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Protein

Protein lifeguard 3

Gene

Tmbim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.2 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 3
Alternative name(s):
Responsive to centrifugal force and shear stress gene 1 protein
Short name:
Protein RECS1
Transmembrane BAX inhibitor motif-containing protein 1
Gene namesi
Name:Tmbim1
Synonyms:Lfg3, Recs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916910 Tmbim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice (older than 14 months) are prone to aortic dilation as well as cystic medial degeneration (CMD).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790911 – 309Protein lifeguard 3Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BJZ3
PRIDEiQ8BJZ3

PTM databases

iPTMnetiQ8BJZ3
PhosphoSitePlusiQ8BJZ3

Expressioni

Tissue specificityi

Expressed in most tissues except spleen, thymus and testis.1 Publication

Gene expression databases

CleanExiMM_TMBIM1

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016309

Structurei

3D structure databases

ProteinModelPortaliQ8BJZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ8BJZ3
KOiK06890
PhylomeDBiQ8BJZ3

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BJZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNPSAPPPY EDHNPLYPGS PPPGGYGQPS VLPGGYPAYP AYPQPGYGHP
60 70 80 90 100
AGYPQPVPPV HPMPMNYGHD YNEEERAGSD SFRPGEWDDR KVRHSFIQKV
110 120 130 140 150
YCIISVQLLI TVAIIAIFTF VEPVGKYVRN NVAVYYVSYA VFLVTYLTLA
160 170 180 190 200
CCQGPRRRFP WDIILLTIFT LALGFVTGTI SSMYENKAVI IAMIITAVVS
210 220 230 240 250
ISVTIFCFQT KVDFTSCTGL FCVLGIVLMV TGIVTSIVLI FKYIYWLHMV
260 270 280 290 300
YAALGAICFT LFLAYDTQLV LGNRKHTISP EDYITGALQI YTDIVYIFTF

VLQLVGSRD
Length:309
Mass (Da):34,393
Last modified:March 1, 2003 - v1
Checksum:i3C33B9879E944B2F
GO
Isoform 2 (identifier: Q8BJZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-161: FTFVEPVGKY...CQGPRRRFPW → STWSMQLWGP...SQAPYRSTQI
     162-309: Missing.

Note: Due to non-canonical splice donor and acceptor sites. No experimental confirmation available.
Show »
Length:164
Mass (Da):18,083
Checksum:i2F658853E8B27745
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U717Q3U717_MOUSE
Protein lifeguard 3
Tmbim1 mCG_114808
309Annotation score:
F6YG30F6YG30_MOUSE
Protein lifeguard 3
Tmbim1
156Annotation score:
D3Z225D3Z225_MOUSE
Protein lifeguard 3
Tmbim1
98Annotation score:
D3Z0A5D3Z0A5_MOUSE
Protein lifeguard 3
Tmbim1
92Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162D → N in BAC43762 (Ref. 1) Curated1
Sequence conflicti186N → T in BAC43762 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008995118 – 161FTFVE…RRFPW → STWSMQLWGPSVSPCSWLMT HSWSWGTGSTPSARRTTSQA PYRSTQI in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_008996162 – 309Missing in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097685 mRNA Translation: BAC43762.1
AK077689 mRNA Translation: BAC36957.1
BC004752 mRNA Translation: AAH04752.1
CCDSiCCDS15044.1 [Q8BJZ3-1]
RefSeqiNP_081430.3, NM_027154.5
UniGeneiMm.261182

Genome annotation databases

GeneIDi69660
KEGGimmu:69660

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097685 mRNA Translation: BAC43762.1
AK077689 mRNA Translation: BAC36957.1
BC004752 mRNA Translation: AAH04752.1
CCDSiCCDS15044.1 [Q8BJZ3-1]
RefSeqiNP_081430.3, NM_027154.5
UniGeneiMm.261182

3D structure databases

ProteinModelPortaliQ8BJZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016309

PTM databases

iPTMnetiQ8BJZ3
PhosphoSitePlusiQ8BJZ3

Proteomic databases

PaxDbiQ8BJZ3
PRIDEiQ8BJZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69660
KEGGimmu:69660

Organism-specific databases

CTDi64114
MGIiMGI:1916910 Tmbim1

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ8BJZ3
KOiK06890
PhylomeDBiQ8BJZ3

Miscellaneous databases

PROiPR:Q8BJZ3
SOURCEiSearch...

Gene expression databases

CleanExiMM_TMBIM1

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLFG3_MOUSE
AccessioniPrimary (citable) accession number: Q8BJZ3
Secondary accession number(s): Q8CH91, Q99KB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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