More...
OrthoDBi
150416at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BMB0

TreeFam database of animal gene trees

More...
TreeFami
TF332401

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1240.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033482, EMSY
IPR005491, ENT_dom
IPR036142, ENT_dom-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16500, PTHR16500, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03735, ENT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01191, ENT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158639, SSF158639, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51138, ENT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BMB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKEKKDLLG
60 70 80 90 100
ELSKVLSIST ERHRAEVRRA VNDERLTTIA HKMNLSLYLG ERPSYSMSGP
110 120 130 140 150
NSSSEWSIEG RRLVPLMPRL VPQTAFTVTA NAVANAAVQH NASLPVPAET
160 170 180 190 200
ASKDGVSCSD EDEKPRKRRR TNSSSSSPVV LKEVPKAVVP VSKTITVPVS
210 220 230 240 250
GSPKMSNIMQ SIANSLPPHM SPVKITFTKP STQTTNTTTQ KVIIVTTSPS
260 270 280 290 300
STFVPNILSK SHNYAAVTKL VPTSVIASTT QKPPVVITAS QASLVTSSSN
310 320 330 340 350
GNSSSTSSPI SSTVAVTTVV SSTPSVVMST VAQGVSTSAI KVASTRLPSP
360 370 380 390 400
KSLVSGPTQI LAQFPKQHQQ SPKQQLQQVQ QQTQQPVAQP SSVSQQQQPQ
410 420 430 440 450
QSALPPGIKP TIQIKQESGV KIITQQVQPS KILPKPVTAT LPTSSNSPIM
460 470 480 490 500
VVSSNGAIMT TKLVTTPTGT QATYTRPTVS PSLGRVATTP GAATYVKTTS
510 520 530 540 550
GSIITVVPKS LATLGGKIIS SNIVSGTTTK ITTIPMTSKP NVIVVQKTTG
560 570 580 590 600
KGTTIQGLPG KNVVTTLLNA GGEKTLQTVP AGAKPAIITA TRPITKMIVT
610 620 630 640 650
QPKGIGSAVQ PAAKIIPTKI VYGQQGKTQV LIKPKPVTFQ ATVVSEQTRQ
660 670 680 690 700
LVTETLQQAS RVADASNSSA QEGKEEPQGY TDSSSSSTES SQSSQDSQPV
710 720 730 740 750
VHVIASRRQD WSEHEIAMET SPTIIYQDVS SESQSATSTI KALLELQQTT
760 770 780 790 800
VKEKLESKPR QPTIDLSQMA VPIQMTQEKR HSPESPSIAV VESELVAEYI
810 820 830 840 850
TTVSHRSQPQ QPSQPQRTLL QHVAQSQTAT QTSVVVKSIP ASSPGAITHI
860 870 880 890 900
MQQALSSHTA FTKHSEELGT EEGEVEEMDT LDPQTGLFYR SALTQSQSTK
910 920 930 940 950
QQKLSQPQLE QTQLQVKTLQ CFQTKQKQTI HLQADQLQHK LTQMPQLSIR
960 970 980 990 1000
HQKLNPLQQE QAQPKPDAQH TQHTVVAKDR QLPTLMAQPP QTVVQVLAVK
1010 1020 1030 1040 1050
TTQQLPKLQQ APNQPKIYVQ PQTPQSQMAL PSSEKQPASQ VEQPIITQGS
1060 1070 1080 1090 1100
SVTKITFEGR QPPTVTKITG GSSVPKLTSP VTSISPIQAS EKTAVSDILQ
1110 1120 1130 1140 1150
MSLMEAQIDT NVEHMVVDPP KKALATNVLT GEAGALPSTH VVVAGMTKCR
1160 1170 1180 1190 1200
ESCSSPSAVG PPLTTRKIEA AGVPTTGQFM RIQNVGQKKA EESPTEIIIQ
1210 1220 1230 1240 1250
AIPQYAIPCH SSSNVVVEPS GLLELNNFTS QQLDDDETAM EQDIDSSTED
1260
GTEPSPSQSA VERS
Length:1,264
Mass (Da):135,291
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4BA591D43912B2A
GO
Isoform 2 (identifier: Q8BMB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: T → TERTDEGTEVAFPLL
     1040-1199: Missing.

