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Entry version 123 (23 Feb 2022)
Sequence version 2 (25 Nov 2008)
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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 54

Gene

Usp54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has no peptidase activity.

By similarity

Caution

Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 54
Alternative name(s):
Inactive ubiquitin-specific peptidase 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926037, Usp54

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000034235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495311 – 1588Inactive ubiquitin carboxyl-terminal hydrolase 54Add BLAST1588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei424PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1
Modified residuei616PhosphoserineCombined sources1
Modified residuei1138PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BL06

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BL06

PeptideAtlas

More...
PeptideAtlasi
Q8BL06

PRoteomics IDEntifications database

More...
PRIDEi
Q8BL06

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
298367 [Q8BL06-1]
298368 [Q8BL06-2]
298369 [Q8BL06-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BL06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BL06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034235, Expressed in lumbar subsegment of spinal cord and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BL06, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BL06, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
219632, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036214

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BL06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 352USPAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni382 – 519DisorderedSequence analysisAdd BLAST138
Regioni555 – 577DisorderedSequence analysisAdd BLAST23
Regioni601 – 624DisorderedSequence analysisAdd BLAST24
Regioni801 – 834DisorderedSequence analysisAdd BLAST34
Regioni1089 – 1182DisorderedSequence analysisAdd BLAST94
Regioni1221 – 1242DisorderedSequence analysisAdd BLAST22
Regioni1491 – 1561DisorderedSequence analysisAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili682 – 712Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi382 – 434Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi435 – 474Polar residuesSequence analysisAdd BLAST40
Compositional biasi495 – 515Polar residuesSequence analysisAdd BLAST21
Compositional biasi603 – 619Polar residuesSequence analysisAdd BLAST17
Compositional biasi1089 – 1119Polar residuesSequence analysisAdd BLAST31
Compositional biasi1130 – 1149Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1506 – 1528Polar residuesSequence analysisAdd BLAST23
Compositional biasi1537 – 1561Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1887, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004234_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BL06

