UniProtKB - Q8BLI4 (DSE_MOUSE)
Protein
Dermatan-sulfate epimerase
Gene
Dse
Organism
Mus musculus (Mouse)
Status
Functioni
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.
Catalytic activityi
- EC:5.1.3.19
: chondroitin sulfate biosynthesis Pathwayi
This protein is involved in the pathway chondroitin sulfate biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway chondroitin sulfate biosynthesis and in Glycan metabolism.
Pathwayi: heparan sulfate biosynthesis
This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.
GO - Molecular functioni
- chondroitin-glucuronate 5-epimerase activity Source: MGI
GO - Biological processi
- chondroitin sulfate biosynthetic process Source: UniProtKB-UniPathway
- chondroitin sulfate metabolic process Source: GO_Central
- dermatan sulfate biosynthetic process Source: MGI
- dermatan sulfate metabolic process Source: GO_Central
- heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Enzyme and pathway databases
BRENDAi | 5.1.3.19, 3474 |
Reactomei | R-MMU-2022923, Dermatan sulfate biosynthesis |
UniPathwayi | UPA00755 UPA00756 |
Names & Taxonomyi
Protein namesi | Recommended name: Dermatan-sulfate epimerase (EC:5.1.3.19)Short name: DS epimerase Alternative name(s): Chondroitin-glucuronate 5-epimerase Squamous cell carcinoma antigen recognized by T-cells 2 Short name: SART-2 |
Gene namesi | Name:Dse Synonyms:Sart2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443455, Dse |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 903 – 923 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 934 – 954 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000223312 | 23 – 958 | Dermatan-sulfate epimeraseAdd BLAST | 936 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 642 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8BLI4 |
jPOSTi | Q8BLI4 |
MaxQBi | Q8BLI4 |
PaxDbi | Q8BLI4 |
PeptideAtlasi | Q8BLI4 |
PRIDEi | Q8BLI4 |
PTM databases
GlyGeni | Q8BLI4, 1 site |
iPTMneti | Q8BLI4 |
PhosphoSitePlusi | Q8BLI4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039497, Expressed in pineal body and 232 other tissues |
Genevisiblei | Q8BLI4, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229367, 1 interactor |
STRINGi | 10090.ENSMUSP00000040074 |
Miscellaneous databases
RNActi | Q8BLI4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the dermatan-sulfate isomerase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPWZ, Eukaryota |
GeneTreei | ENSGT00390000006522 |
HOGENOMi | CLU_308813_0_0_1 |
InParanoidi | Q8BLI4 |
OMAi | LCFVSAY |
OrthoDBi | 588663at2759 |
PhylomeDBi | Q8BLI4 |
TreeFami | TF334118 |
Family and domain databases
Gene3Di | 1.50.10.100, 1 hit |
InterProi | View protein in InterPro IPR008929, Chondroitin_lyas |
SUPFAMi | SSF48230, SSF48230, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8BLI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTHTRGAPS VFFICLLCCV SAFITDENPE VMIPFTNANY DSHPMLYFSR
60 70 80 90 100
KDVAELQLRA ASSHEHIAAR LTEAVHTMLT NPLEYLPPWD PKEYSARWNE
110 120 130 140 150
IYGNNLGALA MFCVLYPENT EARDMAKDYM ERMAAQPSWL VKDAPWDEVP
160 170 180 190 200
LAHSLVGFAT AYDFLYNYLS KTQQETFLEV IANASGYMYE TSYRRGWGFQ
210 220 230 240 250
YLHNHQPTNC MALLTGSLIL MNQGYLQEAY LWTKQVLSIM EKSLVLLREV
260 270 280 290 300
TDGSLYEGVA YGSYTTRSLF QYMFLVQRHF DINHFGHPWL KQHFAFMYRT
310 320 330 340 350
ILPGFQRTVA IADSNYNWFY GPESQLVFLD KFVMRNGSGN WLADQIRRNR
360 370 380 390 400
VVEGPGTPSK GQRWCTLHTE FLWYDASLKP VPPPDFGTPT LHYFEDWGVV
410 420 430 440 450
TYGSALPAEI NRSFLSFKSG KLGGRAIYDI VHRNKYKDWI KGWRNFNAGH
460 470 480 490 500
EHPDQNSFTF APNGVPFITE ALYGPKYTYF NNVLMFSPAV SKSCFSPWEG
