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Protein

General transcription factor 3C polypeptide 2

Gene

Gtf3c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:Gtf3c2
Synonyms:Kiaa0011
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919002 Gtf3c2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509861 – 907General transcription factor 3C polypeptide 2Add BLAST907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei867PhosphoserineBy similarity1
Modified residuei888PhosphoserineBy similarity1
Modified residuei891PhosphothreonineBy similarity1
Modified residuei897PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BL74
MaxQBiQ8BL74
PaxDbiQ8BL74
PeptideAtlasiQ8BL74
PRIDEiQ8BL74

PTM databases

iPTMnetiQ8BL74
PhosphoSitePlusiQ8BL74

Expressioni

Gene expression databases

BgeeiENSMUSG00000106864 Expressed in 321 organ(s), highest expression level in female gonad
ExpressionAtlasiQ8BL74 baseline and differential
GenevisibleiQ8BL74 MM

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.By similarity

Protein-protein interaction databases

BioGridi214900, 15 interactors
IntActiQ8BL74, 15 interactors
MINTiQ8BL74
STRINGi10090.ENSMUSP00000085325

Structurei

3D structure databases

ProteinModelPortaliQ8BL74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati461 – 517WD 1Add BLAST57
Repeati548 – 589WD 2Add BLAST42
Repeati607 – 647WD 3Add BLAST41
Repeati828 – 870WD 4Add BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 154Poly-Leu6

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IG5U Eukaryota
ENOG410YFGF LUCA
GeneTreeiENSGT00390000018632
HOVERGENiHBG056791
InParanoidiQ8BL74
KOiK15200
OMAiKADLMPY
OrthoDBiEOG091G07LV
PhylomeDBiQ8BL74
TreeFamiTF314779

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BL74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM
60 70 80 90 100
SLPPPLPGFE DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR
110 120 130 140 150
RGGRTARGAK RPQQRKPPST PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL
160 170 180 190 200
LLKLSKGLDQ PESPHPKRPP EDFETPSGER PRRRAAQVAL LYLQELAEEL
210 220 230 240 250
STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR DEDFVLQVEG
260 270 280 290 300
EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM
310 320 330 340 350
APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK
360 370 380 390 400
SPLFSVQREG IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP
410 420 430 440 450
VPEGSAASQY VALFSSPDMN ETHPLSQLHS GPGLLQLWGL GTLQQESCPG
460 470 480 490 500
NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP ETLRKAPLLP RLGLLALACS
510 520 530 540 550
DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG SVQASDPSEC
560 570 580 590 600
GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY
610 620 630 640 650
PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK
660 670 680 690 700
RFLSTELSWL LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR
710 720 730 740 750
KGTVWSLSGS DWLGTVAAGD ISGELIAAIL PDMASNPINV KKPAERRFPI
760 770 780 790 800
YKADLIPYQD SPEDQDYSST SSETPNPPKA RTYTETINHH YLLFQDTDLS
810 820 830 840 850
SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP NLDSYGWLVS
860 870 880 890 900
GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS

HCLLPNP
Length:907
Mass (Da):100,275
Last modified:June 7, 2004 - v2
Checksum:iCEC3D374D3280CA7
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7I0D3Z7I0_MOUSE
General transcription factor 3C pol...
Gtf3c2
950Annotation score:
D3YY96D3YY96_MOUSE
General transcription factor 3C pol...
Gtf3c2
136Annotation score:
D3Z2L1D3Z2L1_MOUSE
General transcription factor 3C pol...
Gtf3c2
228Annotation score:
A0A0J9YUJ3A0A0J9YUJ3_MOUSE
General transcription factor 3C pol...
Gtf3c2
175Annotation score:
A0A0J9YV06A0A0J9YV06_MOUSE
General transcription factor 3C pol...
Gtf3c2
88Annotation score:

Sequence cautioni

The sequence BAC31709 differs from that shown. Intron retention.Curated
The sequence BAC97843 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → SS in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti64D → DK in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti146K → E in BAC31709 (PubMed:16141072).Curated1
Sequence conflicti392P → Q in BAC32629 (PubMed:16141072).Curated1
Sequence conflicti622S → N in BAC38975 (PubMed:16141072).Curated1
Sequence conflicti731P → L in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti815Q → L in BAC38975 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008582 mRNA Translation: BAB25760.1
AK012095 mRNA Translation: BAB28026.1
AK043944 mRNA Translation: BAC31709.1 Sequence problems.
AK046192 mRNA Translation: BAC32629.1
AK083636 mRNA Translation: BAC38975.1
AK151300 mRNA Translation: BAE30283.1
AK152439 mRNA Translation: BAE31220.1
AK129033 mRNA Translation: BAC97843.1 Different initiation.
BC034369 mRNA Translation: AAH34369.1
CCDSiCCDS39053.1
RefSeqiNP_082177.2, NM_027901.2
UniGeneiMm.271923

Genome annotation databases

EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000106864
GeneIDi71752
KEGGimmu:71752
UCSCiuc008wxh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008582 mRNA Translation: BAB25760.1
AK012095 mRNA Translation: BAB28026.1
AK043944 mRNA Translation: BAC31709.1 Sequence problems.
AK046192 mRNA Translation: BAC32629.1
AK083636 mRNA Translation: BAC38975.1
AK151300 mRNA Translation: BAE30283.1
AK152439 mRNA Translation: BAE31220.1
AK129033 mRNA Translation: BAC97843.1 Different initiation.
BC034369 mRNA Translation: AAH34369.1
CCDSiCCDS39053.1
RefSeqiNP_082177.2, NM_027901.2
UniGeneiMm.271923

3D structure databases

ProteinModelPortaliQ8BL74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214900, 15 interactors
IntActiQ8BL74, 15 interactors
MINTiQ8BL74
STRINGi10090.ENSMUSP00000085325

PTM databases

iPTMnetiQ8BL74
PhosphoSitePlusiQ8BL74

Proteomic databases

EPDiQ8BL74
MaxQBiQ8BL74
PaxDbiQ8BL74
PeptideAtlasiQ8BL74
PRIDEiQ8BL74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000106864
GeneIDi71752
KEGGimmu:71752
UCSCiuc008wxh.1 mouse

Organism-specific databases

CTDi2976
MGIiMGI:1919002 Gtf3c2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IG5U Eukaryota
ENOG410YFGF LUCA
GeneTreeiENSGT00390000018632
HOVERGENiHBG056791
InParanoidiQ8BL74
KOiK15200
OMAiKADLMPY
OrthoDBiEOG091G07LV
PhylomeDBiQ8BL74
TreeFamiTF314779

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

ChiTaRSiGtf3c2 mouse
PROiPR:Q8BL74
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000106864 Expressed in 321 organ(s), highest expression level in female gonad
ExpressionAtlasiQ8BL74 baseline and differential
GenevisibleiQ8BL74 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C2_MOUSE
AccessioniPrimary (citable) accession number: Q8BL74
Secondary accession number(s): Q3U7Z9
, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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