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Protein

Eukaryotic translation initiation factor 2A

Gene

Eif2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2A
Short name:
eIF-2A
Cleaved into the following chain:
Gene namesi
Name:Eif2a
Synonyms:D3Ertd194e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1098684 Eif2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244671 – 581Eukaryotic translation initiation factor 2AAdd BLAST581
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002860772 – 581Eukaryotic translation initiation factor 2A, N-terminally processedAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Eukaryotic translation initiation factor 2A, N-terminally processedBy similarity1
Modified residuei5PhosphothreonineBy similarity1
Modified residuei503PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BJW6
PaxDbiQ8BJW6
PeptideAtlasiQ8BJW6
PRIDEiQ8BJW6

PTM databases

iPTMnetiQ8BJW6
PhosphoSitePlusiQ8BJW6

Expressioni

Gene expression databases

BgeeiENSMUSG00000027810 Expressed in 262 organ(s), highest expression level in metanephros
CleanExiMM_EIF2A
ExpressionAtlasiQ8BJW6 baseline and differential
GenevisibleiQ8BJW6 MM

Interactioni

Protein-protein interaction databases

BioGridi230831, 5 interactors
IntActiQ8BJW6, 3 interactors
MINTiQ8BJW6
STRINGi10090.ENSMUSP00000029387

Structurei

3D structure databases

ProteinModelPortaliQ8BJW6
SMRiQ8BJW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 63WD 1Add BLAST41
Repeati125 – 163WD 2Add BLAST39
Repeati356 – 401WD 3Add BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili527 – 578Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the WD repeat EIF2A family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2315 Eukaryota
COG5354 LUCA
GeneTreeiENSGT00730000111053
HOGENOMiHOG000193775
HOVERGENiHBG107842
InParanoidiQ8BJW6
KOiK15026
OMAiQKSQTGW
OrthoDBiEOG091G04PE
PhylomeDBiQ8BJW6
TreeFamiTF105866

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13227 PTHR13227, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF017222 eIF2A, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BJW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV LPRESGRNCK VYTFSKDGTL
60 70 80 90 100
FAWSNGEKVN IINVANKGLL HSFDLPKAVC LEFSPNNTVL ATWQPYTTSK
110 120 130 140 150
DGTAGTPNLQ LYDMKTGACL KSFIQKKMQN WCPSWSDDEI ICARNVNNEV
160 170 180 190 200
HFFENNNFNT IANKLHLQKV NDFNLSPGTQ PYKVAVYVPG SKGAPSFVRL
210 220 230 240 250
YQYPNFAGPQ AALANKSFFK ADKVTMLWNK KATAVLVIAS TEVDKTGASY
260 270 280 290 300
YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT
310 320 330 340 350
VFNLKCDPVF DFGTGPRNAA FYSPHGHILV LAGFGNLRGQ MEVWDVKNYK
360 370 380 390 400
LISKPVASDS TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSLLHKY
410 420 430 440 450
DVPSNGELWQ VSWQPFLDGI FPAKTIKYQA VPSEVPSEEP KVATAYRPPA
460 470 480 490 500
LRNKPVTNSK LHEEEPPQNM KPHPGSDKPL SKTALKNQRK HEAKKAAKQE
510 520 530 540 550
ARSDAAPTPV PQSAPRNTVT QSASGDPEVD KKIKNLKKKL KAIEQLKEQA
560 570 580
AAGKQLEKNQ LEKIQKETAL LQELEDLELG V
Length:581
Mass (Da):64,403
Last modified:May 1, 2007 - v2
Checksum:iD485C05ACE5D0908
GO
Isoform 2 (identifier: Q8BJW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-97: PYT → MEK

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):54,136
Checksum:i369EDD5BDBCAC95E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZZ6D3YZZ6_MOUSE
Eukaryotic translation initiation f...
Eif2a
251Annotation score:
D6RFN2D6RFN2_MOUSE
Eukaryotic translation initiation f...
Eif2a
59Annotation score:
D6RGA6D6RGA6_MOUSE
Eukaryotic translation initiation f...
Eif2a
60Annotation score:

Sequence cautioni

The sequence BAC37320 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0249771 – 94Missing in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_02497895 – 97PYT → MEK in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078519 mRNA Translation: BAC37320.1 Different initiation.
BC030447 mRNA Translation: AAH30447.1
BC082557 mRNA Translation: AAH82557.1
CCDSiCCDS17367.1 [Q8BJW6-1]
RefSeqiNP_001005509.1, NM_001005509.2 [Q8BJW6-1]
UniGeneiMm.21617

Genome annotation databases

EnsembliENSMUST00000029387; ENSMUSP00000029387; ENSMUSG00000027810 [Q8BJW6-1]
GeneIDi229317
KEGGimmu:229317
UCSCiuc008phu.2 mouse [Q8BJW6-1]
uc008phv.2 mouse [Q8BJW6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078519 mRNA Translation: BAC37320.1 Different initiation.
BC030447 mRNA Translation: AAH30447.1
BC082557 mRNA Translation: AAH82557.1
CCDSiCCDS17367.1 [Q8BJW6-1]
RefSeqiNP_001005509.1, NM_001005509.2 [Q8BJW6-1]
UniGeneiMm.21617

3D structure databases

ProteinModelPortaliQ8BJW6
SMRiQ8BJW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230831, 5 interactors
IntActiQ8BJW6, 3 interactors
MINTiQ8BJW6
STRINGi10090.ENSMUSP00000029387

PTM databases

iPTMnetiQ8BJW6
PhosphoSitePlusiQ8BJW6

Proteomic databases

EPDiQ8BJW6
PaxDbiQ8BJW6
PeptideAtlasiQ8BJW6
PRIDEiQ8BJW6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029387; ENSMUSP00000029387; ENSMUSG00000027810 [Q8BJW6-1]
GeneIDi229317
KEGGimmu:229317
UCSCiuc008phu.2 mouse [Q8BJW6-1]
uc008phv.2 mouse [Q8BJW6-2]

Organism-specific databases

CTDi83939
MGIiMGI:1098684 Eif2a

Phylogenomic databases

eggNOGiKOG2315 Eukaryota
COG5354 LUCA
GeneTreeiENSGT00730000111053
HOGENOMiHOG000193775
HOVERGENiHBG107842
InParanoidiQ8BJW6
KOiK15026
OMAiQKSQTGW
OrthoDBiEOG091G04PE
PhylomeDBiQ8BJW6
TreeFamiTF105866

Miscellaneous databases

ChiTaRSiEif2a mouse
PROiPR:Q8BJW6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027810 Expressed in 262 organ(s), highest expression level in metanephros
CleanExiMM_EIF2A
ExpressionAtlasiQ8BJW6 baseline and differential
GenevisibleiQ8BJW6 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13227 PTHR13227, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF017222 eIF2A, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF2A_MOUSE
AccessioniPrimary (citable) accession number: Q8BJW6
Secondary accession number(s): Q05C11, Q640P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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