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UniProtKB - Q8BIF2 (RFOX3_MOUSE)

Entry version 133 (02 Dec 2020)
Sequence version 2 (02 Sep 2008)
Previous versions | rss
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Protein

RNA binding protein fox-1 homolog 3

Gene

Rbfox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).2 Publications

Caution

Initial characterization was derived from usage of a monoclonal antibody (A60) directed to an unknown protein called NeuN (PubMed:15605376 and PubMed:1483388), but later identified as RBFOX3.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: MGI
  • mRNA binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 3
Alternative name(s):
Fox-1 homolog C
Hexaribonucleotide-binding protein 3
Short name:
Fox-3
Neuronal nuclei antigen
Short name:
NeuN antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rbfox3
Synonyms:D11Bwg0517e, Hrnbp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:106368, Rbfox3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice have significantly reduced brain weight, impaired neurofilament expression and decreased white matter volume, but normal total body mass. They show increased susceptibility to seizures and reduced anxiety-related behaviors compared with wild type littermates, as well as defective hippocampal gene expression and deficits in synaptic transmission and plasticity in the dentate gyrus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492081 – 374RNA binding protein fox-1 homolog 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei223Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei223Omega-N-methylarginine; alternateCombined sources1
Modified residuei319Asymmetric dimethylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BIF2

PeptideAtlas

More...PeptideAtlasi		Q8BIF2

PRoteomics IDEntifications database

More...PRIDEi		Q8BIF2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BIF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BIF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in brain, including in cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord (at protein level). Not expressed in all neuronal cells within a region, in cerebellum, expression is absent in Purkinje cells (at protein level). Expressed in the retina in the ganglion cells and some cells in the inner nuclear layer, but absent from the photoreceptor cells and most cells in the inner nuclear layer (at protein level).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the neural tube, expressed as early as 9.5 dpc and expression is confined to the nervous system. By 12.5 dpc, can be found in the developing ventral horns and is also detected in the developing dorsal horns as well as in the dorsal root ganglion. Not detected in the ventricular zone, roof plate, floor plate or marginal zone (developing white matter). It is expressed from embryonic stage to adulthood.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid. Expression is up-regulated in P19 cells during neural differentiation upon retinoic acid treatment (at the protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025576, Expressed in lumbar subsegment of spinal cord and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8BIF2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BIF2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei100Interaction with RNABy similarity1
Sitei108Interaction with RNABy similarity1
Sitei109Interaction with RNABy similarity1
Sitei133Interaction with RNABy similarity1
Sitei138Interaction with RNABy similarity1
Sitei142Interaction with RNABy similarity1
Sitei166Interaction with RNABy similarity1
Sitei176Interaction with RNABy similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		206871, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8BIF2, 4 interactors

Molecular INTeraction database

More...MINTi		Q8BIF2

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000017576

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BIF2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BIF2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 175RRMPROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 58Pro-richAdd BLAST55
Compositional biasi242 – 295Pro-richAdd BLAST54

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0125, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048440_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BIF2

Identification of Orthologs from Complete Genome Data

More...OMAi		MLAWHPA

Database of Orthologous Groups

More...OrthoDBi		871288at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BIF2

TreeFam database of animal gene trees

More...TreeFami		TF315942

Family and domain databases

Conserved Domains Database

More...CDDi		cd12407, RRM_FOX1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025670, Fox-1_C_dom
IPR034237, FOX1_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR017325, RNA-bd_Fox-1
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12414, Fox-1_C, 1 hit
PF00076, RRM_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037932, Ataxin_2_bd_A2BP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BIF2-1) [UniParc]FASTAAdd to basket
Also known as: Fox3v1, Fox-3-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP PEHGMTLYTP 
        60         70         80         90        100
AQTHPEQPGT EASTQPIAGT QTVPQADEAA QTDNQQLHPS DPTEKQQPKR 
       110        120        130        140        150
LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFETSSD 
       160        170        180        190        200
ADRAREKLNG TIVEGRKIEV NNATARVMTN KKPGNPYANG WKLNPVVGTV 
       210        220        230        240        250
YGPEFYAVTS FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA APPPPPIPTY 
       260        270        280        290        300
GAALEQTLVK MPVPWAGLAP CPLPPQQTPE PAYPTSPAFP PLSCPFASRV 
       310        320        330        340        350
VYQDGFYGAE IYGGYAAYRY AQPAAATAAA YSDSYGRVYA AADPYHHTIG 
       360        370 
PTATYSIGTM ASLCRGGYSR FTPY
Length:374
Mass (Da):40,610
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC1454ADBCD2B810
GO
Isoform 2 (identifier: Q8BIF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-374: Missing.

