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UniProtKB - Q8BM75 (ARI5B_MOUSE)

Entry version 154 (07 Apr 2021)
Sequence version 3 (28 Jun 2011)
Previous versions | rss
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Protein

AT-rich interactive domain-containing protein 5B

Gene

Arid5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3214842, HDMs demethylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 5B
Short name:
ARID domain-containing protein 5B
Alternative name(s):
Developmentally and sexually retarded with transient immune abnormalities protein
Short name:
Desrt
MRF1-like
Modulator recognition factor protein 2
Short name:
MRF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arid5b
Synonyms:Desrt, Mrf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2175912, Arid5b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

High rate of neonatal mortality. Embryonic growth or birth weight are not effected, while lipid accumulation is severely reduced in brown adipose neonates at 24 hours of age. Mice weigh significantly less than controls from postnatal day 5 onward. Adult mice are lean, with significant reductions in brown and white adipose tissues, and in the percentage of body fat. Mice are also resistant to weight gains and obesity when maintained on high-fat diets.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005821 – 1188AT-rich interactive domain-containing protein 5BAdd BLAST1188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphoserineBy similarity1
Modified residuei337N6,N6-dimethyllysineBy similarity1
Cross-linki446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki494Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki767Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki803Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki810Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki893Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki916Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki920Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki988Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1000Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1013Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1032PhosphoserineBy similarity1
Cross-linki1055Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1070Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1133PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation at Lys-337 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8BM75

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8BM75

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BM75

PeptideAtlas

More...PeptideAtlasi		Q8BM75

PRoteomics IDEntifications database

More...PRIDEi		Q8BM75

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		265096 [Q8BM75-1]
265097 [Q8BM75-2]
265098 [Q8BM75-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BM75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BM75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in lung, heart, small intestine, kidney, muscle and brain. Also expressed in spleen, thymus, endocrine organs and in uterus and testis.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in the intermediate plate mesoderm, and subsequently in the nephrogenic cords of the urogenital ridges. Expressed in the developing limb. Also expressed in the myotome of the somites from 9.5 dpc, the oro-nasopharyngeal ectoderm and underlying mesenchyme, otic vesicles, the gut and its derivatives, and transiently in the liver at 11.5 dpc.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During smooth muscle cell differentiation in vitro. Upon adipogenesis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000019947, Expressed in zygote and 271 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BM75, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		214670, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q8BM75, 1 interactor

Molecular INTeraction database

More...MINTi		Q8BM75

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000020106

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BM75, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q8BM75

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BM75

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 411ARIDPROSITE-ProRule annotationAdd BLAST93

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ARID domain mediates the interaction with DNA.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARID5B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2744, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007985_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BM75

Identification of Orthologs from Complete Genome Data

More...OMAi		DSHPKAC

Database of Orthologous Groups

More...OrthoDBi		368297at2759

TreeFam database of animal gene trees

More...TreeFami		TF324725

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.60, 1 hit
2.30.30.490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030408, ARID5B
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR043151, BAH_sf

