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UniProtKB - Q8BKX7 (ZN410_MOUSE)

Entry version 140 (23 Feb 2022)
Sequence version 2 (03 Oct 2003)
Previous versions | rss
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Protein

Zinc finger protein 410

Gene

Znf410

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416).

Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416).

May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity).

May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity).

However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi221Zinc 1; structuralBy similarity1
Metal bindingi226Zinc 1; structuralBy similarity1
Metal bindingi239Zinc 1; via tele nitrogen; structuralBy similarity1
Metal bindingi243Zinc 1; via tele nitrogen; structuralBy similarity1
Metal bindingi251Zinc 2; structuralBy similarity1
Metal bindingi256Zinc 2; structuralBy similarity1
Metal bindingi269Zinc 2; via tele nitrogen; structuralBy similarity1
Metal bindingi273Zinc 2; via tele nitrogen; structuralBy similarity1
Metal bindingi281Zinc 3; structuralBy similarity1
Metal bindingi286Zinc 3; structuralBy similarity1
Metal bindingi299Zinc 3; via tele nitrogen; structuralBy similarity1
Metal bindingi303Zinc 3; via tele nitrogen; structuralBy similarity1
Metal bindingi311Zinc 4; structuralBy similarity1
Metal bindingi316Zinc 4; structuralBy similarity1
Metal bindingi329Zinc 4; via tele nitrogen; structuralBy similarity1
Metal bindingi333Zinc 4; via tele nitrogen; structuralBy similarity1
Metal bindingi341Zinc 5; structuralBy similarity1
Metal bindingi344Zinc 5; structuralBy similarity1
Metal bindingi357Zinc 5; via tele nitrogen; structuralBy similarity1
Metal bindingi361Zinc 5; via tele nitrogen; structuralBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf410Imported
Synonyms:Apa11 Publication, D12Ertd748eImported, Zfp410Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1289280, Zfp410

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000042472

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and healthy, but display reduced expression of Chd4, leading to rerepression of fetal hemoglobin genes Hbg1 and Hbg2.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475721 – 478Zinc finger protein 410Add BLAST478

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated. O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity.By similarity
Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.By similarity

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8BKX7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BKX7

PRoteomics IDEntifications database

More...PRIDEi		Q8BKX7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BKX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BKX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000042472, Expressed in metanephric loop of Henle and 300 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8BKX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BKX7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDKN2A/p14ARF.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000045550

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BKX7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BKX7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 113DisorderedSequence analysisAdd BLAST30
Regioni187 – 214DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 113Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The five zinc finger domains are necessary and sufficient to bind to DNA.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043629_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BKX7

Identification of Orthologs from Complete Genome Data

More...OMAi		PAEPLMG

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BKX7

TreeFam database of animal gene trees

More...TreeFami		TF333498

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BKX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC 
        60         70         80         90        100
SRLMLPDETP NHANSSKEVP SSAVLRSLQV NVGPDGEETR AQTVQKSPEF 
       110        120        130        140        150
LTTPESPSLL QDLQPSDSTS FILLNLTRAG LGSSAEHFVF VQDETEDSGA 
       160        170        180        190        200
DFLSAESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT GSNGENVHLG 
       210        220        230        240        250
SGDGQPKDSG PLPQAEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNERSFI 
       260        270        280        290        300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR 
       310        320        330        340        350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ 
       360        370        380        390        400
SGSRNVHMRK HHLQLGTTGS QEQDQTAEPL MGSSLLEDAS VPNKNLVSMN 
       410        420        430        440        450
SQSSLGGESL NLSNTNSILG VDDEVLTERA SRPLSSVPDV THHLVTMQSG 
       460        470 
RQSYEVSVLT AVNPQELLNQ GDLTERQT
Length:478
Mass (Da):52,208
Last modified:October 3, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i187BE9F24D9609CB
GO
Isoform 2 (identifier: Q8BKX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-347: GEKPHQCQVCGKT → GTRTCAICRPQIQ
     348-478: Missing.

Show »
Length:347
Mass (Da):38,074
Checksum:iE596B2194966A352
GO
Isoform 3 (identifier: Q8BKX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-345: GEKPHQCQVCG → ELEIEPRASRV
     346-478: Missing.

