Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (02 Jun 2021)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Transmembrane protease serine 7

Gene

Tmprss7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=240 nM for Suc-Ala-Ala-Pro-Arg-pNA1 Publication
  2. KM=534 nM for Suc-Ala-Ala-Pro-Lys-pNA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei632Charge relay systemBy similarity1
    Active sitei680Charge relay systemBy similarity1
    Active sitei776Charge relay systemBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    S01.072

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Transmembrane protease serine 7 (EC:3.4.21.-)
    Alternative name(s):
    Matriptase-3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Tmprss7
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2686594, Tmprss7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 83Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini84 – 829ExtracellularSequence analysisAdd BLAST746

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000278601 – 829Transmembrane protease serine 7Add BLAST829

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi233 ↔ 259By similarity
    Disulfide bondi285 ↔ 308By similarity
    Disulfide bondi351 ↔ 382By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi470 ↔ 482By similarity
    Disulfide bondi477 ↔ 495By similarity
    Disulfide bondi489 ↔ 504By similarity
    Disulfide bondi511 ↔ 530By similarity
    Disulfide bondi524 ↔ 539By similarity
    Disulfide bondi545 ↔ 557By similarity
    Disulfide bondi552 ↔ 571By similarity
    Disulfide bondi565 ↔ 580By similarity
    Disulfide bondi617 ↔ 633By similarity
    Disulfide bondi716 ↔ 782By similarity
    Disulfide bondi748 ↔ 761By similarity
    Disulfide bondi772 ↔ 802By similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei255 – 256CleavageSequence analysis2

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8BIK6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8BIK6

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    259267

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q8BIK6, 2 sites

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8BIK6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in brain, eye, testis, skin, epididymis and salivary gland with lower levels in heart, skeletal muscle, thymus, ovary, prostate and uterus.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000033177, Expressed in frontal cortex and 59 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Forms a heterodimer with SERPINA5.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    228959, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000110209

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8BIK6, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8BIK6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 220SEAPROSITE-ProRule annotationAdd BLAST129
    Domaini233 – 346CUB 1PROSITE-ProRule annotationAdd BLAST114
    Domaini351 – 467CUB 2PROSITE-ProRule annotationAdd BLAST117
    Domaini469 – 505LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
    Domaini503 – 540LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38
    Domaini544 – 581LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
    Domaini592 – 826Peptidase S1PROSITE-ProRule annotationAdd BLAST235

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 52DisorderedSequence analysisAdd BLAST27

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 52Basic residuesSequence analysisAdd BLAST17

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3627, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160085

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_006842_19_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8BIK6

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DHGWWEI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1314811at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF330647

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00041, CUB, 1 hit
    cd00112, LDLa, 2 hits
    cd00190, Tryp_SPc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.10.10, 2 hits
    2.60.120.290, 2 hits
    3.30.70.960, 1 hit
    4.10.400.10, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000859, CUB_dom
    IPR036055, LDL_receptor-like_sf
    IPR023415, LDLR_class-A_CS
    IPR002172, LDrepeatLR_classA_rpt
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR001314, Peptidase_S1A
    IPR000082, SEA_dom
    IPR036364, SEA_dom_sf
    IPR035914, Sperma_CUB_dom_sf
    IPR001254, Trypsin_dom
    IPR018114, TRYPSIN_HIS
    IPR033116, TRYPSIN_SER

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00431, CUB, 1 hit
    PF00057, Ldl_recept_a, 2 hits
    PF01390, SEA, 1 hit
    PF00089, Trypsin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00722, CHYMOTRYPSIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00042, CUB, 1 hit
    SM00192, LDLa, 3 hits
    SM00020, Tryp_SPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49854, SSF49854, 2 hits
    SSF50494, SSF50494, 1 hit
    SSF57424, SSF57424, 3 hits
    SSF82671, SSF82671, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01180, CUB, 2 hits
    PS01209, LDLRA_1, 1 hit
    PS50068, LDLRA_2, 2 hits
    PS50024, SEA, 1 hit
    PS50240, TRYPSIN_DOM, 1 hit
    PS00134, TRYPSIN_HIS, 1 hit
    PS00135, TRYPSIN_SER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8BIK6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDKEKSDPSC KSSDLKISNI SIQVVSVPGK LPGRRPPRKP IGKPRPRKQP
    60 70 80 90 100
    KKRAPFWNVQ NKIILFTVFL FILAVTAWTL LWLYISKTES KDAFYFVGMF
    110 120 130 140 150
    RITNIEFLPE YRQKESREFL SMAKTVQQVV NLVYTTSAFS KFYKQSVVAD
    160 170 180 190 200
    VSSNNKGGLL VHFWIVFVMP HAKGHIFCEE CVAAILKDSI QTSIINRTSV
    210 220 230 240 250
    GSLQGLAVDM DSVVLNAGLR SDYSSAVGSD NGCSRYLYAD HLTLRYPLEI
    260 270 280 290 300
    SATSGQLMCH FKLVAIVGYL IRLSIESIQL EADNCITDSL TVYDSLLPIR
    310 320 330 340 350
    SAILYRICEP TRTLMSFVST NNLMLVILKS PYVRRLAGIR AYFEVIPEQK
    360 370 380 390 400
    CESTILVKEI NSFEGKISSP YYPSYYPPKC KCTWTFQTSL STLGIALKFY
    410 420 430 440 450
    NYSITKKSAK GCEHGWWEIN EHMYCGSYMD HETIFRVPSP LVHIQLQCSS
    460 470 480 490 500
    RLSDKPLLVE YGGYNISQPC PAGSFRCSSG LCVPQAQRCD GVNDCFDESD
    510 520 530 540 550
    ELFCVTVKPA CNSSSFRQHG PLVCDGFRDC EDGQDEQNCT RSIPCTSRTF
    560 570 580 590 600
    KCGNDICFRK QNAQCDGIVD CPDGSDEEGC GCSRSSSFLH RIVGGSDSQE
    610 620 630 640 650
    GTWPWQVSLH FVGSAYCGAS VISREWLLSA AHCFHGNRLS DPTPWTAHLG
    660 670 680 690 700
    MYVQGNAKFI SPVRRIVVHE YYNSQTFDYD IALLQLSIAW PETLKQLIQP
    710 720 730 740 750
    ICIPPAGQKV RSGEKCWVTG WGRRHEADSK GSPVLQQAEV ELIDQTVCVS
    760 770 780 790 800
    TYGIITSRML CAGVMSGKSD ACKGDSGGPL SCRRKSDGKW ILTGIVSWGH
    810 820
    GCGRPNFPGV YTRVSSFVPW IHKYVPSLL
    Length:829
    Mass (Da):92,590
    Last modified:July 27, 2011 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B5971331CB23B6C
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAC32448 differs from that shown. Differs at the N-terminus for unknown reasons.Curated
    The sequence BAC32448 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232G → S in AAY66996 (PubMed:15853774).Curated1
    Sequence conflicti327I → T in AAY66996 (PubMed:15853774).Curated1
    Sequence conflicti469P → Q in BAC32448 (PubMed:16141072).Curated1
    Sequence conflicti483V → I in AAY66996 (PubMed:15853774).Curated1
    Sequence conflicti515S → I in AAY66996 (PubMed:15853774).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    DQ061860 mRNA Translation: AAY66996.1
    AC166572 Genomic DNA No translation available.
    AK045663 mRNA Translation: BAC32448.1 Sequence problems.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS37347.2

