Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ly6/PLAUR domain-containing protein 1

Gene

Lypd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs (PubMed:19246390). May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:26276394, PubMed:25716842). May be involved in the control of anxiety (PubMed:19246390).3 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 1
Alternative name(s):
Ly-6/neurotoxin-like protein 2
Short name:
Lynx2
Gene namesi
Name:Lypd1
Synonyms:Lypdc1
ORF Names:MNCb-0671
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919835 Lypd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased anxiety-like behaviors. Increased glutamatergic activity in response to nicotine in layer V neurons of the medial prefrontal cortex.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000022674321 – 115Ly6/PLAUR domain-containing protein 1Add BLAST95
PropeptideiPRO_0000226744116 – 141Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 54By similarity
Disulfide bondi28 ↔ 37By similarity
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 77By similarity
Disulfide bondi88 ↔ 100By similarity
Disulfide bondi101 ↔ 106By similarity
Lipidationi115GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8BLC3
PRIDEiQ8BLC3

Expressioni

Tissue specificityi

Preferentially expressed in the nervous system. Expressed in embryonic and postnatal postmitotic central and peripheral neurons including subpopulations of motor neurons, sensory neurons, interneurons and neurons of the autonomous nervous system. Expressed around the growing nerves in the limb bud (PubMed:16236524). Expressed at high levels in specific brain regions such as the prefrontal cortex, amygdala, hippocampus, mediodorsal thalamus, dentate gyrus and specific brainstem nuclei (at protein level) (PubMed:19246390).2 Publications

Gene expression databases

BgeeiENSMUSG00000026344 Expressed in 200 organ(s), highest expression level in vestibulocochlear ganglion
CleanExiMM_LYPD1
ExpressionAtlasiQ8BLC3 baseline and differential
GenevisibleiQ8BLC3 MM

Interactioni

Subunit structurei

Interacts with CHRNA4 and nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Chrna4O701743EBI-14035010,EBI-10916203

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48729N
IntActiQ8BLC3, 2 interactors
STRINGi10090.ENSMUSP00000125149

Structurei

3D structure databases

ProteinModelPortaliQ8BLC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 107UPAR/Ly6Add BLAST83

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWWH Eukaryota
ENOG410XU3J LUCA
GeneTreeiENSGT00390000002215
HOGENOMiHOG000113415
HOVERGENiHBG081940
InParanoidiQ8BLC3
OMAiTFCGLFW
OrthoDBiEOG091G0UX4
TreeFamiTF332325

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BLC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVLGIAATF CGLFWLPGLA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV
60 70 80 90 100
QDMCQKEVME QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC
110 120 130 140
CNTPLCNGPR PKKRGSSASA IRPGLLTTLL FFHLALCLAH C
Length:141
Mass (Da):15,261
Last modified:March 1, 2003 - v1
Checksum:i51717F7922C02DAA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXP0E0CXP0_MOUSE
Ly6/PLAUR domain-containing protein...
Lypd1
89Annotation score:
F6TKE8F6TKE8_MOUSE
Ly6/PLAUR domain-containing protein...
Lypd1
29Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59M → T in BAA95101 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041649 mRNA Translation: BAA95101.1
AK012406 mRNA Translation: BAE43232.1
AK045592 mRNA Translation: BAC32428.1
AK082941 mRNA Translation: BAE43380.1
BC058599 mRNA Translation: AAH58599.1
CCDSiCCDS15243.1
RefSeqiNP_001298018.1, NM_001311089.1
NP_001298019.1, NM_001311090.1
NP_659568.2, NM_145100.4
UniGeneiMm.490405

Genome annotation databases

EnsembliENSMUST00000159417; ENSMUSP00000125149; ENSMUSG00000026344
GeneIDi72585
KEGGimmu:72585
UCSCiuc007cki.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041649 mRNA Translation: BAA95101.1
AK012406 mRNA Translation: BAE43232.1
AK045592 mRNA Translation: BAC32428.1
AK082941 mRNA Translation: BAE43380.1
BC058599 mRNA Translation: AAH58599.1
CCDSiCCDS15243.1
RefSeqiNP_001298018.1, NM_001311089.1
NP_001298019.1, NM_001311090.1
NP_659568.2, NM_145100.4
UniGeneiMm.490405

3D structure databases

ProteinModelPortaliQ8BLC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48729N
IntActiQ8BLC3, 2 interactors
STRINGi10090.ENSMUSP00000125149

Proteomic databases

PaxDbiQ8BLC3
PRIDEiQ8BLC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159417; ENSMUSP00000125149; ENSMUSG00000026344
GeneIDi72585
KEGGimmu:72585
UCSCiuc007cki.1 mouse

Organism-specific databases

CTDi116372
MGIiMGI:1919835 Lypd1

Phylogenomic databases

eggNOGiENOG410IWWH Eukaryota
ENOG410XU3J LUCA
GeneTreeiENSGT00390000002215
HOGENOMiHOG000113415
HOVERGENiHBG081940
InParanoidiQ8BLC3
OMAiTFCGLFW
OrthoDBiEOG091G0UX4
TreeFamiTF332325

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

PROiPR:Q8BLC3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026344 Expressed in 200 organ(s), highest expression level in vestibulocochlear ganglion
CleanExiMM_LYPD1
ExpressionAtlasiQ8BLC3 baseline and differential
GenevisibleiQ8BLC3 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLYPD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLC3
Secondary accession number(s): Q3V2X5, Q3V447, Q9JJ96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again