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Protein

Copine-4

Gene

Cpne4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-4Curated
Alternative name(s):
Copine IVBy similarityImported
Gene namesi
Name:Cpne4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921270 Cpne4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448421 – 557Copine-4Add BLAST557

Proteomic databases

MaxQBiQ8BLR2
PaxDbiQ8BLR2
PeptideAtlasiQ8BLR2
PRIDEiQ8BLR2

PTM databases

iPTMnetiQ8BLR2
PhosphoSitePlusiQ8BLR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000032564 Expressed in 83 organ(s), highest expression level in olfactory bulb
CleanExiMM_CPNE4
ExpressionAtlasiQ8BLR2 baseline and differential
GenevisibleiQ8BLR2 MM

Interactioni

Subunit structurei

Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP.By similarity

Protein-protein interaction databases

IntActiQ8BLR2, 1 interactor
STRINGi10090.ENSMUSP00000049663

Structurei

3D structure databases

ProteinModelPortaliQ8BLR2
SMRiQ8BLR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 130C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini141 – 246C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini305 – 507VWFAPROSITE-ProRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ8BLR2
OMAiFLGAMEC
OrthoDBiEOG091G05IT
PhylomeDBiQ8BLR2
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BLR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL
60 70 80 90 100
KMQSHGQWFE VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS
110 120 130 140 150
NHNGLKEADF LGGMECTLGQ IVSQRKLSKS LLKHGNTAGK SSITVIAEEL
160 170 180 190 200
SGNDDYVELA FNARKLDDKD FFSKSDPFLE IFRMNDDATQ QLVHRTEVVM
210 220 230 240 250
NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD FIGEFTSTFK
260 270 280 290 300
EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GMVILNQCKI HKMHSFLDYI
310 320 330 340 350
MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ
360 370 380 390 400
DYDSDKMFPA FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS
410 420 430 440 450
CLPKLQLYGP TNIAPIIQKV AKSASEETNT KEASQYFILL ILTDGVITDM
460 470 480 490 500
ADTREAIVHA SHLPMSVIIV GVGNADFSDM QMLDGDDGIL RSPKGEPVLR
510 520 530 540 550
DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI KPKCSSEVYE

SSRTLAP
Length:557
Mass (Da):62,408
Last modified:March 1, 2003 - v1
Checksum:iB9AAD11F3777F14F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D6C8Q9D6C8_MOUSE
Copine-4
Cpne4
475Annotation score:
D3Z5V2D3Z5V2_MOUSE
Copine-4
Cpne4
108Annotation score:
Q8CEQ2Q8CEQ2_MOUSE
Copine IV, isoform CRA_d
Cpne4 mCG_14749
145Annotation score:
A0A1L1SSY1A0A1L1SSY1_MOUSE
Copine-4
Cpne4
278Annotation score:
A0A1L1SU07A0A1L1SU07_MOUSE
Copine-4
Cpne4
185Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043692 mRNA Translation: BAC31619.1
BC043087 mRNA Translation: AAH43087.1
BC063081 mRNA Translation: AAH63081.1
CCDSiCCDS23461.1
RefSeqiNP_082995.1, NM_028719.1
UniGeneiMm.326240
Mm.442109

Genome annotation databases

EnsembliENSMUST00000057742; ENSMUSP00000049663; ENSMUSG00000032564
GeneIDi74020
KEGGimmu:74020
UCSCiuc009rhr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043692 mRNA Translation: BAC31619.1
BC043087 mRNA Translation: AAH43087.1
BC063081 mRNA Translation: AAH63081.1
CCDSiCCDS23461.1
RefSeqiNP_082995.1, NM_028719.1
UniGeneiMm.326240
Mm.442109

3D structure databases

ProteinModelPortaliQ8BLR2
SMRiQ8BLR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BLR2, 1 interactor
STRINGi10090.ENSMUSP00000049663

PTM databases

iPTMnetiQ8BLR2
PhosphoSitePlusiQ8BLR2

Proteomic databases

MaxQBiQ8BLR2
PaxDbiQ8BLR2
PeptideAtlasiQ8BLR2
PRIDEiQ8BLR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057742; ENSMUSP00000049663; ENSMUSG00000032564
GeneIDi74020
KEGGimmu:74020
UCSCiuc009rhr.1 mouse

Organism-specific databases

CTDi131034
MGIiMGI:1921270 Cpne4

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ8BLR2
OMAiFLGAMEC
OrthoDBiEOG091G05IT
PhylomeDBiQ8BLR2
TreeFamiTF316419

Miscellaneous databases

PROiPR:Q8BLR2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032564 Expressed in 83 organ(s), highest expression level in olfactory bulb
CleanExiMM_CPNE4
ExpressionAtlasiQ8BLR2 baseline and differential
GenevisibleiQ8BLR2 MM

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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