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Entry version 125 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Zinc finger CCCH domain-containing protein 14

Gene

Zc3h14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri681 – 698C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri700 – 718C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zc3h14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919824, Zc3h14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313131 – 735Zinc finger CCCH domain-containing protein 14Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei85PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei240PhosphoserineBy similarity1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei309PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei357N6-acetyllysine; alternateBy similarity1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei390PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei620PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BJ05

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BJ05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BJ05

PeptideAtlas

More...
PeptideAtlasi
Q8BJ05

PRoteomics IDEntifications database

More...
PRIDEi
Q8BJ05

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BJ05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BJ05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hippocampal pyramidal neurons (at protein level) (PubMed:21734151).Expressed in kidney, liver, muscle, heart brain and testes (PubMed:19303045). Expressed in hippocampal pyramidal neurons (PubMed:21734151).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021012, Expressed in testis and 302 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BJ05, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BJ05, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HOOK2.

Interacts with ZFC3H1 in a RNase-sensitive manner.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
217572, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8BJ05, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8BJ05

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105732

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BJ05, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BJ05

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H14 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri681 – 698C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri700 – 718C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3702, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000038430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022605_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BJ05

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESMVHTD

Database of Orthologous Groups

More...
OrthoDBi
893844at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BJ05

TreeFam database of animal gene trees

More...
TreeFami
TF329509

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040366, Nab2/ZC3H14
IPR000571, Znf_CCCH

The PANTHER Classification System

More...
PANTHERi
PTHR14738, PTHR14738, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356, ZnF_C3H1, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103, ZF_C3H1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BJ05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDASI FDSHVPSNKS
110 120 130 140 150
SFSRGDERRH EAAVPPLAVS SSRPEKRDSR VSTSSQEQKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENPLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RLQLHPQQSS AHAAKQLDVQ
260 270 280 290 300
SSQVSEAGRL CEPPVLSSVE DTYSPFFRNN LDKMSIEDEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRIGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYSAVPQKQT LPVAPRTRTS QEELLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NTGKSQGTQQ RQLLSRLQID PVMVETMEMS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDTKCTKA
660 670 680 690 700
DCPFTHMSRR ASILTPKPVS SPAPSSNGQL CRYFPACKKM ECPFYHPKHC
710 720 730
RFNTQCTRPD CTFYHPTITV PPRHALKWIR PQSSE
Length:735
Mass (Da):82,409
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i550696563E7E87C3
GO
Isoform 2 (identifier: Q8BJ05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-582: Missing.

Show »
Length:579
Mass (Da):64,937
Checksum:i71F35EE73B829234
GO
Isoform 3 (identifier: Q8BJ05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-582: Missing.

Show »
Length:604
Mass (Da):67,839
Checksum:iBA1E05A017712FAE
GO
Isoform 4 (identifier: Q8BJ05-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.
     296-426: LPVVSSVVKV...AKGDNTGKSQ → MKMSSRFSSP...LIGFLTEVEK
     452-582: Missing.

Show »
Length:309
Mass (Da):35,073
Checksum:i054E426908EA5224
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VK20A0A1Y7VK20_MOUSE
Zinc finger CCCH domain-containing ...
Zc3h14
238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJD9A0A1Y7VJD9_MOUSE
Zinc finger CCCH domain-containing ...
Zc3h14
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VK72A0A1Y7VK72_MOUSE
Zinc finger CCCH domain-containing ...
Zc3h14
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VP61A0A1Y7VP61_MOUSE
Zinc finger CCCH domain-containing ...
Zc3h14
70Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27D → H in BAC34134 (PubMed:16141072).Curated1
Sequence conflicti665T → A in BAE36101 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331771 – 295Missing in isoform 4. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_033178296 – 426LPVVS…TGKSQ → MKMSSRFSSPSLPVFLSPEP ADLGSLTSASCSLNELGNIS YLLRKIATDINEMKGMKAAI LTVEANLFDLNVRVSQNEAK ISSLEVKMNEYLTSTSECNR QLEDFQERLEFESQSETTDA NLIGFLTEVEK in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_033179427 – 582Missing in isoform 2. 2 PublicationsAdd BLAST156
Alternative sequenceiVSP_033180452 – 582Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST131

