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UniProtKB - Q8BL66 (EEA1_MOUSE)

Entry version 156 (25 May 2022)
Sequence version 2 (27 Sep 2005)
Previous versions | rss
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Protein

Early endosome antigen 1

Gene

Eea1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1358Zinc 1PROSITE-ProRule annotation1
Metal bindingi1361Zinc 1PROSITE-ProRule annotation1
Metal bindingi1374Zinc 2PROSITE-ProRule annotation1
Metal bindingi1377Zinc 2PROSITE-ProRule annotation1
Metal bindingi1382Zinc 1PROSITE-ProRule annotation1
Metal bindingi1385Zinc 1PROSITE-ProRule annotation1
Metal bindingi1402Zinc 2PROSITE-ProRule annotation1
Metal bindingi1405Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri41 – 64C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-168138, Toll Like Receptor 9 (TLR9) Cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Early endosome antigen 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eea1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2442192, Eea1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000036499

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987071 – 1411Early endosome antigen 1Add BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8BL66

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8BL66

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8BL66

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BL66

PeptideAtlas

More...PeptideAtlasi		Q8BL66

PRoteomics IDEntifications database

More...PRIDEi		Q8BL66

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		275903

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00453776

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BL66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BL66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000036499, Expressed in secondary oocyte and 307 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BL66, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.

Interacts with ERBB2 (By similarity).

Interacts with RAB31.

Interacts with SAMD9 AND SAMD9L (By similarity). May interact with PLEKHF2 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		229728, 36 interactors

Protein interaction database and analysis system

More...IntActi		Q8BL66, 29 interactors

Molecular INTeraction database

More...MINTi		Q8BL66

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000061493

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BL66, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8BL66

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BL66

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni476 – 501DisorderedSequence analysisAdd BLAST26
Regioni1189 – 1217DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 1348Sequence analysisAdd BLAST1271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 27Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 64C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWB5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_256550_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BL66

Identification of Orthologs from Complete Genome Data

More...OMAi		FIAVYQH

Database of Orthologous Groups

More...OrthoDBi		753155at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BL66

TreeFam database of animal gene trees

More...TreeFami		TF329698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013087, Znf_C2H2_type
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01363, FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00064, FYVE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50178, ZF_FYVE, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BL66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRRILQRTP GRVGSQGSDL DSSATPINTV DVNNESSSEG FICPQCMKSL 
        60         70         80         90        100
GSADELFKHY QAVHDAGNDS GHGGEAGLAL TRDDITLLRQ EVQDLQASLK 
       110        120        130        140        150
EEKWYSEELK KELEKYQGLQ QQEAKSDGLV TDSSAELQAL EQQLEEAQTE 
       160        170        180        190        200
NFNIKQMKDL FEQKAAQLAT EIADIKSKYD EEKSLRAAAE QKVTHLTEDL 
       210        220        230        240        250
NKQTTVIQDL KTELLQRPGI EDVAVLKKEL VQVQTLMDNM TLERERESEK 
       260        270        280        290        300
LKDECKKLQS EHAHLEATIN QLRSELAKGP QEVAVYVQEI QKLKGSINEL 
       310        320        330        340        350
TQKNQNLTEK LQKKDLDYTH LEEKHNEESA SRKTLQASLH QRDLDCQQLQ 
       360        370        380        390        400
ARLTASESSL QRAQGELSEK AEAAQKLREE LREVESTRQH LKVEVKQLQQ 
       410        420        430        440        450
QREEKEQHGL QLQGEVSQLH CKLLETERQL GEAHGRLKEQ RQLSSEKLME 
       460        470        480        490        500
KEQQVADLQL KLSRLEEQLK EKVTNSTELQ HQLEKSKQQH QEQQALQQSA 
       510        520        530        540        550
TAKLREAQND LEQVLRQIGD KDQKIQNLEA LLQKGKESVS LLEKEREDLY 
       560        570        580        590        600
AKIQAGEGET AVLNQLQEKN HALQQQLTQL TEKLKNQSES HKQAEENLHD 
       610        620        630        640        650
QVQEQKAHLR AAQDRVLSLE TSVSELSSQL NESKEKVSQL DIQIKAKTEL 
       660        670        680        690        700
LLSAEAAKAA QRADLQNHLD TAQHALQDKQ QELNKVSVQL DQLTAKFQEK 
       710        720        730        740        750
QEHCIQLESH LKDHKEKHLS LEQKVEDLEG HIKKLEADAL EVKASKEQAL 
       760        770        780        790        800
QSLQQQRQLS TDLELRNAEL SRELQEQEEV VSCTKLDLQN KSEILENIKQ 
       810        820        830        840        850
TLTKKEEENV VLKQEFEKLS QDSKTQHKEL GDRMQAAVTE LTAVKAQKDA 
       860        870        880        890        900
LLAELSTTKE KLSKVSDSLK NSKSEFEKEN QKGKAAVLDL EKACKELKHQ 
       910        920        930        940        950
LQVQAESALK EQEDLKKSLE KEKETSQQLK IELNSVKGEV SQAQNTLKQK 
       960        970        980        990       1000
EKDEQQLQGT INQLKQSAEQ KKKQIEALQG EVKNAVSQKT VLENKLQQQS 
      1010       1020       1030       1040       1050
SQAAQELAAE KGKLSALQSN YEKCQADLKQ LQSDLYGKES ELLATRQDLK 
      1060       1070       1080       1090       1100
SVEEKLTLAQ EDLISNRNQI GNQNKSIQEL QAAKASLEQD SAKKEALLKE 
      1110       1120       1130       1140       1150
QSKALEDAQR EKSVKEKELV AEKSKLAEME EIKCRQEKEI TKLNEELKSH 
      1160       1170       1180       1190       1200
KQESIKEITN LKDAKQLLIQ QKLELQGRVD SLKAALEQEK ESQQLMREQV 
      1210       1220       1230       1240       1250
KKEEEKRKEE FSEKEAKLHS EIKEKEAGMK KHEENEAKLT MQVTTLNENL 
      1260       1270       1280       1290       1300
GTVKKEWQSS QRRVSELEKQ TDDLRGEIAV LEATVQNNQD ERRALLERCL 
      1310       1320       1330       1340       1350
KGEGEIEKLQ TKALELQRKL DNTTAAVQEL GRENQSLQIK HTQALNRKWA 
      1360       1370       1380       1390       1400
EDNEVQNCMS CGKCFSVTVR RHHCRQCGNI FCAECSTKNA LTPSSKKPVR 
      1410 
VCDACFNDLQ G
Length:1,411
Mass (Da):160,915
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2365A51EF92019FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7A6A0A1W2P7A6_MOUSE
Early endosome antigen 1
Eea1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7K1A0A1W2P7K1_MOUSE
Early endosome antigen 1
Eea1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32647 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225V → I in BAC32647 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC075637 mRNA Translation: AAH75637.1
AK046231 mRNA Translation: BAC32647.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36042.1

