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UniProtKB - Q8BLI0 (ATL1_MOUSE)

Protein

ADAMTS-like protein 1

Gene

Adamtsl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 1
Short name:
ADAMTSL-1
Alternative name(s):
Punctin-1
Gene namesi
Name:Adamtsl1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924989 Adamtsl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000003586129 – 1745ADAMTS-like protein 1Add BLAST1717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 76By similarity
Disulfide bondi49 ↔ 81By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310O-linked (Fuc...) serineBy similarity1
Glycosylationi391O-linked (Fuc...) serineBy similarity1
Glycosylationi451O-linked (Fuc...) threonineBy similarity1
Disulfide bondi534 ↔ 578By similarity
Disulfide bondi538 ↔ 583By similarity
Disulfide bondi549 ↔ 567By similarity
Disulfide bondi775 ↔ 819By similarity
Disulfide bondi779 ↔ 824By similarity
Disulfide bondi790 ↔ 807By similarity
Disulfide bondi874 ↔ 922By similarity
Disulfide bondi1177 ↔ 1225By similarity
Disulfide bondi1283 ↔ 1336By similarity
Disulfide bondi1401 ↔ 1452By similarity

Post-translational modificationi

Glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Disulfide bonds are present.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BLI0
PRIDEiQ8BLI0

PTM databases

iPTMnetiQ8BLI0
PhosphoSitePlusiQ8BLI0

Expressioni

Gene expression databases

BgeeiENSMUSG00000066113 Expressed in 160 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_ADAMTSL1
ExpressionAtlasiQ8BLI0 baseline and differential
GenevisibleiQ8BLI0 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102796

Structurei

3D structure databases

ProteinModelPortaliQ8BLI0
SMRiQ8BLI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 82TSP type-1 1PROSITE-ProRule annotationAdd BLAST50
Domaini376 – 424TSP type-1 2PROSITE-ProRule annotationAdd BLAST49
Domaini436 – 493TSP type-1 3PROSITE-ProRule annotationAdd BLAST58
Domaini522 – 584TSP type-1 4PROSITE-ProRule annotationAdd BLAST63
Domaini607 – 667TSP type-1 5PROSITE-ProRule annotationAdd BLAST61
Domaini703 – 762TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini763 – 825TSP type-1 7PROSITE-ProRule annotationAdd BLAST63
Domaini836 – 938Ig-like C2-type 1Add BLAST103
Domaini1139 – 1241Ig-like C2-type 2Add BLAST103
Domaini1261 – 1352Ig-like C2-type 3Add BLAST92
Domaini1378 – 1468Ig-like C2-type 4Add BLAST91
Domaini1528 – 1591TSP type-1 8PROSITE-ProRule annotationAdd BLAST64
Domaini1649 – 1709TSP type-1 9PROSITE-ProRule annotationAdd BLAST61
Domaini1709 – 1745PLACPROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410YY5R LUCA
GeneTreeiENSGT00930000150871
HOGENOMiHOG000013139
HOVERGENiHBG079989
InParanoidiQ8BLI0
OMAiINTEEPA

