UniProtKB - Q8BIH0 (SP130_MOUSE)
Histone deacetylase complex subunit SAP130
Sap130
Functioni
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).
By similarityGO - Biological processi
- negative regulation of cell migration Source: ComplexPortal
- negative regulation of stem cell population maintenance Source: ComplexPortal
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ComplexPortal
- positive regulation of stem cell population maintenance Source: ComplexPortal
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone deacetylase complex subunit SAP130Alternative name(s): 130 kDa Sin3-associated polypeptide Sin3-associated polypeptide p130 |
Gene namesi | Name:Sap130 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919782, Sap130 |
VEuPathDBi | HostDB:ENSMUSG00000024260 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear speck Source: MGI
- nucleus Source: ComplexPortal
- Sin3 complex Source: ComplexPortal
- Sin3-type complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283737 | 1 – 1057 | Histone deacetylase complex subunit SAP130Add BLAST | 1057 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 206 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 329 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 416 | PhosphoserineCombined sources | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Cross-linki | 794 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 864 | PhosphoserineBy similarity | 1 | |
Modified residuei | 865 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 873 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 878 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 884 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8BIH0 |
jPOSTi | Q8BIH0 |
MaxQBi | Q8BIH0 |
PaxDbi | Q8BIH0 |
PeptideAtlasi | Q8BIH0 |
PRIDEi | Q8BIH0 |
ProteomicsDBi | 257286 [Q8BIH0-1] 257287 [Q8BIH0-2] 257288 [Q8BIH0-3] |
PTM databases
iPTMneti | Q8BIH0 |
PhosphoSitePlusi | Q8BIH0 |
Interactioni
Subunit structurei
Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 (By similarity).
Interacts (released by dead or dying cells) with CLEC4E.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 234593, 9 interactors |
ComplexPortali | CPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant CPX-3443, SIN3A histone deacetylase complex CPX-3444, SIN3B histone deacetylase complex |
IntActi | Q8BIH0, 1 interactor |
MINTi | Q8BIH0 |
STRINGi | 10090.ENSMUSP00000136842 |
Miscellaneous databases
RNActi | Q8BIH0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8BIH0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 69 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 619 – 695 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 718 – 740 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 827 – 873 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 845 – 1057 | Interactions with SIN3A and HDAC1By similarityAdd BLAST | 213 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 35 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 619 – 640 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 723 – 737 | Pro residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQ6P, Eukaryota |
GeneTreei | ENSGT00440000037733 |
InParanoidi | Q8BIH0 |
OrthoDBi | 242848at2759 |
PhylomeDBi | Q8BIH0 |
Family and domain databases
InterProi | View protein in InterPro IPR024137, His_deAcase_cplx_SAP130 IPR031963, SAP130_C |
PANTHERi | PTHR13497, PTHR13497, 1 hit |
Pfami | View protein in Pfam PF16014, SAP130_C, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT
60 70 80 90 100
REHVGPSSSL PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA
110 120 130 140 150
HLTPAVPLSF SEGLMKPPPK PTMPSRPIAP APPSTMSLPP KVPGQVTVTM
160 170 180 190 200
ESSIPQASAI PVATISGQQG HPSNLHHIMT TNVQMSIIRS NAPGPPLHIG
210 220 230 240 250
ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ HLIHQPIQSR
260 270 280 290 300
PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP
310 320 330 340 350
SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA
360 370 380 390 400
AATVAPILAT NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS
410 420 430 440 450
NIPVAKVVPQ QITHTSPRIQ PDYPPERSSL IPISGHRASP NPVAMETRND
460 470 480 490 500
NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP ITSSVSTIRQ YPVSAQAPNS
510 520 530 540 550
TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI STQGIQPAPI
560 570 580 590 600
GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG
610 620 630 640 650
ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA
660 670 680 690 700
