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Entry version 145 (11 Dec 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Serine/threonine-protein kinase SMG1

Gene

Smg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by caffeine, LY294002 and wortmannin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair, Nonsense-mediated mRNA decay
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)
Short name:
SMG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smg1
Synonyms:Kiaa0421
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919742 Smg1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297921 – 3658Serine/threonine-protein kinase SMG1Add BLAST3658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171N6-acetyllysineCombined sources1
Modified residuei3547PhosphothreonineBy similarity1
Modified residuei3553PhosphoserineBy similarity1
Modified residuei3567PhosphoserineCombined sources1
Modified residuei3570PhosphothreonineCombined sources1
Modified residuei3574PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BKX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BKX6

PeptideAtlas

More...
PeptideAtlasi
Q8BKX6

PRoteomics IDEntifications database

More...
PRIDEi
Q8BKX6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BKX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BKX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030655 Expressed in 259 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BKX6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BKX6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain.

Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

Interacts with PRKCI.

Interacts with TELO2 and TTI1.

Interacts with RUVBL1 and RUVBL2.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000032891

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BKX6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1281 – 1864FATPROSITE-ProRule annotationAdd BLAST584
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1815 – 1850HEATAdd BLAST36
Domaini2148 – 2476PI3K/PI4KPROSITE-ProRule annotationAdd BLAST329
Domaini3626 – 3658FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891 Eukaryota
COG5032 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154776

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BKX6

KEGG Orthology (KO)