Family and domain databases

Gene3Di2.20.100.10, 10 hits
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013273 ADAMTS/ADAMTS-like
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF07679 I-set, 4 hits
PF08686 PLAC, 1 hit
PF00090 TSP_1, 7 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00209 TSP1, 12 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF82895 SSF82895, 10 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS50900 PLAC, 1 hit
PS50092 TSP1, 9 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BLI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MECCRRAAPG TPLLVLAFLL LSSRTARSEE DREGLWDAWG PWSECSRTCG 
        60         70         80         90        100
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK 
       110        120        130        140        150
YHGQLYEWLP VSNDPDNPCS LKCQAKGTSL VVELAPKVLD GTRCYTESLD 
       160        170        180        190        200
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSASK 
       210        220        230        240        250
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGIFLVD 
       260        270        280        290        300
NSTVDFQKLP DKEILRMTGP LTADFIIKIH DLGPADSTVQ FIFYQPIIHR 
       310        320        330        340        350
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENVKPKPK 
       360        370        380        390        400
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA 
       410        420        430        440        450
VSCVEEDIQG HVTSVEEWKC MYTPKMPVVQ PCNIFDCPKW LAQEWSPCTV 
       460        470        480        490        500
TCGQGLRYRV VLCIDHRGMH TGGCSAKTKP HIKEECIIPT PCYKPREKLP 
       510        520        530        540        550
IEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIIRCQ 
       560        570        580        590        600
VLLPFSQSVA DLPADECEGP KPASQRACYA GPCNGETPEF NPDNGDGLLG 
       610        620        630        640        650
GLQDLDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR ELADENLCVT 
       660        670        680        690        700
SRRPPQLLKS CNLDPCPASH LLSREMNEVV VLADELCHHP KPSTVQACNR 
       710        720        730        740        750
FNCPPAWYPA QWQLCSRTCG GGIQKRDVLC KQRMADGSFL ELPETFCSAS 
       760        770        780        790        800
KPTSHQGCKK DDCPSEWLLS EWSECSVSCG EGTQTRSAIC QRVLKTGVST 
       810        820        830        840        850
VVNSTLCPPL PFSSSIRPCM LATCARPGRP STKHSPHIAA ARNIYIQTRR 
       860        870        880        890        900
QRKLHFVVGG FAYLLPKTTV VLRCPTRRFR KPLITWEKDG QHSISSAHVT 
       910        920        930        940        950
VAPFGYLKIH RLKPSDAGIY TCSAGPAREQ FVIKLIGGNR KLVARPLSLW 
       960        970        980        990       1000
SEEEEALQVR KTNPKEALQT HKHQNGIFSN GSKAEKRGLT ADPGNRYDDI 
      1010       1020       1030       1040       1050
VSRLLEQGGW PGELLASWEV QDSAERNASS EEDPNAEQAL LHLPFTMVAE 
      1060       1070       1080       1090       1100
QKRLDDILRN LSQQPEELRD LYSKHLVAQL AQDIFRSHLE NQDLLPKPSE 
      1110       1120       1130       1140       1150
QRFPPMAVPA HKHVSGFSSS LRSSSGEAGG GSRRPHRKPA ILRKISAAQQ 
      1160       1170       1180       1190       1200
LSASEVVTHL GQTVALASGT LSVLLHCEAV GNPRPTIHWT RNGEAVQFSD 
      1210       1220       1230       1240       1250
RILLQPDDSL QILAPVEADV GFYTCNATNA LGYDSVSIAV TLAGKPLVKT 
      1260       1270       1280       1290       1300
SRMTVLNTEK PTVTVDIGGT VRTVRGVNVT INCQVAGVPE AEVTWFRNKS 
      1310       1320       1330       1340       1350
KLGSSHHLHE GSSHHLHEGS LLLTDVSFSD QGLYSCRAAN LHGEQTESTQ 
      1360       1370       1380       1390       1400
LLILDPPQVP TQLEDIRALL LATGPNLPSV LMSPLGTQLV LDPGNSALLG 
      1410       1420       1430       1440       1450
CPIKGHPTPN ITWFQNGQPI ATAPGLTHHI WGAGQILRVA NLSGGPQGEF 
      1460       1470       1480       1490       1500
SCLAQNEAGT LLQKASLVIQ DYWWSVDRLA TCSASCGNRG IHQPRLRCLL 
      1510       1520       1530       1540       1550
NTTEVDPEHC TGKPRPAVQP VACNRRDCPS RWMVTSWSAC TRSCGGGVQT 
      1560       1570       1580       1590       1600
RRVTCQKLKA SGISTPVSND MCSQLAKRPV DTQACNQQLC VEWAFSSWGQ 
      1610       1620       1630       1640       1650
CNGPCIGPRL AVQHRQVFCQ TRDGITLPSE QCSALPRPVS TQNCWSEACS 
      1660       1670       1680       1690       1700
VHWRVSLWTL CTATCGNYGF QSRRVECVHV RTNKAVPEHL CSWGPRPANW 
      1710       1720       1730       1740 
QRCNVTPCEN TECRDTTRYC EKVRQLKLCQ LGQFRSRCCG TCGKA
Length:1,745
Mass (Da):192,008
Last modified:June 15, 2010 - v2
Checksum:i5A9E6EBC3C220ABB
GO
Isoform 2 (identifier: Q8BLI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-377: SDGYKQIMPYDLYHPL → RSVQFTCLCMINQVPS
     378-1745: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):41,751
Checksum:iBC96FCE4C5B36259
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWW5E9PWW5_MOUSE
ADAMTS-like protein 1
Adamtsl1
1,753Annotation score:
B7ZCH8B7ZCH8_MOUSE
ADAMTS-like protein 1
Adamtsl1
525Annotation score:
A9Z1Z6A9Z1Z6_MOUSE
ADAMTS-like protein 1
Adamtsl1
203Annotation score:
A0A1D5RMA0A0A1D5RMA0_MOUSE
ADAMTS-like protein 1
Adamtsl1
127Annotation score:
F6WY46F6WY46_MOUSE
ADAMTS-like protein 1
Adamtsl1
243Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039332362 – 377SDGYK…LYHPL → RSVQFTCLCMINQVPS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_039333378 – 1745Missing in isoform 2. 1 PublicationAdd BLAST1368

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045085 mRNA Translation: BAC32213.1
AL824705, AL772130, AL807242 Genomic DNA Translation: CAM13345.2
AL807242, AL772130, AL824705 Genomic DNA Translation: CAM15556.2
AL772130, AL807242, AL824705 Genomic DNA Translation: CAX15654.1
RefSeqiNP_084243.3, NM_029967.3
UniGeneiMm.331690

Genome annotation databases

EnsembliENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1]
GeneIDi77739
KEGGimmu:77739
UCSCiuc008tlr.2 mouse [Q8BLI0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045085 mRNA Translation: BAC32213.1
AL824705, AL772130, AL807242 Genomic DNA Translation: CAM13345.2
AL807242, AL772130, AL824705 Genomic DNA Translation: CAM15556.2
AL772130, AL807242, AL824705 Genomic DNA Translation: CAX15654.1
RefSeqiNP_084243.3, NM_029967.3
UniGeneiMm.331690

3D structure databases

ProteinModelPortaliQ8BLI0
SMRiQ8BLI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102796

PTM databases

iPTMnetiQ8BLI0
PhosphoSitePlusiQ8BLI0

Proteomic databases

PaxDbiQ8BLI0
PRIDEiQ8BLI0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113 [Q8BLI0-1]
GeneIDi77739
KEGGimmu:77739
UCSCiuc008tlr.2 mouse [Q8BLI0-2]

Organism-specific databases

CTDi92949
MGIiMGI:1924989 Adamtsl1

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410YY5R LUCA
GeneTreeiENSGT00930000150871
HOGENOMiHOG000013139
HOVERGENiHBG079989
InParanoidiQ8BLI0
OMAiINTEEPA

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRSiAdamtsl1 mouse
PROiPR:Q8BLI0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066113 Expressed in 160 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_ADAMTSL1
ExpressionAtlasiQ8BLI0 baseline and differential
GenevisibleiQ8BLI0 MM

Family and domain databases

Gene3Di2.20.100.10, 10 hits
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013273 ADAMTS/ADAMTS-like
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF07679 I-set, 4 hits
PF08686 PLAC, 1 hit
PF00090 TSP_1, 7 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00209 TSP1, 12 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF82895 SSF82895, 10 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS50900 PLAC, 1 hit
PS50092 TSP1, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiATL1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLI0
Secondary accession number(s): A2AM52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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