UniProtKB - Q8BJ71 (NUP93_MOUSE)
Nuclear pore complex protein Nup93
Nup93
Functioni
GO - Molecular functioni
- structural constituent of nuclear pore Source: UniProtKB
GO - Biological processi
- nuclear envelope organization Source: UniProtKB
- nuclear pore complex assembly Source: UniProtKB
- poly(A)+ mRNA export from nucleus Source: GO_Central
- positive regulation of SMAD protein signal transduction Source: UniProtKB
- protein import into nucleus Source: GO_Central
- SMAD protein signal transduction Source: UniProtKB
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-159227, Transport of the SLBP independent Mature mRNA R-MMU-159230, Transport of the SLBP Dependant Mature mRNA R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-MMU-191859, snRNP Assembly R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3232142, SUMOylation of ubiquitinylation proteins R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly R-MMU-3371453, Regulation of HSF1-mediated heat shock response R-MMU-4085377, SUMOylation of SUMOylation proteins R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-4615885, SUMOylation of DNA replication proteins R-MMU-5578749, Transcriptional regulation by small RNAs R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear pore complex protein Nup93Alternative name(s): 93 kDa nucleoporin CBP-interacting protein 4 Nucleoporin Nup93 |
Gene namesi | Name:Nup93 Synonyms:Cip4, Kiaa0095 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919055, Nup93 |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity; Peripheral membrane protein By similarity
- nuclear pore complex By similarity
- Nucleus envelope 1 Publication
Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.By similarity
Nucleus
- nuclear envelope Source: UniProtKB
- nuclear membrane Source: UniProtKB
- nuclear periphery Source: UniProtKB
- nuclear pore Source: UniProtKB
Keywords - Cellular componenti
Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124783 | 1 – 819 | Nuclear pore complex protein Nup93Add BLAST | 819 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 52 | PhosphoserineBy similarity | 1 | |
Modified residuei | 66 | PhosphoserineBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | PhosphoserineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineBy similarity | 1 | |
Modified residuei | 430 | PhosphoserineBy similarity | 1 | |
Modified residuei | 767 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8BJ71 |
jPOSTi | Q8BJ71 |
PaxDbi | Q8BJ71 |
PeptideAtlasi | Q8BJ71 |
PRIDEi | Q8BJ71 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00222307 IPI00410800 |
PTM databases
iPTMneti | Q8BJ71 |
PhosphoSitePlusi | Q8BJ71 |
SwissPalmi | Q8BJ71 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032939, Expressed in liver and 298 other tissues |
ExpressionAtlasi | Q8BJ71, baseline and differential |
Genevisiblei | Q8BJ71, MM |
Interactioni
Subunit structurei
Part of the nuclear pore complex (NPC).
Component of the p62 complex, a complex composed of NUP62 and NUP54.
Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct. Does not interact with TPR.
Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling.
By similarityProtein-protein interaction databases
BioGRIDi | 214942, 22 interactors |
ComplexPortali | CPX-4474, Nuclear pore complex |
IntActi | Q8BJ71, 4 interactors |
MINTi | Q8BJ71 |
STRINGi | 10090.ENSMUSP00000105174 |
Miscellaneous databases
RNActi | Q8BJ71, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2168, Eukaryota |
GeneTreei | ENSGT00390000016353 |
HOGENOMi | CLU_011846_1_0_1 |
InParanoidi | Q8BJ71 |
OMAi | RHAHEQN |
OrthoDBi | 187731at2759 |
PhylomeDBi | Q8BJ71 |
TreeFami | TF315118 |
Family and domain databases
InterProi | View protein in InterPro IPR007231, Nucleoporin_int_Nup93/Nic96 |
PANTHERi | PTHR11225, PTHR11225, 1 hit |
Pfami | View protein in Pfam PF04097, Nic96, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR
60 70 80 90 100
TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA
160 170 180 190 200
SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS IEMAYARQIY IYNEKIVSGH
210 220 230 240 250
LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV
260 270 280 290 300
RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
310 320 330 340 350
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT
360 370 380 390 400
WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT
410 420 430 440 450
DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE
460 470 480 490 500
SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK
510 520 530 540 550
LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY
560 570 580 590 600
FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
610 620 630 640 650
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV
660 670 680 690 700
PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD
710 720 730 740 750