TDGMAVRKTL LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA
710 720 730 740 750
TPVTVSLETI SNQNAEQPTV AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL
760 770 780 790 800
STIPGAVPVT PPITTIAATP TLSAPVGGTP STVLGPPVPE IKVKEEAEPV
810 820 830 840 850
DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS PRKKPRKQQH
860 870 880 890 900
VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV
910 920 930 940 950
RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC
960 970 980 990 1000
RAQGWKVHLC AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI
1010 1020 1030 1040 1050
NELIQGNMQR CKLVMDQISE ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK
LKRKEKV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J060 | A0A0R4J060_MOUSE | Histone deacetylase complex subunit... | Sap130 | 1,056 | Annotation score: | ||
J3QNK5 | J3QNK5_MOUSE | Histone deacetylase complex subunit... | Sap130 | 1,057 | Annotation score: | ||
A0A3Q4EC23 | A0A3Q4EC23_MOUSE | Histone deacetylase complex subunit... | Sap130 | 115 | Annotation score: | ||
A0A3Q4EGN6 | A0A3Q4EGN6_MOUSE | Histone deacetylase complex subunit... | Sap130 | 60 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 594 | Missing in BAC35469 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024357 | 1 – 178 | Missing in isoform 2. 1 PublicationAdd BLAST | 178 | |
Alternative sequenceiVSP_024358 | 340 – 348 | KTIFSTGTP → VRTVTPPEG in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_024359 | 349 – 1057 | Missing in isoform 3. 1 PublicationAdd BLAST | 709 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011978 mRNA Translation: BAB27953.1 AK053675 mRNA Translation: BAC35469.1 AK084078 mRNA Translation: BAC39113.1 BC063075 mRNA Translation: AAH63075.1 BC066030 mRNA Translation: AAH66030.1 Different initiation. |
CCDSi | CCDS89207.1 [Q8BIH0-1] |
RefSeqi | NP_766553.1, NM_172965.2 XP_006526014.1, XM_006525951.2 [Q8BIH0-1] XP_006526015.1, XM_006525952.3 [Q8BIH0-1] XP_006526017.1, XM_006525954.3 |
Genome annotation databases
Ensembli | ENSMUST00000235017; ENSMUSP00000157127; ENSMUSG00000024260 [Q8BIH0-1] |
GeneIDi | 269003 |
KEGGi | mmu:269003 |
UCSCi | uc008eib.1, mouse [Q8BIH0-1] uc008eie.1, mouse [Q8BIH0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011978 mRNA Translation: BAB27953.1 AK053675 mRNA Translation: BAC35469.1 AK084078 mRNA Translation: BAC39113.1 BC063075 mRNA Translation: AAH63075.1 BC066030 mRNA Translation: AAH66030.1 Different initiation. |
CCDSi | CCDS89207.1 [Q8BIH0-1] |
RefSeqi | NP_766553.1, NM_172965.2 XP_006526014.1, XM_006525951.2 [Q8BIH0-1] XP_006526015.1, XM_006525952.3 [Q8BIH0-1] XP_006526017.1, XM_006525954.3 |
3D structure databases
AlphaFoldDBi | Q8BIH0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 234593, 9 interactors |
ComplexPortali | CPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant CPX-3443, SIN3A histone deacetylase complex CPX-3444, SIN3B histone deacetylase complex |
IntActi | Q8BIH0, 1 interactor |
MINTi | Q8BIH0 |
STRINGi | 10090.ENSMUSP00000136842 |
PTM databases
iPTMneti | Q8BIH0 |
PhosphoSitePlusi | Q8BIH0 |
Proteomic databases
EPDi | Q8BIH0 |
jPOSTi | Q8BIH0 |
MaxQBi | Q8BIH0 |
PaxDbi | Q8BIH0 |
PeptideAtlasi | Q8BIH0 |
PRIDEi | Q8BIH0 |
ProteomicsDBi | 257286 [Q8BIH0-1] 257287 [Q8BIH0-2] 257288 [Q8BIH0-3] |
Protocols and materials databases
Antibodypediai | 33473, 154 antibodies from 25 providers |
Genome annotation databases
Ensembli | ENSMUST00000235017; ENSMUSP00000157127; ENSMUSG00000024260 [Q8BIH0-1] |
GeneIDi | 269003 |
KEGGi | mmu:269003 |
UCSCi | uc008eib.1, mouse [Q8BIH0-1] uc008eie.1, mouse [Q8BIH0-2] |
Organism-specific databases
CTDi | 79595 |
MGIi | MGI:1919782, Sap130 |
VEuPathDBi | HostDB:ENSMUSG00000024260 |
Phylogenomic databases
eggNOGi | ENOG502QQ6P, Eukaryota |
GeneTreei | ENSGT00440000037733 |
InParanoidi | Q8BIH0 |
OrthoDBi | 242848at2759 |
PhylomeDBi | Q8BIH0 |
Miscellaneous databases
BioGRID-ORCSi | 269003, 19 hits in 77 CRISPR screens |
ChiTaRSi | Sap130, mouse |
PROi | PR:Q8BIH0 |
RNActi | Q8BIH0, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | Q8BIH0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR024137, His_deAcase_cplx_SAP130 IPR031963, SAP130_C |
PANTHERi | PTHR13497, PTHR13497, 1 hit |
Pfami | View protein in Pfam PF16014, SAP130_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SP130_MOUSE | |
Accessioni | Q8BIH0Primary (citable) accession number: Q8BIH0 Secondary accession number(s): Q6NZP5 Q9CSU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | May 25, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families