UniProtKB - Q8BLI0 (ATL1_MOUSE)
Protein
ADAMTS-like protein 1
Gene
Adamtsl1
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated
GO - Molecular functioni
- metalloendopeptidase activity Source: GO_Central
GO - Biological processi
- extracellular matrix organization Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-5173214, O-glycosylation of TSR domain-containing proteins |
Names & Taxonomyi
Protein namesi | Recommended name: ADAMTS-like protein 1Short name: ADAMTSL-1 Alternative name(s): Punctin-1 |
Gene namesi | Name:Adamtsl1 |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924989, Adamtsl1 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | By similarityAdd BLAST | 28 | |
ChainiPRO_0000035861 | 29 – 1745 | ADAMTS-like protein 1Add BLAST | 1717 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 76 | By similarity | ||
Disulfide bondi | 49 ↔ 81 | By similarity | ||
Disulfide bondi | 60 ↔ 66 | By similarity | ||
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 310 | O-linked (Fuc...) serineBy similarity | 1 | |
Glycosylationi | 391 | O-linked (Fuc...) serineBy similarity | 1 | |
Glycosylationi | 451 | O-linked (Fuc...) threonineBy similarity | 1 | |
Disulfide bondi | 534 ↔ 578 | By similarity | ||
Disulfide bondi | 538 ↔ 583 | By similarity | ||
Disulfide bondi | 549 ↔ 567 | By similarity | ||
Disulfide bondi | 775 ↔ 819 | By similarity | ||
Disulfide bondi | 779 ↔ 824 | By similarity | ||
Disulfide bondi | 790 ↔ 807 | By similarity | ||
Disulfide bondi | 874 ↔ 922 | By similarity | ||
Disulfide bondi | 1177 ↔ 1225 | By similarity | ||
Disulfide bondi | 1283 ↔ 1336 | By similarity | ||
Disulfide bondi | 1401 ↔ 1452 | By similarity |
Post-translational modificationi
Glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Disulfide bonds are present.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8BLI0 |
PRIDEi | Q8BLI0 |
PTM databases
GlyGeni | Q8BLI0, 4 sites |
iPTMneti | Q8BLI0 |
PhosphoSitePlusi | Q8BLI0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000066113, Expressed in lumbar subsegment of spinal cord and 182 other tissues |
ExpressionAtlasi | Q8BLI0, baseline and differential |
Genevisiblei | Q8BLI0, MM |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102796 |
Miscellaneous databases
RNActi | Q8BLI0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 82 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 376 – 424 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 436 – 493 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 522 – 584 | TSP type-1 4PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 607 – 667 | TSP type-1 5PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 703 – 762 | TSP type-1 6PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 763 – 825 | TSP type-1 7PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 836 – 938 | Ig-like C2-type 1Add BLAST | 103 | |
Domaini | 1139 – 1241 | Ig-like C2-type 2Add BLAST | 103 | |
Domaini | 1261 – 1352 | Ig-like C2-type 3Add BLAST | 92 | |
Domaini | 1378 – 1468 | Ig-like C2-type 4Add BLAST | 91 | |
Domaini | 1528 – 1591 | TSP type-1 8PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 1649 – 1709 | TSP type-1 9PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 1709 – 1745 | PLACPROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000156243 |
