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Protein

Chromosome transmission fidelity protein 18 homolog

Gene

Chtf18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi369 – 376ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 18 homolog
Gene namesi
Name:Chtf18
Synonyms:Ctf18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384887 Chtf18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003400821 – 969Chromosome transmission fidelity protein 18 homologAdd BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphothreonineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BIW9
MaxQBiQ8BIW9
PaxDbiQ8BIW9
PeptideAtlasiQ8BIW9
PRIDEiQ8BIW9

PTM databases

iPTMnetiQ8BIW9
PhosphoSitePlusiQ8BIW9

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21. Interacts with DDX11.By similarity

Protein-protein interaction databases

BioGridi229573, 1 interactor
STRINGi10090.ENSMUSP00000043896

Structurei

3D structure databases

ProteinModelPortaliQ8BIW9
SMRiQ8BIW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1969 Eukaryota
ENOG410XP8M LUCA
HOGENOMiHOG000067805
HOVERGENiHBG062099
InParanoidiQ8BIW9
KOiK11269
PhylomeDBiQ8BIW9
TreeFamiTF314392

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BIW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDYEEDLYG VEDDFQNQFA AELEVLAELE GTRDQAPPGT LQTPASRPPL
60 70 80 90 100
TFEEAIAGGD TVPRPCPAGS PGNVNRNTRK NVRRDQPAPS SPMVKRPRLD
110 120 130 140 150
VVKKLNFEPD MEELLYPDSP PGDITPPPSP EVFPEMLDAG YSDANADKDL
160 170 180 190 200
MQTLPSPRNR NPVLRRPPIL EDYINVTSTS GERAFLVLRA DLIGPGVQNP
210 220 230 240 250
LLDVHWRGCG QLDLLGVPFA SLKEQVDSKR RQQLLEDAQQ LSDTLHSLRS
260 270 280 290 300
EGEEAVLEGP PAEEPAPGQN TAQHCLWVDE FAPQHYTELL SDDFTNRCLL
310 320 330 340 350
KWLKLWDLVV FGRERPARKP RPGVETTRVG KEATAPGKWK SHEQALEEML
360 370 380 390 400
EAELDPSQRP RQKVALLCGP PGLGKTTLAH VVARHAGYCV VEMNASDDRS
410 420 430 440 450
PEAFRTRIEA ATQMESVLGV GGRPNCLVID EIDGAPTAAI NVLLGILNRK
460 470 480 490 500
GPQEADQGGT AVAAGGRRRR AEGGLLTRPI ICICNDQFTP SLRQLKQQAL
510 520 530 540 550
LLHVPPTLPS RLVQRLQEIS LQHGMRSDPG ALVALCEKTD NDIRACINTL
560 570 580 590 600
QFLYGRGRRE LSVKAVQTTH VGLKDQRKGL FSVWQEVFQL PRTQRRIVGQ
610 620 630 640 650
DLMLPAHALL LSNGDKGSLT LASQRFYHIL RVTTSAGEHE KVVQGLFDNF
660 670 680 690 700
LRLRLRDSSL STVCCALDWL AFDDLLEQAA HRGQSFQLLC YLPFVPAAFH
710 720 730 740 750
VLFASSHVPR ITFPSSQQEA QTRMSQTRNH IQTLVSGMAP TTRSRATPQA
760 770 780 790 800
LVLDTLCLLL DVLAPKLRPV STQLYSAHEK QQLSCLVGTM LAYSLTYHQE
810 820 830 840 850
RTPDGQYLYK LEPNVEEVCR FPELPARKPL TYQAKQLIAR EIEMEKMRRA
860 870 880 890 900
EALAWARSGP QVDQGSSGPA SLWTDSGEKG TRQPAPRNHE QRLEHIMKRA
910 920 930 940 950
TVQEQPERDF FGRVVIRKVA VPSREVEAPQ KDADEWRMGV AVGRSEVWFR
960
FNEGVSNAVR RSLYIRDLL
Length:969
Mass (Da):108,137
Last modified:June 10, 2008 - v2
Checksum:iE0269C507AF514BD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0I4A0A0R4J0I4_MOUSE
CTF18, chromosome transmission fide...
Chtf18 mCG_17653
969Annotation score:
F6ZBE7F6ZBE7_MOUSE
Chromosome transmission fidelity pr...
Chtf18
130Annotation score:
E9PVJ3E9PVJ3_MOUSE
Chromosome transmission fidelity pr...
Chtf18
267Annotation score:
E9Q2M3E9Q2M3_MOUSE
Chromosome transmission fidelity pr...
Chtf18
365Annotation score:
F6YVH6F6YVH6_MOUSE
Chromosome transmission fidelity pr...
Chtf18
109Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti880G → E in AAH24142 (PubMed:15489334).Curated1
Sequence conflicti885A → V in BAC37079 (PubMed:16141072).Curated1
Sequence conflicti898K → T in BAC37079 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077947 mRNA Translation: BAC37079.1
BC024142 mRNA Translation: AAH24142.1
CCDSiCCDS28523.1
RefSeqiNP_663384.2, NM_145409.2
UniGeneiMm.102540

Genome annotation databases

GeneIDi214901
KEGGimmu:214901
UCSCiuc008bbk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077947 mRNA Translation: BAC37079.1
BC024142 mRNA Translation: AAH24142.1
CCDSiCCDS28523.1
RefSeqiNP_663384.2, NM_145409.2
UniGeneiMm.102540

3D structure databases

ProteinModelPortaliQ8BIW9
SMRiQ8BIW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229573, 1 interactor
STRINGi10090.ENSMUSP00000043896

PTM databases

iPTMnetiQ8BIW9
PhosphoSitePlusiQ8BIW9

Proteomic databases

EPDiQ8BIW9
MaxQBiQ8BIW9
PaxDbiQ8BIW9
PeptideAtlasiQ8BIW9
PRIDEiQ8BIW9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi214901
KEGGimmu:214901
UCSCiuc008bbk.2 mouse

Organism-specific databases

CTDi63922
MGIiMGI:2384887 Chtf18

Phylogenomic databases

eggNOGiKOG1969 Eukaryota
ENOG410XP8M LUCA
HOGENOMiHOG000067805
HOVERGENiHBG062099
InParanoidiQ8BIW9
KOiK11269
PhylomeDBiQ8BIW9
TreeFamiTF314392

Miscellaneous databases

PROiPR:Q8BIW9
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTF18_MOUSE
AccessioniPrimary (citable) accession number: Q8BIW9
Secondary accession number(s): Q8R1R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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