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Protein

Peptide chain release factor 1-like, mitochondrial

Gene

Mtrf1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translational termination Source: GO_Central
  • translational termination Source: GO_Central

Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1-like, mitochondrial
Alternative name(s):
Mitochondrial translational release factor 1-like
Gene namesi
Name:Mtrf1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918830 Mtrf1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000033094526 – 373Peptide chain release factor 1-like, mitochondrialAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N5-methylglutamineBy similarity1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ8BJU9
MaxQBiQ8BJU9
PaxDbiQ8BJU9
PeptideAtlasiQ8BJU9
PRIDEiQ8BJU9

PTM databases

PhosphoSitePlusiQ8BJU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000019774 Expressed in 228 organ(s), highest expression level in blastocyst
GenevisibleiQ8BJU9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019908

Structurei

3D structure databases

ProteinModelPortaliQ8BJU9
SMRiQ8BJU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 110Sequence analysisAdd BLAST55

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOGENOMiHOG000074815
HOVERGENiHBG017071
InParanoidiQ8BJU9
KOiK02835
OMAiWKVEIVS
OrthoDBiEOG091G0O7T
PhylomeDBiQ8BJU9
TreeFamiTF313720

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSGFLSGAR RLWARRAFSR TPPPSEELLA RGGPLRAFLE RRVGSEAGGL
60 70 80 90 100
DAGYPQLAAA ARLLSEKERE LRDTESLLHD ENEDLKKLAE SEIALCQKQI
110 120 130 140 150
TELKHQIISL LVPSEEMDGS DLILEVTAGV GGQEAMLFTS EMFDMYQQYA
160 170 180 190 200
AFKRWHFETL EYFPSELGGL RHASASVGGP EAYRHMKFEG GVHRVQRVPK
210 220 230 240 250
TEKQGRIHTS TMTVAILPQP TEIKLVINPK DLRIDTKRAS GAGGQHVNTT
260 270 280 290 300
DSAVRIVHLP TGIISECQQE RSQLKNRELA MKKLRARLYS MHLEEETAKR
310 320 330 340 350
YNARKIQVGT KGRSEKIRTY NFPQNRVTDH RINKSLHDLE SFMQGDCLLD
360 370
DMIQSLKDCS DYEALVEMIS RRD
Length:373
Mass (Da):42,248
Last modified:March 1, 2003 - v1
Checksum:i726392BED81EC36B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036424 mRNA Translation: BAE20502.1
AK078897 mRNA Translation: BAC37446.1
CCDSiCCDS56684.1
RefSeqiNP_780583.1, NM_175374.3
UniGeneiMm.55082

Genome annotation databases

EnsembliENSMUST00000019908; ENSMUSP00000019908; ENSMUSG00000019774
GeneIDi108853
KEGGimmu:108853
UCSCiuc007egi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036424 mRNA Translation: BAE20502.1
AK078897 mRNA Translation: BAC37446.1
CCDSiCCDS56684.1
RefSeqiNP_780583.1, NM_175374.3
UniGeneiMm.55082

3D structure databases

ProteinModelPortaliQ8BJU9
SMRiQ8BJU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019908

PTM databases

PhosphoSitePlusiQ8BJU9

Proteomic databases

EPDiQ8BJU9
MaxQBiQ8BJU9
PaxDbiQ8BJU9
PeptideAtlasiQ8BJU9
PRIDEiQ8BJU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019908; ENSMUSP00000019908; ENSMUSG00000019774
GeneIDi108853
KEGGimmu:108853
UCSCiuc007egi.1 mouse

Organism-specific databases

CTDi54516
MGIiMGI:1918830 Mtrf1l

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOGENOMiHOG000074815
HOVERGENiHBG017071
InParanoidiQ8BJU9
KOiK02835
OMAiWKVEIVS
OrthoDBiEOG091G0O7T
PhylomeDBiQ8BJU9
TreeFamiTF313720

Enzyme and pathway databases

ReactomeiR-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMtrf1l mouse
PROiPR:Q8BJU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019774 Expressed in 228 organ(s), highest expression level in blastocyst
GenevisibleiQ8BJU9 MM

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRF1ML_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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