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Protein

Pumilio homolog 3

Gene

Pum3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio homolog 3Curated
Gene namesi
Name:Pum3Imported
Synonyms:D19Bwg1357eImported, Kiaa0020Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106253 Pum3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759301 – 647Pumilio homolog 3Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BKS9
MaxQBiQ8BKS9
PaxDbiQ8BKS9
PeptideAtlasiQ8BKS9
PRIDEiQ8BKS9

PTM databases

iPTMnetiQ8BKS9
PhosphoSitePlusiQ8BKS9

Expressioni

Tissue specificityi

In the adult eye, expressed primarily in retinal ganglion cells and, to a lesser extent, in the pigmented cells.1 Publication

Interactioni

Subunit structurei

Interacts with PARP1 (via catalytic domain).By similarity

Protein-protein interaction databases

BioGridi206863, 4 interactors
IntActiQ8BKS9, 1 interactor
MINTiQ8BKS9
STRINGi10090.ENSMUSP00000075573

Structurei

3D structure databases

ProteinModelPortaliQ8BKS9
SMRiQ8BKS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 509PUM-HDPROSITE-ProRule annotationAdd BLAST368
Repeati176 – 211Pumilio 1By similarityAdd BLAST36
Repeati212 – 247Pumilio 2By similarityAdd BLAST36
Repeati248 – 276Pumilio 3By similarityAdd BLAST29
Repeati288 – 324Pumilio 4By similarityAdd BLAST37
Repeati325 – 360Pumilio 5By similarityAdd BLAST36
Repeati361 – 396Pumilio 6By similarityAdd BLAST36
Repeati397 – 434Pumilio 7By similarityAdd BLAST38
Repeati435 – 503Pumilio 8By similarityAdd BLAST69
Repeati504 – 550Pumilio 9By similarityAdd BLAST47
Repeati551 – 595Pumilio 10By similarityAdd BLAST45
Repeati596 – 635Pumilio 11By similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi105 – 117Nuclear localization signalBy similarityAdd BLAST13

Domaini

A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2050 Eukaryota
ENOG410XSHY LUCA
HOGENOMiHOG000237322
HOVERGENiHBG052166
InParanoidiQ8BKS9
KOiK14844
OMAiYLQEHAQ
PhylomeDBiQ8BKS9
TreeFamiTF312954

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR040059 PUM3
IPR001313 Pumilio_RNA-bd_rpt
PANTHERiPTHR13389 PTHR13389, 1 hit
PfamiView protein in Pfam
PF08144 CPL, 1 hit
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50302 PUM, 6 hits
PS50303 PUM_HD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BKS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKGKKKFT GKSPQTSQGK NKFHKNSESS SSKTFPRKAV KEGGPKVTSK
60 70 80 90 100
NFEKGATKPG KKGVKQFKNK PQGGKGPKDK FQKANKFSKK RKFQPDGESD
110 120 130 140 150
ESGAKKPKWD DFKKKKKELK QSRQLSDKTN YDIVVRAKHI WESLRRKDCD
160 170 180 190 200
KEKRVKLMSD LQKLIQGKIK TIAFAHDSTR VIQCFIQYGN EEQRKQAFQE
210 220 230 240 250
LQGDLVELSK AKYSRNIVKK FLMYGSKPQV AEIIRSFKGH VRKMLRHSEA
260 270 280 290 300
SAIVEYAYND KAILEQRNML TEELYGNTFQ LYKSADHPTL DKVLELQPAK
310 320 330 340 350
LELIMDEMKQ ILTPMAQKEA VIKHSLVHKV FLDFFTYAPP KPRSELIEAI
360 370 380 390 400
REAVVYLAHT HDGARVAMHC LWHGTPKDRK VIVKTMKTYV EKVANGQYSH
410 420 430 440 450
LVLLAAFDCI DDTKLVKQII ISEIISSLPS IVNDKYGRKV LLYLMSPRDP
460 470 480 490 500
AHTVPELIEL LQKGDGNAHS KKDTAIRRRE LLESISPALL SYLQGHTQEV
510 520 530 540 550
VLDKSACVLV SDMLGSATGD VQPAMDAIAS LAAAELHPGG KDGELHVAEH
560 570 580 590 600
PAGHLVLKWL LEQDKKMKES GKEGCFAKTL VERVGMKNLK SWASINRGAI
610 620 630 640
ILSSLLQSCD QEVVNKVKGG LKPLIPTLEK NKSSSRGIQT LLEKLTA
Length:647
Mass (Da):72,800
Last modified:November 8, 2005 - v2
Checksum:i193533640A3AFE50
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUH4A0A0N4SUH4_MOUSE
Pumilio homolog 3
Pum3
648Annotation score:

Sequence cautioni

The sequence BAC34427 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC40135 differs from that shown. Reason: Frameshift at positions 79 and 632.Curated
The sequence BAE24873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050829 mRNA Translation: BAC34427.1 Different initiation.
AK088081 mRNA Translation: BAC40135.1 Frameshift.
AK141893 mRNA Translation: BAE24873.1 Different initiation.
AK172872 mRNA Translation: BAD32150.1
RefSeqiNP_803425.1, NM_177474.5
XP_006527246.1, XM_006527183.3
UniGeneiMm.261027

Genome annotation databases

GeneIDi52874
KEGGimmu:52874
UCSCiuc008hby.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050829 mRNA Translation: BAC34427.1 Different initiation.
AK088081 mRNA Translation: BAC40135.1 Frameshift.
AK141893 mRNA Translation: BAE24873.1 Different initiation.
AK172872 mRNA Translation: BAD32150.1
RefSeqiNP_803425.1, NM_177474.5
XP_006527246.1, XM_006527183.3
UniGeneiMm.261027

3D structure databases

ProteinModelPortaliQ8BKS9
SMRiQ8BKS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206863, 4 interactors
IntActiQ8BKS9, 1 interactor
MINTiQ8BKS9
STRINGi10090.ENSMUSP00000075573

PTM databases

iPTMnetiQ8BKS9
PhosphoSitePlusiQ8BKS9

Proteomic databases

EPDiQ8BKS9
MaxQBiQ8BKS9
PaxDbiQ8BKS9
PeptideAtlasiQ8BKS9
PRIDEiQ8BKS9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi52874
KEGGimmu:52874
UCSCiuc008hby.1 mouse

Organism-specific databases

CTDi9933
MGIiMGI:106253 Pum3
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2050 Eukaryota
ENOG410XSHY LUCA
HOGENOMiHOG000237322
HOVERGENiHBG052166
InParanoidiQ8BKS9
KOiK14844
OMAiYLQEHAQ
PhylomeDBiQ8BKS9
TreeFamiTF312954

Miscellaneous databases

ChiTaRSiPum3 mouse
PROiPR:Q8BKS9
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR040059 PUM3
IPR001313 Pumilio_RNA-bd_rpt
PANTHERiPTHR13389 PTHR13389, 1 hit
PfamiView protein in Pfam
PF08144 CPL, 1 hit
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50302 PUM, 6 hits
PS50303 PUM_HD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPUM3_MOUSE
AccessioniPrimary (citable) accession number: Q8BKS9
Secondary accession number(s): Q6A0E6, Q8BU15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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