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Protein

HIRA-interacting protein 3

Gene

Hirip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
HIRA-interacting protein 3
Gene namesi
Name:Hirip3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142364 Hirip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670461 – 601HIRA-interacting protein 3Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei134PhosphoserineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei391PhosphothreonineCombined sources1
Modified residuei396PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei564PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei595PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei600PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BLH7
MaxQBiQ8BLH7
PaxDbiQ8BLH7
PeptideAtlasiQ8BLH7
PRIDEiQ8BLH7

PTM databases

iPTMnetiQ8BLH7
PhosphoSitePlusiQ8BLH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000042606 Expressed in 235 organ(s), highest expression level in embryo
ExpressionAtlasiQ8BLH7 baseline and differential
GenevisibleiQ8BLH7 MM

Interactioni

Subunit structurei

Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi231462, 2 interactors
STRINGi10090.ENSMUSP00000035535

Structurei

3D structure databases

ProteinModelPortaliQ8BLH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 337Glu-richSequence analysisAdd BLAST188
Compositional biasi379 – 451Ser-richSequence analysisAdd BLAST73

Phylogenomic databases

eggNOGiENOG410IZNK Eukaryota
ENOG4111SS6 LUCA
GeneTreeiENSGT00390000014062
HOGENOMiHOG000112903
HOVERGENiHBG066199
InParanoidiQ8BLH7
OMAiMARENEM
OrthoDBiEOG091G0CB9
PhylomeDBiQ8BLH7
TreeFamiTF331753

Family and domain databases

InterProiView protein in InterPro
IPR037647 HIRIP3
IPR019098 Histone_chaperone_domain_CHZ
PANTHERiPTHR15410 PTHR15410, 1 hit
PfamiView protein in Pfam
PF09649 CHZ, 1 hit
SMARTiView protein in SMART
SM01082 CHZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BLH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGDEMRKF TRSFFRACPD LSSVTHAIVR QKFLIHVGRD HLEPEEKQAL
60 70 80 90 100
KRLVEEELPK MQADAGTREG KPDFIKVKRS PAPCSDPKKK RFRFNSESES
110 120 130 140 150
SSSPSSPDGS GPSTKNRTTK KTCLRRALKK AVESTDEDHQ TDLDAKMGLE
160 170 180 190 200
ESSEGEAEGS VRSGKVTEEE EDMKQEQKGQ VRKQAGAKDK QVPLKADRKQ
210 220 230 240 250
VREESGSSEE EAVLQRAKVE GSTGANCQEE SEESGEESPA KKKELSEPRS
260 270 280 290 300
RSNRAERTAR ERKSYKQKSR PGRPTGGLRD SEAEKEGGTV GSGDSSEEGE
310 320 330 340 350
AEKEGGTVGS GDSSEKGEAE KEEGTVGSGD SSEEGEEHSV KRKSKVRTQT
360 370 380 390 400
ESGRRQNTSS RDDSNSTQEQ AAAQGTTKSG SLGSSNGDSD TEREVSDSQA
410 420 430 440 450
GQNTKEERKS RSSNKSSKNG QARSCSSSSD SSPEPTGQKG KARSSSSSSD
460 470 480 490 500
SGPEPTGRKA ASRCGEDHPA VARLKRYIRA CGAHRNYKKL LGSCSSHKAR
510 520 530 540 550
LSVLRAELEA LGMKGNPSLE KCRALKLQRE EAAEVAALDV ANIISSTGRP
560 570 580 590 600
RRRNAWNPSG EGTSPGETYR RTLDSEEEQP RQAPPDWSHM RDIISSDGDS

S
Length:601
Mass (Da):65,215
Last modified:March 1, 2003 - v1
Checksum:iF5422EE8F9B92B88
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWU7D3YWU7_MOUSE
HIRA-interacting protein 3
Hirip3
126Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045122 mRNA Translation: BAC32232.1
AK162096 mRNA Translation: BAE36722.1
CH466531 Genomic DNA Translation: EDL17468.1
BC055687 mRNA Translation: AAH55687.1
CCDSiCCDS21849.1
RefSeqiNP_766334.1, NM_172746.3
UniGeneiMm.363427

Genome annotation databases

EnsembliENSMUST00000037248; ENSMUSP00000035535; ENSMUSG00000042606
GeneIDi233876
KEGGimmu:233876
UCSCiuc012ftw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045122 mRNA Translation: BAC32232.1
AK162096 mRNA Translation: BAE36722.1
CH466531 Genomic DNA Translation: EDL17468.1
BC055687 mRNA Translation: AAH55687.1
CCDSiCCDS21849.1
RefSeqiNP_766334.1, NM_172746.3
UniGeneiMm.363427

3D structure databases

ProteinModelPortaliQ8BLH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231462, 2 interactors
STRINGi10090.ENSMUSP00000035535

PTM databases

iPTMnetiQ8BLH7
PhosphoSitePlusiQ8BLH7

Proteomic databases

EPDiQ8BLH7
MaxQBiQ8BLH7
PaxDbiQ8BLH7
PeptideAtlasiQ8BLH7
PRIDEiQ8BLH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037248; ENSMUSP00000035535; ENSMUSG00000042606
GeneIDi233876
KEGGimmu:233876
UCSCiuc012ftw.1 mouse

Organism-specific databases

CTDi8479
MGIiMGI:2142364 Hirip3

Phylogenomic databases

eggNOGiENOG410IZNK Eukaryota
ENOG4111SS6 LUCA
GeneTreeiENSGT00390000014062
HOGENOMiHOG000112903
HOVERGENiHBG066199
InParanoidiQ8BLH7
OMAiMARENEM
OrthoDBiEOG091G0CB9
PhylomeDBiQ8BLH7
TreeFamiTF331753

Miscellaneous databases

PROiPR:Q8BLH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042606 Expressed in 235 organ(s), highest expression level in embryo
ExpressionAtlasiQ8BLH7 baseline and differential
GenevisibleiQ8BLH7 MM

Family and domain databases

InterProiView protein in InterPro
IPR037647 HIRIP3
IPR019098 Histone_chaperone_domain_CHZ
PANTHERiPTHR15410 PTHR15410, 1 hit
PfamiView protein in Pfam
PF09649 CHZ, 1 hit
SMARTiView protein in SMART
SM01082 CHZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIRP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BLH7
Secondary accession number(s): Q3TSF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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