Eif2a

Functionⁱ

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.By similarity

GO - Molecular functionⁱ

mRNA binding Source: GO_Central
ribosome binding Source: UniProtKB
translation initiation factor activity Source: UniProtKB
tRNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of signal transduction
Source: MGI
Inferred from direct assayⁱ
- 18852460
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 16705175
regulation of translation Source: UniProtKB
response to amino acid starvation Source: MGI
ribosome assembly Source: UniProtKB
SREBP signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 18852460
translation
Source: MGI
Inferred from direct assayⁱ
- 7519779

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor
Biological process	Protein biosynthesis, Translation regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 2A Short name: eIF-2A Cleaved into the following chain: Eukaryotic translation initiation factor 2A, N-terminally processed
Gene namesⁱ	Name:Eif2a Synonyms:D3Ertd194e
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1098684 Eif2a

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000424467	1 – 581	Eukaryotic translation initiation factor 2AAdd BLAST	581
Initiator methionineⁱ		Removed; alternateBy similarity
ChainⁱPRO_0000286077	2 – 581	Eukaryotic translation initiation factor 2A, N-terminally processedAdd BLAST	580

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylalanine; in Eukaryotic translation initiation factor 2A, N-terminally processedBy similarity	1
Modified residueⁱ	5	PhosphothreonineBy similarity	1
Modified residueⁱ	503	PhosphoserineBy similarity	1
Modified residueⁱ	513	PhosphoserineBy similarity	1
Modified residueⁱ	522	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8BJW6
PaxDbⁱ	Q8BJW6
PeptideAtlas More...PeptideAtlasⁱ	Q8BJW6
PRIDEⁱ	Q8BJW6

PTM databases

iPTMnetⁱ	Q8BJW6
PhosphoSitePlusⁱ	Q8BJW6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027810
CleanExⁱ	MM_EIF2A
ExpressionAtlasⁱ	Q8BJW6 baseline and differential
Genevisibleⁱ	Q8BJW6 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	230831, 5 interactors
IntActⁱ	Q8BJW6, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q8BJW6
STRINGⁱ	10090.ENSMUSP00000029387

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BJW6
SMRⁱ	Q8BJW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	23 – 63	WD 1Add BLAST	41
Repeatⁱ	125 – 163	WD 2Add BLAST	39
Repeatⁱ	356 – 401	WD 3Add BLAST	46

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	527 – 578	Sequence analysisAdd BLAST		52

Sequence similaritiesⁱ

Belongs to the WD repeat EIF2A family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG2315 Eukaryota COG5354 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111053
HOGENOMⁱ	HOG000193775
HOVERGENⁱ	HBG107842
InParanoidⁱ	Q8BJW6
KEGG Orthology (KO) More...KOⁱ	K15026
OMAⁱ	WQPYTTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04PE
PhylomeDBⁱ	Q8BJW6
TreeFamⁱ	TF105866

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011387 TIF2A IPR013979 TIF_beta_prop-like IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08662 eIF2A, 1 hit
PIRSFⁱ	PIRSF017222 eIF2A, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BJW6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV LPRESGRNCK VYTFSKDGTL 
        60         70         80         90        100
FAWSNGEKVN IINVANKGLL HSFDLPKAVC LEFSPNNTVL ATWQPYTTSK 
       110        120        130        140        150
DGTAGTPNLQ LYDMKTGACL KSFIQKKMQN WCPSWSDDEI ICARNVNNEV 
       160        170        180        190        200
HFFENNNFNT IANKLHLQKV NDFNLSPGTQ PYKVAVYVPG SKGAPSFVRL 
       210        220        230        240        250
YQYPNFAGPQ AALANKSFFK ADKVTMLWNK KATAVLVIAS TEVDKTGASY 
       260        270        280        290        300
YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT 
       310        320        330        340        350
VFNLKCDPVF DFGTGPRNAA FYSPHGHILV LAGFGNLRGQ MEVWDVKNYK 
       360        370        380        390        400
LISKPVASDS TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSLLHKY 
       410        420        430        440        450
DVPSNGELWQ VSWQPFLDGI FPAKTIKYQA VPSEVPSEEP KVATAYRPPA 
       460        470        480        490        500
LRNKPVTNSK LHEEEPPQNM KPHPGSDKPL SKTALKNQRK HEAKKAAKQE 
       510        520        530        540        550
ARSDAAPTPV PQSAPRNTVT QSASGDPEVD KKIKNLKKKL KAIEQLKEQA 
       560        570        580 
AAGKQLEKNQ LEKIQKETAL LQELEDLELG V

Length:581

Mass (Da):64,403

Last modified:May 1, 2007 - v2

Checksum:ⁱD485C05ACE5D0908

GO

Isoform 2 (identifier: Q8BJW6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-94: Missing.
95-97: PYT → MEK