EYHSGHIDRA FDIIDRLKLV PLNQESVEER VAAFRNFSDE IRHNLSEVLL
760 770 780 790 800
ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP
810
YRTSGDTNAR LVQMEVLMN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLQ0 | A0A1D5RLQ0_MOUSE | Nuclear pore complex protein Nup93 | Nup93 | 699 | Annotation score: | ||
A0A1D5RM86 | A0A1D5RM86_MOUSE | Nuclear pore complex protein Nup93 | Nup93 | 18 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 116 | E → K in CAD43733 (Ref. 5) Curated | 1 | |
Sequence conflicti | 463 | F → Y in BAC32337 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 626 | A → V in AAH23140 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 816 – 819 | VLMN → LLSWEVH in BAC32337 (PubMed:16141072).Curated | 4 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010089 | 1 – 123 | Missing in isoform 2. 1 PublicationAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028864 mRNA Translation: BAC26158.1 AK045380 mRNA Translation: BAC32337.1 AK129055 Transcribed RNA Translation: BAC97865.2 Frameshift. AK167105 mRNA Translation: BAE39254.1 AK169693 mRNA Translation: BAE41309.1 BC023140 mRNA Translation: AAH23140.1 AJ505051 Other RNA Translation: CAD43733.1 |
CCDSi | CCDS22540.1 [Q8BJ71-1] |
RefSeqi | NP_765998.1, NM_172410.2 [Q8BJ71-1] XP_006531437.1, XM_006531374.3 XP_006531438.1, XM_006531375.3 XP_006531439.1, XM_006531376.2 [Q8BJ71-2] |
Genome annotation databases
Ensembli | ENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939 [Q8BJ71-1] ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939 [Q8BJ71-1] ENSMUST00000212824; ENSMUSP00000148700; ENSMUSG00000032939 [Q8BJ71-1] |
GeneIDi | 71805 |
KEGGi | mmu:71805 |
UCSCi | uc009mvz.1, mouse [Q8BJ71-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028864 mRNA Translation: BAC26158.1 AK045380 mRNA Translation: BAC32337.1 AK129055 Transcribed RNA Translation: BAC97865.2 Frameshift. AK167105 mRNA Translation: BAE39254.1 AK169693 mRNA Translation: BAE41309.1 BC023140 mRNA Translation: AAH23140.1 AJ505051 Other RNA Translation: CAD43733.1 |
CCDSi | CCDS22540.1 [Q8BJ71-1] |
RefSeqi | NP_765998.1, NM_172410.2 [Q8BJ71-1] XP_006531437.1, XM_006531374.3 XP_006531438.1, XM_006531375.3 XP_006531439.1, XM_006531376.2 [Q8BJ71-2] |
3D structure databases
SMRi | Q8BJ71 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 214942, 22 interactors |
ComplexPortali | CPX-4474, Nuclear pore complex |
IntActi | Q8BJ71, 4 interactors |
MINTi | Q8BJ71 |
STRINGi | 10090.ENSMUSP00000105174 |
PTM databases
iPTMneti | Q8BJ71 |
PhosphoSitePlusi | Q8BJ71 |
SwissPalmi | Q8BJ71 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00222307 IPI00410800 |
Proteomic databases
EPDi | Q8BJ71 |
jPOSTi | Q8BJ71 |
PaxDbi | Q8BJ71 |
PeptideAtlasi | Q8BJ71 |
PRIDEi | Q8BJ71 |
Protocols and materials databases
Antibodypediai | 14851, 121 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939 [Q8BJ71-1] ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939 [Q8BJ71-1] ENSMUST00000212824; ENSMUSP00000148700; ENSMUSG00000032939 [Q8BJ71-1] |
GeneIDi | 71805 |
KEGGi | mmu:71805 |
UCSCi | uc009mvz.1, mouse [Q8BJ71-1] |
Organism-specific databases
CTDi | 9688 |
MGIi | MGI:1919055, Nup93 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2168, Eukaryota |
GeneTreei | ENSGT00390000016353 |
HOGENOMi | CLU_011846_1_0_1 |
InParanoidi | Q8BJ71 |
OMAi | RHAHEQN |
OrthoDBi | 187731at2759 |
PhylomeDBi | Q8BJ71 |
TreeFami | TF315118 |
Enzyme and pathway databases
Reactomei | R-MMU-159227, Transport of the SLBP independent Mature mRNA R-MMU-159230, Transport of the SLBP Dependant Mature mRNA R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-MMU-191859, snRNP Assembly R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3232142, SUMOylation of ubiquitinylation proteins R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly R-MMU-3371453, Regulation of HSF1-mediated heat shock response R-MMU-4085377, SUMOylation of SUMOylation proteins R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-4615885, SUMOylation of DNA replication proteins R-MMU-5578749, Transcriptional regulation by small RNAs R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Miscellaneous databases
BioGRID-ORCSi | 71805, 8 hits in 16 CRISPR screens |
ChiTaRSi | Nup93, mouse |
PROi | PR:Q8BJ71 |
RNActi | Q8BJ71, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032939, Expressed in liver and 298 other tissues |
ExpressionAtlasi | Q8BJ71, baseline and differential |
Genevisiblei | Q8BJ71, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007231, Nucleoporin_int_Nup93/Nic96 |
PANTHERi | PTHR11225, PTHR11225, 1 hit |
Pfami | View protein in Pfam PF04097, Nic96, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUP93_MOUSE | |
Accessioni | Q8BJ71Primary (citable) accession number: Q8BJ71 Secondary accession number(s): Q3TED9 Q8R592 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families