NCBI Reference Sequences

More...RefSeqi		NP_001001932.1, NM_001001932.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000053484; ENSMUSP00000061493; ENSMUSG00000036499

Database of genes from NCBI RefSeq genomes

More...GeneIDi		216238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:216238

UCSC genome browser

More...UCSCi		uc007gwu.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075637 mRNA Translation: AAH75637.1
AK046231 mRNA Translation: BAC32647.1 Sequence problems.
CCDSiCCDS36042.1
RefSeqiNP_001001932.1, NM_001001932.3

3D structure databases

AlphaFoldDBiQ8BL66
SMRiQ8BL66
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229728, 36 interactors
IntActiQ8BL66, 29 interactors
MINTiQ8BL66
STRINGi10090.ENSMUSP00000061493

PTM databases

iPTMnetiQ8BL66
PhosphoSitePlusiQ8BL66

2D gel databases

REPRODUCTION-2DPAGEiIPI00453776

Proteomic databases

EPDiQ8BL66
jPOSTiQ8BL66
MaxQBiQ8BL66
PaxDbiQ8BL66
PeptideAtlasiQ8BL66
PRIDEiQ8BL66
ProteomicsDBi275903

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3127, 524 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		216238

Genome annotation databases

EnsembliENSMUST00000053484; ENSMUSP00000061493; ENSMUSG00000036499
GeneIDi216238
KEGGimmu:216238
UCSCiuc007gwu.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8411
MGIiMGI:2442192, Eea1
VEuPathDBiHostDB:ENSMUSG00000036499

Phylogenomic databases

eggNOGiENOG502QWB5, Eukaryota
GeneTreeiENSGT00940000156910
HOGENOMiCLU_256550_0_0_1
InParanoidiQ8BL66
OMAiFIAVYQH
OrthoDBi753155at2759
PhylomeDBiQ8BL66
TreeFamiTF329698

Enzyme and pathway databases

ReactomeiR-MMU-168138, Toll Like Receptor 9 (TLR9) Cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		216238, 4 hits in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Eea1, mouse

Protein Ontology

More...PROi		PR:Q8BL66
RNActiQ8BL66, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000036499, Expressed in secondary oocyte and 307 other tissues
GenevisibleiQ8BL66, MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013087, Znf_C2H2_type
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178, ZF_FYVE, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEEA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BL66
Secondary accession number(s): Q6DIC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: September 27, 2005
Last modified: May 25, 2022
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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