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UniProtKB - Q8BIZ0 (PCD20_MOUSE)
Protein
Protocadherin-20
Gene
Pcdh20
Organism
Mus musculus (Mouse)
Status
Functioni
Potential calcium-dependent cell-adhesion protein.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin-20 |
Gene namesi | Name:Pcdh20 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443376, Pcdh20 |
VEuPathDBi | HostDB:ENSMUSG00000050505 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 61 – 891 | ExtracellularSequence analysisAdd BLAST | 831 | |
Transmembranei | 892 – 912 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 913 – 952 | CytoplasmicSequence analysisAdd BLAST | 40 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 60 | Sequence analysisAdd BLAST | 60 | |
ChainiPRO_0000004006 | 61 – 952 | Protocadherin-20Add BLAST | 892 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 327 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 681 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 749 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 804 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 845 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 850 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q8BIZ0 |
PaxDbi | Q8BIZ0 |
PRIDEi | Q8BIZ0 |
ProteomicsDBi | 289317 |
PTM databases
GlyGeni | Q8BIZ0, 8 sites |
iPTMneti | Q8BIZ0 |
PhosphoSitePlusi | Q8BIZ0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000050505, Expressed in utricle of membranous labyrinth and 160 other tissues |
Genevisiblei | Q8BIZ0, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000054774 |
Miscellaneous databases
RNActi | Q8BIZ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 210 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 147 | |
Domaini | 211 – 321 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 322 – 536 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 215 | |
Domaini | 537 – 640 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 641 – 743 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 747 – 864 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 118 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU9U, Eukaryota |
GeneTreei | ENSGT00940000156743 |
HOGENOMi | CLU_006480_5_2_1 |
InParanoidi | Q8BIZ0 |
OMAi | NCFASYS |
OrthoDBi | 82835at2759 |
PhylomeDBi | Q8BIZ0 |
TreeFami | TF320624 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 7 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8BIZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGRGNARSL LVQAVSLRPA TWHPCLDMGH LHRPSSRTSH RNLPHVFLLF
60 70 80 90 100
LFVGPFNCLA SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRASGRQN
110 120 130 140 150
QQLLHPERTA SEGNPPLSFS LASGGLSGQY VTLNNRSGEL HTSAQEIDRE
160 170 180 190 200
ALCLDGGGGA AWAGSTSIAS SPSSDSCLLL LDVLVLPQEY FRFVKVKIAI
210 220 230 240 250
RDINDNAPQF PISEISVWVP ENSPVNTRLA IEHPAVDPDV GINGVQTYRL
260 270 280 290 300
LDYHGMFTLD VEENENGERT PYLIVMGALD RETQDQYVSI IIAEDGGSPP
310 320 330 340 350
LLGSATLTIG ISDINDNCPL FIDSQINVTV YGNATVGTPV ATVQAVDRDL
360 370 380 390 400
GTNAQITYSY SQKVPQETKD LFHLDEVTGV IKLSSKIGGS VLQTHKLTIL
410 420 430 440 450
ANGPGCIPAV ITALVSIIKV VFRPPEIVPR YIANEVDGVV YLKELEPVNT
460 470 480 490 500
PIAFFTIRDP EGKYKINCFL DGEGPFRLAP YKPYNNEYLL ETTKPMDYEV
510 520 530 540 550
QSFYEIAVVA WNSEGFHVKR IIKVQLLDDN DNAPVFLQPL IELTIEENNA
560 570 580 590 600
PNAFLTKLYA TDADSGEMGR VSYFLGPDAP SYFSLDSVTG ILTVSTQLDR
610 620 630 640 650
EEKEKYRYTV RAVDCGTPPR ESVATVALTV LDKNDNSPRF INKDFSFFVP
660 670 680 690 700
ENFPGYGEIG VISVTDADAG RNGWVALSVM NQSDIFVIDT GKGMLRAKVS
710 720 730 740 750
LDREQQSSYT LWVEAVDGGE PALSSTTKIT ILLLDINDNP PLVLFPQSNM
760 770 780 790 800
SYLLVLPSTL PGSPVTEVYA VDKDTGMNAV IAYSIIGRRG PRPESFRIDP
810 820 830 840 850
KTGNITLEEA LLQTDYGLHR LLVKVSDHGY PEPLHSTVMV NLFVNDTVSN
860 870 880 890 900
ESYIESLLRK EPEINIEEKE PQISIEPTHR KVESMSCMPT LVALSVISLG
910 920 930 940 950
SITLVTGMGI YICLRKGKKH HREDDNLEVQ IPLKGKIDLC MRERKPVDIS
NI
Sequence cautioni
The sequence BAC34009 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 720 | E → G in BAC38766 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049965 mRNA Translation: BAC34009.1 Different initiation. AK083114 mRNA Translation: BAC38766.1 AC164553 Genomic DNA No translation available. |
CCDSi | CCDS27306.1 |
RefSeqi | NP_848800.3, NM_178685.5 |
Genome annotation databases
Ensembli | ENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505 ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505 |
GeneIDi | 219257 |
KEGGi | mmu:219257 |
UCSCi | uc007uuh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049965 mRNA Translation: BAC34009.1 Different initiation. AK083114 mRNA Translation: BAC38766.1 AC164553 Genomic DNA No translation available. |
CCDSi | CCDS27306.1 |
RefSeqi | NP_848800.3, NM_178685.5 |
3D structure databases
SMRi | Q8BIZ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000054774 |
PTM databases
GlyGeni | Q8BIZ0, 8 sites |
iPTMneti | Q8BIZ0 |
PhosphoSitePlusi | Q8BIZ0 |
Proteomic databases
MaxQBi | Q8BIZ0 |
PaxDbi | Q8BIZ0 |
PRIDEi | Q8BIZ0 |
ProteomicsDBi | 289317 |
Protocols and materials databases
DNASUi | 219257 |
Genome annotation databases
Ensembli | ENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505 ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505 |
GeneIDi | 219257 |
KEGGi | mmu:219257 |
UCSCi | uc007uuh.2, mouse |
Organism-specific databases
CTDi | 64881 |
MGIi | MGI:2443376, Pcdh20 |
VEuPathDBi | HostDB:ENSMUSG00000050505 |
Phylogenomic databases
eggNOGi | ENOG502QU9U, Eukaryota |
GeneTreei | ENSGT00940000156743 |
HOGENOMi | CLU_006480_5_2_1 |
InParanoidi | Q8BIZ0 |
OMAi | NCFASYS |
OrthoDBi | 82835at2759 |
PhylomeDBi | Q8BIZ0 |
TreeFami | TF320624 |
Miscellaneous databases
BioGRID-ORCSi | 219257, 3 hits in 64 CRISPR screens |
PROi | PR:Q8BIZ0 |
RNActi | Q8BIZ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050505, Expressed in utricle of membranous labyrinth and 160 other tissues |
Genevisiblei | Q8BIZ0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 7 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PCD20_MOUSE | |
Accessioni | Q8BIZ0Primary (citable) accession number: Q8BIZ0 Secondary accession number(s): E9QK76, Q8BIV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | September 18, 2013 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot