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Protein

26S proteasome non-ATPase regulatory subunit 5

Gene

Psmd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8941858 Regulation of RUNX3 expression and activity
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 5
Alternative name(s):
26S protease subunit S5 basic
26S proteasome subunit S5B
Gene namesi
Name:Psmd5
Synonyms:Kiaa0072
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914248 Psmd5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001738372 – 50426S proteasome non-ATPase regulatory subunit 5Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BJY1
MaxQBiQ8BJY1
PaxDbiQ8BJY1
PeptideAtlasiQ8BJY1
PRIDEiQ8BJY1

PTM databases

iPTMnetiQ8BJY1
PhosphoSitePlusiQ8BJY1
SwissPalmiQ8BJY1

Expressioni

Gene expression databases

BgeeiENSMUSG00000026869
ExpressionAtlasiQ8BJY1 baseline and differential
GenevisibleiQ8BJY1 MM

Interactioni

Subunit structurei

Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.1 Publication

Protein-protein interaction databases

BioGridi211865, 3 interactors
IntActiQ8BJY1, 1 interactor
STRINGi10090.ENSMUSP00000028225

Structurei

3D structure databases

ProteinModelPortaliQ8BJY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.

Sequence similaritiesi

Belongs to the proteasome subunit S5B/HSM3 family.Curated

Phylogenomic databases

eggNOGiKOG4413 Eukaryota
ENOG410XTFA LUCA
GeneTreeiENSGT00390000013040
HOGENOMiHOG000231963
HOVERGENiHBG053741
InParanoidiQ8BJY1
KOiK06692
OMAiDSPQQVC
OrthoDBiEOG091G09IW
PhylomeDBiQ8BJY1
TreeFamiTF106231

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019538 PSMD5
PANTHERiPTHR13554 PTHR13554, 1 hit
PfamiView protein in Pfam
PF10508 Proteasom_PSMB, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQAVSLLR EVARLEAPLE ELRALQSVVQ AVPLHELREQ AAELRLRPLF
60 70 80 90 100
SLLNQNNREQ TALCVSILER LLQAVEPIHL ARNLRLDLQR GLTHPDDSVK
110 120 130 140 150
TLTLSQIGRI VENSEAVTEI LNNAELLKQI VYCIGGENLS VAKAAIKSLS
160 170 180 190 200
RISLTQAGLE ALFESNLLDD LKNVMKTNDV VRYRVYELII DISSVSSESL
210 220 230 240 250
NYCTTSGLVT QLLKELTGED VLVRATCIEM VTSLAYTHHG RQYLAQEGVI
260 270 280 290 300
DQISNIIVGA DSDPFSGFYL PGFVKFFGNL AVMDSPQQIC ERYPVFLEKV
310 320 330 340 350
FEMADSQDPT MIGVAVDTVG ILGSSVEGKQ VLQKTGTRFE RVLMRVGYQA
360 370 380 390 400
KNASTELKIR CLDAVSSLLY LSPEQQTDDF LGMTESWFSS MSRDSLELFR
410 420 430 440 450
GISNQPFPEL HCAALKVFTA IADQPWAQRL MFNSPGFVEF VMDRSVEHDK
460 470 480 490 500
ASKDAKYELV KALANSKTVA EIFGNSNYLR LRAYLSEGPY YVKPVATTAV

EGAD
Length:504
Mass (Da):55,972
Last modified:January 23, 2007 - v4
Checksum:i66D56A2BD43B895C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158G → V in BAC37265 (PubMed:16141072).Curated1
Sequence conflicti398L → P in BC019112 (PubMed:15489334).Curated1
Sequence conflicti448H → L in BAD90393 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032992 mRNA Translation: BAC28117.1
AK078419 mRNA Translation: BAC37265.1
AK145587 mRNA Translation: BAE26526.1
AK148284 mRNA Translation: BAE28457.1
AL929068 Genomic DNA Translation: CAM27595.1
CH466542 Genomic DNA Translation: EDL08630.1
BC019112 mRNA No translation available.
AK220321 mRNA Translation: BAD90393.1
CCDSiCCDS15953.1
RefSeqiNP_542121.2, NM_080554.2
UniGeneiMm.270632

Genome annotation databases

EnsembliENSMUST00000028225; ENSMUSP00000028225; ENSMUSG00000026869
GeneIDi66998
KEGGimmu:66998
UCSCiuc008jje.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPSMD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BJY1
Secondary accession number(s): A2AUB0
, Q3UFV2, Q5DU49, Q8BMA9, Q8VEE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 123 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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