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Entry version 135 (17 Jun 2020)
Sequence version 2 (22 Nov 2005)
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Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3Curated (EC:2.7.11.22)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdkl3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2388268 Cdkl3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000858221 – 595Cyclin-dependent kinase-like 3Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei158PhosphothreonineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BLF2

PRoteomics IDEntifications database

More...
PRIDEi
Q8BLF2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BLF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BLF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020389 Expressed in testis and 102 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BLF2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BLF2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064315

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BLF2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BLF2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi45 – 51[NKR]KIAxRE7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0593 Eukaryota
ENOG410XNSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_136_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BLF2

KEGG Orthology (KO)

More...
KOi
K08824

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKHRETG

Database of Orthologous Groups

More...
OrthoDBi
398098at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101031

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BLF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE
60 70 80 90 100
IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDVYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGHPF
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKTARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKFIPELR
310 320 330 340 350
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK SVFTNTLLYG NPSLYGKEVD
360 370 380 390 400
RDKRAKELKV RVIKAKGGKG DVPDQKKPEY EGDHRQQGTA DDTQPSSLDK
410 420 430 440 450
KPSVLELTNP LNPSENSDGV KEDPHAGGCM IMPPINLTSS NLLAANLSSN
460 470 480 490 500
LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT
510 520 530 540 550
GQNDQISSGN KRKLNFPKCD RKEFHFPELP FTVQAKEMKG MEVKQIKVLK
560 570 580 590
RESKKTDSSK IPTLLSMDPN QEKQEGGDGD CEGKNLKRNR FFFSR
Length:595
Mass (Da):67,739
Last modified:November 22, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DB415A3EEBC7C4B
GO
Isoform 2 (identifier: Q8BLF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-585: GGDGDCEGKN → QSARHLPGQC
     586-595: Missing.

Show »
Length:585
Mass (Da):66,531
Checksum:i619B377FACD9486D
GO
Isoform 3 (identifier: Q8BLF2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Show »
Length:581
Mass (Da):66,162
Checksum:i9CC3EAE169D206C9
GO
Isoform 4 (identifier: Q8BLF2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-353: FIPELRAKLL...LYGKEVDRDK → KWTETKGPRS...HWTRSLLSWN
     354-595: Missing.

Show »
Length:353
Mass (Da):40,619
Checksum:i7A645EE9FCAE2328
GO
Isoform 5 (identifier: Q8BLF2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MEMYETLGKVGEGSYGT → MKPLEKWEREVMEP
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Show »
Length:578
Mass (Da):66,112
Checksum:iB62583F530F130E8
GO
Isoform 6 (identifier: Q8BLF2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-595: Missing.

Show »
Length:457
Mass (Da):51,901
Checksum:i6FCDD36F51152B61
GO
Isoform 7 (identifier: Q8BLF2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-595: GGDGDCEGKNLKRNRFFFSR → QPVKQVNSNQ

Show »
Length:585
Mass (Da):66,576
Checksum:i6126BAAC992E6F42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AU43B1AU43_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3Z6F2Z3Z6_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AU42B1AU42_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RBI5F6RBI5_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RUB4F6RUB4_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ULF3F6ULF3_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y3R0F6Y3R0_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJ75A0A140LJ75_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RX76F6RX76_MOUSE
Cyclin-dependent kinase-like 3
Cdkl3
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12E → Q in BAC32701 (PubMed:16141072).Curated1
Sequence conflicti23H → Y in BAC37400 (PubMed:16141072).Curated1
Sequence conflicti153P → H in BAC32324 (PubMed:16141072).Curated1
Sequence conflicti352D → E in BAC37400 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0161491 – 17MEMYE…GSYGT → MKPLEKWEREVMEP in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016150295 – 353FIPEL…VDRDK → KWTETKGPRSSKSESLRPKG AKEMSQTRRSQSMKATTASR AQLMTHSPHHWTRSLLSWN in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_016151354 – 595Missing in isoform 4. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_016152458 – 595Missing in isoform 6. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_030154576 – 595GGDGD…FFFSR → QPVKQVNSNQ in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_016154576 – 585GGDGDCEGKN → QSARHLPGQC in isoform 2. 1 Publication10
Alternative sequenceiVSP_016155576 – 581GGDGDC → SLTMYL in isoform 3 and isoform 5. 1 Publication6
Alternative sequenceiVSP_016156582 – 595Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_016157586 – 595Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK043995 mRNA Translation: BAC31729.2
AK045356 mRNA Translation: BAC32324.1
AK046394 mRNA Translation: BAC32701.1
AK050990 mRNA Translation: BAC34488.1
AK078804 mRNA Translation: BAC37400.1
AL669920 Genomic DNA No translation available.
BC028871 mRNA Translation: AAH28871.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24665.1 [Q8BLF2-1]
CCDS48788.1 [Q8BLF2-7]
CCDS48790.1 [Q8BLF2-2]
CCDS48791.1 [Q8BLF2-6]
CCDS48792.1 [Q8BLF2-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001160125.1, NM_001166653.1
NP_001160126.1, NM_001166654.1 [Q8BLF2-2]
NP_001160127.1, NM_001166655.1 [Q8BLF2-6]
NP_001160128.1, NM_001166656.1 [Q8BLF2-7]
NP_001160129.1, NM_001166657.1 [Q8BLF2-4]
NP_722480.3, NM_153785.4 [Q8BLF2-1]
XP_011247178.1, XM_011248876.1
XP_011247179.1, XM_011248877.2 [Q8BLF2-2]
XP_011247180.1, XM_011248878.1 [Q8BLF2-2]
XP_011247181.1, XM_011248879.1
XP_011247182.1, XM_011248880.2 [Q8BLF2-2]
XP_017169911.1, XM_017314422.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389 [Q8BLF2-1]
ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389 [Q8BLF2-7]
ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389 [Q8BLF2-4]
ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389 [Q8BLF2-4]
ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389 [Q8BLF2-6]
ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389 [Q8BLF2-7]
ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389 [Q8BLF2-2]
ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389 [Q8BLF2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
213084

