Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 130 (29 Sep 2021)
Sequence version 2 (05 May 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Trinucleotide repeat-containing gene 6B protein

Gene

Tnrc6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processRNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-426496, Post-transcriptional silencing by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 6B protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnrc6b
Synonyms:Kiaa1093
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443730, Tnrc6b

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000047888

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003739811 – 1810Trinucleotide repeat-containing gene 6B proteinAdd BLAST1810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei913PhosphoserineBy similarity1
Modified residuei1409PhosphoserineCombined sources1
Modified residuei1426PhosphothreonineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1441PhosphothreonineCombined sources1
Modified residuei1793PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BKI2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BKI2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BKI2

PeptideAtlas

More...
PeptideAtlasi
Q8BKI2

PRoteomics IDEntifications database

More...
PRIDEi
Q8BKI2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260644 [Q8BKI2-1]
260645 [Q8BKI2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BKI2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BKI2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047888, Expressed in retina and 287 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BKI2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BKI2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AGO1, AGO2, AGO3 and AGO4.

Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex.

Interacts with PAN3; the interaction mediates the association with the PAN complex.

Interacts with MOV10; the interaction is direct and RNA-dependent.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229484, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-48568N

Protein interaction database and analysis system

More...
IntActi
Q8BKI2, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8BKI2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064336

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BKI2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BKI2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1625 – 1697RRMAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 221DisorderedSequence analysisAdd BLAST221
Regioni37 – 1028Interaction with argonaute proteinsBy similarityAdd BLAST992
Regioni235 – 1080DisorderedSequence analysisAdd BLAST846
Regioni1141 – 1196DisorderedSequence analysisAdd BLAST56
Regioni1191 – 1700Silencing domain; interaction with CNOT1 and PAN3By similarityAdd BLAST510
Regioni1293 – 1329DisorderedSequence analysisAdd BLAST37
Regioni1449 – 1467PABPC1-interacting motif-2 (PAM2)By similarityAdd BLAST19
Regioni1568 – 1619DisorderedSequence analysisAdd BLAST52
Regioni1706 – 1740DisorderedSequence analysisAdd BLAST35
Regioni1786 – 1810DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili33 – 75Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 74Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi75 – 102Polar residuesSequence analysisAdd BLAST28
Compositional biasi168 – 219Polar residuesSequence analysisAdd BLAST52
Compositional biasi242 – 293Polar residuesSequence analysisAdd BLAST52
Compositional biasi303 – 351Polar residuesSequence analysisAdd BLAST49
Compositional biasi359 – 391Polar residuesSequence analysisAdd BLAST33
Compositional biasi399 – 426Polar residuesSequence analysisAdd BLAST28
Compositional biasi437 – 457Polar residuesSequence analysisAdd BLAST21
Compositional biasi468 – 487Polar residuesSequence analysisAdd BLAST20
Compositional biasi500 – 551Polar residuesSequence analysisAdd BLAST52
Compositional biasi563 – 626Polar residuesSequence analysisAdd BLAST64
Compositional biasi639 – 669Polar residuesSequence analysisAdd BLAST31
Compositional biasi671 – 687Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi689 – 783Polar residuesSequence analysisAdd BLAST95
Compositional biasi790 – 808Polar residuesSequence analysisAdd BLAST19
Compositional biasi844 – 860Polar residuesSequence analysisAdd BLAST17
Compositional biasi861 – 885Pro residuesSequence analysisAdd BLAST25
Compositional biasi886 – 901Polar residuesSequence analysisAdd BLAST16
Compositional biasi930 – 947Polar residuesSequence analysisAdd BLAST18
Compositional biasi962 – 990Polar residuesSequence analysisAdd BLAST29
Compositional biasi1005 – 1030Polar residuesSequence analysisAdd BLAST26
Compositional biasi1056 – 1076Polar residuesSequence analysisAdd BLAST21
Compositional biasi1173 – 1196Polar residuesSequence analysisAdd BLAST24
Compositional biasi1293 – 1312Polar residuesSequence analysisAdd BLAST20
Compositional biasi1587 – 1619Polar residuesSequence analysisAdd BLAST33
Compositional biasi1717 – 1736Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQIH, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001298_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BKI2