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_766043.3, NM_172455.3
    XP_006521977.1, XM_006521914.2
    XP_006521978.1, XM_006521915.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000114562; ENSMUSP00000110209; ENSMUSG00000033177

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    208171

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:208171

    UCSC genome browser

    More...
    UCSCi
    uc007ziu.1, mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    DQ061860 mRNA Translation: AAY66996.1
    AC166572 Genomic DNA No translation available.
    AK045663 mRNA Translation: BAC32448.1 Sequence problems.
    CCDSiCCDS37347.2
    RefSeqiNP_766043.3, NM_172455.3
    XP_006521977.1, XM_006521914.2
    XP_006521978.1, XM_006521915.2

    3D structure databases

    SMRiQ8BIK6
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi228959, 5 interactors
    STRINGi10090.ENSMUSP00000110209

    Protein family/group databases

    MEROPSiS01.072

    PTM databases

    GlyGeniQ8BIK6, 2 sites
    PhosphoSitePlusiQ8BIK6

    Proteomic databases

    PaxDbiQ8BIK6
    PRIDEiQ8BIK6
    ProteomicsDBi259267

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    52124, 114 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    208171

    Genome annotation databases

    EnsembliENSMUST00000114562; ENSMUSP00000110209; ENSMUSG00000033177
    GeneIDi208171
    KEGGimmu:208171
    UCSCiuc007ziu.1, mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    344805
    MGIiMGI:2686594, Tmprss7

    Phylogenomic databases

    eggNOGiKOG3627, Eukaryota
    GeneTreeiENSGT00940000160085
    HOGENOMiCLU_006842_19_3_1
    InParanoidiQ8BIK6
    OMAiDHGWWEI
    OrthoDBi1314811at2759
    TreeFamiTF330647

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    208171, 0 hits in 52 CRISPR screens

    Protein Ontology

    More...
    PROi
    PR:Q8BIK6
    RNActiQ8BIK6, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000033177, Expressed in frontal cortex and 59 other tissues

    Family and domain databases

    CDDicd00041, CUB, 1 hit
    cd00112, LDLa, 2 hits
    cd00190, Tryp_SPc, 1 hit
    Gene3Di2.40.10.10, 2 hits
    2.60.120.290, 2 hits
    3.30.70.960, 1 hit
    4.10.400.10, 3 hits
    InterProiView protein in InterPro
    IPR000859, CUB_dom
    IPR036055, LDL_receptor-like_sf
    IPR023415, LDLR_class-A_CS
    IPR002172, LDrepeatLR_classA_rpt
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR001314, Peptidase_S1A
    IPR000082, SEA_dom
    IPR036364, SEA_dom_sf
    IPR035914, Sperma_CUB_dom_sf
    IPR001254, Trypsin_dom
    IPR018114, TRYPSIN_HIS
    IPR033116, TRYPSIN_SER
    PfamiView protein in Pfam
    PF00431, CUB, 1 hit
    PF00057, Ldl_recept_a, 2 hits
    PF01390, SEA, 1 hit
    PF00089, Trypsin, 1 hit
    PRINTSiPR00722, CHYMOTRYPSIN
    SMARTiView protein in SMART
    SM00042, CUB, 1 hit
    SM00192, LDLa, 3 hits
    SM00020, Tryp_SPc, 1 hit
    SUPFAMiSSF49854, SSF49854, 2 hits
    SSF50494, SSF50494, 1 hit
    SSF57424, SSF57424, 3 hits
    SSF82671, SSF82671, 1 hit
    PROSITEiView protein in PROSITE
    PS01180, CUB, 2 hits
    PS01209, LDLRA_1, 1 hit
    PS50068, LDLRA_2, 2 hits
    PS50024, SEA, 1 hit
    PS50240, TRYPSIN_DOM, 1 hit
    PS00134, TRYPSIN_HIS, 1 hit
    PS00135, TRYPSIN_SER, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMPS7_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BIK6
    Secondary accession number(s): E9QME7, Q4PPC3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 27, 2011
    Last modified: June 2, 2021
    This is version 145 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again