Znf2

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 2 Alternative name(s): Zinc finger protein 661 Short name: Zfp-661
Gene namesⁱ	Name:Znf2 Synonyms:Zfp661
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1919430 Zfp661

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274050	1 – 427	Zinc finger protein 2Add BLAST		427

Proteomic databases

PaxDbⁱ	Q8BIQ3
PRIDEⁱ	Q8BIQ3

PTM databases

iPTMnetⁱ	Q8BIQ3
PhosphoSitePlusⁱ	Q8BIQ3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034800 Expressed in 165 organ(s), highest expression level in ureteric bud trunk
CleanExⁱ	MM_ZFP661
Genevisibleⁱ	Q8BIQ3 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	215203, 1 interactor
STRINGⁱ	10090.ENSMUSP00000076637

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BIQ3
SMRⁱ	Q8BIQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 85	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149024
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8BIQ3
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	EPRYQCN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8BIQ3
TreeFamⁱ	TF340946

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 9 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BIQ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI 
        60         70         80         90        100
ISLGLPVPRP DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL 
       110        120        130        140        150
DASRGTLREI HRKQSSLCPK REIQTLTGGP EPEKESPKAR TCKKPLSLDK 
       160        170        180        190        200
GLHQMSAPSK KALTKHQDQE CSECGKTFFD HSSLIRHQRT HTGEKPYDCP 
       210        220        230        240        250
ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL TVHQRIHTGE 
       260        270        280        290        300
KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL 
       310        320        330        340        350
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS 
       360        370        380        390        400
SLTQHQKIHT GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK 
       410        420 
EFSSKSSIIQ HQRRYAKQGI DRGGSMS

Length:427

Mass (Da):48,640

Last modified:March 1, 2003 - v1

Checksum:ⁱAC70BD8A1D246F58

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	62	V → A in AAH52876 (PubMed:15489334).Curated	1
Sequence conflictⁱ	95	T → A in AAH52876 (PubMed:15489334).Curated	1
Sequence conflictⁱ	249	G → E in AAH52876 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK033122 mRNA Translation: BAC28161.1 BC052876 mRNA Translation: AAH52876.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16705.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001104499.1, NM_001111029.1 NP_082417.3, NM_028141.3 XP_006500290.1, XM_006500227.2 XP_011238090.1, XM_011239788.2
UniGeneⁱ	Mm.46715

Genome annotation databases

Ensemblⁱ	ENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800 ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800 ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800 ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800
GeneIDⁱ	72180
KEGGⁱ	mmu:72180
UCSC genome browser More...UCSCⁱ	uc008mfq.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BIQ3	Zinc finger protein 2		PTEAL		483	UniRef50_Q8BIQ3
Uncharacterized protein		PIG		456
Zinc finger protein 2 (Fragment)		HETGA		427
Zinc finger protein 2		FUKDA		386
Zinc finger protein 2		MYODS		477
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK033122 mRNA Translation: BAC28161.1 BC052876 mRNA Translation: AAH52876.1
CCDSⁱ	CCDS16705.1
RefSeqⁱ	NP_001104499.1, NM_001111029.1 NP_082417.3, NM_028141.3 XP_006500290.1, XM_006500227.2 XP_011238090.1, XM_011239788.2
UniGeneⁱ	Mm.46715

3D structure databases

ProteinModelPortalⁱ	Q8BIQ3
SMRⁱ	Q8BIQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	215203, 1 interactor
STRINGⁱ	10090.ENSMUSP00000076637

PTM databases

iPTMnetⁱ	Q8BIQ3
PhosphoSitePlusⁱ	Q8BIQ3

Proteomic databases

PaxDbⁱ	Q8BIQ3
PRIDEⁱ	Q8BIQ3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800 ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800 ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800 ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800
GeneIDⁱ	72180
KEGGⁱ	mmu:72180
UCSCⁱ	uc008mfq.2 mouse

Organism-specific databases

CTDⁱ	72180
MGIⁱ	MGI:1919430 Zfp661

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000149024
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8BIQ3
KOⁱ	K09228
OMAⁱ	EPRYQCN
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8BIQ3
TreeFamⁱ	TF340946

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BIQ3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034800 Expressed in 165 organ(s), highest expression level in ureteric bud trunk
CleanExⁱ	MM_ZFP661
Genevisibleⁱ	Q8BIQ3 MM

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 9 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNF2_MOUSE
Accessionⁱ	Q8BIQ3Primary (citable) accession number: Q8BIQ3 Secondary accession number(s): Q7TPW3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BIQ3 (ZNF2_MOUSE)

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Zinc finger protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