Show »
Length:345
Mass (Da):37,926
Checksum:iDD9F525FD7184872
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VM57A0A1Y7VM57_MOUSE
Zinc finger protein 410
Zfp410
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VP44A0A1Y7VP44_MOUSE
Zinc finger protein 410
Zfp410
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIW1A0A1Y7VIW1_MOUSE
Zinc finger protein 410
Zfp410
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VLP7A0A1Y7VLP7_MOUSE
Zinc finger protein 410
Zfp410
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VKU6A0A1Y7VKU6_MOUSE
Zinc finger protein 410
Zfp410
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VLK1A0A1Y7VLK1_MOUSE
Zinc finger protein 410
Zfp410
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52R → P in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti141V → G in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti264Q → K in BAC28148 (PubMed:16141072).Curated1
Sequence conflicti289Q → P in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti317G → A in AAL82191 (PubMed:12370286).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008490335 – 347GEKPH…VCGKT → GTRTCAICRPQIQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008492335 – 345GEKPHQCQVCG → ELEIEPRASRV in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_008493346 – 478Missing in isoform 3. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_008491348 – 478Missing in isoform 2. 1 PublicationAdd BLAST131

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF295806 mRNA Translation: AAL82191.1
AK033090 mRNA Translation: BAC28148.1
AK053001 mRNA Translation: BAC35235.1
BC021528 mRNA Translation: AAH21528.1
BC052080 mRNA Translation: AAH52080.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS26042.1 [Q8BKX7-1]
CCDS88368.1 [Q8BKX7-3]
CCDS88369.1 [Q8BKX7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001239511.1, NM_001252582.1 [Q8BKX7-2]
NP_001239512.1, NM_001252583.1 [Q8BKX7-3]
NP_659082.1, NM_144833.3 [Q8BKX7-1]
XP_006516148.1, XM_006516085.2 [Q8BKX7-1]
XP_006516149.1, XM_006516086.3 [Q8BKX7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1]
ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3]
ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		52708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:52708

UCSC genome browser

More...UCSCi		uc007oet.2, mouse [Q8BKX7-2]
uc007oev.2, mouse [Q8BKX7-1]
uc007oew.2, mouse [Q8BKX7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295806 mRNA Translation: AAL82191.1
AK033090 mRNA Translation: BAC28148.1
AK053001 mRNA Translation: BAC35235.1
BC021528 mRNA Translation: AAH21528.1
BC052080 mRNA Translation: AAH52080.1
CCDSiCCDS26042.1 [Q8BKX7-1]
CCDS88368.1 [Q8BKX7-3]
CCDS88369.1 [Q8BKX7-2]
RefSeqiNP_001239511.1, NM_001252582.1 [Q8BKX7-2]
NP_001239512.1, NM_001252583.1 [Q8BKX7-3]
NP_659082.1, NM_144833.3 [Q8BKX7-1]
XP_006516148.1, XM_006516085.2 [Q8BKX7-1]
XP_006516149.1, XM_006516086.3 [Q8BKX7-1]

3D structure databases

SMRiQ8BKX7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045550

PTM databases

iPTMnetiQ8BKX7
PhosphoSitePlusiQ8BKX7

Proteomic databases

MaxQBiQ8BKX7
PaxDbiQ8BKX7
PRIDEiQ8BKX7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		126, 190 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		52708

Genome annotation databases

EnsembliENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1]
ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3]
ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2]
GeneIDi52708
KEGGimmu:52708
UCSCiuc007oet.2, mouse [Q8BKX7-2]
uc007oev.2, mouse [Q8BKX7-1]
uc007oew.2, mouse [Q8BKX7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		52708
MGIiMGI:1289280, Zfp410
VEuPathDBiHostDB:ENSMUSG00000042472

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158098
HOGENOMiCLU_043629_1_0_1
InParanoidiQ8BKX7
OMAiPAEPLMG
OrthoDBi1318335at2759
PhylomeDBiQ8BKX7
TreeFamiTF333498

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		52708, 2 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Zfp410, mouse

Protein Ontology

More...PROi		PR:Q8BKX7
RNActiQ8BKX7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000042472, Expressed in metanephric loop of Henle and 300 other tissues
ExpressionAtlasiQ8BKX7, baseline and differential
GenevisibleiQ8BKX7, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN410_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BKX7
Secondary accession number(s): Q8BWB3
, Q8BZZ7, Q8R5L2, Q8VDL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: February 23, 2022
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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