510 520 530 540 550
QVTEDCSSKW SKYKHDLAAS CQGRVIAADE KDGVVFIRGE GVGAYNPMLN
560 570 580 590 600
LKHIQRNLIL LHPQLLLLVD QIHLGEESPL ETAASFFHNV DVPFEETVVD
610 620 630 640 650
GVHGALIRQR DGLYKMYWMD DTGYSEKANF ASVMYPRGYP YNGTNYVNVT
660 670 680 690 700
MHLRSPITRA AYLFIGPSVD VQSFSIHGDP QRLDVFIATS EHAYATYLWT
710 720 730 740 750
GENTGHSAFA QVIADHQKIL FDQSSAIKST AVPEVKDYAA IVEQNLQHFK
760 770 780 790 800
PVFQLLEKQI LSRVQNTASF RKTAERLLRF SDKRQTEEAI DRIFAISQQQ
810 820 830 840 850
RQQRGKSKKS RKAGKHYKFV DAVPDIFAQI EVNEKKIRQK AQVLAQREQP
860 870 880 890 900
IDEDEEMKDL LDFADVTYEK HKNEGSVKGG FGQVRMVTSH NRAPSLSASY
910 920 930 940 950
TRLFLILNIA IFFVMLAMQL TYFQRAQSLH GQRCLYAVLL IDSCVLLWLY
SSCSQSQC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SSJ9 | A0A1L1SSJ9_MOUSE | Dermatan-sulfate epimerase | Dse | 181 | Annotation score: | ||
A0A1L1SUI1 | A0A1L1SUI1_MOUSE | Dermatan-sulfate epimerase | Dse | 353 | Annotation score: |
Sequence cautioni
The sequence BAE31905 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 420 | G → R in BAE31905 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 732 | V → I in BAE31905 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045065 mRNA Translation: BAC32205.1 AK153326 mRNA Translation: BAE31905.1 Different initiation. BC053095 mRNA Translation: AAH53095.1 |
CCDSi | CCDS23776.1 |
RefSeqi | NP_766096.1, NM_172508.2 XP_006512714.1, XM_006512651.3 XP_011241458.1, XM_011243156.2 |
Genome annotation databases
Ensembli | ENSMUST00000048010; ENSMUSP00000040074; ENSMUSG00000039497 |
GeneIDi | 212898 |
KEGGi | mmu:212898 |
UCSCi | uc007eus.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045065 mRNA Translation: BAC32205.1 AK153326 mRNA Translation: BAE31905.1 Different initiation. BC053095 mRNA Translation: AAH53095.1 |
CCDSi | CCDS23776.1 |
RefSeqi | NP_766096.1, NM_172508.2 XP_006512714.1, XM_006512651.3 XP_011241458.1, XM_011243156.2 |
3D structure databases
SMRi | Q8BLI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229367, 1 interactor |
STRINGi | 10090.ENSMUSP00000040074 |
PTM databases
GlyGeni | Q8BLI4, 1 site |
iPTMneti | Q8BLI4 |
PhosphoSitePlusi | Q8BLI4 |
Proteomic databases
EPDi | Q8BLI4 |
jPOSTi | Q8BLI4 |
MaxQBi | Q8BLI4 |
PaxDbi | Q8BLI4 |
PeptideAtlasi | Q8BLI4 |
PRIDEi | Q8BLI4 |
Genome annotation databases
Ensembli | ENSMUST00000048010; ENSMUSP00000040074; ENSMUSG00000039497 |
GeneIDi | 212898 |
KEGGi | mmu:212898 |
UCSCi | uc007eus.1, mouse |
Organism-specific databases
CTDi | 29940 |
MGIi | MGI:2443455, Dse |
Phylogenomic databases
eggNOGi | ENOG502QPWZ, Eukaryota |
GeneTreei | ENSGT00390000006522 |
HOGENOMi | CLU_308813_0_0_1 |
InParanoidi | Q8BLI4 |
OMAi | LCFVSAY |
OrthoDBi | 588663at2759 |
PhylomeDBi | Q8BLI4 |
TreeFami | TF334118 |
Enzyme and pathway databases
UniPathwayi | UPA00755 UPA00756 |
BRENDAi | 5.1.3.19, 3474 |
Reactomei | R-MMU-2022923, Dermatan sulfate biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 212898, 2 hits in 17 CRISPR screens |
ChiTaRSi | Dse, mouse |
PROi | PR:Q8BLI4 |
RNActi | Q8BLI4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039497, Expressed in pineal body and 232 other tissues |
Genevisiblei | Q8BLI4, MM |
Family and domain databases
Gene3Di | 1.50.10.100, 1 hit |
InterProi | View protein in InterPro IPR008929, Chondroitin_lyas |
SUPFAMi | SSF48230, SSF48230, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSE_MOUSE | |
Accessioni | Q8BLI4Primary (citable) accession number: Q8BLI4 Secondary accession number(s): Q3U620 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families