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Protein

Krueppel-like factor 8

Gene

Klf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G1 phase as a downstream target of focal adhesion kinase (FAK) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri270 – 294C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 8
Gene namesi
Name:Klf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442430 Klf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002941681 – 355Krueppel-like factor 8Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylation at Lys-64 represses transcriptional activity and reduces cell cycle progression into the G1 phase. Has no effect on subcellular location.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BLM0
PeptideAtlasiQ8BLM0
PRIDEiQ8BLM0

PTM databases

iPTMnetiQ8BLM0
PhosphoSitePlusiQ8BLM0

Expressioni

Gene expression databases

BgeeiENSMUSG00000041649 Expressed in 24 organ(s), highest expression level in telencephalon
CleanExiMM_KLF8
ExpressionAtlasiQ8BLM0 baseline and differential

Interactioni

Subunit structurei

Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044317

Structurei

3D structure databases

ProteinModelPortaliQ8BLM0
SMRiQ8BLM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri270 – 294C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000232138
HOVERGENiHBG003941
InParanoidiQ8BLM0
KOiK09205
OMAiGQQILHL
OrthoDBiEOG091G1BN0
PhylomeDBiQ8BLM0
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BLM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKFIDNMDV RIKSESGSMQ VFKQVTGPVP TRDPSARADR RNMTSPSFLA
60 70 80 90 100
ASPMENPALF NDIKIEPPEE LLESDFNMPQ VEPVDLSFHK PKAPLQPASM
110 120 130 140 150
LQAPIRPPKP PTAPQAIMVP TSADTVTSAA IPTVLTPGSI LASSQGTGGQ
160 170 180 190 200
PILHVIHTIP SVSLPNKMSG LKTIPLVVQS LPMVYTSLPT DGSPAAITVP
210 220 230 240 250
LIGGDGKSAG SVKVDPASMC PLEFPSDSDE SAIESGSSAL QSLQGFHHEP
260 270 280 290 300
ATMVHMQGEE SLDLKRRRIH QCDFAGCSKV YTKSSHLKAH RRIHTGEKPY
310 320 330 340 350
KCTWDGCSWK FARSDELTRH FRKHTGIKPF RCTDCNRSFS RSDHLSLHRR

RHDTM
Length:355
Mass (Da):38,845
Last modified:March 1, 2003 - v1
Checksum:i8DAA415948F6128F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PWN1A6PWN1_MOUSE
Krueppel-like factor 8
Klf8
19Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044185 mRNA Translation: BAC31807.1
BC070442 mRNA Translation: AAH70442.1
CCDSiCCDS30481.1
RefSeqiNP_776141.1, NM_173780.4
XP_006528916.1, XM_006528853.3
XP_006528921.1, XM_006528858.3
XP_006528922.1, XM_006528859.3
XP_006528923.1, XM_006528860.3
XP_011246123.1, XM_011247821.2
XP_017173992.1, XM_017318503.1
XP_017173993.1, XM_017318504.1
XP_017173994.1, XM_017318505.1
XP_017173995.1, XM_017318506.1
UniGeneiMm.260751
Mm.418152

Genome annotation databases

EnsembliENSMUST00000039545; ENSMUSP00000044317; ENSMUSG00000041649
ENSMUST00000112574; ENSMUSP00000108193; ENSMUSG00000041649
GeneIDi245671
KEGGimmu:245671
UCSCiuc009uqu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044185 mRNA Translation: BAC31807.1
BC070442 mRNA Translation: AAH70442.1
CCDSiCCDS30481.1
RefSeqiNP_776141.1, NM_173780.4
XP_006528916.1, XM_006528853.3
XP_006528921.1, XM_006528858.3
XP_006528922.1, XM_006528859.3
XP_006528923.1, XM_006528860.3
XP_011246123.1, XM_011247821.2
XP_017173992.1, XM_017318503.1
XP_017173993.1, XM_017318504.1
XP_017173994.1, XM_017318505.1
XP_017173995.1, XM_017318506.1
UniGeneiMm.260751
Mm.418152

3D structure databases

ProteinModelPortaliQ8BLM0
SMRiQ8BLM0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044317

PTM databases

iPTMnetiQ8BLM0
PhosphoSitePlusiQ8BLM0

Proteomic databases

PaxDbiQ8BLM0
PeptideAtlasiQ8BLM0
PRIDEiQ8BLM0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039545; ENSMUSP00000044317; ENSMUSG00000041649
ENSMUST00000112574; ENSMUSP00000108193; ENSMUSG00000041649
GeneIDi245671
KEGGimmu:245671
UCSCiuc009uqu.1 mouse

Organism-specific databases

CTDi11279
MGIiMGI:2442430 Klf8

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000232138
HOVERGENiHBG003941
InParanoidiQ8BLM0
KOiK09205
OMAiGQQILHL
OrthoDBiEOG091G1BN0
PhylomeDBiQ8BLM0
TreeFamiTF350556

Miscellaneous databases

PROiPR:Q8BLM0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041649 Expressed in 24 organ(s), highest expression level in telencephalon
CleanExiMM_KLF8
ExpressionAtlasiQ8BLM0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF8_MOUSE
AccessioniPrimary (citable) accession number: Q8BLM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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