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Entry version 151 (29 Sep 2021)
Sequence version 2 (03 Apr 2007)
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Protein

Collagen alpha-1(XVI) chain

Gene

Col16a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1650814, Collagen biosynthesis and modifying enzymes
R-MMU-216083, Integrin cell surface interactions
R-MMU-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XVI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col16a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1095396, Col16a1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000040690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028296022 – 1580Collagen alpha-1(XVI) chainSequence analysisAdd BLAST1559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.Curated
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BLX7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BLX7

PRoteomics IDEntifications database

More...
PRIDEi
Q8BLX7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
283421 [Q8BLX7-1]
283422 [Q8BLX7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BLX7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BLX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BLX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues examined with highest levels of expression observed in heart. Strongly expressed in cortical and medullar regions of kidney and more weakly expressed in lung. Also detected in the ciliary muscle of the eye, on the serosa layer lining the muscularis externa of intestinal tissue, and in the perimysium membrane lining both the cardiac muscle bundle and the smooth muscle tissue of the small intestine. Strongly stained in particulate or granular structures. Not detected in brain or skeletal muscle.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 8 dpc no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By 11 dpc weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040690, Expressed in humerus cartilage element and 308 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BLX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BLX7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
223412, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2994, Collagen type XVI trimer

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035802

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BLX7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BLX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 231Laminin G-likeAdd BLAST182
Domaini375 – 424Collagen-like 1Add BLAST50
Domaini590 – 643Collagen-like 2Add BLAST54
Domaini676 – 725Collagen-like 3Add BLAST50
Domaini797 – 848Collagen-like 4Add BLAST52
Domaini1006 – 1063Collagen-like 5Add BLAST58
Domaini1210 – 1263Collagen-like 6Add BLAST54
Domaini1350 – 1407Collagen-like 7Add BLAST58
Domaini1448 – 1500Collagen-like 8Add BLAST53
Domaini1504 – 1552Collagen-like 9Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni232 – 374Nonhelical region 10 (NC10)Sequence analysisAdd BLAST143
Regioni324 – 547DisorderedSequence analysisAdd BLAST224
Regioni375 – 509Triple-helical region 9 (COL9) with 3 imperfectionsSequence analysisAdd BLAST135
Regioni510 – 524Nonhelical region 9 (NC9)Sequence analysisAdd BLAST15
Regioni525 – 570Triple-helical region 8 (COL8) with 1 imperfectionSequence analysisAdd BLAST46
Regioni571 – 586Nonhelical region 8 (NC8)Sequence analysisAdd BLAST16
Regioni585 – 935DisorderedSequence analysisAdd BLAST351
Regioni587 – 640Triple-helical region 7 (COL7) with 1 imperfectionSequence analysisAdd BLAST54
Regioni641 – 661Nonhelical region 7 (NC7)Sequence analysisAdd BLAST21
Regioni662 – 732Triple-helical region 6 (COL6) with 1 imperfectionSequence analysisAdd BLAST71
Regioni733 – 747Nonhelical region 6 (NC6)Sequence analysisAdd BLAST15
Regioni748 – 870Triple-helical region 5 (COL5) with 3 imperfectionsSequence analysisAdd BLAST123
Regioni871 – 881Nonhelical region 5 (NC5)Sequence analysisAdd BLAST11
Regioni882 – 933Triple-helical region 4 (COL4) with 2 imperfectionsSequence analysisAdd BLAST52
Regioni934 – 967Nonhelical region 4 (NC4)Sequence analysisAdd BLAST34
Regioni968 – 982Triple-helical region 3 (COL3)Sequence analysisAdd BLAST15
Regioni983 – 1005Nonhelical region 3 (NC3)Sequence analysisAdd BLAST23
Regioni995 – 1405DisorderedSequence analysisAdd BLAST411
Regioni1006 – 1409Triple-helical region 2 (COL2) with 2 imperfectionsSequence analysisAdd BLAST404
Regioni1410 – 1448Nonhelical region 2 (NC2)Sequence analysisAdd BLAST39
Regioni1445 – 1523DisorderedSequence analysisAdd BLAST79
Regioni1449 – 1554Triple-helical region 1 (COL1) with 2 imperfectionsSequence analysisAdd BLAST106
Regioni1555 – 1580Nonhelical region 1 (NC1)Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi555 – 557Cell attachment siteSequence analysis3
Motifi1000 – 1002Cell attachment siteSequence analysis3
Motifi1206 – 1208Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi448 – 473Pro residuesSequence analysisAdd BLAST26
Compositional biasi899 – 916Pro residuesSequence analysisAdd BLAST18
Compositional biasi1138 – 1156Pro residuesSequence analysisAdd BLAST19
Compositional biasi1262 – 1281Pro residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.Sequence analysis