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KOi
K08873

Identification of Orthologs from Complete Genome Data

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OMAi
PWKVIIP

Database of Orthologous Groups

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OrthoDBi
26975at2759

TreeFam database of animal gene trees

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TreeFami
TF352560

Family and domain databases

Conserved Domains Database

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CDDi
cd05170 PIKKc_SMG1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR014009 PIK_FAT
IPR031559 SMG1
IPR035175 SMG1_N
IPR039414 SMG1_PIKKc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF15785 SMG1, 1 hit
PF17229 SMG1_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BKX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV
60 70 80 90 100
SSSYGLQPSN SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK
110 120 130 140 150
SLGQELRINN VTSPEFTSVQ HGSRALATKD MRKSQERSMS YSDESRLSNL
160 170 180 190 200
LRRITREDDR DRRLATVKQL KEFIQQPENK LVLVKQLDNI LAAVHDVLNE
210 220 230 240 250
SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS SAKDEVKLLY
260 270 280 290 300
LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL
310 320 330 340 350
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA
360 370 380 390 400
DLAFSTTLLG QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL
410 420 430 440 450
RVFSTVVRSI GERFSPIRGP PITEAYVTDV LYRVMRCVTA ANQVFFSEAV
460 470 480 490 500
LTAANECVGV LLGSLDPSMT IHCDMVITYG LDQLENCQTC GTDYIISVLN
510 520 530 540 550
LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV AVAHAVYQAV
560 570 580 590 600
LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF
610 620 630 640 650
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD
660 670 680 690 700
LAVHFPAIQY AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA
710 720 730 740 750
TKKHFSIILN LLGILLKKDN LNQDTRKLLM TWALEVAVLM KKSETYAPLF
760 770 780 790 800
SLPSFHKFSK GLLANTLVED VNICLQACSS LHALSSSLPD DLLQRCVDVC
810 820 830 840 850
RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS LALRSHMSKA
860 870 880 890 900
PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP
910 920 930 940 950
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA
960 970 980 990 1000
HTLNPDQDVS QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA
1010 1020 1030 1040 1050
NALTSPPKVI RTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF
1060 1070 1080 1090 1100
DLLTEMKTNS LTQGSELEVT IMMVVEALCE LHCPEAIQGI AVWSSSAVGK
1110 1120 1130 1140 1150
NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF DKSVLTLANA
1160 1170 1180 1190 1200
GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA
1210 1220 1230 1240 1250
VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL
1260 1270 1280 1290 1300
PGENINLLAG GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT
1310 1320 1330 1340 1350
ALNHMEQDQK WQSLTENVVK YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL
1360 1370 1380 1390 1400
QLYCSSALEN TVSNRLSTED CLIPLFSDAL RSCKQHDVRP WMQALRYTMY
1410 1420 1430 1440 1450
QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT RLLAQCSEVQ
1460 1470 1480 1490 1500
LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME
1510 1520 1530 1540 1550
MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ
1560 1570 1580 1590 1600
QNLSGLSTLS RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG
1610 1620 1630 1640 1650
QLYHLSSVQA PEVAKSWAAL ASWAYRWGRK VVDNASQGEG VRLLPREKSE
1660 1670 1680 1690 1700
VQNLLPDTIT EEEKERIYGI LGQAVCRPAG IQDEDITLQI TESEDNEDDD
1710 1720 1730 1740 1750
MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS LYKLSCSAYF
1760 1770 1780 1790 1800
TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE
1810 1820 1830 1840 1850
LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS
1860 1870 1880 1890 1900
PHLILYPAIV GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG
1910 1920 1930 1940 1950
SPPASQDSNK DEPKSGLNED QAMMQDCYSK IVDKLSSANP TMVLQVQMLV
1960 1970 1980 1990 2000
AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ QLEDEVKRVQ NNNTLRKEEK
2010 2020 2030 2040 2050
IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD NYGDAIDNAL
2060 2070 2080 2090 2100
EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM
2110 2120 2130 2140 2150
TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY
2160 2170 2180 2190 2200
LFKGLEDLHL DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS
2210 2220 2230 2240 2250
GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN PSIVPRPSEL
2260 2270 2280 2290 2300
YYSKIGPALK TVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS
2310 2320 2330 2340 2350
SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH
2360 2370 2380 2390 2400
IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI
2410 2420 2430 2440 2450
MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR
2460 2470 2480 2490 2500
EMEREITRSL FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL
2510 2520 2530 2540 2550
TDVEKLQGKL LEEIEFLEGA EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA
2560 2570 2580 2590 2600
IQVKLNEFEQ WITHYQAAFN NLEATQLASL LQEISTQMDL GPPSYVPATA
2610 2620 2630 2640 2650
FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH HYATVALQYP
2660 2670 2680 2690 2700
KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF
2710 2720 2730 2740 2750
ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF
2760 2770 2780 2790 2800
LHENGEEGSL SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA
2810 2820 2830 2840 2850
WFLEELCSMS GNVTCLVQLL KQCHLVPQDL DIPNPVEASE AVHLANGVYT
2860 2870 2880 2890 2900
SLQELNSNFR QIIFPEALRC LMKGECTLES MLHELDSLIE QTTDGVPLQT
2910 2920 2930 2940 2950
LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ PRNGSVDETP
2960 2970 2980 2990 3000
KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS
3010 3020 3030 3040 3050
TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ
3060 3070 3080 3090 3100
NTVNGPVQIV NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL
3110 3120 3130 3140 3150
GLTLCSFISA LGVDIIAQVE AKDFGAESKV SVDDLCKKAV EHNIQVGKFS
3160 3170 3180 3190 3200
QLVMNRATVL ASSYDTAWKK HDLVRRLETS ISSCKTSLQR VQLHIAMFQW
3210 3220 3230 3240 3250
QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI GTVQEKLAAL
3260 3270 3280 3290 3300
EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC
3310 3320 3330 3340 3350
SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR
3360 3370 3380 3390 3400
LLQRVDTTLE HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET
3410 3420 3430 3440 3450
IQSLVDSVKT VLTGHNRQLG DVKHLLKAMA KDEEAALADA EDIPYESSVR
3460 3470 3480 3490 3500
QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ EHVEMLQEIT PTLKELKTQS
3510 3520 3530 3540 3550
QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR SNTGQKTQPD
3560 3570 3580 3590 3600
VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ
3610 3620 3630 3640 3650
ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL

YEGWTAWV
Length:3,658
Mass (Da):409,769
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C13F45BE0D35042
GO
Isoform 2 (identifier: Q8BKX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-284: LVMTSLQSILEN → VRARDPQCSAVR
     285-3658: Missing.