The PANTHER Classification System

More...PANTHERi		PTHR13964:SF37, PTHR13964:SF37, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01388, ARID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00501, BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46774, SSF46774, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51011, ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BM75-1) [UniParc]FASTAAdd to basket
Also known as: Mrf2alpha, Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPNSLQWVG SPCGLHGPYI FYKAFQFHLE GKPRILSLGD FFFVRCTPKD 
        60         70         80         90        100
PICIAELQLL WEERTSRQLL SSSKLYFLPE DTPQGRNSDH GEDEVIAVSE 
       110        120        130        140        150
KVIVKLEDLV KWAHSDFSKW RCGLRATPVK TEAFGRNGQK EALLRYRQST 
       160        170        180        190        200
LNSGLNFKDV LKEKADLGED EEETNVIVLS YPQYCRYRSM LKRIQDKPSS 
       210        220        230        240        250
ILTDQFALAL GGIAVVSRNP QILYCRDTFD HPTLIENESV CDEFAPNLKG 
       260        270        280        290        300
RPRKKKTCPQ RRDSFSGSKD PNNNCDGKVI SKVKGEARSA LTKPKNNHNN 
       310        320        330        340        350
CKKTSNEEKP KLSIGEECRA DEQAFLVALY KYMKERKTPI ERIPYLGFKQ 
       360        370        380        390        400
INLWTMFQAA QKLGGYETIT ARRQWKHIYD ELGGNPGSTS AATCTRRHYE 
       410        420        430        440        450
RLILPYERFI KGEEDKPLPP IKPRKQENNT QENENKTKVS GNKRIKQEMA 
       460        470        480        490        500
KNKKEKENTP KPQDTSEVSS EQRKEEETLN HKSAPEPLPA PEVKGKPEGH 
       510        520        530        540        550
KDLGARAPVS RADPEKANET DQGSNSEKEA EEMGDKGLAP LLPSPPLPPE 
       560        570        580        590        600
KDSAPTPGAG KQPLASPSTQ MDSKQEAKPC CFTESPEKDL QGAPFSSFSA 
       610        620        630        640        650
TKPPLTSQNE AEEEQLPATA NYIANCTVKV DQLGSDDIHT ALKQTPKVLV 
       660        670        680        690        700
VQSFDMFKDK DLTGPMNENH GLNYTPLLYS RGNPGIMSPL AKKKLLSQVS 
       710        720        730        740        750
GASLSSSYPY GSPPPLISKK KLIAREDLCS GLSQGHHSQS SDHTAVSRPS 
       760        770        780        790        800
VIQHVQSFKN KASEDRKSIN DIFKHDKLSR SDAHRCGFSK HQLGSLADSY 
       810        820        830        840        850
ILKQETQEGK DKLLEKRAVS HAHVPSFLAD FYSSPHLHSL YRHTEHHLHN 
       860        870        880        890        900
EQSSKYAARD AYQESENGAF LSHKHPEKIH VNYLASLHLQ DKKVAAAEAS 
       910        920        930        940        950
TDDQPTDLSL PKNPHKLTSK VLGLAHSTSG SQEIKGASQF QVVSNQSRDC 
       960        970        980        990       1000
HPKACRVSPM TMSGPKKYPE SLARSGKPHQ VRLENFRKME GMVHPILHRK 
      1010       1020       1030       1040       1050
MSPQNIGAAR PIKRSLEDLD LVIAGKKARA VSPLDPAKEA SGKEKASEQE 
      1060       1070       1080       1090       1100
SEGNKGAYGG HSGAASEGHK LPLSTPIFPG LYSGSLCNSG LNSRLPAGYS 
      1110       1120       1130       1140       1150
HSLQYLKNQT VLSPLMQPLA FHSLVMQRGI FTSPTNSQQL YRHLAAATPV 
      1160       1170       1180 
GSSYGDLLHN SIYPLAGINP QAAFPSSQLS SVHPSTKL
Length:1,188
Mass (Da):131,837
Last modified:June 28, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0B1A99D3E88D71F
GO
Isoform 2 (identifier: Q8BM75-2) [UniParc]FASTAAdd to basket
Also known as: Mrf2beta, Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-244: F → M

Show »
Length:945
Mass (Da):104,015
Checksum:iE43DE82C50BB7C30
GO
Isoform 3 (identifier: Q8BM75-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-276: APNLKGRPRKKKTCPQRRDSFSGSKDPNNNCD → GECFSFTLFETRPNESLFSIHGVSSAGEQGLV
     277-1188: Missing.

Show »
Length:276
Mass (Da):31,400
Checksum:i04D25CE35FE728DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1X7SB62A0A1X7SB62_MOUSE
AT-rich interactive domain-containi...
Arid5b
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF89682 differs from that shown. Reason: Frameshift.Curated
The sequence AAF89682 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC28778 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111K → T in AAF89682 (PubMed:19468303).Curated1
Sequence conflicti287A → G in AAF89682 (PubMed:19468303).Curated1
Sequence conflicti474K → E in AAM93282 (PubMed:12215486).Curated1
Sequence conflicti474K → E in AAM93269 (PubMed:12215486).Curated1
Sequence conflicti474K → E in AAF89682 (PubMed:19468303).Curated1
Sequence conflicti480N → S in AAM93282 (PubMed:12215486).Curated1
Sequence conflicti480N → S in AAM93269 (PubMed:12215486).Curated1
Sequence conflicti480N → S in AAF89682 (PubMed:19468303).Curated1
Sequence conflicti928T → A in AAM93282 (PubMed:12215486).Curated1
Sequence conflicti928T → A in AAM93269 (PubMed:12215486).Curated1
Sequence conflicti1056G → S in AAM93282 (PubMed:12215486).Curated1
Sequence conflicti1056G → S in AAM93269 (PubMed:12215486).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093571 – 243Missing in isoform 2. 1 PublicationAdd BLAST243
Alternative sequenceiVSP_009358244F → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_009359245 – 276APNLK…NNNCD → GECFSFTLFETRPNESLFSI HGVSSAGEQGLV in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_009360277 – 1188Missing in isoform 3. 1 PublicationAdd BLAST912

