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Protein

Lysophosphatidic acid receptor 4

Gene

Lpar4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity).By similarity

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • lysophosphatidic acid binding Source: MGI
  • lysophosphatidic acid receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Chemistry databases

SwissLipidsiSLP:000001576

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 4
Short name:
LPA receptor 4
Short name:
LPA-4
Alternative name(s):
G-protein coupled receptor 23
P2Y purinoceptor 9
Short name:
P2Y9
Purinergic receptor 9
Gene namesi
Name:Lpar4
Synonyms:Gpr23, Lpa4, P2y9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1925384 Lpar4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 203ExtracellularSequence analysisAdd BLAST27
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 254CytoplasmicSequence analysisAdd BLAST30
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini276 – 294ExtracellularSequence analysisAdd BLAST19
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 370CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3321650
GuidetoPHARMACOLOGYi94

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502041 – 370Lysophosphatidic acid receptor 4Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BLG2
PaxDbiQ8BLG2
PRIDEiQ8BLG2

PTM databases

PhosphoSitePlusiQ8BLG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000049929 Expressed in 230 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8BLG2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986

Chemistry databases

BindingDBiQ8BLG2

Structurei

3D structure databases

ProteinModelPortaliQ8BLG2
SMRiQ8BLG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ8BLG2
KOiK04275
OMAiSTTCFEG
OrthoDBiEOG091G0BRE
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BLG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDRRFIDFQ FQDLNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF
60 70 80 90 100
ILGLITNSAS LFVFCFRMKM RSETAIFITN LALSDLLFVC TLPFKIFYNF
110 120 130 140 150
NRHWPFGDTL CKISGTAFLT NIYGSMLFLT CISVDRFLAI VYPFRSRTIR
160 170 180 190 200
TRRNSAIVCA GVWILVLSGG ISASLFSTTN VNNATTTCFE GFSKRVWKTY
210 220 230 240 250
LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI GTNKKKVLKM
260 270 280 290 300
ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCLLERFAK IMYPITLCLA
310 320 330 340 350
TLNCCFDPFI YYFTLESFQK SFYINTHIRM ESLFKTETPL TPKPSLPAIQ
360 370
EEVSDQTTNN GGELMLESTF
Length:370
Mass (Da):41,899
Last modified:July 27, 2011 - v2
Checksum:i05998ED7D8F1F5A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → T in BAC34729 (PubMed:16141072).Curated1
Sequence conflicti57N → S in BAC32299 (PubMed:16141072).Curated1
Sequence conflicti168S → N in BAC34729 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA Translation: BAC32299.1
AK051709 mRNA Translation: BAC34729.1
AL670943 Genomic DNA Translation: CAM18227.1
CH466564 Genomic DNA Translation: EDL14046.1
BC019743 mRNA Translation: AAH19743.1
BC138893 mRNA Translation: AAI38894.1
BC138894 mRNA Translation: AAI38895.1
CCDSiCCDS30345.1
RefSeqiNP_780480.2, NM_175271.4
UniGeneiMm.90147

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929
GeneIDi78134
KEGGimmu:78134
UCSCiuc009ubx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA Translation: BAC32299.1
AK051709 mRNA Translation: BAC34729.1
AL670943 Genomic DNA Translation: CAM18227.1
CH466564 Genomic DNA Translation: EDL14046.1
BC019743 mRNA Translation: AAH19743.1
BC138893 mRNA Translation: AAI38894.1
BC138894 mRNA Translation: AAI38895.1
CCDSiCCDS30345.1
RefSeqiNP_780480.2, NM_175271.4
UniGeneiMm.90147

3D structure databases

ProteinModelPortaliQ8BLG2
SMRiQ8BLG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986

Chemistry databases

BindingDBiQ8BLG2
ChEMBLiCHEMBL3321650
GuidetoPHARMACOLOGYi94
SwissLipidsiSLP:000001576

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BLG2

Proteomic databases

MaxQBiQ8BLG2
PaxDbiQ8BLG2
PRIDEiQ8BLG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929
GeneIDi78134
KEGGimmu:78134
UCSCiuc009ubx.2 mouse

Organism-specific databases

CTDi2846
MGIiMGI:1925384 Lpar4

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ8BLG2
KOiK04275
OMAiSTTCFEG
OrthoDBiEOG091G0BRE
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Miscellaneous databases

PROiPR:Q8BLG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049929 Expressed in 230 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8BLG2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLG2
Secondary accession number(s): A2ADM5, Q8BKK1, Q8VE54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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