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Protein

Protocadherin-20

Gene

Pcdh20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-20
Gene namesi
Name:Pcdh20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2443376 Pcdh20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini61 – 891ExtracellularSequence analysisAdd BLAST831
Transmembranei892 – 912HelicalSequence analysisAdd BLAST21
Topological domaini913 – 952CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 60Sequence analysisAdd BLAST60
ChainiPRO_000000400661 – 952Protocadherin-20Add BLAST892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi845N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi850N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BIZ0
PaxDbiQ8BIZ0
PRIDEiQ8BIZ0

PTM databases

iPTMnetiQ8BIZ0
PhosphoSitePlusiQ8BIZ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000050505 Expressed in 133 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_PCDH20
GenevisibleiQ8BIZ0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054774

Structurei

3D structure databases

ProteinModelPortaliQ8BIZ0
SMRiQ8BIZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 210Cadherin 1PROSITE-ProRule annotationAdd BLAST147
Domaini211 – 321Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini322 – 536Cadherin 3PROSITE-ProRule annotationAdd BLAST215
Domaini537 – 640Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini641 – 743Cadherin 5PROSITE-ProRule annotationAdd BLAST103
Domaini747 – 864Cadherin 6PROSITE-ProRule annotationAdd BLAST118

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFFV Eukaryota
ENOG4110RHM LUCA
GeneTreeiENSGT00920000148958
HOVERGENiHBG053523
InParanoidiQ8BIZ0
KOiK16498
OMAiEIVPRYI
OrthoDBiEOG091G011P
TreeFamiTF320624

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 7 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BIZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGRGNARSL LVQAVSLRPA TWHPCLDMGH LHRPSSRTSH RNLPHVFLLF
60 70 80 90 100
LFVGPFNCLA SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRASGRQN
110 120 130 140 150
QQLLHPERTA SEGNPPLSFS LASGGLSGQY VTLNNRSGEL HTSAQEIDRE
160 170 180 190 200
ALCLDGGGGA AWAGSTSIAS SPSSDSCLLL LDVLVLPQEY FRFVKVKIAI
210 220 230 240 250
RDINDNAPQF PISEISVWVP ENSPVNTRLA IEHPAVDPDV GINGVQTYRL
260 270 280 290 300
LDYHGMFTLD VEENENGERT PYLIVMGALD RETQDQYVSI IIAEDGGSPP
310 320 330 340 350
LLGSATLTIG ISDINDNCPL FIDSQINVTV YGNATVGTPV ATVQAVDRDL
360 370 380 390 400
GTNAQITYSY SQKVPQETKD LFHLDEVTGV IKLSSKIGGS VLQTHKLTIL
410 420 430 440 450
ANGPGCIPAV ITALVSIIKV VFRPPEIVPR YIANEVDGVV YLKELEPVNT
460 470 480 490 500
PIAFFTIRDP EGKYKINCFL DGEGPFRLAP YKPYNNEYLL ETTKPMDYEV
510 520 530 540 550
QSFYEIAVVA WNSEGFHVKR IIKVQLLDDN DNAPVFLQPL IELTIEENNA
560 570 580 590 600
PNAFLTKLYA TDADSGEMGR VSYFLGPDAP SYFSLDSVTG ILTVSTQLDR
610 620 630 640 650
EEKEKYRYTV RAVDCGTPPR ESVATVALTV LDKNDNSPRF INKDFSFFVP
660 670 680 690 700
ENFPGYGEIG VISVTDADAG RNGWVALSVM NQSDIFVIDT GKGMLRAKVS
710 720 730 740 750
LDREQQSSYT LWVEAVDGGE PALSSTTKIT ILLLDINDNP PLVLFPQSNM
760 770 780 790 800
SYLLVLPSTL PGSPVTEVYA VDKDTGMNAV IAYSIIGRRG PRPESFRIDP
810 820 830 840 850
KTGNITLEEA LLQTDYGLHR LLVKVSDHGY PEPLHSTVMV NLFVNDTVSN
860 870 880 890 900
ESYIESLLRK EPEINIEEKE PQISIEPTHR KVESMSCMPT LVALSVISLG
910 920 930 940 950
SITLVTGMGI YICLRKGKKH HREDDNLEVQ IPLKGKIDLC MRERKPVDIS

NI
Length:952
Mass (Da):104,737
Last modified:September 18, 2013 - v3
Checksum:iB5E3BC6FFDC84EB4
GO

Sequence cautioni

The sequence BAC34009 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti720E → G in BAC38766 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049965 mRNA Translation: BAC34009.1 Different initiation.
AK083114 mRNA Translation: BAC38766.1
AC164553 Genomic DNA No translation available.
CCDSiCCDS27306.1
RefSeqiNP_848800.3, NM_178685.5
UniGeneiMm.128861

Genome annotation databases

EnsembliENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505
ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505
GeneIDi219257
KEGGimmu:219257
UCSCiuc007uuh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049965 mRNA Translation: BAC34009.1 Different initiation.
AK083114 mRNA Translation: BAC38766.1
AC164553 Genomic DNA No translation available.
CCDSiCCDS27306.1
RefSeqiNP_848800.3, NM_178685.5
UniGeneiMm.128861

3D structure databases

ProteinModelPortaliQ8BIZ0
SMRiQ8BIZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054774

PTM databases

iPTMnetiQ8BIZ0
PhosphoSitePlusiQ8BIZ0

Proteomic databases

MaxQBiQ8BIZ0
PaxDbiQ8BIZ0
PRIDEiQ8BIZ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505
ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505
GeneIDi219257
KEGGimmu:219257
UCSCiuc007uuh.2 mouse

Organism-specific databases

CTDi64881
MGIiMGI:2443376 Pcdh20

Phylogenomic databases

eggNOGiENOG410IFFV Eukaryota
ENOG4110RHM LUCA
GeneTreeiENSGT00920000148958
HOVERGENiHBG053523
InParanoidiQ8BIZ0
KOiK16498
OMAiEIVPRYI
OrthoDBiEOG091G011P
TreeFamiTF320624

Miscellaneous databases

PROiPR:Q8BIZ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050505 Expressed in 133 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_PCDH20
GenevisibleiQ8BIZ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 7 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD20_MOUSE
AccessioniPrimary (citable) accession number: Q8BIZ0
Secondary accession number(s): E9QK76, Q8BIV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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