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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Gene namesi
Name:Sgta
Synonyms:Sgt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1098703 Sgta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063661 – 315Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphothreonineCombined sources1
Modified residuei85PhosphoserineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei305PhosphothreonineCombined sources1
Modified residuei307PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8BJU0
PeptideAtlasiQ8BJU0
PRIDEiQ8BJU0

PTM databases

iPTMnetiQ8BJU0
PhosphoSitePlusiQ8BJU0
SwissPalmiQ8BJU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000004937 Expressed in 292 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ8BJU0 baseline and differential
GenevisibleiQ8BJU0 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B (PubMed:17034881). Interacts (via TPR repeats) with HSP90AA1. Interacts (via Gln-rich region) with SLC2A1 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (By similarity). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (By similarity). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206659, 4 interactors
CORUMiQ8BJU0
STRINGi10090.ENSMUSP00000005067

Structurei

3D structure databases

ProteinModelPortaliQ8BJU0
SMRiQ8BJU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 125TPR 1Add BLAST34
Repeati126 – 159TPR 2Add BLAST34
Repeati160 – 193TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 288Gln-richAdd BLAST13

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiQ8BJU0
KOiK16365
OMAiNPGFMNM
OrthoDBiEOG091G0C0Q
PhylomeDBiQ8BJU0
TreeFamiTF313092

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BJU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS
60 70 80 90 100
DLALPQTLPE IFEAATSSKQ EMPQDPRAPD RTPPSEEDSA EAERLKTEGN
110 120 130 140 150
EQMKLENFEA AVHLYGKAIE LNPANAVYFC NRAAAYSKLG NYVGAVQDCE
160 170 180 190 200
RAIGIDPGYS KAYGRMGLAL SSLNKHAEAV AYYKKALELD PDNDTYKSNL
210 220 230 240 250
KIAELKLREA PSPTGGVGSL DIAGLLNNPH FITMASSLMN SPQLQQLMSG
260 270 280 290 300
MISGGHNPLG TPGSSPQQSD LASLIQAGQQ FAQQMQQQNP EFVEQIRSQV
310
VRSRTPSASH EEQQE
Length:315
Mass (Da):34,322
Last modified:January 16, 2004 - v2
Checksum:i6FB8D3978CF56D4C
GO
Isoform 2 (identifier: Q8BJU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: Missing.

Show »
Length:314
Mass (Da):34,194
Checksum:iB011B0CAAE4508A9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7I5A0A1W2P7I5_MOUSE
Small glutamine-rich tetratricopept...
Sgta
166Annotation score:
A0A1W2P6P1A0A1W2P6P1_MOUSE
Small glutamine-rich tetratricopept...
Sgta
211Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207L → F in BAC37566 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00930070Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039966 mRNA Translation: BAC30486.1
AK051005 mRNA Translation: BAC34494.1
AK079168 mRNA Translation: BAC37566.1
BC003836 mRNA Translation: AAH03836.1
CCDSiCCDS35990.1 [Q8BJU0-1]
RefSeqiNP_078775.1, NM_024499.1 [Q8BJU0-1]
XP_006513939.1, XM_006513876.3
XP_006513940.1, XM_006513877.1 [Q8BJU0-2]
XP_017169518.1, XM_017314029.1
UniGeneiMm.30068

Genome annotation databases

EnsembliENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937 [Q8BJU0-1]
ENSMUST00000218208; ENSMUSP00000151949; ENSMUSG00000004937 [Q8BJU0-2]
GeneIDi52551
KEGGimmu:52551
UCSCiuc007gft.1 mouse [Q8BJU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039966 mRNA Translation: BAC30486.1
AK051005 mRNA Translation: BAC34494.1
AK079168 mRNA Translation: BAC37566.1
BC003836 mRNA Translation: AAH03836.1
CCDSiCCDS35990.1 [Q8BJU0-1]
RefSeqiNP_078775.1, NM_024499.1 [Q8BJU0-1]
XP_006513939.1, XM_006513876.3
XP_006513940.1, XM_006513877.1 [Q8BJU0-2]
XP_017169518.1, XM_017314029.1
UniGeneiMm.30068

3D structure databases

ProteinModelPortaliQ8BJU0
SMRiQ8BJU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206659, 4 interactors
CORUMiQ8BJU0
STRINGi10090.ENSMUSP00000005067

PTM databases

iPTMnetiQ8BJU0
PhosphoSitePlusiQ8BJU0
SwissPalmiQ8BJU0

Proteomic databases

PaxDbiQ8BJU0
PeptideAtlasiQ8BJU0
PRIDEiQ8BJU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937 [Q8BJU0-1]
ENSMUST00000218208; ENSMUSP00000151949; ENSMUSG00000004937 [Q8BJU0-2]
GeneIDi52551
KEGGimmu:52551
UCSCiuc007gft.1 mouse [Q8BJU0-1]

Organism-specific databases

CTDi6449
MGIiMGI:1098703 Sgta

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiQ8BJU0
KOiK16365
OMAiNPGFMNM
OrthoDBiEOG091G0C0Q
PhylomeDBiQ8BJU0
TreeFamiTF313092

Miscellaneous databases

ChiTaRSiSgta mouse
PROiPR:Q8BJU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004937 Expressed in 292 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ8BJU0 baseline and differential
GenevisibleiQ8BJU0 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGTA_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU0
Secondary accession number(s): Q8BGA6, Q99L52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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