Smarcal1

Functionⁱ

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	417 – 424	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

annealing helicase activity Source: UniProtKB
ATP binding Source: UniProtKB-KW
DNA-dependent ATPase activity
Source: MGI
Inferred from direct assayⁱ
- 10857751
helicase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: UniProtKB
DNA metabolic process Source: UniProtKB
DNA repair Source: InterPro
regulation of transcription by RNA polymerase II Source: UniProtKB
replication fork processing Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC:3.6.4.-) Alternative name(s): HepA-related protein Short name: mharp Sucrose nonfermenting protein 2-like 1
Gene namesⁱ	Name:Smarcal1 Synonyms:Harp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1859183 Smarcal1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000074349	2 – 910	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1Add BLAST		909

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	118	PhosphoserineBy similarity	1
Modified residueⁱ	165	PhosphoserineBy similarity	1

Post-translational modificationⁱ

DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8BJL0
PeptideAtlas More...PeptideAtlasⁱ	Q8BJL0
PRIDEⁱ	Q8BJL0

PTM databases

iPTMnetⁱ	Q8BJL0
PhosphoSitePlusⁱ	Q8BJL0

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with high levels in brain, heart, kidney, liver and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000039354
ExpressionAtlasⁱ	Q8BJL0 baseline and differential
Genevisibleⁱ	Q8BJL0 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RPA2; the interaction is direct and mediates the recruitment by the RPA complex of SMARCAL1 to sites of DNA damage.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000047589

STRINGⁱ

10090.ENSMUSP00000047589

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	203 – 210	Combined sources	8
Beta strandⁱ	213 – 218	Combined sources	6
Helixⁱ	222 – 230	Combined sources	9
Beta strandⁱ	235 – 237	Combined sources	3
Turnⁱ	238 – 241	Combined sources	4
Beta strandⁱ	242 – 246	Combined sources	5
Helixⁱ	247 – 249	Combined sources	3
Helixⁱ	250 – 257	Combined sources	8
Beta strandⁱ	263 – 266	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4O66	X-ray	1.90	A/B/C/D	197-268	[»]
ProteinModelPortalⁱ	Q8BJL0
SMRⁱ	Q8BJL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	199 – 269	HARP 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	286 – 357	HARP 2PROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	404 – 559	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST	156
Domainⁱ	674 – 827	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST	154

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 29	Mediates interaction with RPA2By similarityAdd BLAST		28

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	3 – 34	Sequence analysisAdd BLAST		32

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	508 – 511	DESH box		4

Sequence similaritiesⁱ

Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1000 Eukaryota COG0553 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144109
HOVERGENⁱ	HBG054110
InParanoidⁱ	Q8BJL0
KEGG Orthology (KO) More...KOⁱ	K14440
OMAⁱ	ANMGLTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A1B
PhylomeDBⁱ	Q8BJL0
TreeFamⁱ	TF106474