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF280065 mRNA Translation: AAM93269.1
AF401550 mRNA Translation: AAM93282.1
AK017396 mRNA Translation: BAB30727.1
AK031596 mRNA Translation: BAC27467.1
AK034633 mRNA Translation: BAC28778.1 Different initiation.
AC122293 Genomic DNA No translation available.
AC132588 Genomic DNA No translation available.
AF169968 mRNA Translation: AAF89682.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35929.1 [Q8BM75-1]

NCBI Reference Sequences

More...RefSeqi		NP_076087.2, NM_023598.2 [Q8BM75-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000218532; ENSMUSP00000151665; ENSMUSG00000019947 [Q8BM75-2]
ENSMUST00000219238; ENSMUSP00000151227; ENSMUSG00000019947 [Q8BM75-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		71371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:71371

UCSC genome browser

More...UCSCi		uc007fmf.1, mouse [Q8BM75-2]
uc007fmg.1, mouse [Q8BM75-1]
uc007fmj.1, mouse [Q8BM75-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF280065 mRNA Translation: AAM93269.1
AF401550 mRNA Translation: AAM93282.1
AK017396 mRNA Translation: BAB30727.1
AK031596 mRNA Translation: BAC27467.1
AK034633 mRNA Translation: BAC28778.1 Different initiation.
AC122293 Genomic DNA No translation available.
AC132588 Genomic DNA No translation available.
AF169968 mRNA Translation: AAF89682.1 Sequence problems.
CCDSiCCDS35929.1 [Q8BM75-1]
RefSeqiNP_076087.2, NM_023598.2 [Q8BM75-1]

3D structure databases

BMRBiQ8BM75
SMRiQ8BM75
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214670, 3 interactors
IntActiQ8BM75, 1 interactor
MINTiQ8BM75
STRINGi10090.ENSMUSP00000020106

PTM databases

iPTMnetiQ8BM75
PhosphoSitePlusiQ8BM75

Proteomic databases

EPDiQ8BM75
jPOSTiQ8BM75
PaxDbiQ8BM75
PeptideAtlasiQ8BM75
PRIDEiQ8BM75
ProteomicsDBi265096 [Q8BM75-1]
265097 [Q8BM75-2]
265098 [Q8BM75-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2974, 122 antibodies

The DNASU plasmid repository

More...DNASUi		71371

Genome annotation databases

EnsembliENSMUST00000218532; ENSMUSP00000151665; ENSMUSG00000019947 [Q8BM75-2]
ENSMUST00000219238; ENSMUSP00000151227; ENSMUSG00000019947 [Q8BM75-1]
GeneIDi71371
KEGGimmu:71371
UCSCiuc007fmf.1, mouse [Q8BM75-2]
uc007fmg.1, mouse [Q8BM75-1]
uc007fmj.1, mouse [Q8BM75-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84159
MGIiMGI:2175912, Arid5b

Phylogenomic databases

eggNOGiKOG2744, Eukaryota
GeneTreeiENSGT00940000161078
HOGENOMiCLU_007985_0_0_1
InParanoidiQ8BM75
OMAiDSHPKAC
OrthoDBi368297at2759
TreeFamiTF324725

Enzyme and pathway databases

ReactomeiR-MMU-3214842, HDMs demethylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		71371, 2 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Arid5b, mouse

Protein Ontology

More...PROi		PR:Q8BM75
RNActiQ8BM75, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000019947, Expressed in zygote and 271 other tissues
GenevisibleiQ8BM75, MM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
2.30.30.490, 1 hit
InterProiView protein in InterPro
IPR030408, ARID5B
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR043151, BAH_sf
PANTHERiPTHR13964:SF37, PTHR13964:SF37, 1 hit
PfamiView protein in Pfam
PF01388, ARID, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI5B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BM75
Secondary accession number(s): E9Q523
, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: June 28, 2011
Last modified: April 7, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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