Identification of Orthologs from Complete Genome Data

More...
OMAi
YGAENFH

Database of Orthologous Groups

More...
OrthoDBi
101145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BL06

TreeFam database of animal gene trees

More...
TreeFami
TF336130

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR040142, USP54
IPR028889, USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22975:SF5, PTHR22975:SF5, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BL06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWKRNYFSG SRGSVQGMFA PRSSMSIAPS KGLSNEPGQN SCFLNSALQV
60 70 80 90 100
LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR
110 120 130 140 150
SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC
160 170 180 190 200
ISHQKFAMTL FEQCVCSSCG ATSDPLPFIQ MVHYISTTAL CNQAICMLEK
210 220 230 240 250
REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL
260 270 280 290 300
VWDSEHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG
310 320 330 340 350
KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA
360 370 380 390 400
DPQGTPVSAQ DLPPHAQFLP YTKTCYDSED SGHLTDSECN QKHTSKKGSL
410 420 430 440 450
VERRRSSGRV RRKGDEPQAS GYHSEGETLK EKQAPRNASK SSSSSRLKDF
460 470 480 490 500
KETVSNMIHS RPSLASQTSA GSPCVGRAGD QLDKIPPRNF PLQARGWETE
510 520 530 540 550
STSSEAKSSS SSKYRPTWRP KRESLNIDSI FSKDRRKHCG YTQLRTFPED
560 570 580 590 600
AAKEFTPDEV SKPTANDIKD GGSRSQHKLW GTARPGSHLL EQHPRLIQRM
610 620 630 640 650
ESGYESSERN SSSPVSLDAA PPDSVNVYRD QSTKRPVGFV PSWRHIPKSH
660 670 680 690 700
SSSILEVDCT APMTSWTKTQ PLSDGEVTSR SELDELQEEV VRRAQEQELR
710 720 730 740 750
KKREKELEAA KGFNPHPSRY MDLDELQNQG RSDGFERSLQ EANSIFEESL
760 770 780 790 800
HLEQKGDCAA ALALCNEAIS KLRLTLHDAS SSTHSRALVD KKLQISIRKA
810 820 830 840 850
RSLQDRMQQQ ASSQQPVQPS ASLPSQGGAL PQPTSEQPIT LQVLLNQEAQ
860 870 880 890 900
LEPCKDTELG ATSSFFHSPA SCPELHSSLI PESPVSSVSQ HSPPGTSSLK
910 920 930 940 950
LLTSFEVDSV NRSAFHRQGL PKATGRTEMN SQHECLPLDA LEDRLQGHRE
960 970 980 990 1000
DNSCCSKFPP REGRDIAQDQ LFEGKKNPAD ISMGMPWSYS TGEATSERVI
1010 1020 1030 1040 1050
YSLNSPSSSS AQPSIPPYSS CHPITSAASS PVLHAADPMQ KLNQHVQAQS
1060 1070 1080 1090 1100
LQTSLTSKVV RSSEEPYRLE FPSTKGLVRS LAEQFQKMQN TSTRDVIGSQ
1110 1120 1130 1140 1150
DRSLPNGVRK SSSPSDFMPP LSQGPGREHC RWVKQPRSPD GRERPPCWED
1160 1170 1180 1190 1200
PAAHPPLSMG SGLPDGETSR TAQPRLAEPD MYQGKLPQVT DIRSKELGSS
1210 1220 1230 1240 1250
VNLGTSLPLD SWVNVTRLCD SQVKPSAPGP GDKSSSHDSH PRATCLERSP
1260 1270 1280 1290 1300
ILLHPHWDQD TEQETSELES LYQASLQASS HTAYSDWRSQ DVAWQPLSLA
1310 1320 1330 1340 1350
GSADGMGRRL HSAPGLDLSK PLTAEMEHVL YEPSTVPVSQ DSSNVRKKTL
1360 1370 1380 1390 1400
ETGHHCSSSS SLPVIHDPPV FLLDPKLYPP QPQFLSPDVL MPSMAGEPYR
1410 1420 1430 1440 1450
PPGTSRSVHQ FLAMCDRDET PQGVKYTGRT LNYRSLPHRS RTDASWGPGS
1460 1470 1480 1490 1500
ETNQHIGARV LTMPACKPQL TYTATLPERH QGLQVPHAQS WGNLFHSPSH
1510 1520 1530 1540 1550
PSAVHPGSPP SSNLHVPLRS TWNSGPVLGS RTPGPRRIDM PPDDDWRQSS
1560 1570 1580
YPSQDRHRSP GEERIMFALS NAAGREQNRV RFLQHSRW
Length:1,588
Mass (Da):176,664
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F211ACF4502D584
GO
Isoform 2 (identifier: Q8BL06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     383-402: HLTDSECNQKHTSKKGSLVE → EQPSSPTPPYSQMVGSHTQG
     403-1588: Missing.

Show »
Length:333
Mass (Da):37,637
Checksum:iD31EEEA4F91AA255
GO
Isoform 3 (identifier: Q8BL06-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-402: HLTDSECNQKHTSKKGSLVE → EQPSSPTPPYSQMVGSHTQG
     403-1588: Missing.

Show »
Length:402
Mass (Da):45,458
Checksum:i9608BB155A6FFA39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZXV1F6ZXV1_MOUSE
Inactive ubiquitin carboxyl-termina...
Usp54
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI17845 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI17846 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB31805 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti925G → D in AAH66166 (PubMed:15489334).Curated1
Sequence conflicti925G → D in AAH66175 (PubMed:15489334).Curated1
Sequence conflicti1288R → G in AAI17845 (PubMed:15489334).Curated1
Sequence conflicti1476L → V in BAB31805 (PubMed:16141072).Curated1
Sequence conflicti1574G → E in AAH66166 (PubMed:15489334).Curated1
Sequence conflicti1574G → E in AAH66175 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0204881 – 69Missing in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_035679383 – 402HLTDS…GSLVE → EQPSSPTPPYSQMVGSHTQG in isoform 2 and isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_035680403 – 1588Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST1186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK019588 mRNA Translation: BAB31805.1 Different initiation.
AK036864 mRNA Translation: BAC29609.1
AK047620 mRNA Translation: BAC33102.1
AC146594 Genomic DNA No translation available.
BC066166 mRNA Translation: AAH66166.1
BC066175 mRNA Translation: AAH66175.1
BC117844 mRNA Translation: AAI17845.1 Different initiation.
BC117845 mRNA Translation: AAI17846.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26847.2 [Q8BL06-1]

