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Protein

Transcription factor HES-7

Gene

Hes7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-7
Short name:
mHes7
Alternative name(s):
Hairy and enhancer of split 7
bHLH factor Hes7
Gene namesi
Name:Hes7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2135679 Hes7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14K → R: No loss of repressor activity, somite segmentation disrupted at later stages. 1 Publication1
Mutagenesisi17K → R: Loss of repressor activity. 1 Publication1
Mutagenesisi22K → R: Loss of repressor activity. 1 Publication1
Mutagenesisi25R → W: Loss of repressor activity. 1 Publication1
Mutagenesisi52K → R: Loss of repressor activity. 1 Publication1
Mutagenesisi55K → R: Loss of repressor activity. 1 Publication1
Mutagenesisi58I → V: No loss of repressor activity. 1 Publication1
Mutagenesisi129K → R: No loss of repressor activity. 1 Publication1
Mutagenesisi186D → Y: Partial loss of repressor activity. 1 Publication1
Mutagenesisi211K → R: No loss of repressor activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524231 – 225Transcription factor HES-7Add BLAST225

Proteomic databases

PaxDbiQ8BKT2
PRIDEiQ8BKT2

PTM databases

iPTMnetiQ8BKT2
PhosphoSitePlusiQ8BKT2

Expressioni

Developmental stagei

Dynamic expression in the presomitic mesoderm (PSM). At E8.5, expressed in two bilateral domains: rostral and caudal stripes. The rostral bands are located posterior to the newly formed somite, while the caudal bands extend to the most caudal tip. During E9.0-E12.0 stages, again specifically expressed in two domains of the PSM.2 Publications

Inductioni

By Notch-signaling.1 Publication

Gene expression databases

BgeeiENSMUSG00000023781 Expressed in 51 organ(s), highest expression level in head
CleanExiMM_HES7
GenevisibleiQ8BKT2 MM

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiQ8BKT2
STRINGi10090.ENSMUSP00000024543

Structurei

3D structure databases

ProteinModelPortaliQ8BKT2
SMRiQ8BKT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 69bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini92 – 122OrangePROSITE-ProRule annotationAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 224WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 225Pro-richAdd BLAST98

Domaini

Has a particular type of basic domain which includes a helix-interrupting proline.
The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00730000111282
HOGENOMiHOG000236346
HOVERGENiHBG096052
InParanoidiQ8BKT2
KOiK09087
OMAiAQSMWRP
OrthoDBiEOG091G0XFV
PhylomeDBiQ8BKT2
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032644 HES-7
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PANTHERiPTHR10985:SF84 PTHR10985:SF84, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BKT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTRERAENR DGPKMLKPLV EKRRRDRINR SLEELRLLLL ERTRDQNLRN
60 70 80 90 100
PKLEKAEILE FAVGYLRERS RVEPPGVPRS PGQDAEALAS CYLSGFRECL
110 120 130 140 150
LRLAAFAHDA SPAARSQLFS ALHGYRRPKP PRPEAVDPGL PAPRPPLDPA
160 170 180 190 200
SPILGPALHQ RPPVHQGPPS PRLAWSPSHC SSRAGDSGAP APLTGLLPPP
210 220
PPPYRQDGAP KAPSLPPPAF WRPWP
Length:225
Mass (Da):24,890
Last modified:March 1, 2003 - v1
Checksum:i4B22E7D71A7FF5E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214S → P in BAB39526 (PubMed:11260262).Curated1
Sequence conflicti214S → P in BAB41134 (PubMed:11260262).Curated1
Sequence conflicti214S → P in AAI34379 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049065 mRNA Translation: BAB39526.1
AB050104 Genomic DNA Translation: BAB41134.1
AK050791 mRNA Translation: BAC34412.1
AL645527 Genomic DNA Translation: CAI35247.1
BC134378 mRNA Translation: AAI34379.1
CCDSiCCDS24883.1
RefSeqiNP_149030.2, NM_033041.4
UniGeneiMm.98505

Genome annotation databases

EnsembliENSMUST00000024543; ENSMUSP00000024543; ENSMUSG00000023781
GeneIDi84653
KEGGimmu:84653
UCSCiuc007jpi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049065 mRNA Translation: BAB39526.1
AB050104 Genomic DNA Translation: BAB41134.1
AK050791 mRNA Translation: BAC34412.1
AL645527 Genomic DNA Translation: CAI35247.1
BC134378 mRNA Translation: AAI34379.1
CCDSiCCDS24883.1
RefSeqiNP_149030.2, NM_033041.4
UniGeneiMm.98505

3D structure databases

ProteinModelPortaliQ8BKT2
SMRiQ8BKT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ8BKT2
STRINGi10090.ENSMUSP00000024543

PTM databases

iPTMnetiQ8BKT2
PhosphoSitePlusiQ8BKT2

Proteomic databases

PaxDbiQ8BKT2
PRIDEiQ8BKT2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024543; ENSMUSP00000024543; ENSMUSG00000023781
GeneIDi84653
KEGGimmu:84653
UCSCiuc007jpi.1 mouse

Organism-specific databases

CTDi84667
MGIiMGI:2135679 Hes7

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00730000111282
HOGENOMiHOG000236346
HOVERGENiHBG096052
InParanoidiQ8BKT2
KOiK09087
OMAiAQSMWRP
OrthoDBiEOG091G0XFV
PhylomeDBiQ8BKT2
TreeFamiTF351373

Miscellaneous databases

PROiPR:Q8BKT2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023781 Expressed in 51 organ(s), highest expression level in head
CleanExiMM_HES7
GenevisibleiQ8BKT2 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032644 HES-7
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PANTHERiPTHR10985:SF84 PTHR10985:SF84, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES7_MOUSE
AccessioniPrimary (citable) accession number: Q8BKT2
Secondary accession number(s): A3KPD3, Q99JA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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