InParanoidi | Q8BLI0 |
OMAi | WLLSEWT |
OrthoDBi | 38261at2759 |
Family and domain databases
Gene3Di | 2.20.100.10, 10 hits 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR013273, ADAMTS/ADAMTS-like IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF08686, PLAC, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 4 hits SM00209, TSP1, 12 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF82895, SSF82895, 10 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS50900, PLAC, 1 hit PS50092, TSP1, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BLI0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MECCRRAAPG TPLLVLAFLL LSSRTARSEE DREGLWDAWG PWSECSRTCG
60 70 80 90 100
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK
110 120 130 140 150
YHGQLYEWLP VSNDPDNPCS LKCQAKGTSL VVELAPKVLD GTRCYTESLD
160 170 180 190 200
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSASK
210 220 230 240 250
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGIFLVD
260 270 280 290 300
NSTVDFQKLP DKEILRMTGP LTADFIIKIH DLGPADSTVQ FIFYQPIIHR
310 320 330 340 350
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENVKPKPK
360 370 380 390 400
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA
410 420 430 440 450
VSCVEEDIQG HVTSVEEWKC MYTPKMPVVQ PCNIFDCPKW LAQEWSPCTV
460 470 480 490 500
TCGQGLRYRV VLCIDHRGMH TGGCSAKTKP HIKEECIIPT PCYKPREKLP
510 520 530 540 550
IEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIIRCQ
560 570 580 590 600
VLLPFSQSVA DLPADECEGP KPASQRACYA GPCNGETPEF NPDNGDGLLG
610 620 630 640 650
GLQDLDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR ELADENLCVT
660 670 680 690 700
SRRPPQLLKS CNLDPCPASH LLSREMNEVV VLADELCHHP KPSTVQACNR
710 720 730 740 750
FNCPPAWYPA QWQLCSRTCG GGIQKRDVLC KQRMADGSFL ELPETFCSAS
760 770 780 790 800
KPTSHQGCKK DDCPSEWLLS EWSECSVSCG EGTQTRSAIC QRVLKTGVST
810 820 830 840 850
VVNSTLCPPL PFSSSIRPCM LATCARPGRP STKHSPHIAA ARNIYIQTRR
860 870 880 890 900
QRKLHFVVGG FAYLLPKTTV VLRCPTRRFR KPLITWEKDG QHSISSAHVT
910 920 930 940 950
VAPFGYLKIH RLKPSDAGIY TCSAGPAREQ FVIKLIGGNR KLVARPLSLW
960 970 980 990 1000
SEEEEALQVR KTNPKEALQT HKHQNGIFSN GSKAEKRGLT ADPGNRYDDI
1010 1020 1030 1040 1050
VSRLLEQGGW PGELLASWEV QDSAERNASS EEDPNAEQAL LHLPFTMVAE
1060 1070 1080 1090 1100
QKRLDDILRN LSQQPEELRD LYSKHLVAQL AQDIFRSHLE NQDLLPKPSE
1110 1120 1130 1140 1150
QRFPPMAVPA HKHVSGFSSS LRSSSGEAGG GSRRPHRKPA ILRKISAAQQ
1160 1170 1180 1190 1200
LSASEVVTHL GQTVALASGT LSVLLHCEAV GNPRPTIHWT RNGEAVQFSD
1210 1220 1230 1240 1250
RILLQPDDSL QILAPVEADV GFYTCNATNA LGYDSVSIAV TLAGKPLVKT
1260 1270 1280 1290 1300
SRMTVLNTEK PTVTVDIGGT VRTVRGVNVT INCQVAGVPE AEVTWFRNKS
1310 1320 1330 1340 1350
KLGSSHHLHE GSSHHLHEGS LLLTDVSFSD QGLYSCRAAN LHGEQTESTQ
1360 1370 1380 1390 1400
LLILDPPQVP TQLEDIRALL LATGPNLPSV LMSPLGTQLV LDPGNSALLG
1410 1420 1430 1440 1450
CPIKGHPTPN ITWFQNGQPI ATAPGLTHHI WGAGQILRVA NLSGGPQGEF
1460 1470 1480 1490 1500
SCLAQNEAGT LLQKASLVIQ DYWWSVDRLA TCSASCGNRG IHQPRLRCLL
1510 1520 1530 1540 1550
NTTEVDPEHC TGKPRPAVQP VACNRRDCPS RWMVTSWSAC TRSCGGGVQT
1560 1570 1580 1590 1600
RRVTCQKLKA SGISTPVSND MCSQLAKRPV DTQACNQQLC VEWAFSSWGQ
1610 1620 1630 1640 1650
CNGPCIGPRL AVQHRQVFCQ TRDGITLPSE QCSALPRPVS TQNCWSEACS
1660 1670 1680 1690 1700
VHWRVSLWTL CTATCGNYGF QSRRVECVHV RTNKAVPEHL CSWGPRPANW
