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Protein

Heat shock 70 kDa protein 13

Gene

Hspa13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:Hspa13
Synonyms:Stch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1309463 Hspa13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001355923 – 471Heat shock 70 kDa protein 13Add BLAST449

Proteomic databases

EPDiQ8BM72
PaxDbiQ8BM72
PeptideAtlasiQ8BM72
PRIDEiQ8BM72

PTM databases

PhosphoSitePlusiQ8BM72

Expressioni

Gene expression databases

BgeeiENSMUSG00000032932 Expressed in 246 organ(s), highest expression level in pes
ExpressionAtlasiQ8BM72 baseline and differential
GenevisibleiQ8BM72 MM

Interactioni

Subunit structurei

Binds UBQLN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048817

Structurei

3D structure databases

ProteinModelPortaliQ8BM72
SMRiQ8BM72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00890000139503
HOGENOMiHOG000228135
HOVERGENiHBG098979
InParanoidiQ8BM72
KOiK09491
OMAiIPNRHLR
OrthoDBiEOG091G06OD
PhylomeDBiQ8BM72
TreeFamiTF105047

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BM72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGEMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDGDVYV GYESLELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTPE ELEAEVGRYP FKVLHRNGMA EFSVTSNETI IVSPEFVGSR
160 170 180 190 200
LLLKLKEMAE EYLGMPVANA VISVPAEFDL QQRNSTIQAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKVDVFY VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQHLYKE IYQTYGFLPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
IHQSAQVSVL LTVEGKDSKE PQNGDSELPK DQLTPGDGHH VNRVFRPGLS
360 370 380 390 400
ESKSGKSQVL FETEVSRKLF DALNEDLFQK ILVPIQQVLK EGLLDKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,709
Last modified:March 1, 2003 - v1
Checksum:iF60982FF20A88D55
GO
Isoform 2 (identifier: Q8BM72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-199: LKILR → NSTFD
     200-471: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,574
Checksum:iEB267C3B4D864174
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0Y0D3Z0Y0_MOUSE
Heat shock 70 kDa protein 13
Hspa13 Stch, mCG_128172
260Annotation score:

Sequence cautioni

The sequence BAE39860 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAE39860 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013912195 – 199LKILR → NSTFD in isoform 2. 1 Publication5
Alternative sequenceiVSP_013913200 – 471Missing in isoform 2. 1 PublicationAdd BLAST272

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021006 mRNA Translation: BAB32274.1
AK034643 mRNA Translation: BAC28781.1
AK167839 mRNA Translation: BAE39860.1 Different initiation.
BC085181 mRNA Translation: AAH85181.1
CCDSiCCDS28273.1 [Q8BM72-1]
RefSeqiNP_084477.1, NM_030201.3 [Q8BM72-1]
UniGeneiMm.26704

Genome annotation databases

EnsembliENSMUST00000046283; ENSMUSP00000048817; ENSMUSG00000032932 [Q8BM72-1]
GeneIDi110920
KEGGimmu:110920
UCSCiuc007zrp.2 mouse [Q8BM72-1]
uc007zrr.2 mouse [Q8BM72-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021006 mRNA Translation: BAB32274.1
AK034643 mRNA Translation: BAC28781.1
AK167839 mRNA Translation: BAE39860.1 Different initiation.
BC085181 mRNA Translation: AAH85181.1
CCDSiCCDS28273.1 [Q8BM72-1]
RefSeqiNP_084477.1, NM_030201.3 [Q8BM72-1]
UniGeneiMm.26704

3D structure databases

ProteinModelPortaliQ8BM72
SMRiQ8BM72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048817

PTM databases

PhosphoSitePlusiQ8BM72

Proteomic databases

EPDiQ8BM72
PaxDbiQ8BM72
PeptideAtlasiQ8BM72
PRIDEiQ8BM72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046283; ENSMUSP00000048817; ENSMUSG00000032932 [Q8BM72-1]
GeneIDi110920
KEGGimmu:110920
UCSCiuc007zrp.2 mouse [Q8BM72-1]
uc007zrr.2 mouse [Q8BM72-2]

Organism-specific databases

CTDi6782
MGIiMGI:1309463 Hspa13

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00890000139503
HOGENOMiHOG000228135
HOVERGENiHBG098979
InParanoidiQ8BM72
KOiK09491
OMAiIPNRHLR
OrthoDBiEOG091G06OD
PhylomeDBiQ8BM72
TreeFamiTF105047

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

PROiPR:Q8BM72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032932 Expressed in 246 organ(s), highest expression level in pes
ExpressionAtlasiQ8BM72 baseline and differential
GenevisibleiQ8BM72 MM

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP13_MOUSE
AccessioniPrimary (citable) accession number: Q8BM72
Secondary accession number(s): Q3TII6, Q9D1X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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