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Protein

Zinc finger protein 689

Gene

Znf689

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: InterPro
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:Znf689
Synonyms:Zfp689
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918381 Zfp689

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340091 – 500Zinc finger protein 689Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BKK5
PRIDEiQ8BKK5

PTM databases

iPTMnetiQ8BKK5
PhosphoSitePlusiQ8BKK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000048921 Expressed in 151 organ(s), highest expression level in pharyngeal arch
CleanExiMM_ZFP689
ExpressionAtlasiQ8BKK5 baseline and differential
GenevisibleiQ8BKK5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056610

Structurei

3D structure databases

ProteinModelPortaliQ8BKK5
SMRiQ8BKK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150903
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BKK5
KOiK09228
OMAiQSHKCAQ
OrthoDBiEOG091G02KC
PhylomeDBiQ8BKK5
TreeFamiTF336948

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BKK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPSAPLLL RAVGEAGPTR KRGRRPRALK FVDVAVYFSS EEWGCLQPAQ
60 70 80 90 100
RTLYRDVMRE TYGLLGALGC AGPKPALISW LERNTDDWEP AALDPQEYRR
110 120 130 140 150
WVTFQRKTRS KQKTEEKDVF PPKEAPRKGK RGRKPSKPRL IPRQTSGGPI
160 170 180 190 200
CPDCGCTFPD HLALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECSRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACENC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLSQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCCPN TPNGSPRPLI GGPSQRSSAL
Length:500
Mass (Da):57,082
Last modified:March 1, 2003 - v1
Checksum:i5BF3B828B151E4D2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3V5D3Z3V5_MOUSE
Zinc finger protein 689
Zfp689
360Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450L → V in BAC25939 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028417 mRNA Translation: BAC25939.1
AK051667 mRNA Translation: BAC34710.1
BC052084 mRNA Translation: AAH52084.1
CCDSiCCDS21867.1
RefSeqiNP_780372.2, NM_175163.3
UniGeneiMm.474533

Genome annotation databases

EnsembliENSMUST00000053392; ENSMUSP00000056610; ENSMUSG00000048921
GeneIDi71131
KEGGimmu:71131
UCSCiuc009jvl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028417 mRNA Translation: BAC25939.1
AK051667 mRNA Translation: BAC34710.1
BC052084 mRNA Translation: AAH52084.1
CCDSiCCDS21867.1
RefSeqiNP_780372.2, NM_175163.3
UniGeneiMm.474533

3D structure databases

ProteinModelPortaliQ8BKK5
SMRiQ8BKK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056610

PTM databases

iPTMnetiQ8BKK5
PhosphoSitePlusiQ8BKK5

Proteomic databases

PaxDbiQ8BKK5
PRIDEiQ8BKK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053392; ENSMUSP00000056610; ENSMUSG00000048921
GeneIDi71131
KEGGimmu:71131
UCSCiuc009jvl.2 mouse

Organism-specific databases

CTDi71131
MGIiMGI:1918381 Zfp689

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150903
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BKK5
KOiK09228
OMAiQSHKCAQ
OrthoDBiEOG091G02KC
PhylomeDBiQ8BKK5
TreeFamiTF336948

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q8BKK5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048921 Expressed in 151 organ(s), highest expression level in pharyngeal arch
CleanExiMM_ZFP689
ExpressionAtlasiQ8BKK5 baseline and differential
GenevisibleiQ8BKK5 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN689_MOUSE
AccessioniPrimary (citable) accession number: Q8BKK5
Secondary accession number(s): Q8C1C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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