Show »
Length:284
Mass (Da):31,739
Checksum:i8B0693F8E27FF13D
GO
Isoform 3 (identifier: Q8BKX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-433: LYR → SVF
     434-3658: Missing.

Show »
Length:433
Mass (Da):48,246
Checksum:i4A48D537C9327637
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QPA7J3QPA7_MOUSE
Serine/threonine-protein kinase SMG...
Smg1
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQ22J3QQ22_MOUSE
Serine/threonine-protein kinase SMG...
Smg1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QMR1J3QMR1_MOUSE
Serine/threonine-protein kinase SMG...
Smg1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90238 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti566I → V in BAC33168 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017749273 – 284LVMTS…SILEN → VRARDPQCSAVR in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_017750285 – 3658Missing in isoform 2. 1 PublicationAdd BLAST3374
Alternative sequenceiVSP_017751431 – 433LYR → SVF in isoform 3. 1 Publication3
Alternative sequenceiVSP_017752434 – 3658Missing in isoform 3. 1 PublicationAdd BLAST3225

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC131788 Genomic DNA No translation available.
AC132432 Genomic DNA No translation available.
AK129136 mRNA Translation: BAC97946.1
AK220328 mRNA Translation: BAD90238.1 Different initiation.
AK041264 mRNA Translation: BAC30884.2
AK047829 mRNA Translation: BAC33168.2
AK049391 mRNA Translation: BAC33729.1
AK052331 mRNA Translation: BAC34941.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40102.1 [Q8BKX6-1]

NCBI Reference Sequences

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RefSeqi
NP_001026984.1, NM_001031814.1 [Q8BKX6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655 [Q8BKX6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233789

UCSC genome browser

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UCSCi
uc009jjp.1 mouse [Q8BKX6-1]
uc009jjq.1 mouse [Q8BKX6-3]
uc009jjr.1 mouse [Q8BKX6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131788 Genomic DNA No translation available.
AC132432 Genomic DNA No translation available.
AK129136 mRNA Translation: BAC97946.1
AK220328 mRNA Translation: BAD90238.1 Different initiation.
AK041264 mRNA Translation: BAC30884.2
AK047829 mRNA Translation: BAC33168.2
AK049391 mRNA Translation: BAC33729.1
AK052331 mRNA Translation: BAC34941.1
CCDSiCCDS40102.1 [Q8BKX6-1]
RefSeqiNP_001026984.1, NM_001031814.1 [Q8BKX6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032891

PTM databases

iPTMnetiQ8BKX6
PhosphoSitePlusiQ8BKX6

Proteomic databases

EPDiQ8BKX6
PaxDbiQ8BKX6
PeptideAtlasiQ8BKX6
PRIDEiQ8BKX6

Genome annotation databases

EnsembliENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655 [Q8BKX6-1]
GeneIDi233789
KEGGimmu:233789
UCSCiuc009jjp.1 mouse [Q8BKX6-1]
uc009jjq.1 mouse [Q8BKX6-3]
uc009jjr.1 mouse [Q8BKX6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23049
MGIiMGI:1919742 Smg1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00940000154776
InParanoidiQ8BKX6
KOiK08873
OMAiPWKVIIP
OrthoDBi26975at2759
TreeFamiTF352560

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Smg1 mouse

Protein Ontology

More...
PROi
PR:Q8BKX6
RNActiQ8BKX6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030655 Expressed in 259 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ8BKX6 baseline and differential
GenevisibleiQ8BKX6 MM

Family and domain databases

CDDicd05170 PIKKc_SMG1, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR014009 PIK_FAT
IPR031559 SMG1
IPR035175 SMG1_N
IPR039414 SMG1_PIKKc
PfamiView protein in Pfam
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF15785 SMG1, 1 hit
PF17229 SMG1_N, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMG1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BKX6
Secondary accession number(s): E9QLR6
, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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