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR030101 HARP(SMARCAL1) IPR010003 HARP_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
PANTHERⁱ	PTHR10799:SF731 PTHR10799:SF731, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07443 HARP, 2 hits PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 3 hits
PROSITEⁱ	View protein in PROSITE PS51467 HARP, 2 hits PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BJL0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLPLTEEQR KKIEENRQKA LARRAEKLSE QPQSAASGSS AAGPSQSKQG 
        60         70         80         90        100
SLLNLLAEPS KPVGHASIFK QQNLSNSFPT DQRPHSSRCS QPSPAEETTG 
       110        120        130        140        150
LWKTQGEMST ACPKPNPSPP GASNQPLLGY KSSEGQPQAT WDTGASSSGP 
       160        170        180        190        200
FPRDPELEAK AARPSTSRQS ISDSFYVLGG KTPRTEGRPP NILQTTPQNT 
       210        220        230        240        250
GFLRGACIKT GDRFRVKIGY NQELIAVFKS LPSRHYDSFT KTWDFSMSDY 
       260        270        280        290        300
RALMKAVERL STVSLKPLDE AGGSVGGQTS LPSAPSLTFV TGKCMLISRV 
       310        320        330        340        350
RFEVDIGYSE AVIGLFKQME SRSYDIKTRK WSFLLEEHNK LIARSRELKQ 
       360        370        380        390        400
VQLDPLPKTV TLAFASQLEK TSPKLKADVP EADLSGVDAK LVSSLMPFQR 
       410        420        430        440        450
EGVSFAISKR GRLLLADDMG LGKTVQAICI AAFYRKEWPL LVVVPSSVRF 
       460        470        480        490        500
TWEQAFLRWL PSLSPENINV VVTGKGRLTA GLVNIVSFDL LCKLERQLKT 
       510        520        530        540        550
PFKVVIIDES HFLKNIKTAR CRAAVPILKV AKRVILLSGT PAMSRPAELY 
       560        570        580        590        600
TQIIAVKPTF FPQFHAFGLR YCDAKRLPWG WDYSGSSNLG ELKLLLEEAI 
       610        620        630        640        650
MLRRLKSDVL SQLPAKQRKM VVVNPGRISS RAKAALDAAA KEMTKDKTKQ 
       660        670        680        690        700
QQKEALLVFF NRTAEAKIPC VVEYILDLLD SGREKFLVFA HHKVILDAVA 
       710        720        730        740        750
KELERKNVQH IRIDGSTPSA DREAQCQRFQ LSKGHTVALL SITAANMGLT 
       760        770        780        790        800
FSTADLVVFA ELFWNPGVLI QAEDRVHRIG QTNSVSIHYL VAKGTADDYL 
       810        820        830        840        850
WPLIQEKIKV LGEAGLSETN FSEMTEATDY VHKDPKQKTI YDLFQQSFED 
       860        870        880        890        900
DGNDMEFLEA AESFELGSTS GTSGNISQDL GDLLDEDEGS PPKKSRFEFF 
       910
DNWDSFSSPF

Length:910

Mass (Da):100,840

Last modified:March 1, 2003 - v1

Checksum:ⁱF6B28F847BD6FC18

GO

Isoform 2 (identifier: Q8BJL0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
769-788: LIQAEDRVHRIGQTNSVSIH → GNVARVPLGMPRAEKYKIRK
789-910: Missing.

« Hide

        10         20         30         40         50
MSLPLTEEQR KKIEENRQKA LARRAEKLSE QPQSAASGSS AAGPSQSKQG 
        60         70         80         90        100
SLLNLLAEPS KPVGHASIFK QQNLSNSFPT DQRPHSSRCS QPSPAEETTG 
       110        120        130        140        150
LWKTQGEMST ACPKPNPSPP GASNQPLLGY KSSEGQPQAT WDTGASSSGP 
       160        170        180        190        200
FPRDPELEAK AARPSTSRQS ISDSFYVLGG KTPRTEGRPP NILQTTPQNT 
       210        220        230        240        250
GFLRGACIKT GDRFRVKIGY NQELIAVFKS LPSRHYDSFT KTWDFSMSDY 
       260        270        280        290        300
RALMKAVERL STVSLKPLDE AGGSVGGQTS LPSAPSLTFV TGKCMLISRV 
       310        320        330        340        350
RFEVDIGYSE AVIGLFKQME SRSYDIKTRK WSFLLEEHNK LIARSRELKQ 
       360        370        380        390        400
VQLDPLPKTV TLAFASQLEK TSPKLKADVP EADLSGVDAK LVSSLMPFQR 
       410        420        430        440        450
EGVSFAISKR GRLLLADDMG LGKTVQAICI AAFYRKEWPL LVVVPSSVRF 
       460        470        480        490        500
TWEQAFLRWL PSLSPENINV VVTGKGRLTA GLVNIVSFDL LCKLERQLKT 
       510        520        530        540        550
PFKVVIIDES HFLKNIKTAR CRAAVPILKV AKRVILLSGT PAMSRPAELY 
       560        570        580        590        600
TQIIAVKPTF FPQFHAFGLR YCDAKRLPWG WDYSGSSNLG ELKLLLEEAI 
       610        620        630        640        650
MLRRLKSDVL SQLPAKQRKM VVVNPGRISS RAKAALDAAA KEMTKDKTKQ 
       660        670        680        690        700
QQKEALLVFF NRTAEAKIPC VVEYILDLLD SGREKFLVFA HHKVILDAVA 
       710        720        730        740        750
KELERKNVQH IRIDGSTPSA DREAQCQRFQ LSKGHTVALL SITAANMGLT 
       760        770        780 
FSTADLVVFA ELFWNPGVGN VARVPLGMPR AEKYKIRK

