Pcdh20

Functionⁱ

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protocadherin-20
Gene namesⁱ	Name:Pcdh20
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:2443376 Pcdh20

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	61 – 891	ExtracellularSequence analysisAdd BLAST	831
Transmembraneⁱ	892 – 912	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	913 – 952	CytoplasmicSequence analysisAdd BLAST	40

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 60	Sequence analysisAdd BLAST		60
ChainⁱPRO_0000004006	61 – 952	Protocadherin-20Add BLAST		892

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	135	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	327	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	333	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	681	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	749	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	804	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	845	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	850	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BIZ0
PaxDbⁱ	Q8BIZ0
PRIDEⁱ	Q8BIZ0

PTM databases

iPTMnetⁱ	Q8BIZ0
PhosphoSitePlusⁱ	Q8BIZ0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000050505 Expressed in 133 organ(s), highest expression level in utricle of membranous labyrinth
CleanExⁱ	MM_PCDH20
Genevisibleⁱ	Q8BIZ0 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000054774

STRINGⁱ

10090.ENSMUSP00000054774

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BIZ0
SMRⁱ	Q8BIZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	64 – 210	Cadherin 1PROSITE-ProRule annotationAdd BLAST	147
Domainⁱ	211 – 321	Cadherin 2PROSITE-ProRule annotationAdd BLAST	111
Domainⁱ	322 – 536	Cadherin 3PROSITE-ProRule annotationAdd BLAST	215
Domainⁱ	537 – 640	Cadherin 4PROSITE-ProRule annotationAdd BLAST	104
Domainⁱ	641 – 743	Cadherin 5PROSITE-ProRule annotationAdd BLAST	103
Domainⁱ	747 – 864	Cadherin 6PROSITE-ProRule annotationAdd BLAST	118

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFFV Eukaryota ENOG4110RHM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148958
HOVERGENⁱ	HBG053523
InParanoidⁱ	Q8BIZ0
KEGG Orthology (KO) More...KOⁱ	K16498
OMAⁱ	EIVPRYI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G011P
TreeFamⁱ	TF320624

Family and domain databases

InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 7 hits
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 5 hits PS50268 CADHERIN_2, 6 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8BIZ0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRGRGNARSL LVQAVSLRPA TWHPCLDMGH LHRPSSRTSH RNLPHVFLLF 
        60         70         80         90        100
LFVGPFNCLA SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRASGRQN 
       110        120        130        140        150
QQLLHPERTA SEGNPPLSFS LASGGLSGQY VTLNNRSGEL HTSAQEIDRE 
       160        170        180        190        200
ALCLDGGGGA AWAGSTSIAS SPSSDSCLLL LDVLVLPQEY FRFVKVKIAI 
       210        220        230        240        250
RDINDNAPQF PISEISVWVP ENSPVNTRLA IEHPAVDPDV GINGVQTYRL 
       260        270        280        290        300
LDYHGMFTLD VEENENGERT PYLIVMGALD RETQDQYVSI IIAEDGGSPP 
       310        320        330        340        350
LLGSATLTIG ISDINDNCPL FIDSQINVTV YGNATVGTPV ATVQAVDRDL 
       360        370        380        390        400
GTNAQITYSY SQKVPQETKD LFHLDEVTGV IKLSSKIGGS VLQTHKLTIL 
       410        420        430        440        450
ANGPGCIPAV ITALVSIIKV VFRPPEIVPR YIANEVDGVV YLKELEPVNT 
       460        470        480        490        500
PIAFFTIRDP EGKYKINCFL DGEGPFRLAP YKPYNNEYLL ETTKPMDYEV 
       510        520        530        540        550
QSFYEIAVVA WNSEGFHVKR IIKVQLLDDN DNAPVFLQPL IELTIEENNA 
       560        570        580        590        600
PNAFLTKLYA TDADSGEMGR VSYFLGPDAP SYFSLDSVTG ILTVSTQLDR 
       610        620        630        640        650
EEKEKYRYTV RAVDCGTPPR ESVATVALTV LDKNDNSPRF INKDFSFFVP 
       660        670        680        690        700
ENFPGYGEIG VISVTDADAG RNGWVALSVM NQSDIFVIDT GKGMLRAKVS 
       710        720        730        740        750
LDREQQSSYT LWVEAVDGGE PALSSTTKIT ILLLDINDNP PLVLFPQSNM 
       760        770        780        790        800
SYLLVLPSTL PGSPVTEVYA VDKDTGMNAV IAYSIIGRRG PRPESFRIDP 
       810        820        830        840        850
KTGNITLEEA LLQTDYGLHR LLVKVSDHGY PEPLHSTVMV NLFVNDTVSN 
       860        870        880        890        900
ESYIESLLRK EPEINIEEKE PQISIEPTHR KVESMSCMPT LVALSVISLG 
       910        920        930        940        950
SITLVTGMGI YICLRKGKKH HREDDNLEVQ IPLKGKIDLC MRERKPVDIS 

