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Entry version 114 (17 Jun 2020)
Sequence version 1 (01 Mar 2003)
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Protein

HIRA-interacting protein 3

Gene

Hirip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HIRA-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hirip3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142364 Hirip3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003670461 – 601HIRA-interacting protein 3Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei134PhosphoserineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei391PhosphothreonineCombined sources1
Modified residuei396PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei564PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei595PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei600PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BLH7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BLH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BLH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BLH7

PeptideAtlas

More...
PeptideAtlasi
Q8BLH7

PRoteomics IDEntifications database

More...
PRIDEi
Q8BLH7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BLH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BLH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042606 Expressed in embryo and 234 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BLH7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIRA. Weak interaction with histones H2B and H3.

Interacts with CK2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231462, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035535

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BLH7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 337Glu-richSequence analysisAdd BLAST188
Compositional biasi379 – 451Ser-richSequence analysisAdd BLAST73

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZNK Eukaryota
ENOG4111SS6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038583_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BLH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAPPDWS

Database of Orthologous Groups

More...
OrthoDBi
879744at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BLH7

TreeFam database of animal gene trees

More...
TreeFami
TF331753

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037647 HIRIP3
IPR019098 Histone_chaperone_domain_CHZ

The PANTHER Classification System

More...
PANTHERi
PTHR15410 PTHR15410, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09649 CHZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01082 CHZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BLH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGDEMRKF TRSFFRACPD LSSVTHAIVR QKFLIHVGRD HLEPEEKQAL
60 70 80 90 100
KRLVEEELPK MQADAGTREG KPDFIKVKRS PAPCSDPKKK RFRFNSESES
110 120 130 140 150
SSSPSSPDGS GPSTKNRTTK KTCLRRALKK AVESTDEDHQ TDLDAKMGLE
160 170 180 190 200
ESSEGEAEGS VRSGKVTEEE EDMKQEQKGQ VRKQAGAKDK QVPLKADRKQ
210 220 230 240 250
VREESGSSEE EAVLQRAKVE GSTGANCQEE SEESGEESPA KKKELSEPRS
260 270 280 290 300
RSNRAERTAR ERKSYKQKSR PGRPTGGLRD SEAEKEGGTV GSGDSSEEGE
310 320 330 340 350
AEKEGGTVGS GDSSEKGEAE KEEGTVGSGD SSEEGEEHSV KRKSKVRTQT
360 370 380 390 400
ESGRRQNTSS RDDSNSTQEQ AAAQGTTKSG SLGSSNGDSD TEREVSDSQA
410 420 430 440 450
GQNTKEERKS RSSNKSSKNG QARSCSSSSD SSPEPTGQKG KARSSSSSSD
460 470 480 490 500
SGPEPTGRKA ASRCGEDHPA VARLKRYIRA CGAHRNYKKL LGSCSSHKAR
510 520 530 540 550
LSVLRAELEA LGMKGNPSLE KCRALKLQRE EAAEVAALDV ANIISSTGRP
560 570 580 590 600
RRRNAWNPSG EGTSPGETYR RTLDSEEEQP RQAPPDWSHM RDIISSDGDS

S
Length:601
Mass (Da):65,215
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5422EE8F9B92B88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWU7D3YWU7_MOUSE
HIRA-interacting protein 3
Hirip3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK045122 mRNA Translation: BAC32232.1
AK162096 mRNA Translation: BAE36722.1
CH466531 Genomic DNA Translation: EDL17468.1
BC055687 mRNA Translation: AAH55687.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21849.1

NCBI Reference Sequences

More...
RefSeqi
NP_766334.1, NM_172746.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037248; ENSMUSP00000035535; ENSMUSG00000042606

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
233876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233876

UCSC genome browser

More...
UCSCi
uc012ftw.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045122 mRNA Translation: BAC32232.1
AK162096 mRNA Translation: BAE36722.1
CH466531 Genomic DNA Translation: EDL17468.1
BC055687 mRNA Translation: AAH55687.1
CCDSiCCDS21849.1
RefSeqiNP_766334.1, NM_172746.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi231462, 2 interactors
STRINGi10090.ENSMUSP00000035535

PTM databases

iPTMnetiQ8BLH7
PhosphoSitePlusiQ8BLH7

Proteomic databases

EPDiQ8BLH7
jPOSTiQ8BLH7
MaxQBiQ8BLH7
PaxDbiQ8BLH7
PeptideAtlasiQ8BLH7
PRIDEiQ8BLH7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26925 185 antibodies

Genome annotation databases

EnsembliENSMUST00000037248; ENSMUSP00000035535; ENSMUSG00000042606
GeneIDi233876
KEGGimmu:233876
UCSCiuc012ftw.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8479
MGIiMGI:2142364 Hirip3

Phylogenomic databases

eggNOGiENOG410IZNK Eukaryota
ENOG4111SS6 LUCA
GeneTreeiENSGT00390000014062
HOGENOMiCLU_038583_0_0_1
InParanoidiQ8BLH7
OMAiQAPPDWS
OrthoDBi879744at2759
PhylomeDBiQ8BLH7
TreeFamiTF331753

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
233876 4 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hirip3 mouse

Protein Ontology

More...
PROi
PR:Q8BLH7
RNActiQ8BLH7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042606 Expressed in embryo and 234 other tissues
GenevisibleiQ8BLH7 MM

Family and domain databases

InterProiView protein in InterPro
IPR037647 HIRIP3
IPR019098 Histone_chaperone_domain_CHZ
PANTHERiPTHR15410 PTHR15410, 1 hit
PfamiView protein in Pfam
PF09649 CHZ, 1 hit
SMARTiView protein in SMART
SM01082 CHZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIRP3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BLH7
Secondary accession number(s): Q3TSF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 1, 2003
Last modified: June 17, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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