Note: May be due to an intron retention.

Show »

Length:788

Mass (Da):87,126

Checksum:ⁱAE70BAB0A799A3F8

GO

Isoform 3 (identifier: Q8BJL0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
508-574: DESHFLKNIK...HAFGLRYCDA → VSNGIALKYF...QPLSLCARLS
575-910: Missing.

« Hide

        10         20         30         40         50
MSLPLTEEQR KKIEENRQKA LARRAEKLSE QPQSAASGSS AAGPSQSKQG 
        60         70         80         90        100
SLLNLLAEPS KPVGHASIFK QQNLSNSFPT DQRPHSSRCS QPSPAEETTG 
       110        120        130        140        150
LWKTQGEMST ACPKPNPSPP GASNQPLLGY KSSEGQPQAT WDTGASSSGP 
       160        170        180        190        200
FPRDPELEAK AARPSTSRQS ISDSFYVLGG KTPRTEGRPP NILQTTPQNT 
       210        220        230        240        250
GFLRGACIKT GDRFRVKIGY NQELIAVFKS LPSRHYDSFT KTWDFSMSDY 
       260        270        280        290        300
RALMKAVERL STVSLKPLDE AGGSVGGQTS LPSAPSLTFV TGKCMLISRV 
       310        320        330        340        350
RFEVDIGYSE AVIGLFKQME SRSYDIKTRK WSFLLEEHNK LIARSRELKQ 
       360        370        380        390        400
VQLDPLPKTV TLAFASQLEK TSPKLKADVP EADLSGVDAK LVSSLMPFQR 
       410        420        430        440        450
EGVSFAISKR GRLLLADDMG LGKTVQAICI AAFYRKEWPL LVVVPSSVRF 
       460        470        480        490        500
TWEQAFLRWL PSLSPENINV VVTGKGRLTA GLVNIVSFDL LCKLERQLKT 
       510        520        530        540        550
PFKVVIIVSN GIALKYFVCL DTRKGSTDLG ICVLLGPLWA LRREGNRNRC 
       560        570 
LSFIENDFFI PFLKQPLSLC ARLS

Note: No experimental confirmation available.

Show »

Length:574

Mass (Da):63,218

Checksum:ⁱ0E8930A229E115E8

GO

Isoform 4 (identifier: Q8BJL0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
404-404: S → R
405-910: Missing.

« Hide

        10         20         30         40         50
MSLPLTEEQR KKIEENRQKA LARRAEKLSE QPQSAASGSS AAGPSQSKQG 
        60         70         80         90        100
SLLNLLAEPS KPVGHASIFK QQNLSNSFPT DQRPHSSRCS QPSPAEETTG 
       110        120        130        140        150
LWKTQGEMST ACPKPNPSPP GASNQPLLGY KSSEGQPQAT WDTGASSSGP 
       160        170        180        190        200
FPRDPELEAK AARPSTSRQS ISDSFYVLGG KTPRTEGRPP NILQTTPQNT 
       210        220        230        240        250
GFLRGACIKT GDRFRVKIGY NQELIAVFKS LPSRHYDSFT KTWDFSMSDY 
       260        270        280        290        300
RALMKAVERL STVSLKPLDE AGGSVGGQTS LPSAPSLTFV TGKCMLISRV 
       310        320        330        340        350
RFEVDIGYSE AVIGLFKQME SRSYDIKTRK WSFLLEEHNK LIARSRELKQ 
       360        370        380        390        400
VQLDPLPKTV TLAFASQLEK TSPKLKADVP EADLSGVDAK LVSSLMPFQR 

EGVR

Note: No experimental confirmation available.

