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Protein

Frizzled-10

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Alternative name(s):
CD_antigen: CD350
Gene namesi
Name:Fzd10
Synonyms:Fz10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2136761 Fzd10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 226ExtracellularSequence analysisAdd BLAST205
Transmembranei227 – 247Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 284Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini285 – 312ExtracellularSequence analysisAdd BLAST28
Transmembranei313 – 333Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini334 – 352CytoplasmicSequence analysisAdd BLAST19
Transmembranei353 – 373Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini374 – 394ExtracellularSequence analysisAdd BLAST21
Transmembranei395 – 415Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini416 – 444CytoplasmicSequence analysisAdd BLAST29
Transmembranei445 – 465Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini466 – 503ExtracellularSequence analysisAdd BLAST38
Transmembranei504 – 524Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini525 – 582CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001300622 – 582Frizzled-10Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 96PROSITE-ProRule annotation
Disulfide bondi43 ↔ 89PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 118PROSITE-ProRule annotation
Disulfide bondi107 ↔ 148PROSITE-ProRule annotation
Disulfide bondi111 ↔ 135PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BKG4
PaxDbiQ8BKG4
PRIDEiQ8BKG4

PTM databases

PhosphoSitePlusiQ8BKG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000081683 Expressed in 174 organ(s), highest expression level in midbrain
CleanExiMM_FZD10
ExpressionAtlasiQ8BKG4 baseline and differential
GenevisibleiQ8BKG4 MM

Interactioni

Subunit structurei

Interacts with MYOC (By similarity). Interacts with WNT7B (PubMed:15923619).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220362, 2 interactors
STRINGi10090.ENSMUSP00000114114

Structurei

3D structure databases

ProteinModelPortaliQ8BKG4
SMRiQ8BKG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 151FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi527 – 532Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi580 – 582PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOVERGENiHBG006977
InParanoidiQ8BKG4
KOiK02842
OMAiCKMNNQT
OrthoDBiEOG091G0N5M
TreeFamiTF317907

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026549 FZD10
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF86 PTHR11309:SF86, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT
60 70 80 90 100
TRMPNLMGHE NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV
110 120 130 140 150
STPIPACRVM CEQARLKCSP IMEQFKFRWP DSLDCSKLPN KNDPNYLCME
160 170 180 190 200
APNNGSDEPS RGSGMFPPLF RPQRPHSAQE HPLKDGGPGR AGCDNPGKFH
210 220 230 240 250
HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF FSSAFTVLTF
260 270 280 290 300
LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV
310 320 330 340 350
IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA
360 370 380 390 400
NSSYFHLAAW AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL
410 420 430 440 450
VPLACYLVIG TSFILSGFVA LFHIRRVMKT GGENTDKLEK LMVRIGVFSL
460 470 480 490 500
LYTVPATCVI ACYFYERLNM DYWKMLATQH KCKMNNQTKT PDCLMTTSIP
510 520 530 540 550
AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL KRKSRRKPAS
560 570 580
VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV
Length:582
Mass (Da):65,318
Last modified:March 1, 2003 - v1
Checksum:i3ED4F5340B1505E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509002 mRNA Translation: AAR92468.1
AK052950 mRNA Translation: BAC35217.1
CCDSiCCDS51652.1
RefSeqiNP_780493.1, NM_175284.3
UniGeneiMm.197628

Genome annotation databases

EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683
GeneIDi93897
KEGGimmu:93897
UCSCiuc008zsh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509002 mRNA Translation: AAR92468.1
AK052950 mRNA Translation: BAC35217.1
CCDSiCCDS51652.1
RefSeqiNP_780493.1, NM_175284.3
UniGeneiMm.197628

3D structure databases

ProteinModelPortaliQ8BKG4
SMRiQ8BKG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220362, 2 interactors
STRINGi10090.ENSMUSP00000114114

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BKG4

Proteomic databases

MaxQBiQ8BKG4
PaxDbiQ8BKG4
PRIDEiQ8BKG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683
GeneIDi93897
KEGGimmu:93897
UCSCiuc008zsh.1 mouse

Organism-specific databases

CTDi11211
MGIiMGI:2136761 Fzd10

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOVERGENiHBG006977
InParanoidiQ8BKG4
KOiK02842
OMAiCKMNNQT
OrthoDBiEOG091G0N5M
TreeFamiTF317907

Miscellaneous databases

ChiTaRSiFzd2 mouse
PROiPR:Q8BKG4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000081683 Expressed in 174 organ(s), highest expression level in midbrain
CleanExiMM_FZD10
ExpressionAtlasiQ8BKG4 baseline and differential
GenevisibleiQ8BKG4 MM

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026549 FZD10
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF86 PTHR11309:SF86, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFZD10_MOUSE
AccessioniPrimary (citable) accession number: Q8BKG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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