1710 1720 1730 1740
QRCNVTPCEN TECRDTTRYC EKVRQLKLCQ LGQFRSRCCG TCGKA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PWW5 | E9PWW5_MOUSE | ADAMTS-like protein 1 | Adamtsl1 | 1,753 | Annotation score: | ||
A9Z1Z6 | A9Z1Z6_MOUSE | ADAMTS-like protein 1 | Adamtsl1 | 203 | Annotation score: | ||
B7ZCH8 | B7ZCH8_MOUSE | ADAMTS-like protein 1 | Adamtsl1 | 525 | Annotation score: | ||
A0A1D5RMA0 | A0A1D5RMA0_MOUSE | ADAMTS-like protein 1 | Adamtsl1 | 127 | Annotation score: | ||
F6WY46 | F6WY46_MOUSE | ADAMTS-like protein 1 | Adamtsl1 | 243 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039332 | 362 – 377 | SDGYK…LYHPL → RSVQFTCLCMINQVPS in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_039333 | 378 – 1745 | Missing in isoform 2. 1 PublicationAdd BLAST | 1368 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045085 mRNA Translation: BAC32213.1 AL772130 Genomic DNA No translation available. AL807242 Genomic DNA No translation available. AL824705 Genomic DNA No translation available. |
RefSeqi | NP_084243.3, NM_029967.3 |
Genome annotation databases
Ensembli | ENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1] |
GeneIDi | 77739 |
KEGGi | mmu:77739 |
UCSCi | uc008tlr.2, mouse [Q8BLI0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045085 mRNA Translation: BAC32213.1 AL772130 Genomic DNA No translation available. AL807242 Genomic DNA No translation available. AL824705 Genomic DNA No translation available. |
RefSeqi | NP_084243.3, NM_029967.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102796 |
PTM databases
GlyGeni | Q8BLI0, 4 sites |
iPTMneti | Q8BLI0 |
PhosphoSitePlusi | Q8BLI0 |
Proteomic databases
PaxDbi | Q8BLI0 |
PRIDEi | Q8BLI0 |
Protocols and materials databases
Antibodypediai | 24655, 158 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1] |
GeneIDi | 77739 |
KEGGi | mmu:77739 |
UCSCi | uc008tlr.2, mouse [Q8BLI0-2] |
Organism-specific databases
CTDi | 92949 |
MGIi | MGI:1924989, Adamtsl1 |
Phylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000156243 |
InParanoidi | Q8BLI0 |
OMAi | WLLSEWT |
OrthoDBi | 38261at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-5173214, O-glycosylation of TSR domain-containing proteins |
Miscellaneous databases
BioGRID-ORCSi | 77739, 1 hit in 15 CRISPR screens |
ChiTaRSi | Adamtsl1, mouse |
PROi | PR:Q8BLI0 |
RNActi | Q8BLI0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000066113, Expressed in lumbar subsegment of spinal cord and 182 other tissues |
ExpressionAtlasi | Q8BLI0, baseline and differential |
Genevisiblei | Q8BLI0, MM |
Family and domain databases
Gene3Di | 2.20.100.10, 10 hits 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR013273, ADAMTS/ADAMTS-like IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF08686, PLAC, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 4 hits SM00209, TSP1, 12 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF82895, SSF82895, 10 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS50900, PLAC, 1 hit PS50092, TSP1, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATL1_MOUSE | |
Accessioni | Q8BLI0Primary (citable) accession number: Q8BLI0 Secondary accession number(s): A2AM52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | June 15, 2010 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot