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UniProtKB - Q8BKX7 (ZN410_MOUSE)

Protein

Zinc finger protein 410

Gene

Znf410

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 1
Zinc finger protein APA-1
Gene namesi
Name:Znf410
Synonyms:Apa1, D12Ertd748e, Zfp410
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1289280 Zfp410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475721 – 478Zinc finger protein 410Add BLAST478

Post-translational modificationi

Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8BKX7
PRIDEiQ8BKX7

PTM databases

iPTMnetiQ8BKX7
PhosphoSitePlusiQ8BKX7

Expressioni

Gene expression databases

BgeeiENSMUSG00000042472 Expressed in 275 organ(s), highest expression level in metanephric loop of Henle
CleanExiMM_ZFP410
ExpressionAtlasiQ8BKX7 baseline and differential
GenevisibleiQ8BKX7 MM

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045550

Structurei

3D structure databases

ProteinModelPortaliQ8BKX7
SMRiQ8BKX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000069877
HOVERGENiHBG055280
InParanoidiQ8BKX7
OMAiDDTPNHT
OrthoDBiEOG091G06YO
PhylomeDBiQ8BKX7
TreeFamiTF333498

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BKX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC 
        60         70         80         90        100
SRLMLPDETP NHANSSKEVP SSAVLRSLQV NVGPDGEETR AQTVQKSPEF 
       110        120        130        140        150
LTTPESPSLL QDLQPSDSTS FILLNLTRAG LGSSAEHFVF VQDETEDSGA 
       160        170        180        190        200
DFLSAESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT GSNGENVHLG 
       210        220        230        240        250
SGDGQPKDSG PLPQAEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNERSFI 
       260        270        280        290        300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR 
       310        320        330        340        350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ 
       360        370        380        390        400
SGSRNVHMRK HHLQLGTTGS QEQDQTAEPL MGSSLLEDAS VPNKNLVSMN 
       410        420        430        440        450
SQSSLGGESL NLSNTNSILG VDDEVLTERA SRPLSSVPDV THHLVTMQSG 
       460        470 
RQSYEVSVLT AVNPQELLNQ GDLTERQT
Length:478
Mass (Da):52,208
Last modified:October 3, 2003 - v2
Checksum:i187BE9F24D9609CB
GO
Isoform 2 (identifier: Q8BKX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-347: GEKPHQCQVCGKT → GTRTCAICRPQIQ
     348-478: Missing.

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):38,074
Checksum:iE596B2194966A352
GO
Isoform 3 (identifier: Q8BKX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-345: GEKPHQCQVCG → ELEIEPRASRV
     346-478: Missing.

Show »
Length:345
Mass (Da):37,926
Checksum:iDD9F525FD7184872
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VM57A0A1Y7VM57_MOUSE
Zinc finger protein 410
Zfp410
278Annotation score:
A0A1Y7VKU6A0A1Y7VKU6_MOUSE
Zinc finger protein 410
Zfp410
154Annotation score:
A0A1Y7VLK1A0A1Y7VLK1_MOUSE
Zinc finger protein 410
Zfp410
71Annotation score:
A0A1Y7VP44A0A1Y7VP44_MOUSE
Zinc finger protein 410
Zfp410
130Annotation score:
A0A1Y7VLP7A0A1Y7VLP7_MOUSE
Zinc finger protein 410
Zfp410
44Annotation score:
A0A1Y7VIW1A0A1Y7VIW1_MOUSE
Zinc finger protein 410
Zfp410
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → P in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti141V → G in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti264Q → K in BAC28148 (PubMed:16141072).Curated1
Sequence conflicti289Q → P in AAL82191 (PubMed:12370286).Curated1
Sequence conflicti317G → A in AAL82191 (PubMed:12370286).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008490335 – 347GEKPH…VCGKT → GTRTCAICRPQIQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008492335 – 345GEKPHQCQVCG → ELEIEPRASRV in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_008493346 – 478Missing in isoform 3. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_008491348 – 478Missing in isoform 2. 1 PublicationAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295806 mRNA Translation: AAL82191.1
AK033090 mRNA Translation: BAC28148.1
AK053001 mRNA Translation: BAC35235.1
BC021528 mRNA Translation: AAH21528.1
BC052080 mRNA Translation: AAH52080.1
CCDSiCCDS26042.1 [Q8BKX7-1]
RefSeqiNP_001239511.1, NM_001252582.1 [Q8BKX7-2]
NP_001239512.1, NM_001252583.1 [Q8BKX7-3]
NP_659082.1, NM_144833.3 [Q8BKX7-1]
XP_006516148.1, XM_006516085.2 [Q8BKX7-1]
XP_006516149.1, XM_006516086.3 [Q8BKX7-1]
UniGeneiMm.255150

Genome annotation databases

EnsembliENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1]
ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3]
ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2]
GeneIDi52708
KEGGimmu:52708
UCSCiuc007oet.2 mouse [Q8BKX7-2]
uc007oev.2 mouse [Q8BKX7-1]
uc007oew.2 mouse [Q8BKX7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295806 mRNA Translation: AAL82191.1
AK033090 mRNA Translation: BAC28148.1
AK053001 mRNA Translation: BAC35235.1
BC021528 mRNA Translation: AAH21528.1
BC052080 mRNA Translation: AAH52080.1
CCDSiCCDS26042.1 [Q8BKX7-1]
RefSeqiNP_001239511.1, NM_001252582.1 [Q8BKX7-2]
NP_001239512.1, NM_001252583.1 [Q8BKX7-3]
NP_659082.1, NM_144833.3 [Q8BKX7-1]
XP_006516148.1, XM_006516085.2 [Q8BKX7-1]
XP_006516149.1, XM_006516086.3 [Q8BKX7-1]
UniGeneiMm.255150

3D structure databases

ProteinModelPortaliQ8BKX7
SMRiQ8BKX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045550

PTM databases

iPTMnetiQ8BKX7
PhosphoSitePlusiQ8BKX7

Proteomic databases

PaxDbiQ8BKX7
PRIDEiQ8BKX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472 [Q8BKX7-1]
ENSMUST00000220931; ENSMUSP00000152098; ENSMUSG00000042472 [Q8BKX7-3]
ENSMUST00000222258; ENSMUSP00000152441; ENSMUSG00000042472 [Q8BKX7-2]
GeneIDi52708
KEGGimmu:52708
UCSCiuc007oet.2 mouse [Q8BKX7-2]
uc007oev.2 mouse [Q8BKX7-1]
uc007oew.2 mouse [Q8BKX7-3]

Organism-specific databases

CTDi52708
MGIiMGI:1289280 Zfp410

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000069877
HOVERGENiHBG055280
InParanoidiQ8BKX7
OMAiDDTPNHT
OrthoDBiEOG091G06YO
PhylomeDBiQ8BKX7
TreeFamiTF333498

Miscellaneous databases

PROiPR:Q8BKX7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042472 Expressed in 275 organ(s), highest expression level in metanephric loop of Henle
CleanExiMM_ZFP410
ExpressionAtlasiQ8BKX7 baseline and differential
GenevisibleiQ8BKX7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN410_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX7
Secondary accession number(s): Q8BWB3
, Q8BZZ7, Q8R5L2, Q8VDL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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