Show »
Length:360
Mass (Da):39,051
Checksum:i789CC518B9F6CC92
GO
Isoform 3 (identifier: Q8BIF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-169: Missing.
     361-374: Missing.

Show »
Length:329
Mass (Da):35,638
Checksum:iBB7BA1021A5216D6
GO
Isoform 4 (identifier: Q8BIF2-4) [UniParc]FASTAAdd to basket
Also known as: Fox3v3

The sequence of this isoform differs from the canonical sequence as follows:
     253-299: Missing.
     361-374: Missing.

Show »
Length:313
Mass (Da):34,068
Checksum:i664AB23CC03D9B7A
GO
Isoform 5 (identifier: Q8BIF2-5) [UniParc]FASTAAdd to basket
Also known as: Fox3v2, Fox-3-S

The sequence of this isoform differs from the canonical sequence as follows:
     253-299: Missing.

Show »
Length:327
Mass (Da):35,628
Checksum:i2952868AD8C8E39A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A4W9A2A4W9_MOUSE
RNA-binding protein fox-1 homolog 3
Rbfox3
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZC11B7ZC11_MOUSE
RNA-binding protein fox-1 homolog 3
Rbfox3
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266A → V in BAC37531 (PubMed:19713214).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035219139 – 169Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_043949253 – 299Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_035220361 – 374Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ958310 mRNA Translation: ACY91937.1
FJ958311 mRNA Translation: ACY91938.1
AK079086 mRNA Translation: BAC37531.1
AK160816 mRNA Translation: BAE36031.1
AL591514 Genomic DNA No translation available.
AL591544 Genomic DNA No translation available.
AL591075 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34674.1
BC054403 mRNA Translation: AAH54403.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS25705.1 [Q8BIF2-4]
CCDS25706.1 [Q8BIF2-1]
CCDS70358.1 [Q8BIF2-3]
CCDS70360.1 [Q8BIF2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001020102.2, NM_001024931.2 [Q8BIF2-4]
NP_001034256.1, NM_001039167.1 [Q8BIF2-1]
NP_001034257.1, NM_001039168.1
NP_001272365.1, NM_001285436.1 [Q8BIF2-2]
NP_001272366.1, NM_001285437.1 [Q8BIF2-3]
NP_001272367.1, NM_001285438.1 [Q8BIF2-4]
XP_006533785.1, XM_006533722.3 [Q8BIF2-1]
XP_006533788.1, XM_006533725.3 [Q8BIF2-1]
XP_006533790.1, XM_006533727.3 [Q8BIF2-5]
XP_017170150.1, XM_017314661.1 [Q8BIF2-1]
XP_017170151.1, XM_017314662.1 [Q8BIF2-1]
XP_017170152.1, XM_017314663.1 [Q8BIF2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000017576; ENSMUSP00000017576; ENSMUSG00000025576 [Q8BIF2-1]
ENSMUST00000069343; ENSMUSP00000069598; ENSMUSG00000025576 [Q8BIF2-3]
ENSMUST00000103023; ENSMUSP00000099312; ENSMUSG00000025576 [Q8BIF2-4]
ENSMUST00000106278; ENSMUSP00000101885; ENSMUSG00000025576 [Q8BIF2-4]
ENSMUST00000117731; ENSMUSP00000113636; ENSMUSG00000025576 [Q8BIF2-2]
ENSMUST00000120061; ENSMUSP00000113987; ENSMUSG00000025576 [Q8BIF2-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		52897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:52897

UCSC genome browser

More...UCSCi		uc007mpl.1, mouse [Q8BIF2-4]
uc007mpm.1, mouse [Q8BIF2-5]
uc007mpn.1, mouse [Q8BIF2-1]
uc007mpp.1, mouse [Q8BIF2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ958310 mRNA Translation: ACY91937.1
FJ958311 mRNA Translation: ACY91938.1
AK079086 mRNA Translation: BAC37531.1
AK160816 mRNA Translation: BAE36031.1
AL591514 Genomic DNA No translation available.
AL591544 Genomic DNA No translation available.
AL591075 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34674.1
BC054403 mRNA Translation: AAH54403.1
CCDSiCCDS25705.1 [Q8BIF2-4]
CCDS25706.1 [Q8BIF2-1]
CCDS70358.1 [Q8BIF2-3]
CCDS70360.1 [Q8BIF2-2]
RefSeqiNP_001020102.2, NM_001024931.2 [Q8BIF2-4]
NP_001034256.1, NM_001039167.1 [Q8BIF2-1]
NP_001034257.1, NM_001039168.1
NP_001272365.1, NM_001285436.1 [Q8BIF2-2]
NP_001272366.1, NM_001285437.1 [Q8BIF2-3]
NP_001272367.1, NM_001285438.1 [Q8BIF2-4]
XP_006533785.1, XM_006533722.3 [Q8BIF2-1]
XP_006533788.1, XM_006533725.3 [Q8BIF2-1]
XP_006533790.1, XM_006533727.3 [Q8BIF2-5]
XP_017170150.1, XM_017314661.1 [Q8BIF2-1]
XP_017170151.1, XM_017314662.1 [Q8BIF2-1]
XP_017170152.1, XM_017314663.1 [Q8BIF2-2]

3D structure databases

SMRiQ8BIF2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi206871, 1 interactor
IntActiQ8BIF2, 4 interactors
MINTiQ8BIF2
STRINGi10090.ENSMUSP00000017576

PTM databases

iPTMnetiQ8BIF2
PhosphoSitePlusiQ8BIF2

Proteomic databases

PaxDbiQ8BIF2
PeptideAtlasiQ8BIF2
PRIDEiQ8BIF2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32645, 418 antibodies

Genome annotation databases

EnsembliENSMUST00000017576; ENSMUSP00000017576; ENSMUSG00000025576 [Q8BIF2-1]
ENSMUST00000069343; ENSMUSP00000069598; ENSMUSG00000025576 [Q8BIF2-3]
ENSMUST00000103023; ENSMUSP00000099312; ENSMUSG00000025576 [Q8BIF2-4]
ENSMUST00000106278; ENSMUSP00000101885; ENSMUSG00000025576 [Q8BIF2-4]
ENSMUST00000117731; ENSMUSP00000113636; ENSMUSG00000025576 [Q8BIF2-2]
ENSMUST00000120061; ENSMUSP00000113987; ENSMUSG00000025576 [Q8BIF2-5]
GeneIDi52897
KEGGimmu:52897
UCSCiuc007mpl.1, mouse [Q8BIF2-4]
uc007mpm.1, mouse [Q8BIF2-5]
uc007mpn.1, mouse [Q8BIF2-1]
uc007mpp.1, mouse [Q8BIF2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146713
MGIiMGI:106368, Rbfox3

Phylogenomic databases

eggNOGiKOG0125, Eukaryota
GeneTreeiENSGT00940000159924
HOGENOMiCLU_048440_0_0_1
InParanoidiQ8BIF2
OMAiMLAWHPA
OrthoDBi871288at2759
PhylomeDBiQ8BIF2
TreeFamiTF315942

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		52897, 1 hit in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rbfox3, mouse

Protein Ontology

More...PROi		PR:Q8BIF2
RNActiQ8BIF2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025576, Expressed in lumbar subsegment of spinal cord and 157 other tissues
ExpressionAtlasiQ8BIF2, baseline and differential
GenevisibleiQ8BIF2, MM

Family and domain databases

CDDicd12407, RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670, Fox-1_C_dom
IPR034237, FOX1_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR017325, RNA-bd_Fox-1
IPR000504, RRM_dom
PfamiView protein in Pfam
PF12414, Fox-1_C, 1 hit
PF00076, RRM_1, 1 hit
PIRSFiPIRSF037932, Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFOX3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BIF2
Secondary accession number(s): A2A4W7
, A2A4W8, B7ZC12, B7ZC13, D1GI07, Q3TUE0, Q7TQI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 2, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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