Show »

Length:404

Mass (Da):44,190

Checksum:ⁱ92E5249A242D75A6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	35	A → T in AAH29078 (PubMed:15489334).Curated	1
Sequence conflictⁱ	78	F → L in AAH29078 (PubMed:15489334).Curated	1
Sequence conflictⁱ	529	K → N in BAE32320 (PubMed:16141072).Curated	1
Sequence conflictⁱ	685	K → R in BAC31469 (PubMed:16141072).Curated	1
Sequence conflictⁱ	717 – 725	Missing in AAG47648 (PubMed:10857751).Curated	9
Sequence conflictⁱ	717	T → R in AAF24985 (PubMed:10857751).Curated	1
Sequence conflictⁱ	719 – 721	SAD → TRA in AAF24985 (PubMed:10857751).Curated	3
Sequence conflictⁱ	724 – 725	AQ → LK in AAF24985 (PubMed:10857751).Curated	2
Sequence conflictⁱ	743	T → P in AAF24985 (PubMed:10857751).Curated	1
Sequence conflictⁱ	834	D → A in AAF24985 (PubMed:10857751).Curated	1
Sequence conflictⁱ	834	Missing in AAG47648 (PubMed:10857751).Curated	1
Sequence conflictⁱ	866 – 868	LGS → IKN in AAF24985 (PubMed:10857751).Curated	3

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036216	404	S → R in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_036217	405 – 910	Missing in isoform 4. 1 PublicationAdd BLAST	506
Alternative sequenceⁱVSP_036218	508 – 574	DESHF…RYCDA → VSNGIALKYFVCLDTRKGST DLGICVLLGPLWALRREGNR NRCLSFIENDFFIPFLKQPL SLCARLS in isoform 3. 1 PublicationAdd BLAST	67
Alternative sequenceⁱVSP_036219	575 – 910	Missing in isoform 3. 1 PublicationAdd BLAST	336
Alternative sequenceⁱVSP_012919	769 – 788	LIQAE…SVSIH → GNVARVPLGMPRAEKYKIRK in isoform 2. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_012920	789 – 910	Missing in isoform 2. 1 PublicationAdd BLAST	122

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF088884 mRNA Translation: AAF24985.1 AF209773 Genomic DNA Translation: AAG47648.1 AK042332 mRNA Translation: BAE20630.1 AK043129 mRNA Translation: BAC31469.1 AK077878 mRNA Translation: BAC37047.1 AK083488 mRNA Translation: BAC38933.1 AK154020 mRNA Translation: BAE32320.1 AK169465 mRNA Translation: BAE41189.1 BC029078 mRNA Translation: AAH29078.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35609.1 [Q8BJL0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061287.2, NM_018817.2 [Q8BJL0-1] XP_006496204.1, XM_006496141.3 [Q8BJL0-1] XP_006496205.1, XM_006496142.3 [Q8BJL0-1] XP_006496206.1, XM_006496143.3 [Q8BJL0-1] XP_006496207.1, XM_006496144.1 [Q8BJL0-1]
UniGeneⁱ	Mm.274232

Genome annotation databases

Ensemblⁱ	ENSMUST00000047615; ENSMUSP00000047589; ENSMUSG00000039354 [Q8BJL0-1] ENSMUST00000152225; ENSMUSP00000137833; ENSMUSG00000039354 [Q8BJL0-1]
GeneIDⁱ	54380
KEGGⁱ	mmu:54380
UCSC genome browser More...UCSCⁱ	uc007bko.2 mouse [Q8BJL0-4] uc007bkq.2 mouse [Q8BJL0-3] uc007bkr.2 mouse [Q8BJL0-2] uc007bks.2 mouse [Q8BJL0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8BJL0	UPI0005ABAF0A		MOUSE		800
UPI000A3047F7		MUSPA		910
UPI000A316F5F		MUSCR		910
UPI0003D7394E		MOUSE		616
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (Fragment)		MOUSE		98
+1

