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Protein

F-box only protein 28

Gene

Fbxo28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 28
Gene namesi
Name:Fbxo28
Synonyms:D1Ertd578e, Kiaa0483
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1261890 Fbxo28

Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077251 – 368F-box only protein 28Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineBy similarity1
Modified residuei242PhosphoserineBy similarity1
Modified residuei270PhosphothreonineBy similarity1
Modified residuei344PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BIG4
MaxQBiQ8BIG4
PaxDbiQ8BIG4
PeptideAtlasiQ8BIG4
PRIDEiQ8BIG4

PTM databases

iPTMnetiQ8BIG4
PhosphoSitePlusiQ8BIG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000047539 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_FBXO28
ExpressionAtlasiQ8BIG4 baseline and differential
GenevisibleiQ8BIG4 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi212559, 2 interactors
STRINGi10090.ENSMUSP00000054718

Structurei

3D structure databases

ProteinModelPortaliQ8BIG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 109F-boxPROSITE-ProRule annotationAdd BLAST49

Phylogenomic databases

eggNOGiENOG410IJHM Eukaryota
ENOG410YPFN LUCA
GeneTreeiENSGT00390000002970
HOGENOMiHOG000048043
HOVERGENiHBG051573
InParanoidiQ8BIG4
KOiK10306
OMAiNRGFNLM
OrthoDBiEOG091G0DWO
PhylomeDBiQ8BIG4
TreeFamiTF324672

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039719 FBXO28
PANTHERiPTHR13252 PTHR13252, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BIG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASEERMA EEGGGGHGDG GSCSAAGSAQ RQPPAPPSQA PPPGSQAPAA
60 70 80 90 100
PALAPDHLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR
110 120 130 140 150
MLNQGFLKVE RFHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL
160 170 180 190 200
SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL
210 220 230 240 250
RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL
260 270 280 290 300
FSKQNPSRQE VTKLQQQVRT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
310 320 330 340 350
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGTSSGSGQ SEESPRKRRK
360
ATEAIDSLRK SKRLRNRK
Length:368
Mass (Da):40,978
Last modified:March 1, 2003 - v1
Checksum:i4EA50210B5AFF175
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX52A0A0A6YX52_MOUSE
F-box only protein 28
Fbxo28
126Annotation score:
A0A0A6YVQ6A0A0A6YVQ6_MOUSE
F-box only protein 28
Fbxo28
195Annotation score:
A0A0A6YX00A0A0A6YX00_MOUSE
F-box only protein 28
Fbxo28
143Annotation score:

Sequence cautioni

The sequence AAH55458 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356D → N in BAC36929 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122295 mRNA Translation: BAC65577.1
AK076211 mRNA Translation: BAC36256.1
AK077653 mRNA Translation: BAC36929.1
AK162188 mRNA Translation: BAE36778.1
BC055458 mRNA Translation: AAH55458.1 Different initiation.
BC094542 mRNA Translation: AAH94542.1
CCDSiCCDS15588.1
RefSeqiNP_780336.1, NM_175127.2
UniGeneiMm.30737

Genome annotation databases

EnsembliENSMUST00000051431; ENSMUSP00000054718; ENSMUSG00000047539
GeneIDi67948
KEGGimmu:67948
UCSCiuc007dyb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122295 mRNA Translation: BAC65577.1
AK076211 mRNA Translation: BAC36256.1
AK077653 mRNA Translation: BAC36929.1
AK162188 mRNA Translation: BAE36778.1
BC055458 mRNA Translation: AAH55458.1 Different initiation.
BC094542 mRNA Translation: AAH94542.1
CCDSiCCDS15588.1
RefSeqiNP_780336.1, NM_175127.2
UniGeneiMm.30737

3D structure databases

ProteinModelPortaliQ8BIG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212559, 2 interactors
STRINGi10090.ENSMUSP00000054718

PTM databases

iPTMnetiQ8BIG4
PhosphoSitePlusiQ8BIG4

Proteomic databases

EPDiQ8BIG4
MaxQBiQ8BIG4
PaxDbiQ8BIG4
PeptideAtlasiQ8BIG4
PRIDEiQ8BIG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051431; ENSMUSP00000054718; ENSMUSG00000047539
GeneIDi67948
KEGGimmu:67948
UCSCiuc007dyb.1 mouse

Organism-specific databases

CTDi23219
MGIiMGI:1261890 Fbxo28
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJHM Eukaryota
ENOG410YPFN LUCA
GeneTreeiENSGT00390000002970
HOGENOMiHOG000048043
HOVERGENiHBG051573
InParanoidiQ8BIG4
KOiK10306
OMAiNRGFNLM
OrthoDBiEOG091G0DWO
PhylomeDBiQ8BIG4
TreeFamiTF324672

Miscellaneous databases

ChiTaRSiFbxo28 mouse
PROiPR:Q8BIG4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047539 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_FBXO28
ExpressionAtlasiQ8BIG4 baseline and differential
GenevisibleiQ8BIG4 MM

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039719 FBXO28
PANTHERiPTHR13252 PTHR13252, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX28_MOUSE
AccessioniPrimary (citable) accession number: Q8BIG4
Secondary accession number(s): Q3TS97, Q7TMH9, Q8BIF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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