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Protein

Zinc finger protein 2

Gene

Znf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2
Alternative name(s):
Zinc finger protein 661
Short name:
Zfp-661
Gene namesi
Name:Znf2
Synonyms:Zfp661
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919430 Zfp661

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740501 – 427Zinc finger protein 2Add BLAST427

Proteomic databases

PaxDbiQ8BIQ3
PRIDEiQ8BIQ3

PTM databases

iPTMnetiQ8BIQ3
PhosphoSitePlusiQ8BIQ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000034800 Expressed in 165 organ(s), highest expression level in ureteric bud trunk
CleanExiMM_ZFP661
GenevisibleiQ8BIQ3 MM

Interactioni

Protein-protein interaction databases

BioGridi215203, 1 interactor
STRINGi10090.ENSMUSP00000076637

Structurei

3D structure databases

ProteinModelPortaliQ8BIQ3
SMRiQ8BIQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BIQ3
KOiK09228
OMAiSPYECSV
OrthoDBiEOG091G02KC
PhylomeDBiQ8BIQ3
TreeFamiTF340946

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q8BIQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI
60 70 80 90 100
ISLGLPVPRP DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL
110 120 130 140 150
DASRGTLREI HRKQSSLCPK REIQTLTGGP EPEKESPKAR TCKKPLSLDK
160 170 180 190 200
GLHQMSAPSK KALTKHQDQE CSECGKTFFD HSSLIRHQRT HTGEKPYDCP
210 220 230 240 250
ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL TVHQRIHTGE
260 270 280 290 300
KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
310 320 330 340 350
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS
360 370 380 390 400
SLTQHQKIHT GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK
410 420
EFSSKSSIIQ HQRRYAKQGI DRGGSMS
Length:427
Mass (Da):48,640
Last modified:March 1, 2003 - v1
Checksum:iAC70BD8A1D246F58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62V → A in AAH52876 (PubMed:15489334).Curated1
Sequence conflicti95T → A in AAH52876 (PubMed:15489334).Curated1
Sequence conflicti249G → E in AAH52876 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033122 mRNA Translation: BAC28161.1
BC052876 mRNA Translation: AAH52876.1
CCDSiCCDS16705.1
RefSeqiNP_001104499.1, NM_001111029.1
NP_082417.3, NM_028141.3
XP_006500290.1, XM_006500227.2
XP_011238090.1, XM_011239788.2
UniGeneiMm.46715

Genome annotation databases

EnsembliENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800
ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800
ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800
ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800
GeneIDi72180
KEGGimmu:72180
UCSCiuc008mfq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033122 mRNA Translation: BAC28161.1
BC052876 mRNA Translation: AAH52876.1
CCDSiCCDS16705.1
RefSeqiNP_001104499.1, NM_001111029.1
NP_082417.3, NM_028141.3
XP_006500290.1, XM_006500227.2
XP_011238090.1, XM_011239788.2
UniGeneiMm.46715

3D structure databases

ProteinModelPortaliQ8BIQ3
SMRiQ8BIQ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215203, 1 interactor
STRINGi10090.ENSMUSP00000076637

PTM databases

iPTMnetiQ8BIQ3
PhosphoSitePlusiQ8BIQ3

Proteomic databases

PaxDbiQ8BIQ3
PRIDEiQ8BIQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800
ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800
ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800
ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800
GeneIDi72180
KEGGimmu:72180
UCSCiuc008mfq.2 mouse

Organism-specific databases

CTDi72180
MGIiMGI:1919430 Zfp661

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BIQ3
KOiK09228
OMAiSPYECSV
OrthoDBiEOG091G02KC
PhylomeDBiQ8BIQ3
TreeFamiTF340946

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q8BIQ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034800 Expressed in 165 organ(s), highest expression level in ureteric bud trunk
CleanExiMM_ZFP661
GenevisibleiQ8BIQ3 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF2_MOUSE
AccessioniPrimary (citable) accession number: Q8BIQ3
Secondary accession number(s): Q7TPW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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