UniProtKB - Q8BKX7 (ZN410_MOUSE)
Zinc finger protein 410
Znf410
Functioni
Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416).
Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416).
May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity).
May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity).
However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 221 | Zinc 1; structuralBy similarity | 1 | |
Metal bindingi | 226 | Zinc 1; structuralBy similarity | 1 | |
Metal bindingi | 239 | Zinc 1; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 243 | Zinc 1; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 251 | Zinc 2; structuralBy similarity | 1 | |
Metal bindingi | 256 | Zinc 2; structuralBy similarity | 1 | |
Metal bindingi | 269 | Zinc 2; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 273 | Zinc 2; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 281 | Zinc 3; structuralBy similarity | 1 | |
Metal bindingi | 286 | Zinc 3; structuralBy similarity | 1 | |
Metal bindingi | 299 | Zinc 3; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 303 | Zinc 3; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 311 | Zinc 4; structuralBy similarity | 1 | |
Metal bindingi | 316 | Zinc 4; structuralBy similarity | 1 | |
Metal bindingi | 329 | Zinc 4; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 333 | Zinc 4; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 341 | Zinc 5; structuralBy similarity | 1 | |
Metal bindingi | 344 | Zinc 5; structuralBy similarity | 1 | |
Metal bindingi | 357 | Zinc 5; via tele nitrogen; structuralBy similarity | 1 | |
Metal bindingi | 361 | Zinc 5; via tele nitrogen; structuralBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 243 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 249 – 273 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 279 – 303 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 309 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 339 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- negative regulation of gene expression Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 410Alternative name(s): Another partner for ARF 11 Publication |
Gene namesi | Name:Znf410Imported Synonyms:Apa11 Publication, D12Ertd748eImported, Zfp410Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1289280, Zfp410 |
VEuPathDBi | HostDB:ENSMUSG00000042472 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 1 Publication
Note: Directly binds to the sequence motif 5'-CATCCCATAATA-3'.1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047572 | 1 – 478 | Zinc finger protein 410Add BLAST | 478 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Ubl conjugationProteomic databases
MaxQBi | Q8BKX7 |
PaxDbi | Q8BKX7 |
PRIDEi | Q8BKX7 |
PTM databases
iPTMneti | Q8BKX7 |
PhosphoSitePlusi | Q8BKX7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000042472, Expressed in metanephric loop of Henle and 300 other tissues |
ExpressionAtlasi | Q8BKX7, baseline and differential |
Genevisiblei | Q8BKX7, MM |
Interactioni
Subunit structurei
Interacts with CDKN2A/p14ARF.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045550 |
Miscellaneous databases
RNActi | Q8BKX7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 113 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 187 – 214 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 86 – 113 | Polar residuesSequence analysisAdd BLAST | 28 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 243 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 249 – 273 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 279 – 303 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 309 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 339 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158098 |
HOGENOMi | CLU_043629_1_0_1 |
InParanoidi | Q8BKX7 |
OMAi | PAEPLMG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BKX7 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC
60 70 80 90 100
SRLMLPDETP NHANSSKEVP SSAVLRSLQV NVGPDGEETR AQTVQKSPEF
110 120 130 140 150
LTTPESPSLL QDLQPSDSTS FILLNLTRAG LGSSAEHFVF VQDETEDSGA
160 170 180 190 200
DFLSAESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT GSNGENVHLG
210 220 230 240 250
SGDGQPKDSG PLPQAEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNERSFI
260 270 280 290 300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
310 320 330 340 350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ
360 370 380 390 400
SGSRNVHMRK HHLQLGTTGS QEQDQTAEPL MGSSLLEDAS VPNKNLVSMN
410 420 430 440 450
SQSSLGGESL NLSNTNSILG VDDEVLTERA SRPLSSVPDV THHLVTMQSG