NI

Length:952

Mass (Da):104,737

Last modified:September 18, 2013 - v3

Checksum:ⁱB5E3BC6FFDC84EB4

GO

Sequence cautionⁱ

The sequence BAC34009 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	720	E → G in BAC38766 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK049965 mRNA Translation: BAC34009.1 Different initiation. AK083114 mRNA Translation: BAC38766.1 AC164553 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27306.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848800.3, NM_178685.5
UniGeneⁱ	Mm.128861

Genome annotation databases

Ensemblⁱ	ENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505 ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505
GeneIDⁱ	219257
KEGGⁱ	mmu:219257
UCSC genome browser More...UCSCⁱ	uc007uuh.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BIZ0	Pcdh20 protein (Fragment)		MOUSE		944	UniRef100_Q8BIZ0
Uncharacterized protein (Fragment)		MOUSE		865
Uncharacterized protein		MOUSE		273
Pcdh20 protein		MOUSE		259

Protein	Similar proteins		Species	Score	Length	Source
Q8BIZ0	Pcdh20 protein (Fragment)		MOUSE		944	UniRef90_Q8BIZ0
Uncharacterized protein		LOXAF		945
UPI00033395E8		ECHTE		953
Uncharacterized protein (Fragment)		MOUSE		865
Uncharacterized protein		MOUSE		273
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8BIZ0	Protocadherin-20		HUMAN		951	UniRef50_Q8N6Y1
protocadherin-20		TARSY		1010
Uncharacterized protein		MANLE		952
Uncharacterized protein		AOTNA		952
Uncharacterized protein		NOMLE		952
+354

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK049965 mRNA Translation: BAC34009.1 Different initiation. AK083114 mRNA Translation: BAC38766.1 AC164553 Genomic DNA No translation available.
CCDSⁱ	CCDS27306.1
RefSeqⁱ	NP_848800.3, NM_178685.5
UniGeneⁱ	Mm.128861

3D structure databases

ProteinModelPortalⁱ	Q8BIZ0
SMRⁱ	Q8BIZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000054774

STRINGⁱ

10090.ENSMUSP00000054774

PTM databases

iPTMnetⁱ	Q8BIZ0
PhosphoSitePlusⁱ	Q8BIZ0

Proteomic databases

MaxQBⁱ	Q8BIZ0
PaxDbⁱ	Q8BIZ0
PRIDEⁱ	Q8BIZ0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505 ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505
GeneIDⁱ	219257
KEGGⁱ	mmu:219257
UCSCⁱ	uc007uuh.2 mouse

Organism-specific databases

CTDⁱ	64881
MGIⁱ	MGI:2443376 Pcdh20

Phylogenomic databases

eggNOGⁱ	ENOG410IFFV Eukaryota ENOG4110RHM LUCA
GeneTreeⁱ	ENSGT00920000148958
HOVERGENⁱ	HBG053523
InParanoidⁱ	Q8BIZ0
KOⁱ	K16498
OMAⁱ	EIVPRYI
OrthoDBⁱ	EOG091G011P
TreeFamⁱ	TF320624

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BIZ0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000050505 Expressed in 133 organ(s), highest expression level in utricle of membranous labyrinth
CleanExⁱ	MM_PCDH20
Genevisibleⁱ	Q8BIZ0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 7 hits
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 5 hits PS50268 CADHERIN_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCD20_MOUSE
Accessionⁱ	Q8BIZ0Primary (citable) accession number: Q8BIZ0 Secondary accession number(s): E9QK76, Q8BIV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	September 18, 2013
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BIZ0 (PCD20_MOUSE)

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Protocadherin-20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