Protein	Similar proteins		Species	Score	Length
Q8BJL0	UPI0005ABAF0A		MOUSE		800
UPI000A3047F7		MUSPA		910
UPI000A316F5F		MUSCR		910
UPI0003957972		PSEHU		965
UPI00053400F1		Corvus cornix cornix		971
+35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF088884 mRNA Translation: AAF24985.1 AF209773 Genomic DNA Translation: AAG47648.1 AK042332 mRNA Translation: BAE20630.1 AK043129 mRNA Translation: BAC31469.1 AK077878 mRNA Translation: BAC37047.1 AK083488 mRNA Translation: BAC38933.1 AK154020 mRNA Translation: BAE32320.1 AK169465 mRNA Translation: BAE41189.1 BC029078 mRNA Translation: AAH29078.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35609.1 [Q8BJL0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061287.2, NM_018817.2 [Q8BJL0-1] XP_006496204.1, XM_006496141.3 [Q8BJL0-1] XP_006496205.1, XM_006496142.3 [Q8BJL0-1] XP_006496206.1, XM_006496143.3 [Q8BJL0-1] XP_006496207.1, XM_006496144.1 [Q8BJL0-1]
UniGeneⁱ	Mm.274232

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4O66	X-ray	1.90	A/B/C/D	197-268	[»]
ProteinModelPortalⁱ	Q8BJL0
SMRⁱ	Q8BJL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000047589

STRINGⁱ

10090.ENSMUSP00000047589

PTM databases

iPTMnetⁱ	Q8BJL0
PhosphoSitePlusⁱ	Q8BJL0

Proteomic databases

PaxDbⁱ	Q8BJL0
PeptideAtlas More...PeptideAtlasⁱ	Q8BJL0
PRIDEⁱ	Q8BJL0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047615; ENSMUSP00000047589; ENSMUSG00000039354 [Q8BJL0-1] ENSMUST00000152225; ENSMUSP00000137833; ENSMUSG00000039354 [Q8BJL0-1]
GeneIDⁱ	54380
KEGGⁱ	mmu:54380
UCSC genome browser More...UCSCⁱ	uc007bko.2 mouse [Q8BJL0-4] uc007bkq.2 mouse [Q8BJL0-3] uc007bkr.2 mouse [Q8BJL0-2] uc007bks.2 mouse [Q8BJL0-1]

Organism-specific databases

CTDⁱ	50485
MGIⁱ	MGI:1859183 Smarcal1

Phylogenomic databases

eggNOGⁱ	KOG1000 Eukaryota COG0553 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144109
HOVERGENⁱ	HBG054110
InParanoidⁱ	Q8BJL0
KEGG Orthology (KO) More...KOⁱ	K14440
OMAⁱ	ANMGLTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A1B
PhylomeDBⁱ	Q8BJL0
TreeFamⁱ	TF106474

Miscellaneous databases

ChiTaRSⁱ	Smarcal1 mouse
Protein Ontology More...PROⁱ	PR:Q8BJL0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039354
ExpressionAtlasⁱ	Q8BJL0 baseline and differential
Genevisibleⁱ	Q8BJL0 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR030101 HARP(SMARCAL1) IPR010003 HARP_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
PANTHERⁱ	PTHR10799:SF731 PTHR10799:SF731, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07443 HARP, 2 hits PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 3 hits
PROSITEⁱ	View protein in PROSITE PS51467 HARP, 2 hits PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMAL1_MOUSE
Accessionⁱ	Q8BJL0Primary (citable) accession number: Q8BJL0 Secondary accession number(s): Q3TEQ9 Q9QYC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	March 1, 2003
	Last modified:	April 25, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8BJL0 (SMAL1_MOUSE)

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