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK006009 mRNA Translation: BAB24364.1
AK048046 mRNA Translation: BAC33222.1
AK050226 mRNA Translation: BAC34134.1
AK160937 mRNA Translation: BAE36101.1
BC021797 mRNA Translation: AAH21797.1
BC024824 mRNA Translation: AAH24824.1
BC024856 mRNA Translation: AAH24856.1
BC026610 mRNA Translation: AAH26610.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26099.1 [Q8BJ05-3]
CCDS26100.1 [Q8BJ05-1]
CCDS49138.1 [Q8BJ05-2]
CCDS49139.1 [Q8BJ05-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001008506.2, NM_001008506.2 [Q8BJ05-3]
NP_001153579.1, NM_001160107.1 [Q8BJ05-2]
NP_001153580.1, NM_001160108.1 [Q8BJ05-4]
NP_083610.2, NM_029334.2 [Q8BJ05-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000021399; ENSMUSP00000021399; ENSMUSG00000021012 [Q8BJ05-4]
ENSMUST00000057000; ENSMUSP00000055879; ENSMUSG00000021012 [Q8BJ05-2]
ENSMUST00000110104; ENSMUSP00000105731; ENSMUSG00000021012 [Q8BJ05-3]
ENSMUST00000110105; ENSMUSP00000105732; ENSMUSG00000021012 [Q8BJ05-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
75553

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:75553

UCSC genome browser

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UCSCi
uc007org.1, mouse [Q8BJ05-1]
uc007orh.1, mouse [Q8BJ05-3]
uc007ori.1, mouse [Q8BJ05-2]
uc007orl.2, mouse [Q8BJ05-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006009 mRNA Translation: BAB24364.1
AK048046 mRNA Translation: BAC33222.1
AK050226 mRNA Translation: BAC34134.1
AK160937 mRNA Translation: BAE36101.1
BC021797 mRNA Translation: AAH21797.1
BC024824 mRNA Translation: AAH24824.1
BC024856 mRNA Translation: AAH24856.1
BC026610 mRNA Translation: AAH26610.1
CCDSiCCDS26099.1 [Q8BJ05-3]
CCDS26100.1 [Q8BJ05-1]
CCDS49138.1 [Q8BJ05-2]
CCDS49139.1 [Q8BJ05-4]
RefSeqiNP_001008506.2, NM_001008506.2 [Q8BJ05-3]
NP_001153579.1, NM_001160107.1 [Q8BJ05-2]
NP_001153580.1, NM_001160108.1 [Q8BJ05-4]
NP_083610.2, NM_029334.2 [Q8BJ05-1]

3D structure databases

SMRiQ8BJ05
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi217572, 2 interactors
IntActiQ8BJ05, 2 interactors
MINTiQ8BJ05
STRINGi10090.ENSMUSP00000105732

PTM databases

iPTMnetiQ8BJ05
PhosphoSitePlusiQ8BJ05

Proteomic databases

EPDiQ8BJ05
jPOSTiQ8BJ05
PaxDbiQ8BJ05
PeptideAtlasiQ8BJ05
PRIDEiQ8BJ05

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26309, 136 antibodies

Genome annotation databases

EnsembliENSMUST00000021399; ENSMUSP00000021399; ENSMUSG00000021012 [Q8BJ05-4]
ENSMUST00000057000; ENSMUSP00000055879; ENSMUSG00000021012 [Q8BJ05-2]
ENSMUST00000110104; ENSMUSP00000105731; ENSMUSG00000021012 [Q8BJ05-3]
ENSMUST00000110105; ENSMUSP00000105732; ENSMUSG00000021012 [Q8BJ05-1]
GeneIDi75553
KEGGimmu:75553
UCSCiuc007org.1, mouse [Q8BJ05-1]
uc007orh.1, mouse [Q8BJ05-3]
uc007ori.1, mouse [Q8BJ05-2]
uc007orl.2, mouse [Q8BJ05-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79882
MGIiMGI:1919824, Zc3h14

Phylogenomic databases

eggNOGiKOG3702, Eukaryota
GeneTreeiENSGT00440000038430
HOGENOMiCLU_022605_0_0_1
InParanoidiQ8BJ05
OMAiESMVHTD
OrthoDBi893844at2759
PhylomeDBiQ8BJ05
TreeFamiTF329509

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
75553, 3 hits in 15 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Zc3h14, mouse

Protein Ontology

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PROi
PR:Q8BJ05
RNActiQ8BJ05, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000021012, Expressed in testis and 302 other tissues
ExpressionAtlasiQ8BJ05, baseline and differential
GenevisibleiQ8BJ05, MM

Family and domain databases

InterProiView protein in InterPro
IPR040366, Nab2/ZC3H14
IPR000571, Znf_CCCH
PANTHERiPTHR14738, PTHR14738, 2 hits
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 3 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3HE_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BJ05
Secondary accession number(s): A0PJE7
, A1A4A9, Q3TU70, Q8BIY8, Q8R3Q8, Q8R3R2, Q9DAA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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