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Protein

Protein RCC2

Gene

Rcc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RCC2
Gene namesi
Name:Rcc2
Synonyms:Kiaa1470
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919784 Rcc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Centromere, Chromosome, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066531 – 520Protein RCC2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei18PhosphothreonineBy similarity1
Modified residuei41PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei340PhosphothreonineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BK67
MaxQBiQ8BK67
PaxDbiQ8BK67
PeptideAtlasiQ8BK67
PRIDEiQ8BK67

PTM databases

iPTMnetiQ8BK67
PhosphoSitePlusiQ8BK67
SwissPalmiQ8BK67

Expressioni

Inductioni

Induced by TP53/p53 in response to oxidative stress and DNA damage.1 Publication

Gene expression databases

BgeeiENSMUSG00000040945 Expressed in 307 organ(s), highest expression level in forelimb bud
CleanExiMM_RCC2
ExpressionAtlasiQ8BK67 baseline and differential
GenevisibleiQ8BK67 MM

Interactioni

Subunit structurei

Interacts with RAC1 (PubMed:25074804). Interacts with nucleotide-free and with GDP and GTP-bound forms of RAC1, with a slight preference for GDP-bound RAC1. Binds preferentially to the nucleotide-free form of RAC1. Interacts with CORO1C. Interacts with microtubules (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224469, 3 interactors
IntActiQ8BK67, 4 interactors
MINTiQ8BK67
STRINGi10090.ENSMUSP00000038144

Structurei

3D structure databases

ProteinModelPortaliQ8BK67
SMRiQ8BK67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 163RCC1 1Add BLAST63
Repeati166 – 217RCC1 2Add BLAST52
Repeati219 – 269RCC1 3Add BLAST51
Repeati271 – 345RCC1 4Add BLAST75
Repeati346 – 399RCC1 5Add BLAST54
Repeati401 – 445RCC1 6Add BLAST45
Repeati446 – 499RCC1 7Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni316 – 323Required for interaction with RAC1By similarity8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1427 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000232061
HOVERGENiHBG080538
InParanoidiQ8BK67
OMAiVDCKGNL
OrthoDBiEOG091G07AD
PhylomeDBiQ8BK67
TreeFamiTF101168

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 4 hits
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BK67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRKKGAAWE EPSSGNGTAR AGPRRRGGPA GRKRERPERC SSSSGGGSSG
60 70 80 90 100
DEDGPELDGA PGGGKRTARP ATAGKAAGAA AIITEPEHTK ERVKLEGSKC
110 120 130 140 150
KGQLLIFGAT NWDLIGRKEV PKQQAAYRNL GQNLWGPHRY GCLSGVRVRT
160 170 180 190 200
VVSGSCAAHS LLITTEGKLW SWGRNEKGQL GHGDTKRVEA PRLIEALSHE
210 220 230 240 250
AIVLAACGRN HTLALTDTGS VFAFGENKMG QLGLGNQTDA VPSPAQIMYN
260 270 280 290 300
GQPITKMACG AEFSMLMDCK GNLYSFGCPE YGQLGHNSDG KFIARAQRIE
310 320 330 340 350
YDCELVPRRV AIFIEKTKDG QILPVPNVVV RDVACGANHT LVLDSQKRVF
360 370 380 390 400
SWGFGGYGRL GHAEQKDEMV PRLVKLFDFP GRGATQIYAG YTCSFAVSEV
410 420 430 440 450
GGLFFWGATN TSRESTMYPK AVQDLCGWRI RSLACGKSSI IVAADESTIS
460 470 480 490 500
WGPSPTFGEL GYGDHKPKSS TAAQEVKTLD GIFSEQVAMG YSHSLVIARD
510 520
ESEAEKEKLQ RLPEYTPRTL
Length:520
Mass (Da):55,983
Last modified:March 1, 2003 - v1
Checksum:i06E7B90EA721C373
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AWQ2A2AWQ2_MOUSE
Protein RCC2
Rcc2
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076040 mRNA Translation: BAC36140.1
AL954710 Genomic DNA No translation available.
BC086666 mRNA Translation: AAH86666.1
AK129370 mRNA Translation: BAC98180.1
CCDSiCCDS18852.1
RefSeqiNP_776292.1, NM_173867.5
XP_006538534.1, XM_006538471.3
UniGeneiMm.253

Genome annotation databases

EnsembliENSMUST00000038893; ENSMUSP00000038144; ENSMUSG00000040945
ENSMUST00000071169; ENSMUSP00000071163; ENSMUSG00000040945
GeneIDi108911
KEGGimmu:108911
UCSCiuc008vna.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076040 mRNA Translation: BAC36140.1
AL954710 Genomic DNA No translation available.
BC086666 mRNA Translation: AAH86666.1
AK129370 mRNA Translation: BAC98180.1
CCDSiCCDS18852.1
RefSeqiNP_776292.1, NM_173867.5
XP_006538534.1, XM_006538471.3
UniGeneiMm.253

3D structure databases

ProteinModelPortaliQ8BK67
SMRiQ8BK67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224469, 3 interactors
IntActiQ8BK67, 4 interactors
MINTiQ8BK67
STRINGi10090.ENSMUSP00000038144

PTM databases

iPTMnetiQ8BK67
PhosphoSitePlusiQ8BK67
SwissPalmiQ8BK67

Proteomic databases

EPDiQ8BK67
MaxQBiQ8BK67
PaxDbiQ8BK67
PeptideAtlasiQ8BK67
PRIDEiQ8BK67

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038893; ENSMUSP00000038144; ENSMUSG00000040945
ENSMUST00000071169; ENSMUSP00000071163; ENSMUSG00000040945
GeneIDi108911
KEGGimmu:108911
UCSCiuc008vna.2 mouse

Organism-specific databases

CTDi55920
MGIiMGI:1919784 Rcc2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1427 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000232061
HOVERGENiHBG080538
InParanoidiQ8BK67
OMAiVDCKGNL
OrthoDBiEOG091G07AD
PhylomeDBiQ8BK67
TreeFamiTF101168

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiRcc2 mouse
PROiPR:Q8BK67
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040945 Expressed in 307 organ(s), highest expression level in forelimb bud
CleanExiMM_RCC2
ExpressionAtlasiQ8BK67 baseline and differential
GenevisibleiQ8BK67 MM

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 4 hits
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRCC2_MOUSE
AccessioniPrimary (citable) accession number: Q8BK67
Secondary accession number(s): A2AWQ3, Q6ZPQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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