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:213084

UCSC genome browser

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UCSCi
uc007iuv.2 mouse [Q8BLF2-1]
uc007iux.2 mouse [Q8BLF2-4]
uc007iuz.2 mouse [Q8BLF2-2]
uc011xul.1 mouse [Q8BLF2-7]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043995 mRNA Translation: BAC31729.2
AK045356 mRNA Translation: BAC32324.1
AK046394 mRNA Translation: BAC32701.1
AK050990 mRNA Translation: BAC34488.1
AK078804 mRNA Translation: BAC37400.1
AL669920 Genomic DNA No translation available.
BC028871 mRNA Translation: AAH28871.1
CCDSiCCDS24665.1 [Q8BLF2-1]
CCDS48788.1 [Q8BLF2-7]
CCDS48790.1 [Q8BLF2-2]
CCDS48791.1 [Q8BLF2-6]
CCDS48792.1 [Q8BLF2-4]
RefSeqiNP_001160125.1, NM_001166653.1
NP_001160126.1, NM_001166654.1 [Q8BLF2-2]
NP_001160127.1, NM_001166655.1 [Q8BLF2-6]
NP_001160128.1, NM_001166656.1 [Q8BLF2-7]
NP_001160129.1, NM_001166657.1 [Q8BLF2-4]
NP_722480.3, NM_153785.4 [Q8BLF2-1]
XP_011247178.1, XM_011248876.1
XP_011247179.1, XM_011248877.2 [Q8BLF2-2]
XP_011247180.1, XM_011248878.1 [Q8BLF2-2]
XP_011247181.1, XM_011248879.1
XP_011247182.1, XM_011248880.2 [Q8BLF2-2]
XP_017169911.1, XM_017314422.1

3D structure databases

SMRiQ8BLF2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064315

PTM databases

iPTMnetiQ8BLF2
PhosphoSitePlusiQ8BLF2

Proteomic databases

PaxDbiQ8BLF2
PRIDEiQ8BLF2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2061 189 antibodies

Genome annotation databases

EnsembliENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389 [Q8BLF2-1]
ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389 [Q8BLF2-7]
ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389 [Q8BLF2-4]
ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389 [Q8BLF2-4]
ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389 [Q8BLF2-6]
ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389 [Q8BLF2-7]
ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389 [Q8BLF2-2]
ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389 [Q8BLF2-2]
GeneIDi213084
KEGGimmu:213084
UCSCiuc007iuv.2 mouse [Q8BLF2-1]
uc007iux.2 mouse [Q8BLF2-4]
uc007iuz.2 mouse [Q8BLF2-2]
uc011xul.1 mouse [Q8BLF2-7]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51265
MGIiMGI:2388268 Cdkl3

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00940000161317
HOGENOMiCLU_000288_136_1_1
InParanoidiQ8BLF2
KOiK08824
OMAiCKHRETG
OrthoDBi398098at2759
TreeFamiTF101031

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
213084 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cdkl3 mouse

Protein Ontology

More...
PROi
PR:Q8BLF2
RNActiQ8BLF2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020389 Expressed in testis and 102 other tissues
ExpressionAtlasiQ8BLF2 baseline and differential
GenevisibleiQ8BLF2 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDKL3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BLF2
Secondary accession number(s): A2ACR7
, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLN9, Q8BVE0, Q8K134
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 17, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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