Show »
Length:1,118
Mass (Da):120,119
Checksum:iCA649C85E97E26E4
GO
Isoform 3 (identifier: Q8BMB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-96: KMNLSLYLGERPSYS → N

Show »
Length:1,250
Mass (Da):133,665
Checksum:iCAB7FCE9DFC838FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPW3A0A0U1RPW3_MOUSE
BRCA2-interacting transcriptional r...
Emsy
735Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPK1A0A0U1RPK1_MOUSE
BRCA2-interacting transcriptional r...
Emsy
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNN7A0A0U1RNN7_MOUSE
BRCA2-interacting transcriptional r...
Emsy
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNQ4A0A0U1RNQ4_MOUSE
BRCA2-interacting transcriptional r...
Emsy
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPN4A0A0U1RPN4_MOUSE
BRCA2-interacting transcriptional r...
Emsy
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQ63A0A0U1RQ63_MOUSE
BRCA2-interacting transcriptional r...
Emsy
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH20109 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC039956 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti975V → A in BC039956 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01043282 – 96KMNLS…RPSYS → N in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_010433802T → TERTDEGTEVAFPLL in isoform 2. 1 Publication1
Alternative sequenceiVSP_0104341040 – 1199Missing in isoform 2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC020109 mRNA Translation: AAH20109.1 Different initiation.
BC039956 mRNA No translation available.
BC089304 mRNA Translation: AAH89304.1
AK032985 mRNA Translation: BAC28113.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40028.1 [Q8BMB0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_758484.2, NM_172280.2 [Q8BMB0-1]
XP_006507693.1, XM_006507630.3 [Q8BMB0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038359; ENSMUSP00000038216; ENSMUSG00000035401 [Q8BMB0-2]
ENSMUST00000205276; ENSMUSP00000145858; ENSMUSG00000035401 [Q8BMB0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233545

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:233545

UCSC genome browser

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UCSCi
uc009iko.1, mouse [Q8BMB0-1]
uc009ikp.1, mouse [Q8BMB0-2]
uc009ikr.1, mouse [Q8BMB0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020109 mRNA Translation: AAH20109.1 Different initiation.
BC039956 mRNA No translation available.
BC089304 mRNA Translation: AAH89304.1
AK032985 mRNA Translation: BAC28113.2
CCDSiCCDS40028.1 [Q8BMB0-1]
RefSeqiNP_758484.2, NM_172280.2 [Q8BMB0-1]
XP_006507693.1, XM_006507630.3 [Q8BMB0-2]

3D structure databases

SMRiQ8BMB0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231423, 6 interactors
IntActiQ8BMB0, 3 interactors
STRINGi10090.ENSMUSP00000038216

PTM databases

GlyGeniQ8BMB0, 7 sites
iPTMnetiQ8BMB0
PhosphoSitePlusiQ8BMB0

Proteomic databases

jPOSTiQ8BMB0
PaxDbiQ8BMB0
PeptideAtlasiQ8BMB0
PRIDEiQ8BMB0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31192, 173 antibodies

Genome annotation databases

EnsembliENSMUST00000038359; ENSMUSP00000038216; ENSMUSG00000035401 [Q8BMB0-2]
ENSMUST00000205276; ENSMUSP00000145858; ENSMUSG00000035401 [Q8BMB0-1]
GeneIDi233545
KEGGimmu:233545
UCSCiuc009iko.1, mouse [Q8BMB0-1]
uc009ikp.1, mouse [Q8BMB0-2]
uc009ikr.1, mouse [Q8BMB0-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56946
MGIiMGI:1924203, Emsy

Phylogenomic databases

eggNOGiKOG4675, Eukaryota
GeneTreeiENSGT00390000009554
HOGENOMiCLU_007404_0_0_1
InParanoidiQ8BMB0
OMAiXVSCSDE
OrthoDBi150416at2759
PhylomeDBiQ8BMB0
TreeFamiTF332401

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
233545, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Emsy, mouse

Protein Ontology

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PROi
PR:Q8BMB0
RNActiQ8BMB0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035401, Expressed in forelimb bud and 286 other tissues
GenevisibleiQ8BMB0, MM

Family and domain databases

Gene3Di1.10.1240.40, 1 hit
InterProiView protein in InterPro
IPR033482, EMSY
IPR005491, ENT_dom
IPR036142, ENT_dom-like_sf
PANTHERiPTHR16500, PTHR16500, 1 hit
PfamiView protein in Pfam
PF03735, ENT, 1 hit
SMARTiView protein in SMART
SM01191, ENT, 1 hit
SUPFAMiSSF158639, SSF158639, 1 hit
PROSITEiView protein in PROSITE
PS51138, ENT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMSY_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BMB0
Secondary accession number(s): Q5FWK5, Q80XU1, Q8VDW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 7, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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