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UniProtKB - Q8BIQ3 (ZNF2_MOUSE)
Protein
Zinc finger protein 2
Gene
Znf2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 169 – 191 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 2CuratedAlternative name(s): Zinc finger protein 661 Short name: Zfp-661 |
Gene namesi | Name:Znf2Imported Synonyms:Zfp661 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919430, Zfp661 |
VEuPathDBi | HostDB:ENSMUSG00000034800 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274050 | 1 – 427 | Zinc finger protein 2Add BLAST | 427 |
Proteomic databases
jPOSTi | Q8BIQ3 |
PaxDbi | Q8BIQ3 |
PRIDEi | Q8BIQ3 |
PTM databases
iPTMneti | Q8BIQ3 |
PhosphoSitePlusi | Q8BIQ3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034800, Expressed in ureteric bud trunk and 198 other tissues |
Genevisiblei | Q8BIQ3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 215203, 1 interactor |
STRINGi | 10090.ENSMUSP00000105995 |
Miscellaneous databases
RNActi | Q8BIQ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 111 – 142 | DisorderedSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 169 – 191 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160826 |
HOGENOMi | CLU_002678_0_7_1 |
InParanoidi | Q8BIQ3 |
OMAi | TKPEIHG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BIQ3 |
TreeFami | TF340946 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
Q8BIQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI
60 70 80 90 100
ISLGLPVPRP DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL
110 120 130 140 150
DASRGTLREI HRKQSSLCPK REIQTLTGGP EPEKESPKAR TCKKPLSLDK
160 170 180 190 200
GLHQMSAPSK KALTKHQDQE CSECGKTFFD HSSLIRHQRT HTGEKPYDCP
210 220 230 240 250
ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL TVHQRIHTGE
260 270 280 290 300
KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
310 320 330 340 350
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS
360 370 380 390 400
SLTQHQKIHT GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK
410 420
EFSSKSSIIQ HQRRYAKQGI DRGGSMS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | V → A in AAH52876 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 95 | T → A in AAH52876 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 249 | G → E in AAH52876 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033122 mRNA Translation: BAC28161.1 BC052876 mRNA Translation: AAH52876.1 |
CCDSi | CCDS16705.1 |
RefSeqi | NP_001104499.1, NM_001111029.1 NP_082417.3, NM_028141.3 XP_006500290.1, XM_006500227.2 XP_011238090.1, XM_011239788.2 |
Genome annotation databases
Ensembli | ENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800 ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800 ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800 ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800 |
GeneIDi | 72180 |
KEGGi | mmu:72180 |
UCSCi | uc008mfq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033122 mRNA Translation: BAC28161.1 BC052876 mRNA Translation: AAH52876.1 |
CCDSi | CCDS16705.1 |
RefSeqi | NP_001104499.1, NM_001111029.1 NP_082417.3, NM_028141.3 XP_006500290.1, XM_006500227.2 XP_011238090.1, XM_011239788.2 |
3D structure databases
AlphaFoldDBi | Q8BIQ3 |
SMRi | Q8BIQ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215203, 1 interactor |
STRINGi | 10090.ENSMUSP00000105995 |
PTM databases
iPTMneti | Q8BIQ3 |
PhosphoSitePlusi | Q8BIQ3 |
Proteomic databases
jPOSTi | Q8BIQ3 |
PaxDbi | Q8BIQ3 |
PRIDEi | Q8BIQ3 |
Protocols and materials databases
Antibodypediai | 72445, 147 antibodies from 23 providers |
DNASUi | 72180 |
Genome annotation databases
Organism-specific databases
CTDi | 72180 |
MGIi | MGI:1919430, Zfp661 |
VEuPathDBi | HostDB:ENSMUSG00000034800 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160826 |
HOGENOMi | CLU_002678_0_7_1 |
InParanoidi | Q8BIQ3 |
OMAi | TKPEIHG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BIQ3 |
TreeFami | TF340946 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 72180, 2 hits in 71 CRISPR screens |
PROi | PR:Q8BIQ3 |
RNActi | Q8BIQ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034800, Expressed in ureteric bud trunk and 198 other tissues |
Genevisiblei | Q8BIQ3, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF2_MOUSE | |
Accessioni | Q8BIQ3Primary (citable) accession number: Q8BIQ3 Secondary accession number(s): Q7TPW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families