« Hide

        10         20         30         40         50
MEKTSKDGTA GTPNLQLYDM KTGACLKSFI QKKMQNWCPS WSDDEIICAR 
        60         70         80         90        100
NVNNEVHFFE NNNFNTIANK LHLQKVNDFN LSPGTQPYKV AVYVPGSKGA 
       110        120        130        140        150
PSFVRLYQYP NFAGPQAALA NKSFFKADKV TMLWNKKATA VLVIASTEVD 
       160        170        180        190        200
KTGASYYGEQ TLHYIATNGE SAVVQLPKNG PIYDVVWNSS STEFCAVYGF 
       210        220        230        240        250
MPAKATVFNL KCDPVFDFGT GPRNAAFYSP HGHILVLAGF GNLRGQMEVW 
       260        270        280        290        300
DVKNYKLISK PVASDSTYFA WCPDGEHILT ATCAPRLRVN NGYKIWHYTG 
       310        320        330        340        350
SLLHKYDVPS NGELWQVSWQ PFLDGIFPAK TIKYQAVPSE VPSEEPKVAT 
       360        370        380        390        400
AYRPPALRNK PVTNSKLHEE EPPQNMKPHP GSDKPLSKTA LKNQRKHEAK 
       410        420        430        440        450
KAAKQEARSD AAPTPVPQSA PRNTVTQSAS GDPEVDKKIK NLKKKLKAIE 
       460        470        480 
QLKEQAAAGK QLEKNQLEKI QKETALLQEL EDLELGV

Note: No experimental confirmation available.

Show »

Length:487

Mass (Da):54,136

Checksum:ⁱ369EDD5BDBCAC95E

GO

Sequence cautionⁱ

The sequence BAC37320 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024977	1 – 94	Missing in isoform 2. 1 PublicationAdd BLAST		94
Alternative sequenceⁱVSP_024978	95 – 97	PYT → MEK in isoform 2. 1 Publication		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK078519 mRNA Translation: BAC37320.1 Different initiation. BC030447 mRNA Translation: AAH30447.1 BC082557 mRNA Translation: AAH82557.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17367.1 [Q8BJW6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005509.1, NM_001005509.2 [Q8BJW6-1]
UniGeneⁱ	Mm.21617

Genome annotation databases

Ensemblⁱ	ENSMUST00000029387; ENSMUSP00000029387; ENSMUSG00000027810 [Q8BJW6-1]
GeneIDⁱ	229317
KEGGⁱ	mmu:229317
UCSC genome browser More...UCSCⁱ	uc008phu.2 mouse [Q8BJW6-1] uc008phv.2 mouse [Q8BJW6-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length
Q8BJW6	Eukaryotic translation initiation factor 2A		HUMAN		585
UPI0007A6B04E		MINNA		608
UPI000788BDDF		ROUAE		594
eukaryotic translation initiation factor 2A isoform X2		ODORO		593
Eukaryotic translation initiation factor 2A		FELCA		593
+97

Protein	Similar proteins		Species	Score	Length
Q8BJW6	Eukaryotic translation initiation factor 2A		HUMAN		585
UPI0007A6B04E		MINNA		608
UPI000788BDDF		ROUAE		594
UPI00072E4C13		ACIJB		593
UPI000904840D		PANPR		593
+440
Q8BJW6-2	UPI000C87BF2C		PTEVA		533
Eukaryotic translation initiation factor 2A		Cebus capucinus imitator		524
Eukaryotic translation initiation factor 2A		PANPA		524
Eukaryotic translation initiation factor 2A		RHIRO		524
Eukaryotic translation initiation factor 2A		MACMU		524
+118

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK078519 mRNA Translation: BAC37320.1 Different initiation. BC030447 mRNA Translation: AAH30447.1 BC082557 mRNA Translation: AAH82557.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17367.1 [Q8BJW6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005509.1, NM_001005509.2 [Q8BJW6-1]
UniGeneⁱ	Mm.21617

3D structure databases

ProteinModelPortalⁱ	Q8BJW6
SMRⁱ	Q8BJW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230831, 5 interactors
IntActⁱ	Q8BJW6, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q8BJW6
STRINGⁱ	10090.ENSMUSP00000029387

PTM databases

iPTMnetⁱ	Q8BJW6
PhosphoSitePlusⁱ	Q8BJW6

Proteomic databases

EPDⁱ	Q8BJW6
PaxDbⁱ	Q8BJW6
PeptideAtlas More...PeptideAtlasⁱ	Q8BJW6
PRIDEⁱ	Q8BJW6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029387; ENSMUSP00000029387; ENSMUSG00000027810 [Q8BJW6-1]
GeneIDⁱ	229317
KEGGⁱ	mmu:229317
UCSC genome browser More...UCSCⁱ	uc008phu.2 mouse [Q8BJW6-1] uc008phv.2 mouse [Q8BJW6-2]

Organism-specific databases

CTDⁱ	83939
MGIⁱ	MGI:1098684 Eif2a

Phylogenomic databases

eggNOGⁱ	KOG2315 Eukaryota COG5354 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111053
HOGENOMⁱ	HOG000193775
HOVERGENⁱ	HBG107842
InParanoidⁱ	Q8BJW6
KEGG Orthology (KO) More...KOⁱ	K15026
OMAⁱ	WQPYTTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04PE
PhylomeDBⁱ	Q8BJW6
TreeFamⁱ	TF105866

Miscellaneous databases

ChiTaRSⁱ	Eif2a mouse
Protein Ontology More...PROⁱ	PR:Q8BJW6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027810
CleanExⁱ	MM_EIF2A
ExpressionAtlasⁱ	Q8BJW6 baseline and differential
Genevisibleⁱ	Q8BJW6 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011387 TIF2A IPR013979 TIF_beta_prop-like IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08662 eIF2A, 1 hit
PIRSFⁱ	PIRSF017222 eIF2A, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EIF2A_MOUSE
Accessionⁱ	Q8BJW6Primary (citable) accession number: Q8BJW6 Secondary accession number(s): Q05C11, Q640P8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	July 18, 2018
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BJW6 (EIF2A_MOUSE)

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Eukaryotic translation initiation factor 2A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