460 470
RQSYEVSVLT AVNPQELLNQ GDLTERQT
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VM57 | A0A1Y7VM57_MOUSE | Zinc finger protein 410 | Zfp410 | 278 | Annotation score: | ||
A0A1Y7VP44 | A0A1Y7VP44_MOUSE | Zinc finger protein 410 | Zfp410 | 130 | Annotation score: | ||
A0A1Y7VIW1 | A0A1Y7VIW1_MOUSE | Zinc finger protein 410 | Zfp410 | 96 | Annotation score: | ||
A0A1Y7VLP7 | A0A1Y7VLP7_MOUSE | Zinc finger protein 410 | Zfp410 | 44 | Annotation score: | ||
A0A1Y7VKU6 | A0A1Y7VKU6_MOUSE | Zinc finger protein 410 | Zfp410 | 154 | Annotation score: | ||
A0A1Y7VLK1 | A0A1Y7VLK1_MOUSE | Zinc finger protein 410 | Zfp410 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | R → P in AAL82191 (PubMed:12370286).Curated | 1 | |
Sequence conflicti | 141 | V → G in AAL82191 (PubMed:12370286).Curated | 1 | |
Sequence conflicti | 264 | Q → K in BAC28148 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 289 | Q → P in AAL82191 (PubMed:12370286).Curated | 1 | |
Sequence conflicti | 317 | G → A in AAL82191 (PubMed:12370286).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008490 | 335 – 347 | GEKPH…VCGKT → GTRTCAICRPQIQ in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_008492 | 335 – 345 | GEKPHQCQVCG → ELEIEPRASRV in isoform 3. 2 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_008493 | 346 – 478 | Missing in isoform 3. 2 PublicationsAdd BLAST | 133 | |
Alternative sequenceiVSP_008491 | 348 – 478 | Missing in isoform 2. 1 PublicationAdd BLAST | 131 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295806 mRNA Translation: AAL82191.1 AK033090 mRNA Translation: BAC28148.1 AK053001 mRNA Translation: BAC35235.1 BC021528 mRNA Translation: AAH21528.1 BC052080 mRNA Translation: AAH52080.1 |
CCDSi | CCDS26042.1 [Q8BKX7-1] CCDS88368.1 [Q8BKX7-3] CCDS88369.1 [Q8BKX7-2] |
RefSeqi | NP_001239511.1, NM_001252582.1 [Q8BKX7-2] NP_001239512.1, NM_001252583.1 [Q8BKX7-3] NP_659082.1, NM_144833.3 [Q8BKX7-1] XP_006516148.1, XM_006516085.2 [Q8BKX7-1] XP_006516149.1, XM_006516086.3 [Q8BKX7-1] |
Genome annotation databases
Ensembli | ENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1] ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3] ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2] |
GeneIDi | 52708 |
KEGGi | mmu:52708 |
UCSCi | uc007oet.2, mouse [Q8BKX7-2] uc007oev.2, mouse [Q8BKX7-1] uc007oew.2, mouse [Q8BKX7-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295806 mRNA Translation: AAL82191.1 AK033090 mRNA Translation: BAC28148.1 AK053001 mRNA Translation: BAC35235.1 BC021528 mRNA Translation: AAH21528.1 BC052080 mRNA Translation: AAH52080.1 |
CCDSi | CCDS26042.1 [Q8BKX7-1] CCDS88368.1 [Q8BKX7-3] CCDS88369.1 [Q8BKX7-2] |
RefSeqi | NP_001239511.1, NM_001252582.1 [Q8BKX7-2] NP_001239512.1, NM_001252583.1 [Q8BKX7-3] NP_659082.1, NM_144833.3 [Q8BKX7-1] XP_006516148.1, XM_006516085.2 [Q8BKX7-1] XP_006516149.1, XM_006516086.3 [Q8BKX7-1] |
3D structure databases
SMRi | Q8BKX7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045550 |
PTM databases
iPTMneti | Q8BKX7 |
PhosphoSitePlusi | Q8BKX7 |
Proteomic databases
MaxQBi | Q8BKX7 |
PaxDbi | Q8BKX7 |
PRIDEi | Q8BKX7 |
Protocols and materials databases
Antibodypediai | 126, 190 antibodies from 22 providers |
DNASUi | 52708 |
Genome annotation databases
Ensembli | ENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1] ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3] ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2] |
GeneIDi | 52708 |
KEGGi | mmu:52708 |
UCSCi | uc007oet.2, mouse [Q8BKX7-2] uc007oev.2, mouse [Q8BKX7-1] uc007oew.2, mouse [Q8BKX7-3] |
Organism-specific databases
CTDi | 52708 |
MGIi | MGI:1289280, Zfp410 |
VEuPathDBi | HostDB:ENSMUSG00000042472 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158098 |
HOGENOMi | CLU_043629_1_0_1 |
InParanoidi | Q8BKX7 |
OMAi | PAEPLMG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BKX7 |
TreeFami | TF333498 |
Miscellaneous databases
BioGRID-ORCSi | 52708, 2 hits in 64 CRISPR screens |
ChiTaRSi | Zfp410, mouse |
PROi | PR:Q8BKX7 |
RNActi | Q8BKX7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042472, Expressed in metanephric loop of Henle and 300 other tissues |
ExpressionAtlasi | Q8BKX7, baseline and differential |
Genevisiblei | Q8BKX7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN410_MOUSE | |
Accessioni | Q8BKX7Primary (citable) accession number: Q8BKX7 Secondary accession number(s): Q8BWB3 Q8VDL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | October 3, 2003 | |
Last modified: | February 23, 2022 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot