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Entry version 136 (02 Jun 2021)
Sequence version 2 (15 Jun 2010)
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Protein

ADAMTS-like protein 1

Gene

Adamtsl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADAMTS-like protein 1
Short name:
ADAMTSL-1
Alternative name(s):
Punctin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924989, Adamtsl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28By similarityAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003586129 – 1745ADAMTS-like protein 1Add BLAST1717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 76By similarity
Disulfide bondi49 ↔ 81By similarity
Disulfide bondi60 ↔ 66By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310O-linked (Fuc...) serineBy similarity1
Glycosylationi391O-linked (Fuc...) serineBy similarity1
Glycosylationi451O-linked (Fuc...) threonineBy similarity1
Disulfide bondi534 ↔ 578By similarity
Disulfide bondi538 ↔ 583By similarity
Disulfide bondi549 ↔ 567By similarity
Disulfide bondi775 ↔ 819By similarity
Disulfide bondi779 ↔ 824By similarity
Disulfide bondi790 ↔ 807By similarity
Disulfide bondi874 ↔ 922By similarity
Disulfide bondi1177 ↔ 1225By similarity
Disulfide bondi1283 ↔ 1336By similarity
Disulfide bondi1401 ↔ 1452By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Disulfide bonds are present.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BLI0

PRoteomics IDEntifications database

More...
PRIDEi
Q8BLI0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277066 [Q8BLI0-1]
277067 [Q8BLI0-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BLI0, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BLI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BLI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066113, Expressed in lumbar subsegment of spinal cord and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BLI0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BLI0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102796

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BLI0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 82TSP type-1 1PROSITE-ProRule annotationAdd BLAST50
Domaini376 – 424TSP type-1 2PROSITE-ProRule annotationAdd BLAST49
Domaini436 – 493TSP type-1 3PROSITE-ProRule annotationAdd BLAST58
Domaini522 – 584TSP type-1 4PROSITE-ProRule annotationAdd BLAST63
Domaini607 – 667TSP type-1 5PROSITE-ProRule annotationAdd BLAST61
Domaini703 – 762TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini763 – 825TSP type-1 7PROSITE-ProRule annotationAdd BLAST63
Domaini836 – 938Ig-like C2-type 1Add BLAST103
Domaini1139 – 1241Ig-like C2-type 2Add BLAST103
Domaini1261 – 1352Ig-like C2-type 3Add BLAST92
Domaini1378 – 1468Ig-like C2-type 4Add BLAST91
Domaini1528 – 1591TSP type-1 8PROSITE-ProRule annotationAdd BLAST64
Domaini1649 – 1709TSP type-1 9PROSITE-ProRule annotationAdd BLAST61
Domaini1709 – 1745PLACPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni966 – 991DisorderedSequence analysisAdd BLAST26
Regioni1114 – 1137DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156243

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BLI0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLLSEWT

Database of Orthologous Groups

More...
OrthoDBi
38261at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 10 hits
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 3 hits
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00209, TSP1, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 4 hits
SSF82895, SSF82895, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50900, PLAC, 1 hit
PS50092, TSP1, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BLI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MECCRRAAPG TPLLVLAFLL LSSRTARSEE DREGLWDAWG PWSECSRTCG
60 70 80 90 100
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK
110 120 130 140 150
YHGQLYEWLP VSNDPDNPCS LKCQAKGTSL VVELAPKVLD GTRCYTESLD
160 170 180 190 200
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSASK
210 220 230 240 250
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGIFLVD
260 270 280 290 300
NSTVDFQKLP DKEILRMTGP LTADFIIKIH DLGPADSTVQ FIFYQPIIHR
310 320 330 340 350
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENVKPKPK
360 370 380 390 400
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA
410 420 430 440 450
VSCVEEDIQG HVTSVEEWKC MYTPKMPVVQ PCNIFDCPKW LAQEWSPCTV
460 470 480 490 500
TCGQGLRYRV VLCIDHRGMH TGGCSAKTKP HIKEECIIPT PCYKPREKLP
510 520 530 540 550
IEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIIRCQ
560 570 580 590 600
VLLPFSQSVA DLPADECEGP KPASQRACYA GPCNGETPEF NPDNGDGLLG
610 620 630 640 650
GLQDLDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR ELADENLCVT
660 670 680 690 700
SRRPPQLLKS CNLDPCPASH LLSREMNEVV VLADELCHHP KPSTVQACNR
710 720 730 740 750
FNCPPAWYPA QWQLCSRTCG GGIQKRDVLC KQRMADGSFL ELPETFCSAS
760 770 780 790 800
KPTSHQGCKK DDCPSEWLLS EWSECSVSCG EGTQTRSAIC QRVLKTGVST
810 820 830 840 850
VVNSTLCPPL PFSSSIRPCM LATCARPGRP STKHSPHIAA ARNIYIQTRR
860 870 880 890 900
QRKLHFVVGG FAYLLPKTTV VLRCPTRRFR KPLITWEKDG QHSISSAHVT
910 920 930 940 950
VAPFGYLKIH RLKPSDAGIY TCSAGPAREQ FVIKLIGGNR KLVARPLSLW
960 970 980 990 1000
SEEEEALQVR KTNPKEALQT HKHQNGIFSN GSKAEKRGLT ADPGNRYDDI
1010 1020 1030 1040 1050
VSRLLEQGGW PGELLASWEV QDSAERNASS EEDPNAEQAL LHLPFTMVAE
1060 1070 1080 1090 1100
QKRLDDILRN LSQQPEELRD LYSKHLVAQL AQDIFRSHLE NQDLLPKPSE
1110 1120 1130 1140 1150
QRFPPMAVPA HKHVSGFSSS LRSSSGEAGG GSRRPHRKPA ILRKISAAQQ
1160 1170 1180 1190 1200
LSASEVVTHL GQTVALASGT LSVLLHCEAV GNPRPTIHWT RNGEAVQFSD
1210 1220 1230 1240 1250
RILLQPDDSL QILAPVEADV GFYTCNATNA LGYDSVSIAV TLAGKPLVKT
1260 1270 1280 1290 1300
SRMTVLNTEK PTVTVDIGGT VRTVRGVNVT INCQVAGVPE AEVTWFRNKS
1310 1320 1330 1340 1350
KLGSSHHLHE GSSHHLHEGS LLLTDVSFSD QGLYSCRAAN LHGEQTESTQ
1360 1370 1380 1390 1400
LLILDPPQVP TQLEDIRALL LATGPNLPSV LMSPLGTQLV LDPGNSALLG
1410 1420 1430 1440 1450
CPIKGHPTPN ITWFQNGQPI ATAPGLTHHI WGAGQILRVA NLSGGPQGEF
1460 1470 1480 1490 1500
SCLAQNEAGT LLQKASLVIQ DYWWSVDRLA TCSASCGNRG IHQPRLRCLL
1510 1520 1530 1540 1550
NTTEVDPEHC TGKPRPAVQP VACNRRDCPS RWMVTSWSAC TRSCGGGVQT
1560 1570 1580 1590 1600
RRVTCQKLKA SGISTPVSND MCSQLAKRPV DTQACNQQLC VEWAFSSWGQ
1610 1620 1630 1640 1650
CNGPCIGPRL AVQHRQVFCQ TRDGITLPSE QCSALPRPVS TQNCWSEACS
1660 1670 1680 1690 1700
VHWRVSLWTL CTATCGNYGF QSRRVECVHV RTNKAVPEHL CSWGPRPANW
1710 1720 1730 1740
QRCNVTPCEN TECRDTTRYC EKVRQLKLCQ LGQFRSRCCG TCGKA
Length:1,745
Mass (Da):192,008
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A9E6EBC3C220ABB
GO
Isoform 2 (identifier: Q8BLI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-377: SDGYKQIMPYDLYHPL → RSVQFTCLCMINQVPS
     378-1745: Missing.