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001074_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BLX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIFSVPQ

Database of Orthologous Groups

More...
OrthoDBi
1295141at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BLX7

TreeFam database of animal gene trees

More...
TreeFami
TF332900

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8BLX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTSWAPGLW VLGLWATFSH GTNIGERCPT SQQEGLKLEH SSDPSTNVTG
60 70 80 90 100
FNLIRRLNLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF
110 120 130 140 150
ALVLTVLLKK HTFRNTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD
160 170 180 190 200
GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCVSAS SQPLGPRQSI
210 220 230 240 250
RPGGHVFLGL DAEQGKPVSF DLQQAHIYCD PELVLEEGCC EILPGGCPPE
260 270 280 290 300
TSKSRRDTQS NELIEINPQT EGKVYTRCFC LEEPQNSKVD AQLMGRNIQK
310 320 330 340 350
AERGTKVHQG TGVNECPPCA HSARESNVTL GPSGLKGGKG ERGLTGPSGP
360 370 380 390 400
KGEKGARGND CVRVSPDAPL QCVEGPKGEK GESGDLGPPG LPGPTGQKGQ
410 420 430 440 450
KGEKGDGGLK GLPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG
460 470 480 490 500
PPGLPGPPGI GLPGTPGDPG GPPGPKGEKG SSGIPGKEGP GGKPGKPGVP
510 520 530 540 550
GTKGEKGDPC EVCPTLPEGS QNFVGLPGKP GPKGEPGDPA PAWEGLGTVG
560 570 580 590 600
LKGDRGDPGI QGMKGEKGEP CSSCSSGVGA QHLGPSPGHG LPGLPGTSGI
610 620 630 640 650
PGPRGLKGEK GSFGDTGPAG VPGSPGPVGP AGIKGAKGEP CEPCTALSEL
660 670 680 690 700
QDGDMRVVHL PGPAGEKGEP GSPGFGLPGK QGKAGERGLK GQKGDAGNPG
710 720 730 740 750
DPGTPGITGQ PGISGEPGIR GPAGPKGEKG DGCTACPSLQ GALTDVSGLP
760 770 780 790 800
GKPGPKGEPG PEGVGHPGKP GQPGLPGVQG PPGPKGTQGE PGPPGTGAEG
810 820 830 840 850
PQGEPGTQGL PGTQGLPGPR GPPGSAGEKG AQGSPGPKGA IGPMGPPGAG
860 870 880 890 900
VSGPPGQKGS RGEKGEPGEC SCPSRGEPIF SGMPGAPGLW MGSSSQPGPQ
910 920 930 940 950
GPPGVPGPPG PPGMPGLQGV PGHNGLPGQP GLTAELGSLP IEKHLLKSIC
960 970 980 990 1000
GDCAQGQTAH PAFLLEKGEK GDQGIPGVPG FDNCARCFIE RERPRAEEAR
1010 1020 1030 1040 1050
GDNSEGEPGC SGSPGLPGPP GMPGQRGEEG PPGMRGSPGP PGPIGLQGER
1060 1070 1080 1090 1100
GLTGLTGDKG EPGPPGQPGY PGAMGPPGLP GIKGERGYTG PSGEKGESGP
1110 1120 1130 1140 1150
PGSEGLPGPQ GPAGPRGERG PQGSSGEKGD QGFQGQPGFP GPPGPPGFPG
1160 1170 1180 1190 1200
KAGAPGPPGP QAEKGSEGIR GPSGLPGSPG PPGPPGIQGP AGLDGLDGKD
1210 1220 1230 1240 1250
GKPGLRGDPG PAGPPGLMGP PGFKGKTGHP GLPGPKGDCG KPGPPGSSGR
1260 1270 1280 1290 1300
PGAEGEPGAM GPQGRPGPPG HLGPPGQPGP PGLSTVGLKG DRGVPGERGL
1310 1320 1330 1340 1350
AGLPGQPGTP GHPGPPGEPG SDGAAGKEGP PGKQGLYGPP GPKGDPGPAG
1360 1370 1380 1390 1400
QKGQAGEKGR SGMPGGPGKS GSMGPIGPPG PAGERGHPGS PGPAGNPGLP
1410 1420 1430 1440 1450
GLPGSMGDMV NYDDIKRFIR QEIIKLFDER MAYYTSRMQF PMEVAAAPGR
1460 1470 1480 1490 1500
PGPPGKDGAP GRPGAPGSPG LPGQIGREGR QGLPGMRGLP GTKGEKGDIG
1510 1520 1530 1540 1550
VGIAGENGLP GPPGPQGPPG YGKMGATGPM GQQGIPGIPG PPGPMGQPGK
1560 1570 1580
AGHCNPSDCF GAMPMEQQYP PMKSMKGPFG
Length:1,580
Mass (Da):155,805
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC01635F6E410E3A
GO
Isoform 21 Publication (identifier: Q8BLX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Show »
Length:150
Mass (Da):14,823
Checksum:iD956EF9160987FC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0X4E9Q0X4_MOUSE
Collagen alpha-1(XVI) chain
Col16a1
1,046Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFV7A3KFV7_MOUSE
Collagen alpha-1(XVI) chain
Col16a1
1,283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFV2A3KFV2_MOUSE
Collagen alpha-1(XVI) chain
Col16a1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFV6A3KFV6_MOUSE
Collagen alpha-1(XVI) chain
Col16a1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFV1A3KFV1_MOUSE
Collagen alpha-1(XVI) chain
Col16a1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti726K → R in BAC30765 (PubMed:16141072).Curated1
Sequence conflicti1119R → Q in BAC30765 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0523751 – 1430Missing in isoform 2. 1 PublicationAdd BLAST1430

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK012212 mRNA Translation: BAB28100.1
AK040971 mRNA Translation: BAC30765.1
AL606925 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38889.1 [Q8BLX7-1]

NCBI Reference Sequences

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RefSeqi
NP_082542.3, NM_028266.5 [Q8BLX7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044565; ENSMUSP00000035802; ENSMUSG00000040690 [Q8BLX7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
107581

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107581

UCSC genome browser

More...
UCSCi
uc008uyr.2, mouse [Q8BLX7-1]
uc008uyv.2, mouse [Q8BLX7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012212 mRNA Translation: BAB28100.1
AK040971 mRNA Translation: BAC30765.1
AL606925 Genomic DNA No translation available.
CCDSiCCDS38889.1 [Q8BLX7-1]
RefSeqiNP_082542.3, NM_028266.5 [Q8BLX7-1]

3D structure databases

SMRiQ8BLX7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi223412, 3 interactors
ComplexPortaliCPX-2994, Collagen type XVI trimer
STRINGi10090.ENSMUSP00000035802

PTM databases

GlyGeniQ8BLX7, 2 sites
iPTMnetiQ8BLX7
PhosphoSitePlusiQ8BLX7

Proteomic databases

jPOSTiQ8BLX7
PaxDbiQ8BLX7
PRIDEiQ8BLX7
ProteomicsDBi283421 [Q8BLX7-1]
283422 [Q8BLX7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8436, 62 antibodies

The DNASU plasmid repository

More...
DNASUi
107581

Genome annotation databases

EnsembliENSMUST00000044565; ENSMUSP00000035802; ENSMUSG00000040690 [Q8BLX7-1]
GeneIDi107581
KEGGimmu:107581
UCSCiuc008uyr.2, mouse [Q8BLX7-1]
uc008uyv.2, mouse [Q8BLX7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1307
MGIiMGI:1095396, Col16a1
VEuPathDBiHostDB:ENSMUSG00000040690

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000161782
HOGENOMiCLU_001074_2_2_1
InParanoidiQ8BLX7
OMAiCIFSVPQ
OrthoDBi1295141at2759
PhylomeDBiQ8BLX7
TreeFamiTF332900

Enzyme and pathway databases

ReactomeiR-MMU-1650814, Collagen biosynthesis and modifying enzymes
R-MMU-216083, Integrin cell surface interactions
R-MMU-8948216, Collagen chain trimerization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
107581, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Col16a1, mouse

Protein Ontology

More...
PROi
PR:Q8BLX7
RNActiQ8BLX7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040690, Expressed in humerus cartilage element and 308 other tissues
ExpressionAtlasiQ8BLX7, baseline and differential
GenevisibleiQ8BLX7, MM

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01391, Collagen, 6 hits
SMARTiView protein in SMART
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOGA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BLX7
Secondary accession number(s): A3KFV5, Q9CZS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 29, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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