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Protein

Fibrinogen silencer-binding protein

Gene

Fsbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen silencer-binding protein
Gene namesi
Name:Fsbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:5301008 Fsbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873531 – 299Fibrinogen silencer-binding proteinAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BKE5
PRIDEiQ8BKE5

PTM databases

PhosphoSitePlusiQ8BKE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000094595 Expressed in 22 organ(s), highest expression level in embryonic stem cell
GenevisibleiQ8BKE5 MM

Interactioni

Subunit structurei

Interacts with APBA1 (via PDZ 1 and 2 domains).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137082

Structurei

3D structure databases

ProteinModelPortaliQ8BKE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVMX Eukaryota
ENOG4111FZT LUCA
GeneTreeiENSGT00390000008778
HOGENOMiHOG000112654
HOVERGENiHBG051662
OMAiCWDIIAD
OrthoDBiEOG091G0EVL
PhylomeDBiQ8BKE5
TreeFamiTF331896

Family and domain databases

InterProiView protein in InterPro
IPR028002 Myb_DNA-bind_5
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BKE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGKARSSNF TLSEKLDLLN LVKPYVKILE EHTNKNSVIV EKNRCWDVIA
60 70 80 90 100
VNYNAIGVDR PPRTAQGLRS LYKRLKEYAK QELLQQKEAQ SEFKSSVSEP
110 120 130 140 150
TKQVMEMIPQ IASFGLIRDR SHIQSANLDE TAQAGTSSLQ VMVDHHPVAI
160 170 180 190 200
TVEVKQEEDI KPSPPLVSNP QLSDTLEQRE EHELMHVVEG SESPSLSSVD
210 220 230 240 250
MRMTSSPSSV PRRDEIFHQE SGEHFRSLLR CDPQVLQMLK EEHQIILENQ
260 270 280 290
KNFGLYVQEK RDGLRRRQRL EEELLRAKIE VEKLKATRLR RDLPEYSSL
Length:299
Mass (Da):34,403
Last modified:March 1, 2003 - v1
Checksum:iCC0A2936D0642E7E
GO
Isoform 2 (identifier: Q8BKE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,487
Checksum:iE30E7AA8B09070E3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107751 – 141Missing in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053419 mRNA Translation: BAC35379.1
AK078439 mRNA Translation: BAC37274.1
CCDSiCCDS57263.1 [Q8BKE5-1]
RefSeqiNP_001243071.1, NM_001256142.1 [Q8BKE5-1]
NP_001243074.1, NM_001256145.1
UniGeneiMm.249437
Mm.491200

Genome annotation databases

EnsembliENSMUST00000180239; ENSMUSP00000137082; ENSMUSG00000094595 [Q8BKE5-1]
GeneIDi100503583
623474
KEGGimmu:100503583
UCSCiuc008rzt.2 mouse [Q8BKE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053419 mRNA Translation: BAC35379.1
AK078439 mRNA Translation: BAC37274.1
CCDSiCCDS57263.1 [Q8BKE5-1]
RefSeqiNP_001243071.1, NM_001256142.1 [Q8BKE5-1]
NP_001243074.1, NM_001256145.1
UniGeneiMm.249437
Mm.491200

3D structure databases

ProteinModelPortaliQ8BKE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137082

PTM databases

PhosphoSitePlusiQ8BKE5

Proteomic databases

PaxDbiQ8BKE5
PRIDEiQ8BKE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180239; ENSMUSP00000137082; ENSMUSG00000094595 [Q8BKE5-1]
GeneIDi100503583
623474
KEGGimmu:100503583
UCSCiuc008rzt.2 mouse [Q8BKE5-1]

Organism-specific databases

CTDi100861412
25788
MGIiMGI:5301008 Fsbp

Phylogenomic databases

eggNOGiENOG410IVMX Eukaryota
ENOG4111FZT LUCA
GeneTreeiENSGT00390000008778
HOGENOMiHOG000112654
HOVERGENiHBG051662
OMAiCWDIIAD
OrthoDBiEOG091G0EVL
PhylomeDBiQ8BKE5
TreeFamiTF331896

Miscellaneous databases

PROiPR:Q8BKE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000094595 Expressed in 22 organ(s), highest expression level in embryonic stem cell
GenevisibleiQ8BKE5 MM

Family and domain databases

InterProiView protein in InterPro
IPR028002 Myb_DNA-bind_5
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSBP_MOUSE
AccessioniPrimary (citable) accession number: Q8BKE5
Secondary accession number(s): Q8BJX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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