NCBI Reference Sequences

More...
RefSeqi
NP_084456.2, NM_030180.2 [Q8BL06-1]
XP_006519768.1, XM_006519705.3 [Q8BL06-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022356; ENSMUSP00000022356; ENSMUSG00000034235 [Q8BL06-1]
ENSMUST00000035340; ENSMUSP00000036214; ENSMUSG00000034235 [Q8BL06-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:78787

UCSC genome browser

More...
UCSCi
uc007skb.1, mouse [Q8BL06-1]
uc007skc.1, mouse [Q8BL06-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019588 mRNA Translation: BAB31805.1 Different initiation.
AK036864 mRNA Translation: BAC29609.1
AK047620 mRNA Translation: BAC33102.1
AC146594 Genomic DNA No translation available.
BC066166 mRNA Translation: AAH66166.1
BC066175 mRNA Translation: AAH66175.1
BC117844 mRNA Translation: AAI17845.1 Different initiation.
BC117845 mRNA Translation: AAI17846.1 Different initiation.
CCDSiCCDS26847.2 [Q8BL06-1]
RefSeqiNP_084456.2, NM_030180.2 [Q8BL06-1]
XP_006519768.1, XM_006519705.3 [Q8BL06-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi219632, 2 interactors
STRINGi10090.ENSMUSP00000036214

Protein family/group databases

MEROPSiC19.080

PTM databases

iPTMnetiQ8BL06
PhosphoSitePlusiQ8BL06

Proteomic databases

MaxQBiQ8BL06
PaxDbiQ8BL06
PeptideAtlasiQ8BL06
PRIDEiQ8BL06
ProteomicsDBi298367 [Q8BL06-1]
298368 [Q8BL06-2]
298369 [Q8BL06-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
54962, 78 antibodies from 17 providers

The DNASU plasmid repository

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DNASUi
78787

Genome annotation databases

EnsembliENSMUST00000022356; ENSMUSP00000022356; ENSMUSG00000034235 [Q8BL06-1]
ENSMUST00000035340; ENSMUSP00000036214; ENSMUSG00000034235 [Q8BL06-1]
GeneIDi78787
KEGGimmu:78787
UCSCiuc007skb.1, mouse [Q8BL06-1]
uc007skc.1, mouse [Q8BL06-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
159195
MGIiMGI:1926037, Usp54
VEuPathDBiHostDB:ENSMUSG00000034235

Phylogenomic databases

eggNOGiKOG1887, Eukaryota
GeneTreeiENSGT00940000155571
HOGENOMiCLU_004234_0_0_1
InParanoidiQ8BL06
OMAiYGAENFH
OrthoDBi101145at2759
PhylomeDBiQ8BL06
TreeFamiTF336130

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
78787, 6 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Usp54, mouse

Protein Ontology

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PROi
PR:Q8BL06
RNActiQ8BL06, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034235, Expressed in lumbar subsegment of spinal cord and 247 other tissues
ExpressionAtlasiQ8BL06, baseline and differential
GenevisibleiQ8BL06, MM

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR040142, USP54
IPR028889, USP_dom
PANTHERiPTHR22975:SF5, PTHR22975:SF5, 3 hits
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235, USP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP54_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BL06
Secondary accession number(s): Q149D8
, Q149D9, Q6NZE1, Q8BZ28, Q9D2I9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 25, 2008
Last modified: February 23, 2022
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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