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Protein

Smad nuclear-interacting protein 1

Gene

Snip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencing

Names & Taxonomyi

Protein namesi
Recommended name:
Smad nuclear-interacting protein 1
Gene namesi
Name:Snip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2156003 Snip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720101 – 383Smad nuclear-interacting protein 1Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei33PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei145PhosphoserineBy similarity1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei381PhosphoserineBy similarity1

Post-translational modificationi

Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BIZ6
MaxQBiQ8BIZ6
PaxDbiQ8BIZ6
PeptideAtlasiQ8BIZ6
PRIDEiQ8BIZ6

PTM databases

iPTMnetiQ8BIZ6
PhosphoSitePlusiQ8BIZ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000050213 Expressed in 280 organ(s), highest expression level in brown adipose tissue
CleanExiMM_SNIP1
GenevisibleiQ8BIZ6 MM

Interactioni

Subunit structurei

Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BIZ6, 1 interactor
STRINGi10090.ENSMUSP00000060721

Structurei

3D structure databases

ProteinModelPortaliQ8BIZ6
SMRiQ8BIZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331FHAPROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 194Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 180Arg-richAdd BLAST119
Compositional biasi374 – 377Poly-Glu4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1882 Eukaryota
ENOG4111F4H LUCA
GeneTreeiENSGT00730000110659
HOGENOMiHOG000264922
HOVERGENiHBG056615
InParanoidiQ8BIZ6
KOiK13108
OMAiLKYHEPA
OrthoDBiEOG091G0M70
PhylomeDBiQ8BIZ6
TreeFamiTF312797

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BIZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAGKSERER SGRRRHRSGD ALTTVVVKQE RLSPEPVAHR RPDAPAASLS
60 70 80 90 100
PPAAEPGHSG HRGSRARSPA KKKSKSSGRR SKSPRTKRSQ SPHYPMVKVK
110 120 130 140 150
QEREDHPRRG REDRQHREPS EQEHRRARNS ERDRHRGHSR QGRSSDERPV
160 170 180 190 200
SGQDRDRDSQ NLQAQEEERD FHNARRREHR QQNESAGSEA QEVIPRPAGN
210 220 230 240 250
RSKEVPVKEK PSFELSGALL EDTNTFRGVV IKYSEPPEAR IPKKRWRLYP
260 270 280 290 300
FKNDEVLPVM YIHRQSAYLL GRHRRIADIP IDHPSCSKQH AVFQYRLVEY
310 320 330 340 350
TRADGTVGRR VKPYIIDLGS GNGTFLNNKR IEPQRYYELK EKDVLKFGFS
360 370 380
SREYVLLHES SDTSELDRKE DEDDEEEEMV SDS
Length:383
Mass (Da):44,415
Last modified:March 1, 2003 - v1
Checksum:i0ADD646D4CB952BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223T → P in BAC33680 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040571 mRNA Translation: BAE20582.1
AK049254 mRNA Translation: BAC33638.1
AK049318 mRNA Translation: BAC33680.1
AK132768 mRNA Translation: BAE21347.1
AK143801 mRNA Translation: BAE25543.1
BC064067 mRNA Translation: AAH64067.1
CCDSiCCDS18636.1
RefSeqiNP_780455.2, NM_175246.4
UniGeneiMm.22548

Genome annotation databases

EnsembliENSMUST00000052183; ENSMUSP00000060721; ENSMUSG00000050213
GeneIDi76793
KEGGimmu:76793
UCSCiuc008urq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040571 mRNA Translation: BAE20582.1
AK049254 mRNA Translation: BAC33638.1
AK049318 mRNA Translation: BAC33680.1
AK132768 mRNA Translation: BAE21347.1
AK143801 mRNA Translation: BAE25543.1
BC064067 mRNA Translation: AAH64067.1
CCDSiCCDS18636.1
RefSeqiNP_780455.2, NM_175246.4
UniGeneiMm.22548

3D structure databases

ProteinModelPortaliQ8BIZ6
SMRiQ8BIZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BIZ6, 1 interactor
STRINGi10090.ENSMUSP00000060721

PTM databases

iPTMnetiQ8BIZ6
PhosphoSitePlusiQ8BIZ6

Proteomic databases

EPDiQ8BIZ6
MaxQBiQ8BIZ6
PaxDbiQ8BIZ6
PeptideAtlasiQ8BIZ6
PRIDEiQ8BIZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052183; ENSMUSP00000060721; ENSMUSG00000050213
GeneIDi76793
KEGGimmu:76793
UCSCiuc008urq.2 mouse

Organism-specific databases

CTDi79753
MGIiMGI:2156003 Snip1

Phylogenomic databases

eggNOGiKOG1882 Eukaryota
ENOG4111F4H LUCA
GeneTreeiENSGT00730000110659
HOGENOMiHOG000264922
HOVERGENiHBG056615
InParanoidiQ8BIZ6
KOiK13108
OMAiLKYHEPA
OrthoDBiEOG091G0M70
PhylomeDBiQ8BIZ6
TreeFamiTF312797

Miscellaneous databases

PROiPR:Q8BIZ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050213 Expressed in 280 organ(s), highest expression level in brown adipose tissue
CleanExiMM_SNIP1
GenevisibleiQ8BIZ6 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BIZ6
Secondary accession number(s): Q3V106, Q8BIZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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