Identification of Orthologs from Complete Genome Data

More...
OMAi
NASWPPX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BKI2

TreeFam database of animal gene trees

More...
TreeFami
TF329702

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12712, RRM_TNRC6B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033500, TNRC6B
IPR034925, TNRC6B_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF32, PTHR13020:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BKI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQTNEGEVEE ESSSQVEQED FVMEGHGKTP PPGEESKQEK EQEREEQLME
60 70 80 90 100
DKKRKKEDKK KKEATQKVTE QKTKVPEVTK PSLSQPTAAS PIGSSPSPPV
110 120 130 140 150
NGGNNAKRVA VPNGQPPSAA RYMPREVPPR FRCQQDHKVL LKRGQPPPPS
160 170 180 190 200
CMLLGGGAGP PPCTAPGANP NNNAQVTGAL LQSESGTAPE STLGGAAASN
210 220 230 240 250
YANSTWGPGA SSNSGASPNP IHIWDKVIVD GSDMEEWPCI ASKDTESSSE
260 270 280 290 300
NTTDNNSASN PGSEKSSLPG STTSNKGKGS QCQAASSGNE CNLGVWKSDP
310 320 330 340 350
KAKSVQPPNS TSDSNNGLGN WRSTSGQDRI GPGSGFSNFN PNSNPSAWPA
360 370 380 390 400
LVQEGTSRKG ALETESSSSS AQVSTVGQAS REQQSKMENA GVNFVVSGRE
410 420 430 440 450
QAQIHNTDGP KNGNTNSLNL SSPNPMENKG MPFGMGLGNT SRSTDAPSQS
460 470 480 490 500
TGDRKTGSVG SWGAARGPSG TDTVSGQSNS GNNGNNGKDR EDSWKGASVP
510 520 530 540 550
KPTGSKSDSW DNNNRSTGGS WNFGPQDNND NKWGEGNKMT SGVSQGEWKQ
560 570 580 590 600
PTGSDELKIG EWSGPNQPNS STGAWDNQKG HPLPENQGNA QAPCWGRSSS
610 620 630 640 650
SAGSEVGGQS TGSNHKAGSS DSHNSGRRSY RPTHPDCQAV LQTLLSRTDL
660 670 680 690 700
DPRVLSNTGW GQTQIKQDTV WDIEEVPRPE GKSDKGTEGW ESAATQTKNS
710 720 730 740 750
GGWGDAPSQS NQMKSGWGEL SASTEWKDPK STGGWNDYKN NNSSNWGGGR
760 770 780 790 800
ADEKTPSSWN ESSCKDQGWG GGRQPNQGWT SGKNGWGEEV DQVKNNNWES
810 820 830 840 850
SANKPVSGWG EGGQNEIGTW GNGGNTNLAS KGGWEDCKRS PAWNETGRQP
860 870 880 890 900
NSWNKQHQQQ QQPPPPQPEA SGSWGGPPPP PQGNVRPSNS NWSSGPQPTT
910 920 930 940 950
PKDDEPSGWE EPSPQSISRK MDIDDGTSAW GDPNSYNYKN VNLWDKNSQG
960 970 980 990 1000
GPAPREPNLP TPMTGKSASV WSKSTPPAPD NGTSAWGEPN ESSPGWGEMD
1010 1020 1030 1040 1050
DAGASTTGWG NTPANAPNAM KPNSKSMQDG WGESDGPVTG ARHPSWEEED
1060 1070 1080 1090 1100
DGGVWNTAGS QGSTSSHNSA SWGQGGKKQM KCSLKGGNND SWMNPLAKQF
1110 1120 1130 1140 1150
SNMGLLSQTE DNPSSKMDLS VDKKFDVDKR TMNLGDFNDI MRKDRPGFRP
1160 1170 1180 1190 1200
PNSKDLGTTD SGPYFEKGGS HGLFGNSTAQ SRGLHTPVQP LSSSPGLRAQ
1210 1220 1230 1240 1250
VPPQFISPQV SASMLKQFPN SGLNPGLFNV GPQLSPQQIA MLSQLPQIPQ
1260 1270 1280 1290 1300
FQLACQLLLQ QQQQQQQLLQ NQRKISQAVR QQQEQQLARM VSALQQQQQQ
1310 1320 1330 1340 1350
QQQQQRQPSM KHSPSHPVGP KPHLDNMVPN ALNVGLPDLP TKGPIPGYGS
1360 1370 1380 1390 1400
GFSSGGMDYG MVGGKEAGTE SRFKQWTSMM EGLPSVATQE ATMHKNGAIV
1410 1420 1430 1440 1450
APGKTRGGSP YNQFDIIPGD TLGGHTGPAG DSWLPAKSPP TNKIGSKSSN
1460 1470 1480 1490 1500
ASWPPEFQPG VPWKGIQNID PESDPYVTPG SVLGGTTTSP IVDTDHQLLR
1510 1520 1530 1540 1550
DNTTGSNSSL NTSLPSPGAW PYSASDNSFT NVHSTSAKFP DYKSTWSPDP
1560 1570 1580 1590 1600
IGHNPTHLSN KMWKNHISSR NTTPLTRPPP GLTNPKPASP WSSTAPRSVR
1610 1620 1630 1640 1650
GWGTQDSRIA SASTWSDGGS VRPSYWLVLH NLTPQIDGST LRTICMQHGP
1660 1670 1680 1690 1700
LLTFHLNLTQ GTALIRYSTK QEAAKAQTAL HMCVLGNTTI LAEFATEDEV
1710 1720 1730 1740 1750
SRFLAQAQPP TPAATPSAPA TGWQSLETSQ NQADPVGPAL NLFGGSTGLG
1760 1770 1780 1790 1800
QWSSSAGGSS GADLAGTSLW GPPNYSSSLW GVPTVEDPHR MGSPAPLLPG
1810
DLLGGGSDSI
Length:1,810
Mass (Da):191,963
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70F0A3A88CE7C7C5
GO
Isoform 2 (identifier: Q8BKI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-38: KQ → MR
     970-979: VWSKSTPPAP → GRYQLFSHRS
     980-1810: Missing.