Show »
Length:377
Mass (Da):41,751
Checksum:iBC96FCE4C5B36259
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWW5E9PWW5_MOUSE
ADAMTS-like protein 1
Adamtsl1
1,753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMA0A0A1D5RMA0_MOUSE
ADAMTS-like protein 1
Adamtsl1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCH8B7ZCH8_MOUSE
ADAMTS-like protein 1
Adamtsl1
525Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A9Z1Z6A9Z1Z6_MOUSE
ADAMTS-like protein 1
Adamtsl1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WY46F6WY46_MOUSE
ADAMTS-like protein 1
Adamtsl1
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039332362 – 377SDGYK…LYHPL → RSVQFTCLCMINQVPS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_039333378 – 1745Missing in isoform 2. 1 PublicationAdd BLAST1368

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK045085 mRNA Translation: BAC32213.1
AL772130 Genomic DNA No translation available.
AL807242 Genomic DNA No translation available.
AL824705 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_084243.3, NM_029967.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
77739

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:77739

UCSC genome browser

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UCSCi
uc008tlr.2, mouse [Q8BLI0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045085 mRNA Translation: BAC32213.1
AL772130 Genomic DNA No translation available.
AL807242 Genomic DNA No translation available.
AL824705 Genomic DNA No translation available.
RefSeqiNP_084243.3, NM_029967.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102796

PTM databases

GlyGeniQ8BLI0, 4 sites
iPTMnetiQ8BLI0
PhosphoSitePlusiQ8BLI0

Proteomic databases

PaxDbiQ8BLI0
PRIDEiQ8BLI0
ProteomicsDBi277066 [Q8BLI0-1]
277067 [Q8BLI0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24655, 164 antibodies

The DNASU plasmid repository

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DNASUi
77739

Genome annotation databases

EnsembliENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1]
GeneIDi77739
KEGGimmu:77739
UCSCiuc008tlr.2, mouse [Q8BLI0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92949
MGIiMGI:1924989, Adamtsl1

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000156243
InParanoidiQ8BLI0
OMAiWLLSEWT
OrthoDBi38261at2759

Enzyme and pathway databases

ReactomeiR-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
77739, 1 hit in 50 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Adamtsl1, mouse

Protein Ontology

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PROi
PR:Q8BLI0
RNActiQ8BLI0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000066113, Expressed in lumbar subsegment of spinal cord and 192 other tissues
ExpressionAtlasiQ8BLI0, baseline and differential
GenevisibleiQ8BLI0, MM

Family and domain databases

Gene3Di2.20.100.10, 10 hits
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF07679, I-set, 3 hits
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00209, TSP1, 12 hits
SUPFAMiSSF48726, SSF48726, 4 hits
SSF82895, SSF82895, 10 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50900, PLAC, 1 hit
PS50092, TSP1, 9 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BLI0
Secondary accession number(s): A2AM52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: June 2, 2021
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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