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Protein

Activator of 90 kDa heat shock protein ATPase homolog 1

Gene

Ahsa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).By similarity1 Publication

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • chaperone binding Source: MGI
  • Hsp90 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 1
Short name:
AHA1
Gene namesi
Name:Ahsa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2387603 Ahsa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158211 – 338Activator of 90 kDa heat shock protein ATPase homolog 1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N6-acetyllysineBy similarity1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei193PhosphoserineBy similarity1
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei212N6-acetyllysineBy similarity1
Modified residuei223Phosphotyrosine; by ABLBy similarity1

Post-translational modificationi

Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BK64
MaxQBiQ8BK64
PaxDbiQ8BK64
PRIDEiQ8BK64

2D gel databases

REPRODUCTION-2DPAGEiQ8BK64

PTM databases

iPTMnetiQ8BK64
PhosphoSitePlusiQ8BK64
SwissPalmiQ8BK64

Expressioni

Inductioni

By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene expression databases

BgeeiENSMUSG00000021037 Expressed in 268 organ(s), highest expression level in ear
ExpressionAtlasiQ8BK64 baseline and differential
GenevisibleiQ8BK64 MM

Interactioni

Subunit structurei

Interacts with HSPCA/HSP90 (By similarity). Interacts with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:29127155). Interacts with HSP90AB1 (PubMed:22022502). Interacts with GCH1 (By similarity). Interacts with SRPK1 (By similarity). Interacts with FLCN (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229959, 3 interactors
IntActiQ8BK64, 4 interactors
MINTiQ8BK64
STRINGi10090.ENSMUSP00000021425

Structurei

3D structure databases

ProteinModelPortaliQ8BK64
SMRiQ8BK64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiKOG2936 Eukaryota
COG5580 LUCA
GeneTreeiENSGT00390000006429
HOGENOMiHOG000242852
HOVERGENiHBG065806
InParanoidiQ8BK64
OMAiEYYVRSI
OrthoDBiEOG091G0BRP
PhylomeDBiQ8BK64
TreeFamiTF313680

Family and domain databases

Gene3Di3.15.10.20, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR013538 Activator_of_Hsp90_ATPase
IPR036338 Aha1
IPR015310 AHSA1_N
IPR023393 START-like_dom_sf
PfamiView protein in Pfam
PF09229 Aha1_N, 1 hit
PF08327 AHSA1, 1 hit
SMARTiView protein in SMART
SM01000 Aha1_N, 1 hit
SUPFAMiSSF103111 SSF103111, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8BK64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTEKL KTLFLAVRVE
60 70 80 90 100
NEEGKCEVTE VNKLDGEASI NNRKGKLIFF YEWTIKLNWT GTSKSGVQYK
110 120 130 140 150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEDG VKLLREAVGI
160 170 180 190 200
YISTLKTEFT QGMILPTVNG ESVDPVGQPA LKTETCKAKS APSKSQAKPV
210 220 230 240 250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA ALEADRGGKF
260 270 280 290 300
HMVDGNVTGE FTDLVPEKHI AMKWRFKSWP EGHFATITLT FIDKNGETEL
310 320 330
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF
Length:338
Mass (Da):38,117
Last modified:April 30, 2003 - v2
Checksum:iC4F0F94FF44F9FB3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VM19A0A1Y7VM19_MOUSE
Activator of 90 kDa heat shock prot...
Ahsa1
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192P → L in BAC36160 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076069 mRNA Translation: BAC36160.1
BC023857 mRNA Translation: AAH23857.1
BC025552 mRNA Translation: AAH25552.1
CCDSiCCDS26075.1
RefSeqiNP_666148.1, NM_146036.1
UniGeneiMm.22626

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037
GeneIDi217737
KEGGimmu:217737
UCSCiuc007oit.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAHSA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BK64
Secondary accession number(s): Q8R3E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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