Show »
Length:943
Mass (Da):99,891
Checksum:iB11D333CE3B24E15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRG1A0A2I3BRG1_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6b
958Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPE5A0A2I3BPE5_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6b
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti904D → Y in BAC34813 (PubMed:16141072).Curated1
Sequence conflicti1576T → P in BAC65722 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0372941 – 36Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_03729537 – 38KQ → MR in isoform 2. 1 Publication2
Alternative sequenceiVSP_037296970 – 979VWSKSTPPAP → GRYQLFSHRS in isoform 2. 1 Publication10
Alternative sequenceiVSP_037297980 – 1810Missing in isoform 2. 1 PublicationAdd BLAST831

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC125540 Genomic DNA No translation available.
AC126682 Genomic DNA No translation available.
AK051922 mRNA Translation: BAC34813.1
AK122440 mRNA Translation: BAC65722.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37146.1 [Q8BKI2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_659061.2, NM_144812.2 [Q8BKI2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000067689; ENSMUSP00000064336; ENSMUSG00000047888 [Q8BKI2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213988

UCSC genome browser

More...
UCSCi
uc007wvt.1, mouse [Q8BKI2-1]
uc007wvu.2, mouse [Q8BKI2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125540 Genomic DNA No translation available.
AC126682 Genomic DNA No translation available.
AK051922 mRNA Translation: BAC34813.1
AK122440 mRNA Translation: BAC65722.1
CCDSiCCDS37146.1 [Q8BKI2-1]
RefSeqiNP_659061.2, NM_144812.2 [Q8BKI2-1]

3D structure databases

SMRiQ8BKI2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229484, 8 interactors
DIPiDIP-48568N
IntActiQ8BKI2, 5 interactors
MINTiQ8BKI2
STRINGi10090.ENSMUSP00000064336

PTM databases

iPTMnetiQ8BKI2
PhosphoSitePlusiQ8BKI2

Proteomic databases

EPDiQ8BKI2
jPOSTiQ8BKI2
PaxDbiQ8BKI2
PeptideAtlasiQ8BKI2
PRIDEiQ8BKI2
ProteomicsDBi260644 [Q8BKI2-1]
260645 [Q8BKI2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
294, 103 antibodies

The DNASU plasmid repository

More...
DNASUi
213988

Genome annotation databases

EnsembliENSMUST00000067689; ENSMUSP00000064336; ENSMUSG00000047888 [Q8BKI2-1]
GeneIDi213988
KEGGimmu:213988
UCSCiuc007wvt.1, mouse [Q8BKI2-1]
uc007wvu.2, mouse [Q8BKI2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23112
MGIiMGI:2443730, Tnrc6b
VEuPathDBiHostDB:ENSMUSG00000047888

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QQIH, Eukaryota
GeneTreeiENSGT00940000155813
HOGENOMiCLU_001298_1_0_1
InParanoidiQ8BKI2
OMAiNASWPPX
PhylomeDBiQ8BKI2
TreeFamiTF329702

Enzyme and pathway databases

ReactomeiR-MMU-426496, Post-transcriptional silencing by small RNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
213988, 2 hits in 48 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tnrc6b, mouse

Protein Ontology

More...
PROi
PR:Q8BKI2
RNActiQ8BKI2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047888, Expressed in retina and 287 other tissues
ExpressionAtlasiQ8BKI2, baseline and differential
GenevisibleiQ8BKI2, MM

Family and domain databases

CDDicd12712, RRM_TNRC6B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033500, TNRC6B
IPR034925, TNRC6B_RRM
PANTHERiPTHR13020:SF32, PTHR13020:SF32, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR6B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BKI2
Secondary accession number(s): Q80TK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: September 29, 2021
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again